Mangiferin induces radiosensitization in glioblastoma cells by inhibiting nonhomologous end joining.

Abstract:

:Although surgery and high‑dose radiotherapy have been the standard treatments for glioblastoma multiforme (GBM), these therapies are palliative, due to the high risk of local relapse. Emerging evidence has demonstrated that DNA double‑strand break (DSB) repair serves a critical role in resistance to radiotherapy. Previous studies have revealed that mangiferin possesses anti‑neoplastic effects on human lung adenocarcinoma and ovarian cancer. The present study aimed to investigate the role of mangiferin in radio‑sensitivity inhuman GBM. Through in vitro experiments, decreased proliferation and increased DNA damage were observed in cells pretreated with mangiferin following radiation. Further study of the repair pathway indicated that mangiferin inhibits the non‑homologous end‑joining (NHEJ) DSB repair pathway. Furthermore, studies on key proteins in the NHEJ DSB repair pathway revealed that mangiferin inhibited the phosphorylation of serine‑protein kinase ATM, TP53‑binding protein 1 and γ‑histone H2AX (γ‑H2AX). In addition, observations on the average percentages of γ‑H2AX‑positive cells and the average number of γ‑H2AX foci per cell suggested that treatment with mangiferin decreased the number of γ‑H2AX foci in GBM cells following radiation. However, mangiferin selectively inhibited DSB repair in GBM cells, and was not able to trigger DSB repair inhibition in normal neuronal Schwann cells. Through in vivo tumor‑bearing mouse experiments, a smaller tumor volume, decreased tumor weight and prolonged life span were observed in mice treated with mangiferin following radiation. Therefore, xenograft GBM models clearly demonstrated that treatment with mangiferin treatment may increase tumor sensitivity to radiotherapy. Taken together, as demonstrated by in vivo and in vitro data, mangiferin may be a potential novel therapeutic drug for improving the radiation sensitivity of glioblastoma.

journal_name

Oncol Rep

journal_title

Oncology reports

authors

Mu F,Liu T,Zheng H,Xie X,Lei T,He X,Du S,Tong R,Wang Y

doi

10.3892/or.2018.6756

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

3663-3673

issue

6

eissn

1021-335X

issn

1791-2431

journal_volume

40

pub_type

杂志文章
  • Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration.

    abstract::Head and neck cancer is the sixth most common cancer worldwide and laryngeal cancer represents the largest subgroup. However, the molecular mechanism underlying its malignant behavior and progression is not clarified. Accumulating evidence has shown that Notch1 signaling pathway plays a central role in carcinogenesis,...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or_00000504

    authors: Jiao J,Qin Z,Li S,Liu H,Lu Z

    更新日期:2009-10-01 00:00:00

  • Prognostic impact of δ-like ligand 4 and Notch1 in acute myeloid leukemia.

    abstract::Notch signaling plays a critical role in embryonic vascular development and tumor angiogenesis. The present study was conducted to investigate the prognostic role of the angiogenesis-related Notch ligand and the receptor in acute myeloid leukemia (AML) and assess whether their expre...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.1943

    authors: Zhang J,Ma D,Ye J,Zang S,Lu F,Yang M,Qu X,Sun X,Ji C

    更新日期:2012-10-01 00:00:00

  • Quantification of human telomerase reverse transcriptase mRNA in testicular germ cell tumors by quantitative fluorescence real-time RT-PCR.

    abstract::Telomerase is a ribonucleoprotein enzyme which is endogenously expressed in germ, stem and tumor cells, but absent in benign somatic cells. The two major telomerase components are human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT). It has been shown that hTERT is rate-limiting for telomerase...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Schrader M,Burger AM,Müller M,Krause H,Straub B,Smith GL,Newlands ES,Miller K

    更新日期:2002-09-01 00:00:00

  • Human chorionic gonadotropin β regulates epithelial-mesenchymal transition and metastasis in human ovarian cancer.

    abstract::Human chorionic gonadotropin β (β-hCG) is a well-known and accurate marker for the diagnosis and monitoring of pregnancy, trophoblastic tumors and ovarian germ cell tumors. Recently, β-hCG has been found to be closely related to poor prognosis and metastasis in various other malignant tumors, while its role and mechan...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5818

    authors: Liu N,Peng SM,Zhan GX,Yu J,Wu WM,Gao H,Li XF,Guo XQ

    更新日期:2017-09-01 00:00:00

  • Mammary tumors in splenectomized rats.

    abstract::The objective of this study was to examine how splenectomy affects the immune response, particularly T cells, in chemically-induced mammary tumors. Female rats were splenectomized and then exposed to 9,10-dimethyl-1,2-benz(a)anthracene (DMBA) to induce mammary tumors. Splenectomy significantly decreased the rate of tu...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.9.1.185

    authors: Kossoy G,Ben-Hur H,Lifschitz O,Zusman I

    更新日期:2002-01-01 00:00:00

  • Use of CA15‑3 for screening breast cancer: An antibody‑lectin sandwich assay for detecting glycosylation of CA15‑3 in sera.

    abstract::Elevated serum CA15‑3 assessed by enzyme‑linked immunosorbent assay (ELISA) has been considered a diagnostic marker of breast cancer. However, accumulating data indicate that the current ELISA system for detecting CA15‑3, which targets the peptide backbone of CA15‑3, is not sufficiently sensitive to detect early or lo...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6433

    authors: Choi JW,Moon BI,Lee JW,Kim HJ,Jin Y,Kim HJ

    更新日期:2018-07-01 00:00:00

  • MicroRNA-128 suppresses cell growth and metastasis in colorectal carcinoma by targeting IRS1.

    abstract::Evidence has shown that microRNAs play important roles in tumor development, progression, and metastasis. miR-128 has been reported to be deregulated in different tumor types, whereas the function of miR-128 in colorectal carcinoma (CRC) largely remains to be elucidated. The aim of the present study was to investigate...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4251

    authors: Wu L,Shi B,Huang K,Fan G

    更新日期:2015-11-01 00:00:00

  • Epigenetic modulation of AR gene expression in prostate cancer DU145 cells with the combination of sodium butyrate and 5'-Aza-2'-deoxycytidine.

    abstract::The androgen receptor (AR) plays an essential role in the development and progression of prostate cancer. Castration-resistant prostate cancer (CRPC) is a consequence of androgen deprivation therapy. Unchecked CRPC followed by metastasis is lethal. Some CRPCs show decreased AR gene expression due to epigenetic mechani...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.5000

    authors: Fialova B,Luzna P,Gursky J,Langova K,Kolar Z,Trtkova KS

    更新日期:2016-10-01 00:00:00

  • CLDN5 affects lncRNAs acting as ceRNA dynamics contributing to regulating blood‑brain barrier permeability in tumor brain metastasis.

    abstract::The blood‑brain barrier (BBB) constitutes an efficient organization of tight junctions that limits the delivery of tumor to the brain. The principal tight junction protein in BBB is claudin‑5 (CLDN5), but its mechanism of action remains largely unknown. Long non‑coding RNAs (lncRNAs) are aberrantly expressed in many c...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6208

    authors: Ma SC,Li Q,Peng JY,Zhouwen JL,Zhang DN,Zhang CB,Jiang WG,Jia W

    更新日期:2018-03-01 00:00:00

  • SOCS4 expressed by recombinant HSV protects against cytokine storm in a mouse model.

    abstract::Oncolytic viruses are genetically engineered viruses designed for the treatment of solid tumors, and are often coupled with the antitumor immunity of the host. The challenge of using oncolytic herpes simplex virus (oHSV) as an efficacious oncolytic agent is the potential host tissue damage caused by the production of ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6935

    authors: Ren S,Chen X,Huang R,Zhou GG,Yuan Z

    更新日期:2019-03-01 00:00:00

  • Norcantharidin enhances ABT-263-mediated anticancer activity in neuroblastoma cells by upregulation of Noxa.

    abstract::Neuroblastoma is an aggressive childhood disease. Even with intensive conventional treatments, the long term survival rate for children with neuroblastoma remains less than 40%, highlighting the importance of finding new therapies. Bcl-2 family proteins play crucial roles in survival, proliferation and chemotherapeuti...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3228

    authors: Wang X,Gu Z,Li G,Zhang S,Cao Z,Yang Z,Liu G

    更新日期:2014-08-01 00:00:00

  • Plasma levels and expression of vascular endothelial growth factor-A in human localized prostate cancer.

    abstract::Although the impact of vascular endothelial growth factor (VEGF) is clearly established in advanced prostate cancer (PCa), its role in localized PCa remains to be determined. The aim of our study was to analyse the plasma levels of VEGF-A and the expression of VEGF-A in prostatic tissue in a population of patients wit...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Peyromaure M,Badoual C,Camparo P,Grabar S,Goulvestre C,Fulla Y,Vieillefond A,Mao K,Dinh-Xuan AT

    更新日期:2007-07-01 00:00:00

  • miR520c blocks EMT progression of human breast cancer cells by repressing STAT3.

    abstract::Breast cancer is one of the most malignant diseases world-wide and it ranks the first among female cancers. Masses of intrinsic and extrinsic factors, especially the inflammatory factors can lead to breast cancer. Aberrant activation and accumulation of key molecules can lead to inflammation associated carcinogenesis....

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5393

    authors: Wang N,Wei L,Huang Y,Wu Y,Su M,Pang X,Wang N,Ji F,Zhong C,Chen T,Li B

    更新日期:2017-03-01 00:00:00

  • STMN1, a prognostic predictor of esophageal squamous cell carcinoma, is a marker of the activation of the PI3K pathway.

    abstract::The esophageal squamous cell carcinoma (ESCC) subtype with STMN1 overexpression has a high likelihood of lymphatic metastatic recurrence. However, the underlying mechanism remains to be further elucidated. We assessed the expression level of STMN1 and PTEN in 96 pN0 ESCC patient tissues using immunohistochemistry and ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.6145

    authors: Jiang W,Huang S,Song L,Wang Z

    更新日期:2018-02-01 00:00:00

  • Impact of genetic profiles on the efficacy of anti-EGFR antibodies in metastatic colorectal cancer with KRAS mutation.

    abstract::Reports indicate that, even in KRAS-mutated colon cancer, there are subsets of patients who benefit from anti-EGFR monoclonal antibody (MoAb) treatment. The aim of the present study was to identify genetic profiles that contribute to the responsiveness of metastatic colorectal cancer (mCRC) to anti-EGFR MoAb. We retro...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3179

    authors: Kishiki T,Ohnishi H,Masaki T,Ohtsuka K,Ohkura Y,Furuse J,Sugiyama M,Watanabe T

    更新日期:2014-07-01 00:00:00

  • Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells.

    abstract::Zinc finger protein 403 (ZFP403), located on human chromosome 17q12‑21, is closely associated with the development of cancer. However, to date, there are a limited number of studies on the biological functions of this gene, particularly in prostate cancer (PCa). The results of the present study demonstrated that compa...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2020.7786

    authors: Xu X,Zhu Z,Xu Y,Tian S,Jiang Y,Zhao H

    更新日期:2020-12-01 00:00:00

  • Histone deacetylase 4 increases progressive epithelial ovarian cancer cells via repression of p21 on fibrillar collagen matrices.

    abstract::Histone deacetylase (HDAC) 4 is an emerging target in cancer therapeutics, but little is known about the function of HDAC4 in gynecologic malignancies. Therefore we investigated the mechanism of HDAC4 promoting the proliferation of epithelial ovarian cancer cells (OV). In this study, we observed that the proliferation...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4423

    authors: Shen YF,Wei AM,Kou Q,Zhu QY,Zhang L

    更新日期:2016-02-01 00:00:00

  • Predictive factors in patients with advanced and metastatic squamous cell carcinoma of the head and neck: a study based on SWOG protocol S0420.

    abstract::To evaluate the prognostic values of different protein expression in the progression of squamous cell carcinoma of the head and neck (SCCHN) patients, we conducted immunohistochemical (IHC) analysis in tissue samples of different patients enrolled on SWOG protocol S0420. S0420 was a phase II trial to evaluate the effi...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2374

    authors: Mehta S,Moon J,Hashmi M,Leblanc M,Huang CH,Rinehart E,Wolf GT,Urba SG,Banerjee SK,Williamson S

    更新日期:2013-06-01 00:00:00

  • PI3Kβ inhibitor AZD6482 exerts antiproliferative activity and induces apoptosis in human glioblastoma cells.

    abstract::Glioblastoma is the most common type of primary brain tumour in adults, and its pathogenesis is particularly complicated. Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6845

    authors: Xu PF,Yang JA,Liu JH,Yang X,Liao JM,Yuan FE,Liu BH,Chen QX

    更新日期:2019-01-01 00:00:00

  • Inhibition of pancreatic cancer and potentiation of gemcitabine effects by the extract of Pao Pereira.

    abstract::Lack of effective therapy is a major problem in the treatment of pancreatic cancer. In the present study, we investigated a natural product, the extract of Pao Pereira (Pao), for its anti-pancreatic cancer effect in vitro and in vivo, either alone or in combination with the first-line chemotherapeutic drug gemcitabine...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2461

    authors: Yu J,Drisko J,Chen Q

    更新日期:2013-07-01 00:00:00

  • Phosphorylation state of tumor-suppressor gene p53 product overexpressed in skin tumors.

    abstract::Post-transcriptional modification of p53 by phosphorylation has been proposed as an important mechanism of p53 stabilization and functional regulation. However, little is known about the phosphorylation state of mutant p53 protein overexpressed in human tumors. We evaluated immunohistochemically the p53 phosphorylatio...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Matsumoto M,Furihata M,Kurabayashi A,Ohtsuki Y

    更新日期:2004-11-01 00:00:00

  • MicroRNA-124 inhibits cell proliferation and migration by regulating SNAI2 in breast cancer.

    abstract::MicroRNA (miRNA) is a type of endogenous non‑coding RNA implicated in various cellular processes. Studies have shown that miR-124 is involved in the malignant progression of cancer, but little is known concerning its potential role in breast cancer. Therefore, the purpose of this study was to conduct a functional anal...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.5163

    authors: Du S,Li H,Sun X,Li D,Yang Y,Tao Z,Li Q,Liu K

    更新日期:2016-12-01 00:00:00

  • Carbon ions and X‑rays induce pro‑inflammatory effects in 3D oral mucosa models with and without PBMCs.

    abstract::Oral mucositis is a severe complication of radiotherapy. Hence, it may constitute a serious medical safety risk for astronauts during extended space flights, such as missions to Mars, during which they are exposed to heavy-ion irradiation. For risk assessment of developing radiation-induced mucositis, a three-dimensio...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3441

    authors: Tschachojan V,Schroer H,Averbeck N,Mueller-Klieser W

    更新日期:2014-11-01 00:00:00

  • Clinical factors in prediction of prognosis after anterior resection with total mesorectal excision for carcinoma of the rectum.

    abstract::The aim of the study was to estimate the long-term results and the prognostic value of clinical and pathological factors following R0 anterior resection with total mesorectal excision (TME). Ninety-eight consecutive patients with histologically confirmed rectal cancer were studied prospectively with five-year follow-u...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Szynglarewicz B,Matkowski R,Forgacz J,Pudelko M,Smorag Z,Dryl J,Kornafel J

    更新日期:2007-02-01 00:00:00

  • Thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in hepatocellular carcinoma and metastatic liver cancer.

    abstract::Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) are considered to be key enzymes affecting the prognosis for patients with various cancers. We tried to prove the correlation of TP and DPD expression in hepatocellular carcinoma (HCC) and liver metastasis. We quantified TP and DPD levels by an enz...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Hotta T,Kobayashi Y,Taniguchi K,Johata K,Sahara M,Watanabe T,Ochiai M,Tanimura H,Tsubota YT

    更新日期:2004-08-01 00:00:00

  • In vivo antitumor effect of ascorbic acid, lysine, proline and green tea extract on human colon cancer cell HCT 116 xenografts in nude mice: evaluation of tumor growth and immunohistochemistry.

    abstract::Colorectal cancer is the second most deadly cancer in the United States. When diagnosed early, current treatments bring a limited success; however, once metastasis occurs, radiation and chemotherapy are generally ineffective. Structural changes in the ECM are necessary for cell migration during tissue remodeling. Matr...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Roomi MW,Ivanov V,Kalinovsky T,Niedzwiecki A,Rath M

    更新日期:2005-03-01 00:00:00

  • Oxymatrine inhibits the migration of human colorectal carcinoma RKO cells via inhibition of PAI-1 and the TGF-β1/Smad signaling pathway.

    abstract::Transforming growth factor-β1 (TGF-β1) signaling has been shown to play a critical role in the development of epithelial-mesenchymal transition (EMT). PAI-1 is one of the most important target genes in the TGF-β/Smad signaling pathway, which can hinder the degradation of ECM composition and may promote cell invasion a...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.5292

    authors: Wang X,Liu C,Wang J,Fan Y,Wang Z,Wang Y

    更新日期:2017-02-01 00:00:00

  • P2Y2 nucleotide receptor-mediated extracellular signal-regulated kinases and protein kinase C activation induces the invasion of highly metastatic breast cancer cells.

    abstract::Tumor metastasis is considered the main cause of mortality in cancer patients, thus it is important to investigate the differences between high- and low-metastatic cancer cells. Our previous study showed that the highly metastatic breast cancer cell line MDA-MB-231 released higher levels of ATP and exhibited higher P2...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.3972

    authors: Eun SY,Ko YS,Park SW,Chang KC,Kim HJ

    更新日期:2015-07-01 00:00:00

  • Loss of mitochondrial DNA enhances angiogenic and invasive potential of hepatoma cells.

    abstract::Mitochondrial DNA (mtDNA) mutations are frequently found in a variety of tumors. However, the role of mtDNA mutations in tumor behavior is poorly understood. We explored the effects of mtDNA mutations on tumor phenotype employing mtDNA-depleted SK-Hep1 rho0 hepatoma cells. Expression of hypoxia inducible factor (HIF)-...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Cheon H,Moon HE,Lee MS,Kim SS

    更新日期:2010-03-01 00:00:00

  • EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.

    abstract::Esophageal cancer (EC) has a globally increasing incidence with poor curative treatment options and survival rates. Crucial risk factors are exposure to toxins or carcinogens. Microsomal epoxide hydrolase (mEH) is a biotransformation enzyme essential for the detoxification of xenobiotics. Polymorphisms in exon 3 and e...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.1734

    authors: Dura P,Bregitha CV,Te Morsche RH,Roelofs HM,Kristinsson JO,Wobbes T,Witteman BJ,Tan AC,Drenth JP,Peters WH

    更新日期:2012-06-01 00:00:00