Possible mechanism of growth inhibition by Scutellaria baicalensis in an estrogen-responsive mouse tumor cell line.

abstract：:Case 1: a patient was diagnosed as having ascending colon cancer with right ovarian metastasis, and underwent palliative right hemicolectomy plus oophorectomy. The tumor was a well-differentiated adenocarcinoma with right ovarian metastasis, and the disease was classified as stage IV. Oral chemotherapy with UFT plus L...

journal_title：Oncology reports

authors： mukai M,Moriya H,Himeno S,Oida Y,mukohyama S,Nishi T,Nakasaki H,Satoh S,Makuuchi H

更新日期：2001-09-01 00:00:00

abstract：:The degradation of basement membranes by tumor cells involves secretion and activation of proteinases, such as the matrix metalloproteinases (MMPs), and results from an imbalance between their inhibitors and activators that are controlled by various growth factors or cytokines, among which TGF-β(1) may be the most int...

journal_title：Oncology reports

authors： Jin H,Xie X,Hu B,Gao F,Zhou J,Zhang Y,Du L,Wang X,Zhao L,Zhang X,Shen L,Liao Y,Tang J

更新日期：2013-02-01 00:00:00

abstract：:ETS‑domain containing protein (Elk1) is reported to be a member of the ETS oncogene family, and promotes tumorigenesis in cancer such as bladder, prostate and ovarian. Nevertheless, the role of Elk1 in thyroid cancer progression remains unclear. In the present study, we aimed to investigate the role and underlying mol...

journal_title：Oncology reports

authors： Kong Y,Yin J,Fu Y,Chen Y,Zhou Y,Geng X

更新日期：2018-09-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients with epithelial growth factor receptor (EGFR) mutations and bone metastases are often concurrently administered tyrosine kinase inhibitors (TKIs) and bisphosphonates. Yet, the effects and mechanisms of these agents are unclear. In the present study, we aimed to ascertain whe...

journal_title：Oncology reports

authors： Feng C,Liu X,Li X,Guo F,Huang C,Qin Q,Wang Y

更新日期：2016-06-01 00:00:00

abstract：:Statins are the most effective drugs used in the reduction of intracellular synthesis of cholesterol. Numerous studies have confirmed that statins reduce the risk of multiple types of cancers. Statin use in cancer patients is associated with reduced cancer-related mortality. Epithelial-to-mesenchymal transition (EMT),...

journal_title：Oncology reports

authors： Fan Z,Jiang H,Wang Z,Qu J

更新日期：2016-08-01 00:00:00

abstract：:Mammary small cell carcinoma (SmCC) is a very rare neoplasm with a poor prognosis compared with other invasive carcinomas. We studied the histological and immunohistochemical profiles of two cases of mammary SmCC, and compared them with those of five cases of carcinoma with endocrine features (CEF) and five cases of i...

journal_title：Oncology reports

authors： Yamamoto J,Ohshima K,Nabeshima K,Ikeda S,Iwasaki H,Kikuchi M

更新日期：2004-04-01 00:00:00

abstract：:Codonolactone (CLT), a natural product, is the major bioactive component of Atractylodes lancea, and also found in a range of other medical herbs, such as Codonopsis pilosula, Chloranthus henryi Hemsl and Atractylodes macrocephala Koidz. This sesquiterpene lactone has been demonstrated to exhibit a range of activities...

journal_title：Oncology reports

authors： Fu J,Ke X,Tan S,Liu T,Wang S,Ma J,Lu H

更新日期：2016-01-01 00:00:00

abstract：:Cadmium and nickel have been classified as carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. Given their prevalence in the environment, the fact that cadmium and nickel may cause diseases including cancer even at low doses is a cause for concern. However, the exact ...

journal_title：Oncology reports

authors： Kwon JY,Weon JI,Koedrith P,Park KS,Kim IS,Seo YR

更新日期：2013-09-01 00:00:00

abstract：:Post‑transcriptional mechanisms are an important approach in the treatment of cancer, and may also be hijacked by tumor cells to help adapt to the local microenvironment. Filamin B (FLNB), an actin‑binding protein that provides crucial scaffolds for cell motility and signaling, has also been identified as an RNA‑bindi...

journal_title：Oncology reports

authors： Ma HR,Cao L,Wang F,Cheng C,Jiang R,Zhou H,Xie Z,Wuermanbieke S,Qian Z

更新日期：2020-05-01 00:00:00

abstract：:Recent studies suggest that long non-coding RNAs (lncRNAs) play crucial roles in many types of human malignant cancers. However, the function of lncRNAs in benign tumors remains poorly understood. In the present study, to explored the potential roles of lncRNAs in benign epithelial ovarian cysts (BEOCs) which commonly...

journal_title：Oncology reports

authors： Liu X,Dai C,Jia G,Xu S,Fu Z,Xu J,Li Q,Ruan H,Xu P

更新日期：2017-08-01 00:00:00

abstract：:Gastric cancer is currently the fourth most common cancer and the third leading cause of cancer‑associated mortality worldwide. Studies have identified that certain biomarkers contribute to the prognosis, diagnosis and treatment of gastric cancer. However, the biomarkers of gastric cancer are rarely used clinically. T...

journal_title：Oncology reports

authors： Yuan J,Tan L,Yin Z,Tao K,Wang G,Shi W,Gao J

更新日期：2019-01-01 00:00:00

abstract：:The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we dis...

journal_title：Oncology reports

authors： Malas S,Harrasser M,Lacy KE,Karagiannis SN

更新日期：2014-09-01 00:00:00

abstract：:Histone acetylation is one of the key chromatin modifications that control gene transcription during development and tumorigenesis. Recently, it was reported that the histone deacetylase inhibitor, Trichostatin A (TSA), induces growth arrest and apoptosis in tumors. However, the mol...

journal_title：Oncology reports

authors： Anh TD,Ahn MY,Kim SA,Yoon JH,Ahn SG

更新日期：2012-02-01 00:00:00

abstract：:Given such differences as relative tumor burden, the optimal dose and schedule for postoperative adjuvant chemotherapy of microscopic disease might be expected to differ significantly from therapy of advanced higher volume disease. We investigated this hypothesis by determining the optimal dose and schedule of the 5-F...

journal_title：Oncology reports

authors： Uchida J,Okabe H,Nakano K,Fujioka A,Saito H,Sugimoto Y,Oka T,Fukushima M

更新日期：2007-08-01 00:00:00

abstract：:ZNF703, a member of the NET/Nlz family of zinc finger transcription factors, contributes to aspects of developmental growth and patterning across evolutionarily diverse species. ZNF703 has been identified as a novel oncogene in human breast cancer. In the present study, we investigated the expression of ZNF703 in gast...

journal_title：Oncology reports

authors： Yang G,Ma F,Zhong M,Fang L,Peng Y,Xin X,Zhong J,Yuan F,Gu H,Zhu W,Zhang Y

更新日期：2014-04-01 00:00:00

abstract：:Despite intense research in the field of breast cancer it still remains the most common cancer in women in the Western world. A decreasing trend in mortality was mainly achieved by improved early detection which led to an increased incidence of ductal carcinoma in situ (DCIS) of the breast. For the patient's prognosis...

journal_title：Oncology reports

authors： Schmid BC,Rudas M,Fabjani G,Speiser P,Kaserer K,Leodolter S,Zeillinger R

更新日期：2003-11-01 00:00:00

abstract：:Normal breast development is controlled by a balance between cell proliferation and apoptosis. The balance between the two parameters is crucial for determining the growth or regression of breast tumours in response to therapies and treatments. Therefore, it is necessary to understand the role of apoptosis in tumour p...

journal_title：Oncology reports

authors： Puertollano MA,Carrera MP,Puertollano E,Alvarez de Cienfuegos G,Ramirez-Expósito MJ,De Pablo MA,Martinez-Martos JM

更新日期：2008-09-01 00:00:00

abstract：:Monoclonal antibody therapy for immune checkpoint blockade has achieved promising results for several types of malignant tumors. For the future treatment of gastrointestinal stromal tumors (GISTs) by immune checkpoint blockade, expression of immune checkpoint-related molecules that suppress antitumor immunity in GISTs...

journal_title：Oncology reports

authors： Komita H,Koido S,Hayashi K,Kan S,Ito M,Kamata Y,Suzuki M,Homma S

更新日期：2015-10-01 00:00:00

abstract：:The incidence of malignant melanoma has increased greatly in recent decades presenting a high mortality rate despite intensive efforts in this area of research. Recent studies indicate that the chemokine receptor 4 (CXCR4) plays a critical role in cancer. Thus, it has been reported that CXCL12 binding to CXCR4 initiat...

journal_title：Oncology reports

authors： André ND,Silva VA,Watanabe MA,De Lucca FL

更新日期：2016-04-01 00:00:00

abstract：:The aim of the present study was to search for an effective regimen among existing chemotherapies for head and neck squamous cell carcinoma (HNSCC). Among the tested drugs, we focused on combined SN-38, which is the active metabolite produced from irinotecan hydrochloride - a type I DNA topoisomerase inhibitor - after...

journal_title：Oncology reports

authors： Nanbu T,Umemura N,Ohkoshi E,Nanbu K,Sakagami H,Shimada J

更新日期：2018-01-01 00:00:00

abstract：:The expression of CDR1‑AS, a representative circular RNA, is closely linked with poor prognosis in gastrointestinal cancers, such as colon, liver, and pancreatic cancers. Although it is well known that CDR1‑AS antagonizes microRNA‑7 function through its sequence similarities in the brain, its biological function and l...

journal_title：Oncology reports

authors： Tanaka E,Miyakawa Y,Kishikawa T,Seimiya T,Iwata T,Funato K,Odawara N,Sekiba K,Yamagami M,Suzuki T,Ishibashi R,Otsuka M,Koike K

更新日期：2019-10-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a common type of esophageal cancer and is prevalent worldwide. Understanding the mechanisms underlying its formation and the search for more effective therapeutic strategies are critical due to the occurrence of chemotherapeutic drug resistance. The aim of the present study...

journal_title：Oncology reports

authors： Wang X,Cheng G,Zhang T,Deng L,Xu K,Xu X,Wang W,Zhou Z,Feng Q,Chen D,Bi N,Wang L

更新日期：2020-01-01 00:00:00

abstract：:At present, acute promyelocytic leukemia (APL) is the most curable form of acute myeloid leukemia and can be treated using all-trans retinoic acid and arsenic trioxide. However, the current treatment of APL is associated with some issues such as drug toxicity, resistance and relapse. Therefore, other strategies are ne...

journal_title：Oncology reports

authors： Zhao Y,Zhong L,Liu L,Yao SF,Chen M,Li LW,Shan ZL,Xiao CL,Gan LG,Xu T,Liu BZ

更新日期：2018-08-01 00:00:00

abstract：:The antitumor effect of photodynamic therapy (PDT) mediated by a novel photosensitizer I (Ps I; {γ-[N-poly(ethyleneglycol)]folic acid}-5,10,15-tris(3-hydroxyphenyl)-20-(4-carboxyphenyl)chlorin), in which chlorin was used as a photoactive unit, folic acid as a tumor‑targeting warhead, and polyethylene glycol as a linke...

journal_title：Oncology reports

authors： Li PX,Mu JH,Xiao HL,Li DH

更新日期：2015-01-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of human esophageal cancer in East Asia. In the present study, we explored the tumor suppressive function of microRNA-181d (miR-181d) in ESCC. Quantitative RT-PCR was used to assess gene levels of miR‑181d in both ESCC cell lines and clinical samples...

journal_title：Oncology reports

authors： Li D,Shi M,Ji H,Chen G,Jiang H,Wang Z

更新日期：2016-10-01 00:00:00

abstract：:The deficiencies of nucleotide excision repair (NER) factors are involved in rare genetic diseases such as xeroderma pigmentosum (XP) with increased risk of developing cancer on sun-exposed areas of the skin. However, the abnormality of NER factors in human sporadic carcinoma remains unclear. Loss of heterozygosity (L...

journal_title：Oncology reports

authors： Miyashita H,Mori S,Tanda N,Nakayama K,Kanzaki A,Sato A,Morikawa H,Motegi K,Takebayashi Y,Fukumoto M

更新日期：2001-09-01 00:00:00

abstract：:Casticin, a polymethoxyflavone, has been reported to exert anticancer activities. The objectives of this study were to examine the molecular mechanisms by which casticin induces the growth inhibition and cell cycle arrest in human hepatocellular carcinoma (HCC) cells. The HCC cell l...

journal_title：Oncology reports

authors： He L,Yang X,Cao X,Liu F,Quan M,Cao J

更新日期：2013-01-01 00:00:00

abstract：:Isocitrate dehydrogenase 2 (IDH2) is a mitochondrial NADP-dependent isocitrate dehydrogenase. It is considered to be a novel tumor suppressor in several types of tumors. However, the role and related mechanism of IDH2 in osteosarcoma remain unknown. The expression and significance of IDH2 were investigated by immunohi...

journal_title：Oncology reports

authors： Yi WR,Li ZH,Qi BW,Ernest ME,Hu X,Yu AX

更新日期：2016-04-01 00:00:00

abstract：:The metastasis-associated (MTA) gene family is a critical component of the nucleosome remodeling and histone deacetylase complex, and plays an important role in metastatic processes. We systematically evaluated dysregulation of the MTA family to clarify their clinical significance in gastric cancer (GC). One hundred a...

journal_title：Oncology reports

authors： Okugawa Y,Mohri Y,Tanaka K,Kawamura M,Saigusa S,Toiyama Y,Ohi M,Inoue Y,Miki C,Kusunoki M

更新日期：2016-10-01 00:00:00

abstract：:SET domain bifurcated 1 (SETDB1) is a histone H3 lysine 9 methyltransferase that is highly expressed in various tumor types, including breast cancer. However, how SETDB1 functions in breast cancer is unclear. In the present study, proliferation, migration and invasion assays were performed to explore the role of SETDB...

journal_title：Oncology reports

authors： Yang W,Su Y,Hou C,Chen L,Zhou D,Ren K,Zhou Z,Zhang R,Liu X

更新日期：2019-02-01 00:00:00