Overexpression of miR-140-5p inhibits lipopolysaccharide-induced human intervertebral disc inflammation and degeneration by downregulating toll-like receptor 4.

abstract：:Human telomerase reverse transcriptase (hTERT) plays an important role in the development of tumors and has been investigated as a potent target for anticancer therapy. In the present study, we constructed a recombinant adenovirus, Ad-EGFP-C197 which was capable of expressing COOH‑terminal polypeptide of hTERT (amino ...

journal_title：Oncology reports

authors： Wu X,Chen J,Cao Y,Xie B,Li H,Zhou P,Qiu Y,Pang J

更新日期：2015-12-01 00:00:00

abstract：:Breast cancer is the most common malignancy in women, and metastasis is the leading cause of death in breast cancer patients. Previous studies have shown that epithelial‑mesenchymal transition (EMT) is involved in the metastasis of breast cancer, but the metabolic reprogramming and regulation mechanisms involved in th...

journal_title：Oncology reports

authors： Liu QQ,Huo HY,Ao S,Liu T,Yang L,Fei ZY,Zhang ZQ,Ding L,Cui QH,Lin J,Yu M,Xiong W

更新日期：2020-09-01 00:00:00

abstract：:Treatment of patients affected by advanced or inoperable GIST was revolutionized by the use of the tyrosine kinase inhibitors. Despite the fact that most patients have a good durable response of disease, they develop a resistance to treatments after a median time of 24 months. The acquired resistance is an emerging as...

journal_title：Oncology reports

authors： Maleddu A,Pantaleo MA,Nannini M,Di Battista M,Saponara M,Lolli C,Biasco G

更新日期：2009-06-01 00:00:00

abstract：:MicroRNA-154 (miR-154) has been identified as a tumor suppressor in several types of human cancers; however, its clinical significance and function in human hepatocellular carcinoma (HCC) remain unclear. The aim of the present study was to analyze the clinical significance and cellular function of miR-154 in HCC patie...

journal_title：Oncology reports

authors： Pang X,Huang K,Zhang Q,Zhang Y,Niu J

更新日期：2015-12-01 00:00:00

abstract：:The aberrant expression of miR107‑5p is closely related to the development of several types of human cancers. However, the role of miR‑107‑5p in endometrial carcinoma (EC) has not been fully confirmed. In the present study, we aimed to explore the function of miR‑107‑5p in EC carcinogenesis. EC samples and normal endo...

journal_title：Oncology reports

authors： Bao W,Zhang Y,Li S,Fan Q,Qiu M,Wang Y,Li Y,Ji X,Yang Y,Sang Z,Xu W,Yang Y,Wu S,Zhu Y

更新日期：2019-03-01 00:00:00

abstract：:The molecular mechanisms underlying the biological effects of carbon ions are unclear. The aim of this study was to explore the Wnt/β‑catenin pathway in regulating carbon ion (12C6+) radiation‑induced cellular toxicity. HLY78 is a Wnt‑specific small molecular modulator, whose effects on 12C6+ radiation‑induced damage ...

journal_title：Oncology reports

authors： Si J,Zhang J,Gan L,Guo M,Xie Y,Di C,Sun C,Wang F,Yan J,Zhang H

更新日期：2020-07-01 00:00:00

abstract：:To evaluate the prognostic values of different protein expression in the progression of squamous cell carcinoma of the head and neck (SCCHN) patients, we conducted immunohistochemical (IHC) analysis in tissue samples of different patients enrolled on SWOG protocol S0420. S0420 was a phase II trial to evaluate the effi...

journal_title：Oncology reports

authors： Mehta S,Moon J,Hashmi M,Leblanc M,Huang CH,Rinehart E,Wolf GT,Urba SG,Banerjee SK,Williamson S

更新日期：2013-06-01 00:00:00

abstract：:Ginsenoside is known to have potential cancer-preventive activities. The major active components in red ginseng consist of a variety of ginsenosides including Rg3, Rg5 and Rk1, each of which has different pharmacological activities. Among these, Rg3 has been reported to exert anticancer activities through inhibition o...

journal_title：Oncology reports

authors： Choi YJ,Lee HJ,Kang DW,Han IH,Choi BK,Cho WH

更新日期：2013-09-01 00:00:00

abstract：:Colorectal cancer (CRC) is a common malignancy globally. The aim of the present study was to explore the role and the working mechanism of circular RNA NADPH oxidase 4 (circNOX4; circBase ID, hsa_circ_0023990) in CRC. Reverse transcription‑quantitative (RT‑q)PCR was used to examine the expression of circNOX4, NOX4 mRN...

journal_title：Oncology reports

authors： Wang X,Tao G,Huang D,Liang S,Zheng D

更新日期：2020-11-01 00:00:00

abstract：:Numerous studies have demonstrated that triptolide induces cell cycle arrest and apoptosis in human cancer cell lines. However, triptolide-induced DNA damage and inhibition of DNA repair gene expression in human skin cancer cells has not previously been reported. We sought the effects of triptolide on DNA damage and a...

journal_title：Oncology reports

authors： Chueh FS,Chen YL,Hsu SC,Yang JS,Hsueh SC,Ji BC,Lu HF,Chung JG

更新日期：2013-02-01 00:00:00

abstract：:Sunitinib is a novel, multi-targeted receptor tyrosine kinase inhibitor, which has demonstrated evidence of improved survival when compared to interferon (IFN)-alpha in patients with metastatic renal cell carcinoma (RCC). Recently published National Institute for Health and Clinical Excellence guidance recommends suni...

journal_title：Oncology reports

authors： Ansari J,Fatima A,Fernando K,Collins S,James ND,Porfiri E

更新日期：2010-08-01 00:00:00

abstract：:The authors of the above article drew to our attention that they had identified three instances of data overlapping between data panels, suggesting that data purportedly showing results obtained under different experimental conditions had been derived from the same original source. Comparing between the two figures, t...

journal_title：Oncology reports

authors： Ji CX,Fan YH,Xu F,Lv SG,Ye MH,Wu MJ,Zh XG,Wu L

更新日期：2020-11-01 00:00:00

abstract：:The expression of CDR1‑AS, a representative circular RNA, is closely linked with poor prognosis in gastrointestinal cancers, such as colon, liver, and pancreatic cancers. Although it is well known that CDR1‑AS antagonizes microRNA‑7 function through its sequence similarities in the brain, its biological function and l...

journal_title：Oncology reports

authors： Tanaka E,Miyakawa Y,Kishikawa T,Seimiya T,Iwata T,Funato K,Odawara N,Sekiba K,Yamagami M,Suzuki T,Ishibashi R,Otsuka M,Koike K

更新日期：2019-10-01 00:00:00

abstract：:B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi1) is directly involved in cell growth, proliferation and self-renewal of cancer stem cells (CSCs). The aim of the present study was to assess the role of Bmi1 in the maintenance of stemness properties and tumorigenicity of human bladder CSC-like side ...

journal_title：Oncology reports

authors： Zhu D,Wan X,Huang H,Chen X,Liang W,Zhao F,Lin T,Han J,Xie W

更新日期：2014-02-01 00:00:00

abstract：:Photodynamic therapy (PDT) using photosensitizer can induce diverse cellular responses, including apoptosis. Recently, it has been reported that PDT using methylaminolaevulinate may be effective in basal cell carcinoma. However, it is largely unknown whether PDT using a natural product such as curcumin can induce apop...

journal_title：Oncology reports

authors： Park K,Lee JH

更新日期：2007-03-01 00:00:00

abstract：:Despite the high response rates of small cell lung cancer (SCLC) to first-line cisplatin-based chemotherapies, most patients with SCLC will eventually experience disease progression. Accordingly, novel chemotherapeutic regimens are desired. This in vitro study was carried out in order to develop novel chemotherapeutic...

journal_title：Oncology reports

authors： Takeda K,Suyama H,Igishi T,Shigeoka Y,Matsumoto S,Yamasaki A,Hashimoto K,Sumikawa T,Morita M,Ueda Y,Shimizu E

更新日期：2008-04-01 00:00:00

abstract：:Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, ...

journal_title：Oncology reports

authors： Akagi J,Baba H

更新日期：2019-01-01 00:00:00

abstract：:The NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme is implicated in protection against oxidative stress and carcinogenesis. NQO1 C609T genetic polymorphism was reported to be associated with an increased risk for cancers, including breast cancer. However, there is still lack of evidence whether higher oxidative stress...

journal_title：Oncology reports

authors： Tseng LM,Yin PH,Tsai YF,Chi CW,Wu CW,Lee LM,Lee HC

更新日期：2009-05-01 00:00:00

abstract：:To investigate the antitumor action of arsenic trioxide (As2O3) by intratumoral injection into solid tumors, tumor growth inhibition (TGI) and angiogenesis of heterotransplanted esophageal carcinoma in mice was carried out. The cultured human esophageal carcinoma cells were inoculated into both laterals of the abdomin...

journal_title：Oncology reports

authors： Shen ZY,Shen J,Chen MH,Wu XY,Wu MH,Zeng Y

更新日期：2003-11-01 00:00:00

abstract：:Frequent frameshift mutations in the DNA mismatch repair genes hMSH3, and hMSH6, have been reported in colorectal and endometrial cancers with microsatellite instability, however, it is unclear whether they are similarly altered in ovarian endometrioid carcinoma. In this study, we examined frequency of frameshift muta...

journal_title：Oncology reports

authors： Albarracin CT,Silva EG,Malpica A,Luthra R,Liu J

更新日期：2004-12-01 00:00:00

abstract：:Diallyl disulfide (DADS) has shown potential as a therapeutic agent in various cancers. Previously, we found that myeloid cell leukemia sequence 1 (Mcl1) was downregulated in DADS-induced cell cycle arrest in HL-60 human leukemia cells. Here, we investigated the role of this protein...

journal_title：Oncology reports

authors： Yi L,Ji XX,Tan H,Feng MY,Tang Y,Wen L,Su Q

更新日期：2012-06-01 00:00:00

abstract：:H-, K- and N-ras gene mutations were analyzed in lung cancer from Thai patients. Thirteen out of 58 cases (22%) harbored the mutations. Ten cases showed K-ras gene mutations at codon 12, 1 case presented a mutation at codon 13 and another case exhibited a mutation at codon 63. Silent mutations of N-ras gene in codons ...

journal_title：Oncology reports

authors： Petmitr S,Wongsommart D,Chaksangchaichot P,Pakeetoot T,Sutinont P,Sirivaidyapong P,Karalak A

更新日期：2003-09-01 00:00:00

abstract：:We radiographically evaluated the response of primary lesions to chemotherapy in 101 patients with inoperable advanced gastric cancer. The median survival time in the 50 responders (49.5%) was 379 days, as compared with only 210 days in the 51 non-responders (50.1%) (p<0. 001). Morphologic changes of the gastric mucos...

journal_title：Oncology reports

authors： Yamazaki I,Koizumi W,Kondo I,Saigenji K

更新日期：2000-11-01 00:00:00

abstract：:Loss of E-cadherin expression and gain of N-cadherin expression ('cadherin switch') is shown to be characteristic in epithelial to mesenchymal transition (EMT), a mechanism associated with cancer progression. Furthermore, the prognostic role of P-cadherin in different cancers is controversial. The aim of this study wa...

journal_title：Oncology reports

authors： Jäger T,Becker M,Eisenhardt A,Tilki D,Tötsch M,Schmid KW,Romics I,Rübben H,Ergün S,Szarvas T

更新日期：2010-04-01 00:00:00

abstract：:Secreted frizzled-related protein 1 (SFRP1) is a candidate tumor suppressor gene located at 8p11.2 and antagonizes the Wnt signaling pathway. Epigenetic inactivation of SFRP1 by methylation of its promoter CpG island has recently been reported in several types of cancers. In the present study, we examined the expressi...

journal_title：Oncology reports

authors： Awakura Y,Nakamura E,Ito N,Kamoto T,Ogawa O

更新日期：2008-11-01 00:00:00

abstract：:The MTA1 gene has been identified as metastasis-associated gene and has been seen to correlate with the degree of invasion and lymphatic metastasis in gastric, colorectal, and esophageal carcinomas. We investigated the possible role of MTA1 gene expression in hepatocellular carcinoma (HCC). The mRNA expression level o...

journal_title：Oncology reports

authors： Hamatsu T,Rikimaru T,Yamashita Y,Aishima S,Tanaka S,Shirabe K,Shimada M,Toh Y,Sugimachi K

更新日期：2003-05-01 00:00:00

abstract：:Mutations of the von Hippel-Lindau (VHL) tumor suppressor gene cause hereditary and sporadic renal cell carcinomas (RCCs). The best characterized function of VHL protein is suppression of the α subunit of hypoxia inducible factor (HIF). Additional VHL functions have been reported, including induction of senescence upo...

journal_title：Oncology reports

authors： Macher-Goeppinger S,Bermejo JL,Schirmacher P,Pahernik S,Hohenfellner M,Roth W

更新日期：2013-11-01 00:00:00

abstract：:Rab is a large subfamily of small GTPases which play an important role in multiple processes relating to cellular transportation and modulation of the cytoskeleton. Novel gene Rab-like 3 (Rabl3), which we originally reported as a new member belonging to this subfamily, may participate in other processes in human cance...

journal_title：Oncology reports

authors： Li Q,Wang L,Zeng L,Zhang Y,Li K,Jin P,Su B,Wang L

更新日期：2010-08-01 00:00:00

abstract：:The aims of this study were to investigate the expression levels of beta-catenin, Pin1 and cyclin D1 in salivary adenoid cystic carcinomas (SACC ) and to evaluate its clinical importance, furthermore, to elucidate whether beta-catenin expression was aberrant in SACC and whether Pin1 was involved in aberrant beta-caten...

journal_title：Oncology reports

authors： Zhou CX,Gao Y

更新日期：2006-09-01 00:00:00

abstract：:A crucial step in the path to the malignant transformation of cells and tumor formation is immortalization, which essentially depends on telomere maintenance. The aim of this study was to investigate the role of telomerase in the progression of Barrett's esophagus. Telomerase activi...

journal_title：Oncology reports

authors： Qin X,Qi B,Zhao B

更新日期：2013-04-01 00:00:00