Mutational analysis of ras gene family in lung cancer in Thai.

abstract：:Sedum sarmentosum Bunge, a traditional Chinese herbal medicine, has a wide range of clinical applications including antibiosis, anti-inflammation and anti-oxidation. In the present study, we identified that its extract (SSBE) exerts pancreatic anticancer activity in vitro and in vivo. In the cultured pancreatic cancer...

journal_title：Oncology reports

authors： Bai Y,Chen B,Hong W,Liang Y,Zhou M,Zhou L

更新日期：2016-05-01 00:00:00

abstract：:Beta1-6 branching of L-PHA reactive oligosaccharides, one of the N-glycan structures, plays an important role in the biological behavior of various tumor cell lines. We reported previously that the expression of L-PHA reactive oligosaccharides was closely associated with the prognosis of patients with human diffuse la...

journal_title：Oncology reports

authors： Suzuki O,Nozawa Y,Abe M

更新日期：2005-01-01 00:00:00

abstract：:Pentoxifylline is commonly used in the treatment of peripheral vascular diseases. It improves microcirculatory flow and tissue perfusion. Moreover, pentoxifylline displays some immunomodulatory properties that presumably might affect the anticancer response. Therefore, the aim of the present study was to evaluate the ...

journal_title：Oncology reports

authors： Grzela T,Lazarczyk M,Niderla J,Golab J,Lazarczyk MA,Skopinski P

更新日期：2003-11-01 00:00:00

abstract：:Gasdermin D (GSDMD) is a newly discovered pyroptosis executive protein, which can be cleaved by inflammatory caspases and is essential for secretion of IL‑1β, making it a critical mediator of inflammation. However, the precise role of GSDMD in carcinogenesis remains nearly unknown. Considering the vital role of inflam...

journal_title：Oncology reports

authors： Gao J,Qiu X,Xi G,Liu H,Zhang F,Lv T,Song Y

更新日期：2018-10-01 00:00:00

abstract：:A patient who had undergone radical gastrectomy for synchronous gastric cancer (T(1)N(0)M(0), stage I) and duodenal cancer (Tis, stage 0) in November 1987 was found to have esophageal cancer in November 1994, and underwent radical thoracolaparotomy at our hospital (T(1)N(0)M(0), stage I). After follow-up for about 3.5...

journal_title：Oncology reports

authors： Mukai M,Makuuchi H,Mukohyama S,Oida Y,Himeno S,Nishi T,Nakazaki H,Satoh S

更新日期：2001-01-01 00:00:00

abstract：:lncRNA metastasis-associated lung adencarcinoma transcript 1 (MALAT1) plays an important role in the metastasis of lung cancer. Yet, its role in bone metastasis and the related mechanism remain unknown. The present study aimed to investigate the role of lncRNA MALAT1 in the bone metastasis of non-small cell lung cance...

journal_title：Oncology reports

authors： Liu M,Sun W,Liu Y,Dong X

更新日期：2016-09-01 00:00:00

abstract：:Vasohibin-1 (VASH1) has recently been isolated as a novel inhibitor of angiogenesis. Several studies have demonstrated that VASH1 plays important roles in tumor angiogenesis but the role of this angiogenic inhibitor in renal cell carcinoma (RCC) has not been elucidated. We previously reported that VASH1 expression is ...

journal_title：Oncology reports

authors： Zhao G,Na R,Li L,Xiao H,Ding N,Sun Y,Han R

更新日期：2017-08-01 00:00:00

abstract：:The use of prognostic markers for breast cancer allows therapeutic strategies to be defined more efficiently. The expression of glutathione (GSH) and glutathione peroxidase (GPX) in tumor cells has been evaluated as a predictor of prognosis and response to cytotoxic treatments. Its immunoexpression was assessed in 63 ...

journal_title：Oncology reports

authors： Jardim BV,Moschetta MG,Leonel C,Gelaleti GB,Regiani VR,Ferreira LC,Lopes JR,Zuccari DA

更新日期：2013-09-01 00:00:00

abstract：:Quercetin, a kind of flavonoid, is found in edible fruits and vegetables and has anti-tumorigenic activity. However, the mechanism of activity has not been elucidated. We show for the first time that gadd45 is a molecular target of quercetin, which inhibits growth of human cervical cancer HeLa cells. Apoptosis was det...

journal_title：Oncology reports

authors： Yoshida T,Maeda A,Horinaka M,Shiraishi T,Nakata S,Wakada M,Yogosawa S,Sakai T

更新日期：2005-11-01 00:00:00

abstract：:MicroRNAs (miRs) have emerged as prospective tools for human cancer therapy, including hepatocellular carcinoma (HCC) therapy. Previous studies have suggested that miR-381 functions as oncogenic or tumor-suppressive miRs in other cancer types. However, the role of miR-381 in HCC remains unknown. The present study inve...

journal_title：Oncology reports

authors： Zhang Q,Zhao S,Pang X,Chi B

更新日期：2016-03-01 00:00:00

abstract：:Case 1: a patient was diagnosed as having ascending colon cancer with right ovarian metastasis, and underwent palliative right hemicolectomy plus oophorectomy. The tumor was a well-differentiated adenocarcinoma with right ovarian metastasis, and the disease was classified as stage IV. Oral chemotherapy with UFT plus L...

journal_title：Oncology reports

authors： mukai M,Moriya H,Himeno S,Oida Y,mukohyama S,Nishi T,Nakasaki H,Satoh S,Makuuchi H

更新日期：2001-09-01 00:00:00

abstract：:It has been revealed that the induction of epithelial‑mesenchymal transition (EMT) is associated with drug resistance, leading to tumor recurrence and metastasis. Recent studies have shown that chemotherapeutic agents, besides their therapeutic effects, can induce EMT and enhance invasive and metastatic properties of ...

journal_title：Oncology reports

authors： Chun SY,Kim S,Nam KS

更新日期：2017-08-01 00:00:00

abstract：:Retinoblastoma, a well-vascularized tumor that is dependent on a very robust angiogenic response, is the most common intraocular malignancy in children. Tissue factor (TF) is known to regulate tumor progression and in the present study we demonstrated that TF regulates tumor angioge...

journal_title：Oncology reports

authors： Song HB,Park KD,Kim JH,Kim DH,Yu YS,Kim JH

更新日期：2012-12-01 00:00:00

abstract：:Mammary small cell carcinoma (SmCC) is a very rare neoplasm with a poor prognosis compared with other invasive carcinomas. We studied the histological and immunohistochemical profiles of two cases of mammary SmCC, and compared them with those of five cases of carcinoma with endocrine features (CEF) and five cases of i...

journal_title：Oncology reports

authors： Yamamoto J,Ohshima K,Nabeshima K,Ikeda S,Iwasaki H,Kikuchi M

更新日期：2004-04-01 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is involved in malignant transformation and the biological aggressiveness of several human malignancies. Growing evidence indicates that EZH2 may be an appropriate therapeutic target for malignancies, including cholangiocarcinoma. Recently, an S-adenosyl-L-homocysteine hydrolase inhi...

journal_title：Oncology reports

authors： Nakagawa S,Sakamoto Y,Okabe H,Hayashi H,Hashimoto D,Yokoyama N,Tokunaga R,Sakamoto K,Kuroki H,Mima K,Beppu T,Baba H

更新日期：2014-02-01 00:00:00

abstract：:The aim of this study was to investigate the function of the ING1 gene in lung carcinoma. To detect the inhibitory effect of ING1 in human lung cancer, recombinant ING1b plasmids were transfected into two lung cancer cell lines with different p53 status, A549 with wild-type p53 (wtp53) and SK-MES-1 with mutant p53. Ap...

journal_title：Oncology reports

authors： Luo ZG,Tang H,Li B,Zhu Z,Ni CR,Zhu MH

更新日期：2011-04-01 00:00:00

abstract：:Cyclin D1 expression is closely related with ER status in breast cancer. We executed this study to evaluate whether therapeutic response to tamoxifen varies with levels of cyclin D1 expression in 66 ER positive breast cancer patients having solitary bone metastasis. Treatment response to tamoxifen and correlation betw...

journal_title：Oncology reports

authors： Han S,Park K,Bae BN,Kim KH,Kim HJ,Kim YD,Kim HY

更新日期：2003-01-01 00:00:00

abstract：:Glioblastoma is the most common type of primary brain tumour in adults, and its pathogenesis is particularly complicated. Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic ...

journal_title：Oncology reports

authors： Xu PF,Yang JA,Liu JH,Yang X,Liao JM,Yuan FE,Liu BH,Chen QX

更新日期：2019-01-01 00:00:00

abstract：:Esophageal cancer is one of the most aggressive cancers in the world. Novel preventive and therapeutic strategies tend to target the key molecules involved in the signaling transduction pathways for cell growth. It is known that FAK and mTOR are important controllers of cell growth. TAE226, a novel small molecule comp...

journal_title：Oncology reports

authors： Wang ZG,Fukazawa T,Nishikawa T,Watanabe N,Sakurama K,Motoki T,Takaoka M,Hatakeyama S,Omori O,Ohara T,Tanabe S,Fujiwara Y,Shirakawa Y,Yamatsuji T,Tanaka N,Naomoto Y

更新日期：2008-12-01 00:00:00

abstract：:Sesquiterpene lactones have been confirmed to have potential antitumor activity. Here, we demonstrated that Eupalinolide O (EO), a novel sesquiterpene lactone isolated from Eupatorium lindleyanum DC., showed significant anticancer activity against human MDA-MB-468 breast cancer cells. The cytotoxicity induced by EO wa...

journal_title：Oncology reports

authors： Yang B,Zhao Y,Lou C,Zhao H

更新日期：2016-11-01 00:00:00

abstract：:The present study explored the correlation of ecotropic viral integration site 5 (EVI5) expression with clinicopathological features and prognosis in hepatocellular carcinoma (HCC). A total of 205 HCC patients were included retrospectively. Quantitative real-time polymerase chain reaction (RT-qPCR) and western blottin...

journal_title：Oncology reports

authors： Tang J,Ou J,Xu C,Yi C,Xue F,Xu L,Lai F,Tang J,Li S,Kang T,Ding W,Wang B

更新日期：2017-10-01 00:00:00

abstract：:Inhibition of epidermal growth factor receptor (EGFR) signalling has emerged as a new treatment strategy for oral squamous cell carcinoma (OSCC). Previously, we found that loss of EGFR expression in OSCC was associated with epithelial-mesenchymal transition (EMT), and may have functional implications with regard to re...

journal_title：Oncology reports

authors： Kitahara H,Hirai M,Kato K,Bou-Gharios G,Nakamura H,Kawashiri S

更新日期：2016-12-01 00:00:00

abstract：:High-mobility group protein box 1 (HMGB1) released from dying tumor cells promotes tumor progression, on the other hand HMGB1 activates dendritic cells and triggers anti-neoplastic response of T-cells in chemotherapy and radiotherapy. HMGB1 expression is up-regulated in many kinds of tumors. To investigate HMGB1 expre...

journal_title：Oncology reports

authors： Shen X,Hong L,Sun H,Shi M,Song Y

更新日期：2009-09-01 00:00:00

abstract：:The aim of the present study was to investigate the role of miR‑203a‑3p in colorectal cancer (CRC) and identify the target gene of microRNA (miR)‑203a‑3p. A total of 59 sets of cancer tissues and corresponding adjacent non‑tumor tissues were collected from CRC patients (aged 31‑78 years) between October 2016 and May 2...

journal_title：Oncology reports

authors： Qian Z,Gong L,Mou Y,Han Y,Zheng S

更新日期：2019-11-01 00:00:00

abstract：:Cisplatin (CDDP)‑based combination chemotherapy is the standard for muscle‑invasive bladder cancer (MIBC). However, nearly all patients undergoing CDDP chemotherapy become refractory due to the development of CDDP resistance. Therefore, clarification of the mechanisms of CDDP resistance is urgently needed. The transcr...

journal_title：Oncology reports

authors： Sekino Y,Sakamoto N,Ishikawa A,Honma R,Shigematsu Y,Hayashi T,Sentani K,Oue N,Teishima J,Matsubara A,Yasui W

更新日期：2019-05-01 00:00:00

abstract：:In the present study, we investigated the role of lysyl oxidase‑like 2 (LOXL2), the correlation between LOXL2 and epithelial to mesenchymal transition (EMT) and the effects of using β‑aminopropionitrile (BAPN) to inhibit LOXL2 with the aim of reducing tumor progression in hepatocellular carcinoma (HCC). The expression...

journal_title：Oncology reports

authors： Ninomiya G,Yamada S,Hayashi M,Takeda S,Suenaga M,Takami H,Kanda M,Iwata N,Niwa Y,Tanaka C,Kobayashi D,Fujii T,Nakayama G,Sugimoto H,Koike M,Fujiwara M,Kodera Y

更新日期：2018-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are reported to be involved in renal hypoxia/reoxygenation (H/R) damage. To investigate this further, human kidney (HK‑2) cells were cultured, subjected to H/R and the function of miR‑30a‑5p and glutamate dehydrogenase 1 (GLUD1) was evaluated. The results showed that, miR‑30‑5p was downregulated and...

journal_title：Oncology reports

authors： He Y,Lang X,Cheng D,Zhang T,Yang Z,Xiong R

更新日期：2020-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) play an important role in the genesis and development of gastric cancer. In the present study, we determined whether miRNA-135a-5p expression was increased in gastric cancer compared with adjacent non-tumor tissues using 20 pairs of gastric cancer and para-carcinoma tissue samples which were assesse...

journal_title：Oncology reports

authors： Pan Y,Ren F,Zhang W,Liu G,Yang D,Hu J,Feng K,Feng Y

更新日期：2014-12-01 00:00:00

abstract：:Thrombospondin-1 (TSP1) is known to possess tumor suppressor functions. In contradiction, TSP1 enhances the stromal vascularization and growth of certain cancers. A cell adhesion receptor, CD36, has been shown to interact with a ligand TSP1. We studied how CD36 affects the growth of the osteosarcoma cell line (HOS) ex...

journal_title：Oncology reports

authors： Yamazaki H,Handa A,Nishi M,Tokunaga T,Tomisawa M,Hatanaka H,Abe Y,Kijima H,Ueyama Y,Nakamura M

更新日期：2004-02-01 00:00:00

abstract：:Epigenetic alterations have been reported in colorectal neoplasia which can either complement or in some cases be predisposed to genetic alterations such as K-ras mutations. We examined the promoter methylation status of the CDKN2A and O6-methylguanine-DNA methyltransferase (MGMT) genes, after sodium bisulfite convers...

journal_title：Oncology reports

authors： Menigatti M,Pedroni M,Verrone AM,Borghi F,Scarselli A,Benatti P,Losi L,Di Gregorio C,Schär P,Marra G,Ponz de Leon M,Roncucci L

更新日期：2007-06-01 00:00:00