lncRNA FOXP4‑AS1 predicts poor prognosis and accelerates the progression of mantle cell lymphoma through the miR‑423‑5p/NACC1 pathway.

abstract：:Androgen receptor (AR) expression in prostate cancer (CaP) cells varies due to the multiple changes including epigenetic modifications such as DNA methylation and histone deacetylation. DNA methyltransferase and histone deacetylase inhibitors are promising for the treatment of CaP. The aim of our study was to analyze ...

journal_title：Oncology reports

authors： Fialova B,Smesny Trtkova K,Paskova L,Langova K,Kolar Z

更新日期：2013-05-01 00:00:00

abstract：:The association between inflammatory infiltration, fibrosis, necrosis and mucinous content in rectal cancers, and their relationship to preoperative radiotherapy (RT) clinicopathological and biological factors (p53, apoptosis and Cox-2) is not fully characterised. We analysed these histopathological parameters and the...

journal_title：Oncology reports

authors： Knutsen A,Adell G,Sun XF

更新日期：2006-08-01 00:00:00

abstract：:Circulating tumor cells (CTCs) or CTC clusters are considered as suitable and relevant targets for liquid biopsy as they more accurately indicate cancer progression, the therapeutic effects of treatment and allows for monitoring of cancer metastasis in real‑time. Among the various methods for isolating CTCs, size‑base...

journal_title：Oncology reports

authors： Xiang A,Xue M,Ren F,Wang L,Ye Z,Li D,Ji Q,Ji G,Lu Z

更新日期：2020-06-01 00:00:00

abstract：:This study was mainly focused on the development of a dual-ligand liposomal delivery system for targeting the delivery of paclitaxel (PTX) to lung cancer. The specific ligand peptide HAIYPRH (T7) and the cationic cell-penetrating peptide TAT were connected with phospholipid via a polyethylene glycol (PEG) spacer to pr...

journal_title：Oncology reports

authors： Wang RH,Cao HM,Tian ZJ,Jin B,Wang Q,Ma H,Wu J

更新日期：2015-02-01 00:00:00

abstract：:Homeobox containing 1 (HMBOX1) is a novel transcription repressor that is significantly downregulated in human liver cancer tissues and cell lines, but the exact biological function of HMBOX1 in liver cancer is still unknown. We observed a negative association between HMBOX1 expression level and the clinical stages of...

journal_title：Oncology reports

authors： Zhao H,Jia H,Han Q,Zhang J

更新日期：2018-09-01 00:00:00

abstract：:Differentiation of breast cancer has been receiving increasing attention in attempts to minimize the numbers of excisional biopsies for benign tumors. Doppler spectral parameters, such as peak systolic velocity (PSV) and pulsatility index (PI), have been used but these are unable to differentiate breast cancers and be...

journal_title：Oncology reports

authors： Mesaki K,Hisa N,Kubota K,Hisa N,Ogawa Y,Yoshida S

更新日期：2003-07-01 00:00:00

abstract：:We conducted a study to determine whether the expression levels of genes in tumors were correlated with the survival of patients after complete resection of non-small cell lung cancer (NSCLC). The expression levels of 1176 genes in resected tumor specimens from 28 patients were analyzed using the Atlastrade mark Human...

journal_title：Oncology reports

authors： Oshita F,Sekiyama A,Ito H,Kameda Y,Miyagi Y

更新日期：2006-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence in males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation with regard to sex factors affecting disease progression. In the present stud...

journal_title：Oncology reports

authors： Wu Y,Yao N,Feng Y,Tian Z,Yang Y,Zhao Y

更新日期：2019-09-01 00:00:00

abstract：:To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the co...

journal_title：Oncology reports

authors： Ge MH,Chen C,Xu JJ,Ling ZQ

更新日期：2011-08-01 00:00:00

abstract：:The classical pathway involving receptor activator of nuclear factor‑κB (RANK) and its ligand (RANKL) induces the activation of osteoclasts and the migration of a variety of tumor cells, including breast and lung cancer. In our previous study, the expression of RANK was identified on the surface of gastric cancer cell...

journal_title：Oncology reports

authors： Wang Y,Song Y,Che X,Zhang L,Wang Q,Zhang X,Qu J,Li Z,Xu L,Zhang Y,Fan Y,Hou K,Liu Y,Qu X

更新日期：2018-09-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) families are receptors for ligands that initiate extracellular or intracellular signaling, such as lipopolysaccharides (LPS). It has been reported that TLR4 activation resulted in the upregulation of a coordinated set of proinflammatory mediators and inhibition of matrix expression in the i...

journal_title：Oncology reports

authors： Zhang Q,Weng Y,Jiang Y,Zhao S,Zhou D,Xu N

更新日期：2018-08-01 00:00:00

abstract：:To evaluate the prognostic values of different protein expression in the progression of squamous cell carcinoma of the head and neck (SCCHN) patients, we conducted immunohistochemical (IHC) analysis in tissue samples of different patients enrolled on SWOG protocol S0420. S0420 was a phase II trial to evaluate the effi...

journal_title：Oncology reports

authors： Mehta S,Moon J,Hashmi M,Leblanc M,Huang CH,Rinehart E,Wolf GT,Urba SG,Banerjee SK,Williamson S

更新日期：2013-06-01 00:00:00

abstract：:The tumor necrosis factor receptor (TNFR)-associated factor 4 (TRAF4) is a member of TRAF family proteins that act as major signal transducers of the TNF receptor and the interleukin-1 receptor/Toll-like receptor (IL-1R/TLR) superfamily. TRAF4 has been reported to be overexpressed in various human cancers. However, th...

journal_title：Oncology reports

authors： Ahmed F,Shiraishi T,Vessella RL,Kulkarni P

更新日期：2013-12-01 00:00:00

abstract：:In the development and progression of cancer, tumor suppressor genes may be silenced by mechanisms such as methylation. Thus the discovery of new genes silenced by methylation may uncover new tumor suppressor genes, and improve our understanding of cancer biology. In this study we investigated the methylation of 19 ge...

journal_title：Oncology reports

authors： Tsunoda S,Smith E,De Young NJ,Wang X,Tian ZQ,Liu JF,Jamieson GG,Drew PA

更新日期：2009-04-01 00:00:00

abstract：:Treatment of patients affected by advanced or inoperable GIST was revolutionized by the use of the tyrosine kinase inhibitors. Despite the fact that most patients have a good durable response of disease, they develop a resistance to treatments after a median time of 24 months. The acquired resistance is an emerging as...

journal_title：Oncology reports

authors： Maleddu A,Pantaleo MA,Nannini M,Di Battista M,Saponara M,Lolli C,Biasco G

更新日期：2009-06-01 00:00:00

abstract：:Although the impact of vascular endothelial growth factor (VEGF) is clearly established in advanced prostate cancer (PCa), its role in localized PCa remains to be determined. The aim of our study was to analyse the plasma levels of VEGF-A and the expression of VEGF-A in prostatic tissue in a population of patients wit...

journal_title：Oncology reports

authors： Peyromaure M,Badoual C,Camparo P,Grabar S,Goulvestre C,Fulla Y,Vieillefond A,Mao K,Dinh-Xuan AT

更新日期：2007-07-01 00:00:00

abstract：:Quercetin, a naturally occurring flavonoid abundant in fruits and vegetables, has been demonstrated as a multipotent bioflavonoid with great potential for the prevention and treatment of cancer. Apoptosis is thought to be an important response to most chemotherapeutic agents in leukemia cells. However, the underlying ...

journal_title：Oncology reports

authors： Lee WJ,Chen YR,Tseng TH

更新日期：2011-02-01 00:00:00

abstract：:The ING1 gene is involved in the regulation of the cell cycle, senescence, and apoptosis and is a novel candidate tumor suppressor gene. ING2, another gene in the ING family, was identified and cloned. The functions of ING1 and ING2 largely depend on the activity of p53. To determine whether an alteration in these gen...

journal_title：Oncology reports

authors： Okano T,Gemma A,Hosoya Y,Hosomi Y,Nara M,Kokubo Y,Yoshimura A,Shibuya M,Nagashima M,Harris CC,Kudoh S

更新日期：2006-03-01 00:00:00

abstract：:H-, K- and N-ras gene mutations were analyzed in lung cancer from Thai patients. Thirteen out of 58 cases (22%) harbored the mutations. Ten cases showed K-ras gene mutations at codon 12, 1 case presented a mutation at codon 13 and another case exhibited a mutation at codon 63. Silent mutations of N-ras gene in codons ...

journal_title：Oncology reports

authors： Petmitr S,Wongsommart D,Chaksangchaichot P,Pakeetoot T,Sutinont P,Sirivaidyapong P,Karalak A

更新日期：2003-09-01 00:00:00

abstract：:Aberrant expression of microRNAs has been identified as regulators of biological processes of hepatocellular carcinoma (HCC) by negatively regulating protein-coding mRNAs. Several studies have demonstrated that miR-638 expression was dysregulated in various human cancers. However, the clinical significance and underly...

journal_title：Oncology reports

authors： Zhang Y,Zhang D,Jiang J,Dong L

更新日期：2017-01-01 00:00:00

abstract：:In this study the performance of various intelligent methodologies is compared in the task of pap-smear diagnosis. The selected intelligent methodologies are briefly described and explained, and then, the acquired results are presented and discussed for their comprehensibility and usefulness to medical staff, either f...

journal_title：Oncology reports

authors： Dounias G,Bjerregaard B,Jantzen J,Tsakonas A,Ampazis N,Panagi G,Panourgias E

更新日期：2006-01-01 00:00:00

abstract：:The present study aimed to explore the relationship between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‑TKIs) and the expression of the cancer stem cell (CSC)‑related markers. Specimens of 72 cases of lung adenocarcinoma with significantly different therapeutic effects of the firs...

journal_title：Oncology reports

authors： Hu F,Li C,Zheng X,Zhang H,Shen Y,Zhou L,Yang X,Han B,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:Miconazole (MIC), an antifungal agent, diplays anti‑tumorigenic activity in various types of human cancers, including bladder cancer, yet its mechanism of antitumor action is not well understood. In the present study, we demonstrated that, in a cell viability assay, MIC had a cytotoxic effect on human T24, J82 and TSG...

journal_title：Oncology reports

authors： Yuan SY,Shiau MY,Ou YC,Huang YC,Chen CC,Cheng CL,Chiu KY,Wang SS,Tsai KJ

更新日期：2017-06-01 00:00:00

abstract：:Resistance to etoposide has been associated with the overexpression of P-glycoprotein and MRP1 in human tumor cells. However, the role of BCRP in resistance to etoposide has not been clearly established, especially the significance of arginine 482 mutations in drug transport (cellul...

journal_title：Oncology reports

authors： Eddabra L,Wenner T,El Btaouri H,Baranek T,Madoulet C,Cornillet-Lefebvre P,Morjani H

更新日期：2012-01-01 00:00:00

abstract：:T cell-mediated cell immunity is the main anti-tumor immunity in which the effector T cells need specific antigen and costimulatory signals. One of the vaccines applied in tumor immunotherapy is the gene-modified tumor cell vaccine. One potential method to increase cell epitope density is to link the antigen with the ...

journal_title：Oncology reports

authors： Fang L,Wang K,Liu X,Zhang L,Zhang X,Qian L,Lu J,Qian G,Ge S

更新日期：2008-06-01 00:00:00

abstract：:P5, which is a member of the protein disulfide isomerase family, possesses isomerase and chaperone activity in vitro; however, the physiological functions of this enzyme in cells remain unclear. To understand the important roles of P5 in cancer cells, the present study examined its expression on the surface of normal ...

journal_title：Oncology reports

authors： Horibe T,Torisawa A,Masuda Y,Kawakami K

更新日期：2019-02-01 00:00:00

abstract：:Arginine is a critical amino acid in specific cancer types including hepatocellular carcinoma (HCC) and melanoma. Novel molecular mechanisms and therapeutic targets in arginine metabolism-mediated cancer formation await further identification. Our laboratory has previously demonstrated that arginine metabolic enzyme a...

journal_title：Oncology reports

authors： Hung YH,Huang HL,Chen WC,Yen MC,Cho CY,Weng TY,Wang CY,Chen YL,Chen LT,Lai MD

更新日期：2017-02-01 00:00:00

abstract：:Mammary small cell carcinoma (SmCC) is a very rare neoplasm with a poor prognosis compared with other invasive carcinomas. We studied the histological and immunohistochemical profiles of two cases of mammary SmCC, and compared them with those of five cases of carcinoma with endocrine features (CEF) and five cases of i...

journal_title：Oncology reports

authors： Yamamoto J,Ohshima K,Nabeshima K,Ikeda S,Iwasaki H,Kikuchi M

更新日期：2004-04-01 00:00:00

abstract：:Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Frequent metastasis and recurrence are the main reasons for the poor prognosis of PC patients. Thus, the discovery of new biomarkers and wider insights into the mechanisms involved in pancreatic tumorigenesis and metastasis is cruc...

journal_title：Oncology reports

authors： Ma D,Jing X,Shen B,Liu X,Cheng X,Wang B,Fu Z,Peng C,Qiu W

更新日期：2016-08-01 00:00:00

abstract：:The identification of the specific molecular targets, which underlie liver carcinogenesis is essential for the establishment of an effective strategy for the prevention and/or treatment of hepatocellular carcinomas (HCCs). We previously found that a malfunction of RXRalpha due to its aberrant phosphorylation was assoc...

journal_title：Oncology reports

authors： Ando N,Shimizu M,Okuno M,Matsushima-Nishiwaki R,Tsurumi H,Tanaka T,Moriwaki H

更新日期：2007-10-01 00:00:00