Valproic acid suppresses the self-renewal and proliferation of head and neck cancer stem cells.

abstract：:Human telomerase reverse transcriptase (hTERT) plays an important role in the development of tumors and has been investigated as a potent target for anticancer therapy. In the present study, we constructed a recombinant adenovirus, Ad-EGFP-C197 which was capable of expressing COOH‑terminal polypeptide of hTERT (amino ...

journal_title：Oncology reports

authors： Wu X,Chen J,Cao Y,Xie B,Li H,Zhou P,Qiu Y,Pang J

更新日期：2015-12-01 00:00:00

abstract：:Temozolomide (TMZ), as a kind of alkylating agent, is widely utilized for the treatment of glioblastoma (GBM). However, temozolomide resistance (TR) often develops quickly and results in tumor recurrence and poor outcome. Recent advances have demonstrated that miRNAs exert critical roles in chemoresistance. Downregula...

journal_title：Oncology reports

authors： Qian Z,Zhou S,Zhou Z,Yang X,Que S,Lan J,Qiu Y,Lin Y

更新日期：2017-11-01 00:00:00

abstract：:Invasiveness and metastasis may seriously affect the prognosis of small cell lung cancer (SCLC). In the present study, we analyzed the effects and inherent mechanisms of action of polysialic acid-modified neural cell adhesion molecule (NCAM) on the invasive and metastatic potential of SCLC. Gene transfection and short...

journal_title：Oncology reports

authors： Gong L,Zhou X,Yang J,Jiang Y,Yang H

更新日期：2017-01-01 00:00:00

abstract：:In a screen for thoracic malignancy-associated markers, thyroid stimulating hormone receptor (TSHR) was identified as a candidate as it binds to the previously-characterized lung cancer marker NKX2-1. We screened for mutations in all coding regions of the TSHR gene in 96 lung adenoc...

journal_title：Oncology reports

authors： Kim JW,Lee S,Lui N,Choi H,Mulvihill M,Fang LT,Kang HC,Kwon YW,Jablons D,Kim IJ

更新日期：2012-10-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant intracranial tumor. Although the affected patients are usually treated with surgery combined with radiotherapy and chemotherapy, the median survival time for GBM patients is still approximately 12‑14 months. Identifying the key molecular mechanisms and targets of GBM...

journal_title：Oncology reports

authors： Miao L,Jiang Z,Wang J,Yang N,Qi Q,Zhou W,Feng Z,Li W,Zhang Q,Huang B,Chen A,Zhang D,Zhao P,Li X

更新日期：2019-08-01 00:00:00

abstract：:Livistona chinensis seeds have been used for centuries to clinically treat various types of cancer. Our published data suggest that Livistona chinensis seeds are able to inhibit hepatocellular carcinoma (HCC) growth in vitro and in vivo via promotion of mitochondrial-dependent apoptosis. To further elucidate the molec...

journal_title：Oncology reports

authors： Lin W,Zhao J,Cao Z,Zhuang Q,Zheng L,Zeng J,Hong Z,Peng J

更新日期：2014-04-01 00:00:00

abstract：:The usefulness of the in vitro chemosensitivity test, the collagen gel droplet embedded culture drug- sensitivity test (CD-DST, Int J Oncol 11: 449, 1997), in cisplatin-based combined chemotherapy for postoperative recurrent tumors in non-small cell lung cancer (NSCLC) patients was retrospectively analyzed. CD-DST dat...

journal_title：Oncology reports

authors： Higashiyama M,Kodama K,Yokouchi H,Takami K,Nakagawa H,Imamura F,Minamigawa K,Kobayashi H

更新日期：2001-03-01 00:00:00

abstract：:Prostate cancer is the second most commonly diagnosed cancer in men in Poland after lung cancer and the third leading cause of cancer-related mortality after lung and colon cancer. The etiology of most cases of prostate cancer are not fully known, and therefore it is essential to search for the molecular basis of pros...

journal_title：Oncology reports

authors： Nowacka-Zawisza M,Wiśnik E

更新日期：2017-11-01 00:00:00

abstract：:The objective of the present study was to explore the in vitro and in vivo anticancer effects of Platycodin D (PD), derived from Platycodin grandiflorum, on highly metastatic MDA-MB-231 breast cancer cells. Using the MTT assay, we found that PD inhibited MDA-MB-231 cell growth in a concentration-dependent manner, with...

journal_title：Oncology reports

authors： Kong Y,Lu ZL,Wang JJ,Zhou R,Guo J,Liu J,Sun HL,Wang H,Song W,Yang J,Xu HX

更新日期：2016-09-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is one of the most malignant and aggressive tumors, and has a very poor prognosis with a mean survival time of <2 years, despite intensive treatment using chemo-radiation. Therefore, novel therapeutic approaches including immunotherapy have been developed against GBM. For the purpose of i...

journal_title：Oncology reports

authors： Akiyama Y,Komiyama M,Miyata H,Yagoto M,Ashizawa T,Iizuka A,Oshita C,Kume A,Nogami M,Ito I,Watanabe R,Sugino T,Mitsuya K,Hayashi N,Nakasu Y,Yamaguchi K

更新日期：2014-04-01 00:00:00

abstract：:To investigate the antitumor action of arsenic trioxide (As2O3) by intratumoral injection into solid tumors, tumor growth inhibition (TGI) and angiogenesis of heterotransplanted esophageal carcinoma in mice was carried out. The cultured human esophageal carcinoma cells were inoculated into both laterals of the abdomin...

journal_title：Oncology reports

authors： Shen ZY,Shen J,Chen MH,Wu XY,Wu MH,Zeng Y

更新日期：2003-11-01 00:00:00

abstract：:Squamous cell carcinoma (SCC) is histologically the most prominent type of cervical cancer. There is accumulating evidence suggesting that microRNAs (miRNAs) play important regulatory roles in the biological processes of cervical squamous cell carcinoma (CSCC). Deciphering the miRNA regulatory network in CSCC could de...

journal_title：Oncology reports

authors： Lin W,Feng M,Chen G,Zhou Z,Li J,Ye Y

更新日期：2017-03-01 00:00:00

abstract：:KIAA1199 is a gene included in the Human Unidentified Gene-Encoded (HUGE) large protein database which contains more than 2,400 members identified in the Kazusa cDNA sequencing project. Early studies described KIAA1199 as an inner ear-specific protein in which 3 point mutations were found to be associated with non‑syn...

journal_title：Oncology reports

authors： Zhang Y,Jia S,Jiang WG

更新日期：2014-04-01 00:00:00

abstract：:Inhibitor of DNA-binding protein 1 (ID1) is commonly abnormally overexpressed in colorectal cancer (CRC); yet, the functional significance of ID1 in the growth and invasive properties of CRC cells remains largely unclear. The present study investigated the effects of ID1 downregulation on the cell growth and metastati...

journal_title：Oncology reports

authors： Lai X,Liao J,Lin W,Huang C,Li J,Lin J,Chen Q,Ye Y

更新日期：2014-07-01 00:00:00

abstract：:Synovial sarcomas (SS) consistently show a characteristic chromosomal translocation, t(X;18)(p11;q11), which usually leads to the formation of 2 chimeric fusion transcripts, SYT-SSX1 and -SSX2. A recent multi-institutional retrospective study revealed that the SYT-SSX fusion type emerged as the only independent signif...

journal_title：Oncology reports

authors： Saito T,Oda Y,Kawaguchi K,Takahira T,Yamamoto H,Tanaka K,Matsuda S,Sakamoto A,Iwamoto Y,Tsuneyoshi M

更新日期：2004-05-01 00:00:00

abstract：:Prognostic factors and the role of post-operative radiotherapy (PORT) in patients with pN1 nodal stage following surgery for NSCLC were identified. The clinical course of 211 patients with pN1 nodal involvement following thoracic surgery were reviewed, 97 of them received PORT. Multi-variate survival analysis with res...

journal_title：Oncology reports

authors： Willner J,Wiens V,Jachmann M,Haubitz I,Flentje M

更新日期：2004-09-01 00:00:00

abstract：:This study was conducted to assess protective effect of an antioxidant protein, sericin, on tumor promotion in the 7,12-dimethylbenz (alpha) anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol 13-acetate (TPA)-promoted mouse skin tumorigenesis model. In experiment 1, sericin was applied topically to DMBA-initiat...

journal_title：Oncology reports

authors： Zhaorigetu S,Yanaka N,Sasaki M,Watanabe H,Kato N

更新日期：2003-05-01 00:00:00

abstract：:The degradation of basement membranes by tumor cells involves secretion and activation of proteinases, such as the matrix metalloproteinases (MMPs), and results from an imbalance between their inhibitors and activators that are controlled by various growth factors or cytokines, among which TGF-β(1) may be the most int...

journal_title：Oncology reports

authors： Jin H,Xie X,Hu B,Gao F,Zhou J,Zhang Y,Du L,Wang X,Zhao L,Zhang X,Shen L,Liao Y,Tang J

更新日期：2013-02-01 00:00:00

abstract：:Lysyl oxidase is an important extracellular matrix remodeling enzyme and plays critical roles in tumor progression and development. Its tumor-suppressor activity has been shown to depend on the propeptide region. Previous studies have reported that the expression levels of lysyl oxidase propeptide (LOX-PP) are associa...

journal_title：Oncology reports

authors： Zheng Y,Wang X,Wang H,Yan W,Zhang Q,Chang X

更新日期：2014-04-01 00:00:00

abstract：:Tumor metastasis is considered the main cause of mortality in cancer patients, thus it is important to investigate the differences between high- and low-metastatic cancer cells. Our previous study showed that the highly metastatic breast cancer cell line MDA-MB-231 released higher levels of ATP and exhibited higher P2...

journal_title：Oncology reports

authors： Eun SY,Ko YS,Park SW,Chang KC,Kim HJ

更新日期：2015-07-01 00:00:00

abstract：:Loss of proliferative control and failure to undergo cellular differentiation are key events during carcinogenesis. We recently identified a new potential tumor suppressor gene named MTUS1 (mitochondrial tumor suppressor 1), down-regulated in undifferentiated tumor cell lines, inhibiting tumor cell proliferation after...

journal_title：Oncology reports

authors： Zuern C,Heimrich J,Kaufmann R,Richter KK,Settmacher U,Wanner C,Galle J,Seibold S

更新日期：2010-01-01 00:00:00

abstract：:The use of prognostic markers for breast cancer allows therapeutic strategies to be defined more efficiently. The expression of glutathione (GSH) and glutathione peroxidase (GPX) in tumor cells has been evaluated as a predictor of prognosis and response to cytotoxic treatments. Its immunoexpression was assessed in 63 ...

journal_title：Oncology reports

authors： Jardim BV,Moschetta MG,Leonel C,Gelaleti GB,Regiani VR,Ferreira LC,Lopes JR,Zuccari DA

更新日期：2013-09-01 00:00:00

abstract：:Perylenequinones that generate reactive oxygen species (ROS) when illuminated with visible light have been recommended as photodynamic chemotherapeutic agents. One of these is calphostin C (CalC), the action of the photo-activated derivative of which, CalCphiE, has been ascribed to its ability to selectively and irrev...

journal_title：Oncology reports

authors： Chiarini A,Whitfield JF,Pacchiana R,Marconi M,Armato U,Dal Prà I

更新日期：2010-04-01 00:00:00

abstract：:The MSH6 gene is one of the mismatch repair genes involved in Lynch syndrome and its mutations account for 10-20% of Lynch syndrome. Although previous studies suggested that the difference of the geographical region affects the clinical phenotype of Lynch syndrome, there has been no report on the detailed features of ...

journal_title：Oncology reports

authors： Terui H,Tachikawa T,Kakuta M,Nishimura Y,Yatsuoka T,Yamaguchi K,Yura K,Akagi K

更新日期：2013-12-01 00:00:00

abstract：:Regulatory T cells (Tregs) play an important role in maintaining immunological tolerance. However, this mechanism is one of the major obstacles to overcome when attempting to improve antitumor immunity. Protein-bound polysaccharide‑K (PSK) has been used clinically as an antitumor drug, and one of its antitumor mechani...

journal_title：Oncology reports

authors： Aoki R,Iijima H,Kato M,Uchida M,Wada T,Murata M,Ogawa K,Naritaka Y,Yoshimatsu K

更新日期：2014-01-01 00:00:00

abstract：:This study was designed to investigate the effect of pseudo-G-Rh2, a novel metabolite of ginsenoside Rh2, on the apoptosis of SGC-7901 human gastric cancer cells. Pseudo-G-Rh2 demonstrated antitumor activity and significantly inhibited the proliferation of SGC-7901 cells in a concen...

journal_title：Oncology reports

authors： Qu X,Qu S,Yu X,Xu H,Chen Y,Ma X,Sui D

更新日期：2011-12-01 00:00:00

abstract：:Leptin may be involved in the pathogenesis of numerous cancer types by activation of cellular signal-transduction pathways. In this study, we analyzed the role of leptin and the mechanism(s) underlying its action in cervical carcinoma cells. Firstly, we examined the expression of leptin in 80 cases of cervical carcino...

journal_title：Oncology reports

authors： Yuan Y,Zhang J,Cai L,Ding C,Wang X,Chen H,Wang X,Yan J,Lu J

更新日期：2013-06-01 00:00:00

abstract：:Non‑small cell lung cancer (NSCLC) is the leading cause of cancer‑related deaths worldwide. Cisplatin‑based chemotherapy currently represents the main treatment option for patients with NSCLC. The aim of the present study was to evaluate effect of single nucleotide polymorphisms (SNPs) within the excision repair cross...

journal_title：Oncology reports

authors： Li M,Chen R,Ji B,Fan C,Wang G,Yue C,Jin G

更新日期：2021-01-14 00:00:00

abstract：:Adoptive immunotherapy requires the isolation of CD8+ T cells specific for tumor-associated antigens, their expansion in vitro and their transfusion to the patient to mediate a therapeutic effect. MUC1 is an important adenocarcinoma antigen immunogenic for T cells. The MUC1-derived SAPDTRPA (MUC1-8-mer) peptide is a p...

journal_title：Oncology reports

authors： Atzin-Méndez JA,López-González JS,Báez R,Arenas-Del Angel MC,Montaño LF,Silva-Adaya D,Lascurain R,Gorocica P

更新日期：2016-01-01 00:00:00

abstract：:Cell cycle analysis has become increasingly important in verifying the effect of anti-tumor drugs and cytokinetic research. In the early methods of cell cycle analysis, the flow cytometry relied on DNA content, and therefore, the cell cycle could be only broken into three stages: G(0)/G(1), S, and G(2)/M phase. It cou...

journal_title：Oncology reports

authors： Qin J,Tao D,Duan R,Leng Y,Shen M,Zhou H,Feng Y,Gao C,Yu Y,Li QQ,Hu J,Gong J

更新日期：2002-09-01 00:00:00