MicroRNA-302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma.

abstract：:Though patients with EGFR mutations are initially responsive to EGFR-tyrosine kinase inhibitors (TKIs), most tumors ultimately acquire resistance to EGFR-TKIs. The most frequently reported mechanism is EGFR T790M mutation. In this study, using a droplet digital PCR (ddPCR) system, we assessed optimal conditions for a ...

journal_title：Oncology reports

authors： Suzawa K,Yamamoto H,Ohashi K,Hashida S,Tomida S,Kubo T,Maki Y,Soh J,Tsukuda K,Kiura K,Miyoshi S,Toyooka S

更新日期：2017-05-01 00:00:00

abstract：:Inflammasomes can identify endogenous danger signals as an inflammatory immune response. As the most common inflammasome, the NLR pyrin family domain containing 3 (NLRP3) inflammasome is associated with the pathogenesis of different tumors. However, the function of the NLRP3 inflammasome in esophageal cancer (EC) has ...

journal_title：Oncology reports

authors： Yu S,Yin JJ,Miao JX,Li SG,Huang CZ,Huang N,Fan TL,Li XN,Wang YH,Han SN,Zhang LR

更新日期：2020-04-01 00:00:00

abstract：:Heparanase is endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix and basement membrane. Heparanase has been thought to have an important role in the process of cancer invasion and metastasis. Recent studies have revealed that heparanase has multifunctional mo...

journal_title：Oncology reports

authors： Naomoto Y,Takaoka M,Okawa T,Nobuhisa T,Gunduz M,Tanaka N

更新日期：2005-07-01 00:00:00

abstract：:The long non‑coding RNA (lncRNA) PVT1 plays vital roles in the tumorigenesis and development of various types of cancer. However, the potential expression profiling, functions and pathways of PVT1 in HCC remain unknown. PVT1 was knocked down in SMMC‑7721 cells, and a miRNA microarray analysis was performed to detect t...

journal_title：Oncology reports

authors： Zhang Y,Mo WJ,Wang X,Zhang TT,Qin Y,Wang HL,Chen G,Wei DM,Dang YW

更新日期：2018-07-01 00:00:00

abstract：:Colorectal cancer is the second most deadly cancer in the United States. When diagnosed early, current treatments bring a limited success; however, once metastasis occurs, radiation and chemotherapy are generally ineffective. Structural changes in the ECM are necessary for cell migration during tissue remodeling. Matr...

journal_title：Oncology reports

authors： Roomi MW,Ivanov V,Kalinovsky T,Niedzwiecki A,Rath M

更新日期：2005-03-01 00:00:00

abstract：:Combined chemotherapy with 5-fluorouracil and leucovorin (LV) has been widely used for the treatment of patients with colorectal cancer. Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), whic...

journal_title：Oncology reports

authors： Tsukioka S,Sakamoto E,Tsujimoto H,Nakagawa F,Saito H,Uchida J,Kiniwa M,Fukushima M

更新日期：2011-05-01 00:00:00

abstract：:Although ascorbate (Vitamin C) has been shown to inhibit cell growth and induce cell death in variety of cancer cells, results reported in other studies are inconsistent with this conclusion. It was previously reported that ascorbate induces apoptosis in human breast cancer cells. However, the molecular mechanism for ...

journal_title：Oncology reports

authors： Hong SW,Jin DH,Hahm ES,Yim SH,Lim JS,Kim KI,Yang Y,Lee SS,Kang JS,Lee WJ,Lee WK,Lee MS

更新日期：2007-10-01 00:00:00

abstract：:Luteolin was recently demonstrated to suppress tumor growth by interfering with nuclear factor (NF)‑κB activation. As the NF‑κB pathway plays a critical role in muscular atrophy associated with cancer cachexia, we aimed to investigate the potential of luteolin to alleviate cancer‑associated cachexia in a Lewis lung ca...

journal_title：Oncology reports

authors： Chen T,Li B,Xu Y,Meng S,Wang Y,Jiang Y

更新日期：2018-08-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor-γ (PPAR-γ) coactivator-1β (PGC-1β) is a well-established regulator of mitochondrial biogenesis. However, the underlying mechanism of PGC-1β action remains elusive. This study reveals that knockdown of endogenous PGC-1β by short-hairpin RNA (shRNA) leads to a decrease in t...

journal_title：Oncology reports

authors： Wang L,Liu Q,Li F,Qiu J,Fan H,Ma H,Zhu Y,Wu L,Han X,Yang Z,Jiang H,Wei J,Xia H

更新日期：2013-10-01 00:00:00

abstract：:The present study was carried out to investigate the clinical significance of TMPRSS3 and TNFRSF11B in breast cancer. Thus, the expression levels of TMPRSS3 and TNFRSF11B and the correlation with prognosis in patients with breast cancer were analyzed in silico using gene microarray and hierarchical clustering analysis...

journal_title：Oncology reports

authors： Luo P,Lu G,Fan LL,Zhong X,Yang H,Xie R,Lv Z,Lv QZ,Fu D,Yang LX,Ma Y

更新日期：2017-04-01 00:00:00

abstract：:We conducted a clinical pharmacological evaluation of paclitaxel/carboplatin combination in Japanese patients with non-small cell lung cancer. The purpose of this study was to identify the optimal dose of this combination and to investigate the relationships between the pharmacokinetic profiles of these 2 drugs, serum...

journal_title：Oncology reports

authors： Daga H,Isobe T,Miyazaki M,Fujitaka K,Kondo K,Kohno N

更新日期：2004-06-01 00:00:00

abstract：:Breast cancer is the most common cancer type and the leading cause of cancer‑associated mortality in women across the majority of countries. In general, the incidence of breast cancer has been decreasing in developed countries over the previous 20 years, while it has increased in the other areas, such as the Asian‑Pac...

journal_title：Oncology reports

authors： Han R,Zhao J,Lu L

更新日期：2020-06-01 00:00:00

abstract：:Ribonucleotide reductase M2 subunit (RRM2) is one of the two subunits of human ribonucleotide reductase which plays a critical role in tumor progression. The aim of the present study was to analyze its expression, clinical significance and biological functions in gastric adenocarcinoma. We observed the upregulation of...

journal_title：Oncology reports

authors： Kang W,Tong JH,Chan AW,Zhao J,Wang S,Dong Y,Sin FM,Yeung S,Cheng AS,Yu J,To K

更新日期：2014-06-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a process implicated in cancer progression in which the underlying cellular changes have been identified mainly using in vitro models. We determined the expression of some putative EMT biomarkers including E-cadherin, beta-catenin, zinc finger factor Snail (Snail), transfo...

journal_title：Oncology reports

authors： Logullo AF,Nonogaki S,Pasini FS,Osório CA,Soares FA,Brentani MM

更新日期：2010-02-01 00:00:00

abstract：:In the present study, we identified a gene termed Nbla10993 whose expression levels are higher in favorable neuroblastomas versus unfavorable ones. Structural analysis showed that Nbla10993 is a novel splicing variant of the ER-associated protein of 140 kDa (ERAP140), which lacks the central acidic as well as the COOH...

journal_title：Oncology reports

authors： Arai H,Ozaki T,Niizuma H,Nakamura Y,Ohira M,Takano K,Matsumoto M,Nakagawara A

更新日期：2008-06-01 00:00:00

abstract：:Histamine receptor H3 (HRH3) is mainly expressed in the central nervous system, where it is involved in the regulation of the release of various neurotransmitters in the brain. Recent studies have demonstrated that the expression of HRH3 is upregulated in several types of cancer. However, the functional effect of HRH3...

journal_title：Oncology reports

authors： Yu D,Zhao J,Wang Y,Hu J,Zhao Q,Li J,Zhu J

更新日期：2019-06-01 00:00:00

abstract：:In recent years an extensive series of synthetic combretastatin A-4 (CA-4)-azetidinone (β-lactam) hybrids were designed and synthesised with a view to improve the stability, therapeutic efficacy and aqueous solubility of CA-4. Lead compounds containing a 3,4,5-trimethoxy aromatic ring at position 1 and a variety of su...

journal_title：Oncology reports

authors： Greene LM,Wang S,O'Boyle NM,Bright SA,Reid JE,Kelly P,Meegan MJ,Zisterer DM

更新日期：2013-06-01 00:00:00

abstract：:Leptin may be involved in the pathogenesis of numerous cancer types by activation of cellular signal-transduction pathways. In this study, we analyzed the role of leptin and the mechanism(s) underlying its action in cervical carcinoma cells. Firstly, we examined the expression of leptin in 80 cases of cervical carcino...

journal_title：Oncology reports

authors： Yuan Y,Zhang J,Cai L,Ding C,Wang X,Chen H,Wang X,Yan J,Lu J

更新日期：2013-06-01 00:00:00

abstract：:We conducted a study to determine whether the expression levels of genes in tumors were correlated with the survival of patients after complete resection of non-small cell lung cancer (NSCLC). The expression levels of 1176 genes in resected tumor specimens from 28 patients were analyzed using the Atlastrade mark Human...

journal_title：Oncology reports

authors： Oshita F,Sekiyama A,Ito H,Kameda Y,Miyagi Y

更新日期：2006-10-01 00:00:00

abstract：:The development of drug resistance represents a major complication in the effective treatment of breast cancer. Epigenetic therapy, through the use of histone deacetylase inhibitors (HDACi) or demethylation agents, is an emerging area of therapeutic targeting in a number of ontologi...

journal_title：Oncology reports

authors： Rhodes LV,Nitschke AM,Segar HC,Martin EC,Driver JL,Elliott S,Nam SY,Li M,Nephew KP,Burow ME,Collins-Burow BM

更新日期：2012-01-01 00:00:00

abstract：:The overexpression of EGFR and/or HER-2 is associated with tumor cell resistance to chemotherapy, radiotherapy, disease progression and poor prognosis in patients with a variety of malignant tumors. Treatment combining the EGFR-targeting drug, gefitinib (ZD1839, Iressa) with the HER-2-targeting drug, trastuzumab (Herc...

journal_title：Oncology reports

authors： Kondo N,Ishiguro Y,Kimura M,Sano D,Fujita K,Sakakibara A,Taguchi T,Toth G,Matsuda H,Tsukuda M

更新日期：2008-08-01 00:00:00

abstract：:The estrogen receptor (ER) expression and HER2 amplification are important factors in determining the prognosis and therapy of breast cancer. Interactions between the two signaling pathways for example resulted in ERalpha-dependent regulation of HER2 expression in breast cancer cells. In this study, we investigated to...

journal_title：Oncology reports

authors： Lattrich C,Juhasz-Boess I,Ortmann O,Treeck O

更新日期：2008-03-01 00:00:00

abstract：:To ascertain the implications of loss of imprinting (LOI) of the insulin-like growth factor II gene (IGF2) for carcinogenesis, the precise frequency of LOI in colorectal carcinoma was examined using a laser capture microdissection method, and compared to the matched normal colorectal mucosa. LOI was examined by PCR-re...

journal_title：Oncology reports

authors： Maenaka S,Hikichi T,Imai MA,Minamoto T,Kawahara E

更新日期：2006-04-01 00:00:00

abstract：:Overexpression or amplification of G1 cyclins has been demonstrated in various types of human cancers. Overexpression of cyclin D1, an accelerator of cell cycle, is thought to be an early event in colonic multistage carcinogenesis, but its expression at transformation from benign to neoplastic foci is not clear. We an...

journal_title：Oncology reports

authors： Izawa H,Yamamoto H,Ikeda M,Ikeda K,Fukunaga H,Yasui M,Ikenaga M,Sekimoto M,Monden T,Matsuura N,Monden M

更新日期：2002-11-01 00:00:00

abstract：:The abilities of 5,6-benzoflavone (5,6-BF, a synthetic flavonoid), indole-3-carbinol (I3C, a plant derived product) or diindolylmethane (DIM, a condensation product of I3C) to alter the induction of mammary cancers induced by the carcinogens 7,12-dimethylbenzanthracene (DMBA) or N-methyl-N-nitrosourea (MNU) were evalu...

journal_title：Oncology reports

authors： Lubet RA,Heckman BM,De Flora SL,Steele VE,Crowell JA,Juliana MM,Grubbs CJ

更新日期：2011-09-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and cancer. Among the pathogenic factors of HBV, HBV X protein (HBx) is attracting increased attention. Although it is documented that HBx is a multifunctional regulator that modulates cell inflammation and apoptosis, the exact mechanism r...

journal_title：Oncology reports

authors： Gao WY,Li D,Cai DE,Huang XY,Zheng BY,Huang YH,Chen ZX,Wang XZ

更新日期：2017-01-01 00:00:00

abstract：:The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present study included 81 consecutive patients with confirmed diagnoses of r...

journal_title：Oncology reports

authors： Shoji H,Motegi M,Takakusagi Y,Asao T,Kuwano H,Takahashi T,Ogoshi K

更新日期：2017-02-01 00:00:00

abstract：:OCT4B1, a splice variant of OCT4, is a key regulator in maintaining the properties of pluripotency and self-renewal in embryonic stem (ES) cells. Recent results have shown that OCT4B1 is involved in tumorigenesis. However, the contribution of OCT4B1 in the tumorigenesis and drug resistance of colon cancer remains to b...

journal_title：Oncology reports

authors： Wen KM,Zhang GH,Li J,Chen ZQ,Cheng YL,Su X,Zeng QL

更新日期：2015-12-01 00:00:00

abstract：:Extracellular matrix remodeling crucial to tumorigenesis involves proteolytic enzymes, primarily matrix metalloproteinases (MMPs). MMP production is stimulated by multiple factors, including the extracellular matrix metallo-proteinase inducer EMMPRIN/CD147. Overexpression of EMMPRIN...

journal_title：Oncology reports

authors： Takahashi M,Suzuki S,Ishikawa K

更新日期：2012-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence in males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation with regard to sex factors affecting disease progression. In the present stud...

journal_title：Oncology reports

authors： Wu Y,Yao N,Feng Y,Tian Z,Yang Y,Zhao Y

更新日期：2019-09-01 00:00:00