High lymphatic vessel density correlates with overexpression of VEGF-C in gastric cancer.

abstract：:Cancer stimulates macrophage infiltration and encourages angiogenesis, which is necessary for tumor growth and invasion. It seems, that the influence of photodynamic therapy (PDT) on immune cells and immune regulators plays a crucial role in this process. In order to study this effect, the influence of δ-aminolevulini...

journal_title：Oncology reports

authors： Kawczyk-Krupka A,Czuba Z,Szliszka E,Król W,Sieroń A

更新日期：2011-07-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been widely accepted as critical molecules playing regulatory roles in various biological processes, including proliferation, differentiation and apoptotic/ferroptotic/necrotic cell death. Emerging evidence suggests that ROS may be involved in the induction of epithelial‑to‑mesenchym...

journal_title：Oncology reports

authors： Peng G,Tang Z,Xiang Y,Chen W

更新日期：2019-02-01 00:00:00

abstract：:The components of the Wnt-signaling pathway are mutated in tumors, but the relationship between these components and cervical cancer has not been elucidated. In this study, we used immunohistochemistry, single strand confirmation polymorphism (SSCP) and direct sequencing methods to analyze the mutation and protein exp...

journal_title：Oncology reports

authors： Su TH,Chang JG,Yeh KT,Lin TH,Lee TP,Chen JC,Lin CC

更新日期：2003-09-01 00:00:00

abstract：:microRNAs are an abundant class of short endogenous non-coding RNAs that function as important regulators of multiple target genes and participate in diverse biological roles in carcinogenesis. However, the role of miR-7 in lung cancer remains unclear and requires further elucidation. In the present study, we found a ...

journal_title：Oncology reports

authors： Li J,Zheng Y,Sun G,Xiong S

更新日期：2014-12-01 00:00:00

abstract：:v-ets erythroblastosis virus E26 oncogene homolog 1 (ETS-1) plays crucial roles in a spectrum of malignancies. ETS-1 has gained attention in cancer research for its importance in cell migration, invasion and proliferation. In the present study, we focused on the effect of ETS-1 on epithelial-mesenchymal transition (EM...

journal_title：Oncology reports

authors： Li C,Wang Z,Chen Y,Zhou M,Zhang H,Chen R,Shi F,Wang C,Rui Z

更新日期：2015-02-01 00:00:00

abstract：:Loss of E-cadherin expression and gain of N-cadherin expression ('cadherin switch') is shown to be characteristic in epithelial to mesenchymal transition (EMT), a mechanism associated with cancer progression. Furthermore, the prognostic role of P-cadherin in different cancers is controversial. The aim of this study wa...

journal_title：Oncology reports

authors： Jäger T,Becker M,Eisenhardt A,Tilki D,Tötsch M,Schmid KW,Romics I,Rübben H,Ergün S,Szarvas T

更新日期：2010-04-01 00:00:00

abstract：:The development and progression of epithelial cancers are the result of an imbalance in signals promoting and inhibiting cellular proliferation and apoptosis. The aim of this study is to evaluate the expression of cell-cycle and apoptosis regulators and correlate them with clinical outcome in the most frequent carcino...

journal_title：Oncology reports

authors： Abdulkader I,Sánchez L,Cameselle-Teijeiro J,Gude F,Chávez JE,López-López R,Forteza J,Fraga M

更新日期：2005-12-01 00:00:00

abstract：:Hepatocellular carcinoma is the most common type of liver cancer. The risk of hepatocellular carcinoma for type 2 diabetic patients is greater than that for non-diabetic individuals although the mechanism is unclear. The cancer suppressor resveratrol inhibits cancer cell proliferation partly through the STAT3 signalin...

journal_title：Oncology reports

authors： Li Y,Zhu W,Li J,Liu M,Wei M

更新日期：2013-12-01 00:00:00

abstract：:Histone deacetylases (HDACs) have been shown to play important roles in the regulation of chromatin remodeling by histone deacetylation, and their expression is induced in several types of cancer. In addition, they are known to be associated with resistance to anticancer drugs. However, the relevance of HDAC4 in chemo...

journal_title：Oncology reports

authors： Yu SL,Lee DC,Son JW,Park CG,Lee HY,Kang J

更新日期：2013-09-01 00:00:00

abstract：:Long non‑coding RNA (lncRNA) forkhead box P4 antisense RNA 1 (FOXP4‑AS1) has been determined to function as an oncogene in various types of cancer. However, the biological function and the underlying mechanisms of FOXP4‑AS1 in mantle cell lymphoma (MCL) remain to be uncovered. The expression and the associated clinico...

journal_title：Oncology reports

authors： Tao HF,Shen JX,Hou ZW,Chen SY,Su YZ,Fang JL

更新日期：2020-12-11 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) and its metabolite prostaglandin E2 (PGE2) can potentially affect most of the events in cancer development, including promotion of proliferation, resistance to apoptosis, angiogenesis, immune suppression and invasion. However, worldwide attention has predominantly centered on the cardiovascula...

journal_title：Oncology reports

authors： Li M,Tan SY,Wang XF

更新日期：2014-12-01 00:00:00

abstract：:Endocannabinoids and ceramides have demonstrated growth inhibition, cell death induction and pro-apoptotic activity in cancer research. In the present study, we describe the profiles of two major endocannabinoids, ceramides, free fatty acids and relevant metabolic enzymes in 47 pairs of human colorectal cancer tissues...

journal_title：Oncology reports

authors： Chen L,Chen H,Li Y,Li L,Qiu Y,Ren J

更新日期：2015-07-01 00:00:00

abstract：:The long-term effort in investigating chemical methods to eliminate only cancer cells has improved our knowledge and has led to the development of new drugs. The targets for cancer treatment may be large polymeric molecules such as DNA or microtubules as well as regulatory pathways for tumor development and cell survi...

journal_title：Oncology reports

authors： Stathopoulos GP

更新日期：2002-11-01 00:00:00

abstract：:We have recently noticed an accidental error in part of a figure which appeared in the above‑mentioned article. In Fig. 3A, the image for the HGC27‑pEF, 15 h panel was mistakenly replicated as the HGC27‑KD, 0 h panel in the same figure, and the AGS‑pEF, 15 h and AGS KD, 0 h panels were mistakenly switched with each ot...

journal_title：Oncology reports

authors： Gao XY,Li L,Wang XH,Wen XZ,Ji K,Ye L,Cai J,Jiang WG,Ji JF

更新日期：2018-04-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in tumor invasion, but their prognostic significance is still under discussion. We set out to analyze the epithelial and stromal expression of MMP-2, MMP-7, MMP-9, MT1-MMP, TIMP-1 and TIMP-2 in advanced epithelial ovarian cancers and to ...

journal_title：Oncology reports

authors： Brun JL,Cortez A,Lesieur B,Uzan S,Rouzier R,Daraï E

更新日期：2012-04-01 00:00:00

abstract：:The objective of the study was to investigate the dynamic changes of cortisol and soluble TNF-alpha p-55 and p-75 receptors in serum of advanced cancer patients during 24 h. The examined group consisted of 42 patients suffering from advanced gastrointestinal neoplasms (colorectal, gastric and pancreatic cancer). Serum...

journal_title：Oncology reports

authors： Zubelewicz-Szkodzinska B,Muc-Wierzgon M,Wierzgon J,Brodziak A

更新日期：2001-01-01 00:00:00

abstract：:Following the publication of this paper, it was drawn to the authors' attention by an interested reader that certain of the tumours featured in Fig. 6A of the above paper were strikingly similar to those featured in Fig. 8A of an article appearing in International Journal of Oncology (Fan F-Y, Deng R, Yi H, Sun H-P, Z...

journal_title：Oncology reports

authors： Zhang L,Liang X,Li Y

更新日期：2021-01-01 00:00:00

abstract：:The purpose of this study was to investigate the radioprotective effect of HGFs (GM-CSF, IL-3 and SCF) in irradiated human peripheral blood mononuclear cells (PBMCs) in vitro, and the survival effect of lethally irradiated C3H mice in vivo. The irradiation of human PBMCs using a (137)Cs irradiator showed a dose-depend...

journal_title：Oncology reports

authors： Kim JY,Oh SJ,Park HK,Yoon JS,Kim ES,Kim ES,Kim CS,Lee YY,Kim BK

更新日期：2005-06-01 00:00:00

abstract：:Depressed and flat surface lesions are not easy to identify with routine colonoscopies during screening for colorectal cancer (CRC). Identifying clinically relevant genes that influence tumor shape could be useful when screening for the presence of depressed lesions. Total RNA was extracted from tumor cells collected ...

journal_title：Oncology reports

authors： Kida H,Takano Y,Yamamoto K,Mori M,Yanaga K,Tanaka J,Kudo SE,Mimori K

更新日期：2014-08-01 00:00:00

abstract：:Hyperplasia suppressor gene (HSG) is a novel gene that markedly suppresses the mitogenetic stimuli or injury mediated by vascular smooth muscle cell proliferation. Herein we provide experimental evidence to show that HSG can also play a key role in tumor proliferation. Down-regulation of HSG protein in hepatocellular ...

journal_title：Oncology reports

authors： Wang W,Zhu F,Wang S,Wei J,Jia C,Zhang Y,Zhou L,Xie H,Zheng S

更新日期：2010-07-01 00:00:00

abstract：:The MSH6 gene is one of the mismatch repair genes involved in Lynch syndrome and its mutations account for 10-20% of Lynch syndrome. Although previous studies suggested that the difference of the geographical region affects the clinical phenotype of Lynch syndrome, there has been no report on the detailed features of ...

journal_title：Oncology reports

authors： Terui H,Tachikawa T,Kakuta M,Nishimura Y,Yatsuoka T,Yamaguchi K,Yura K,Akagi K

更新日期：2013-12-01 00:00:00

abstract：:Nuclear factor (NF)-κB is the key transcription factor involved in the inflammatory responses, and its activation aggravates tumors. Peptidoglycan (PGN), a main cell wall component of Gram-positive bacteria, stimulates Toll-like receptor 2 (TLR-2) and activates a number of inflammat...

journal_title：Oncology reports

authors： Echigo R,Sugimoto N,Yachie A,Ohno-Shosaku T

更新日期：2012-10-01 00:00:00

abstract：:Regulator of G protein signaling 5 (RGS5) belongs to the R4 subfamily of RGS proteins, a family of GTPase activating proteins, which is dynamically regulated in various biological processes including blood pressure regulation, smooth muscle cell pathology, fat metabolism and tumor angiogenesis. Low-expression of RGS5 ...

journal_title：Oncology reports

authors： Xu Z,Zuo Y,Wang J,Yu Z,Peng F,Chen Y,Dong Y,Hu X,Zhou Q,Ma H,Bao Y,Chen M

更新日期：2015-06-01 00:00:00

abstract：:A phase II trial of vinorelbine and low dose prednisone in hormone-refractory metastatic prostate cancer was conducted in order to investigate its safety, efficacy and impact on quality of life. Vinorelbine was administered at the dose of 25 mg/m(2) i.v. weekly for 12 weeks and then biweekly, along with 10 mg of daily...

journal_title：Oncology reports

authors： Robles C,Furst AJ,Sriratana P,Lai S,Chua L,Donnelly E,Solomon J,Sundaram M,Feun L,Savaraj N

更新日期：2003-07-01 00:00:00

abstract：:Tetraarsenic oxide (As4O6, TAO) is a new arsenic compound that inhibits cell growth and induces apoptosis in human cervical cancer cell lines. In the present study, we report that the growth of tumor cells (CaSki) was inhibited by treatment with TAO alone or in combination with cisp...

journal_title：Oncology reports

authors： Byun JM,Jeong DH,Lee DS,Kim JR,Park SG,Kang MS,Kim YN,Lee KB,Sung MS,Kim KT

更新日期：2013-04-01 00:00:00

abstract：:New therapeutic strategies are needed for colorectal cancer (CRC) treatment. MicroRNAs are involved in cancer‑pertinent cellular processes, including chemoresistance. As miR‑302a is an embryonic stem cell‑specific microRNA, studies on miR‑302a have focused on its role in human stem cells. Studies analyzing miR‑302 fun...

journal_title：Oncology reports

authors： Liu N,Li J,Zhao Z,Han J,Jiang T,Chen Y,Hou N,Huang C

更新日期：2017-01-01 00:00:00

abstract：:DNA damage sensor proteins are recognized as upstream components of the DNA damage checkpoint signaling pathway and are required for cell cycle control and the induction of apoptosis. hRad9 plays an important role as an upstream regulator of checkpoint signaling. In our previous studies, we confirmed the significant a...

journal_title：Oncology reports

authors： Yuki T,Maniwa Y,Doi T,Okada K,Nishio W,Hayashi Y,Okita Y

更新日期：2008-11-01 00:00:00

abstract：:Selenium has been associated with anticancer activity by affecting multiple cellular processes. We reasoned that the simultaneous modulation of multiple radioresponse regulators by selenium should increase radiosensitivity if selenium is combined with radiation in cancer therapy. Therefore, we explored the possibility...

journal_title：Oncology reports

authors： Shin SH,Yoon MJ,Kim M,Kim JI,Lee SJ,Lee YS,Bae S

更新日期：2007-01-01 00:00:00

abstract：:The molecular mechanisms underlying the biological effects of carbon ions are unclear. The aim of this study was to explore the Wnt/β‑catenin pathway in regulating carbon ion (12C6+) radiation‑induced cellular toxicity. HLY78 is a Wnt‑specific small molecular modulator, whose effects on 12C6+ radiation‑induced damage ...

journal_title：Oncology reports

authors： Si J,Zhang J,Gan L,Guo M,Xie Y,Di C,Sun C,Wang F,Yan J,Zhang H

更新日期：2020-07-01 00:00:00

abstract：:Frequent frameshift mutations in the DNA mismatch repair genes hMSH3, and hMSH6, have been reported in colorectal and endometrial cancers with microsatellite instability, however, it is unclear whether they are similarly altered in ovarian endometrioid carcinoma. In this study, we examined frequency of frameshift muta...

journal_title：Oncology reports

authors： Albarracin CT,Silva EG,Malpica A,Luthra R,Liu J

更新日期：2004-12-01 00:00:00