Ascorbate (vitamin C) induces cell death through the apoptosis-inducing factor in human breast cancer cells.

abstract：:DEK, a transcription factor, is involved in mRNA splicing, transcriptional control, cell division and differentiation. Recent studies suggest that DEK overexpression can promote tumorigenesis in a wide range of cancer cell types. However, little is known concerning the status of DEK in pancreatic ductal adenocarcinoma...

journal_title：Oncology reports

authors： Sun J,Bi F,Yang Y,Zhang Y,Jin A,Li J,Lin Z

更新日期：2017-02-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), and microvessel density (MVD) have been reported to be significantly related to carcinogenesis and to tumoral progression. The aim of the study was to analyse immunohistochemically the overexpression of COX-2 and VEGF, and the MVD between one another...

journal_title：Oncology reports

authors： Raspollini MR,Amunni G,Villanucci A,Boddi V,Baroni G,Taddei A,Taddei GL

更新日期：2004-02-01 00:00:00

abstract：:Interleukin-15 (IL-15) has important anabolic effects on muscle protein metabolism through a decrease in the ATP-ubiquitin-dependent proteolytic pathway. The role of IL-15 in human cancer cachexia is unknown. The aim of this study was to assess the relationship between interleukin-1...

journal_title：Oncology reports

authors： Martínez-Hernández PL,Hernanz-Macías Á,Gómez-Candela C,Grande-Aragón C,Feliu-Batlle J,Castro-Carpeño J,Martínez-Muñoz I,Zurita-Rosa L,Villarino-Sanz M,Prados-Sánchez C,Sánchez García-Girón J

更新日期：2012-10-01 00:00:00

abstract：:Fluoroquinolones affect the proliferation and apoptotic cell death of several human malignancies. Therefore, we investigated whether new 6-aminoquinolone derivatives, initially synthesized as anti-HIV agents, could affect the proliferation and apoptotic cell death of human prostate cancer cell lines. PC3 and LNCaP cel...

journal_title：Oncology reports

authors： Minelli A,Bellezza I,Siciliano E,Liguori L,Tabarrini O,Cecchetti V,Fravolini A

更新日期：2005-06-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant intracranial tumor. Although the affected patients are usually treated with surgery combined with radiotherapy and chemotherapy, the median survival time for GBM patients is still approximately 12‑14 months. Identifying the key molecular mechanisms and targets of GBM...

journal_title：Oncology reports

authors： Miao L,Jiang Z,Wang J,Yang N,Qi Q,Zhou W,Feng Z,Li W,Zhang Q,Huang B,Chen A,Zhang D,Zhao P,Li X

更新日期：2019-08-01 00:00:00

abstract：:To investigate whether the expression of Topoisomerase II-alpha (TII-alpha) can serve as a prognostic factor in renal cell carcinoma (RCC), histological sections from 27 renal tumors were stained immunohistochemically for TII-alpha expression. The percentage of positive cells in the area of greatest staining was recor...

journal_title：Oncology reports

authors： Dekel Y,Frede T,Kugel V,Neumann G,Rassweiler J,Koren R

更新日期：2005-07-01 00:00:00

abstract：:We have previously demonstrated that gastric and intestinal endocrine cell (End-cell) marker expression is important for assessment of the histogenesis of endocrine cell tumors. However, the End-cell phenotypes of carcinoid tumors in the rectum remain largely unclear. We therefore examined marker expression of rectal ...

journal_title：Oncology reports

authors： Hirata Y,Mizoshita T,Mizushima T,Shimura T,Mori Y,Kubota E,Wada T,Ogasawara N,Tanida S,Kataoka H,Sasaki M,Kamiya T,Tsukamoto T,Tatematsu M,Joh T

更新日期：2009-01-01 00:00:00

abstract：:It has been revealed that the induction of epithelial‑mesenchymal transition (EMT) is associated with drug resistance, leading to tumor recurrence and metastasis. Recent studies have shown that chemotherapeutic agents, besides their therapeutic effects, can induce EMT and enhance invasive and metastatic properties of ...

journal_title：Oncology reports

authors： Chun SY,Kim S,Nam KS

更新日期：2017-08-01 00:00:00

abstract：:Chromosome 13 presents frequent allelic loss in esophageal squamous cell carcinomas (ESCC). However, no ESCC suppressor gene has been identified from this chromosome. To define common deletion regions that possibly contain the ESCC suppressor gene(s), we performed a mapping of allelic loss in 50 esophageal squamous ce...

journal_title：Oncology reports

authors： Guo GM,Huang XP,Dong JT,Caia Y,Xu X,Han YL,Wu M,Zhan QM,Wang MR

更新日期：2005-12-01 00:00:00

abstract：:Bisphosphonates (BPs) inhibit bone resorption by preventing osteoclast maturation and apoptosis induction. Recently, BPs have also been shown to have antitumor effects against various types of carcinomas in vitro and in vivo. In this study, we investigated the antitumor effect of zoledronic acid (ZOL), a third generat...

journal_title：Oncology reports

authors： Tamura T,Shomori K,Nakabayashi M,Fujii N,Ryoke K,Ito H

更新日期：2011-04-01 00:00:00

abstract：:Melanoma is a malignant tumor of the melanocytes. microRNAs (miRNAs) are emerging as important regulators of cancer-related processes. A thorough understanding of miRNAs in melanoma progression is important for developing new therapeutic targets. miRNA expression was detected by quantitative PCR. In vitro, MTT assay, ...

journal_title：Oncology reports

authors： Wang HF,Chen H,Ma MW,Wang JA,Tang TT,Ni LS,Yu JL,Li YZ,Bai BX

更新日期：2013-07-01 00:00:00

abstract：:Miconazole (MIC), an antifungal agent, diplays anti‑tumorigenic activity in various types of human cancers, including bladder cancer, yet its mechanism of antitumor action is not well understood. In the present study, we demonstrated that, in a cell viability assay, MIC had a cytotoxic effect on human T24, J82 and TSG...

journal_title：Oncology reports

authors： Yuan SY,Shiau MY,Ou YC,Huang YC,Chen CC,Cheng CL,Chiu KY,Wang SS,Tsai KJ

更新日期：2017-06-01 00:00:00

abstract：:Temozolomide (TMZ), as a kind of alkylating agent, is widely utilized for the treatment of glioblastoma (GBM). However, temozolomide resistance (TR) often develops quickly and results in tumor recurrence and poor outcome. Recent advances have demonstrated that miRNAs exert critical roles in chemoresistance. Downregula...

journal_title：Oncology reports

authors： Qian Z,Zhou S,Zhou Z,Yang X,Que S,Lan J,Qiu Y,Lin Y

更新日期：2017-11-01 00:00:00

abstract：:Prostate cancer is the second most commonly diagnosed cancer in men in Poland after lung cancer and the third leading cause of cancer-related mortality after lung and colon cancer. The etiology of most cases of prostate cancer are not fully known, and therefore it is essential to search for the molecular basis of pros...

journal_title：Oncology reports

authors： Nowacka-Zawisza M,Wiśnik E

更新日期：2017-11-01 00:00:00

abstract：:As tumor-associated antigens are not well characterized for the majority of human tumors, polyvalent vaccines prepared with whole-tumor antigens are an attractive approach for tumor vaccination. Vascular endothelial growth factor receptor-2 (VEGFR2), as a model antigen with which to...

journal_title：Oncology reports

authors： Yan HX,Cheng P,Wei HY,Shen GB,Fu LX,Ni J,Wu Y,Wei YQ

更新日期：2013-04-01 00:00:00

abstract：:Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid carcinoma with a poor prognosis. Thus, suitable preclinical tumor models are required for the development of new ATC therapies. In the present study, orthotopic tumor xenograft models were established using ATC cell lines and SCID mice, and tumor invasion an...

journal_title：Oncology reports

authors： Aoyama M,Takizawa H,Otani T,Inoue S,Kawakita N,Tsuboi M,Bando Y,Uehara H,Kondo K,Tangoku A

更新日期：2020-10-01 00:00:00

abstract：:In this study the performance of various intelligent methodologies is compared in the task of pap-smear diagnosis. The selected intelligent methodologies are briefly described and explained, and then, the acquired results are presented and discussed for their comprehensibility and usefulness to medical staff, either f...

journal_title：Oncology reports

authors： Dounias G,Bjerregaard B,Jantzen J,Tsakonas A,Ampazis N,Panagi G,Panourgias E

更新日期：2006-01-01 00:00:00

abstract：:We have studied the effects of Saiboku-to, a traditional Chinese medicine having suppressive activities for leukotriene production and release, on the proliferation of the estrogen-responsive mouse Leydig tumor cell line B-1F. In our previous reports, it is shown that Saiboku-to promotes, but Scutellaria baicalensis, ...

journal_title：Oncology reports

authors： Murashima T,Katayama H,Shojiro K,Nishizawa Y

更新日期：2011-05-01 00:00:00

abstract：:The aim of the present study was to screen gastric cancer (GC) tissue and adjacent tissue for differences in mRNA and circular (circRNA) expression, to analyze the differences in circRNA and mRNA expression, and to investigate the circRNA expression in gastric carcinoma and its mechanism. circRNA and mRNA differential...

journal_title：Oncology reports

authors： Sui W,Shi Z,Xue W,Ou M,Zhu Y,Chen J,Lin H,Liu F,Dai Y

更新日期：2017-03-01 00:00:00

abstract：:Drug resistance is one of the major obstacles to chemotherapy of ovarian cancer. Studies with cell lines can serve as an initial screen for agents that might modulate drug resistance. To establish more appropriate models of drug resistance and explore whether the differences exist in the different drug resistant subli...

journal_title：Oncology reports

authors： Yan XD,Li M,Yuan Y,Mao N,Pan LY

更新日期：2007-05-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is the second most common hepatic cancer with high resistance to current chemotherapies and extremely poor prognosis. The present study aimed to examine the effects of schisandrin B (Sch B) on CCA cells both in vitro and in vivo and to examine its underlying mechanism. We found that Sch B inhi...

journal_title：Oncology reports

authors： Yang X,Wang S,Mu Y,Zheng Y

更新日期：2016-10-01 00:00:00

abstract：:Although radiotherapy is routinely administered to high-risk endometrial carcinoma and offer a significant disease-free survival advantage, the therapeutic effect is sometimes limited by the occurrence of radioresistance. To determine the patterns of gene expression responsible for the radioresistance and to search fo...

journal_title：Oncology reports

authors： Du XL,Jiang T,Wen ZQ,Li QS,Gao R,Wang F

更新日期：2009-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is an aggressive disease with a poor outcome due to the high incidence of metastasis. Cancer stem cells (CSCs) have been identified to be responsible for tumor progression and may be generated by epithelial-mesenchymal transition (EMT) characteristics. CD133 is a specific surface marker ...

journal_title：Oncology reports

authors： Liu YM,Li XF,Liu H,Wu XL

更新日期：2015-12-01 00:00:00

abstract：:We radiographically evaluated the response of primary lesions to chemotherapy in 101 patients with inoperable advanced gastric cancer. The median survival time in the 50 responders (49.5%) was 379 days, as compared with only 210 days in the 51 non-responders (50.1%) (p<0. 001). Morphologic changes of the gastric mucos...

journal_title：Oncology reports

authors： Yamazaki I,Koizumi W,Kondo I,Saigenji K

更新日期：2000-11-01 00:00:00

abstract：:Signaling pathways that activate mTOR (mammalian target of rapamycin) are altered in many human cancers and these alterations are associated with prognosis and treatment response. mTOR inhibition can restore sensitivity to DNA damaging agents such as cisplatin. The rapamycin derivat...

journal_title：Oncology reports

authors： Mauceri HJ,Sutton HG,Darga TE,Kocherginsky M,Kochanski J,Weichselbaum RR,Vokes EE

更新日期：2012-05-01 00:00:00

abstract：:Significance of expression of cytokine induced nitric oxide synthase (iNOS) in colorectal carcinoma remains controversial. The aim of the current study was to elucidate the significance of immunohistochemical expression of iNOS in colorectal carcinoma. The subjects were the 54 patients with colorectal carcinoma, inclu...

journal_title：Oncology reports

authors： Nozoe T,Yasuda M,Honda M,Inutsuka S,Korenaga D

更新日期：2002-05-01 00:00:00

abstract：:The mechanisms of drug resistance in cancer are not fully elucidated. To study the drug resistance of gastric cancer, we analyzed gene expression and DNA methylation profiles of 5-fluorouracil (5-FU)- and cisplatin (CDDP)-resistant gastric cancer cells and biopsy specimens. Drug-resistant gastric cancer cells were est...

journal_title：Oncology reports

authors： Maeda O,Ando T,Ohmiya N,Ishiguro K,Watanabe O,Miyahara R,Hibi Y,Nagai T,Yamada K,Goto H

更新日期：2014-04-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a highly lethal malignant tumor arising from the biliary tract epithelium. Chronic inflammatory conditions, including primary sclerosing cholangitis, liver fluke infestation, and hepatolithiasis, are considered risk factors, but the cause is still unknown in most cases. Recent advances in m...

journal_title：Oncology reports

authors： Isomoto H

更新日期：2009-08-01 00:00:00

abstract：:Immunotherapy with autologous dendritic cells (DCs) loaded with tumor lysate(s) from allogeneic tumor cell lines is a novel strategy to induce immune responses in cancer patients. We report on a pilot trial of autologous DCs pulsed with tumor cell lysate derived from allogeneic medullary thyroid carcinoma (MTC) cell l...

journal_title：Oncology reports

authors： Bachleitner-Hofmann T,Friedl J,Hassler M,Hayden H,Dubsky P,Sachet M,Rieder E,Pfragner R,Brostjan C,Riss S,Niederle B,Gnant M,Stift A

更新日期：2009-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers worldwide. Long non-coding RNAs (lncRNAs) have been confirmed to play a critical regulatory role in various biological processes including carcinogenesis, which indicates that lncRNAs are valuable biomarkers and therapeutic targets. The novel lncRNA prostate ca...

journal_title：Oncology reports

authors： Yang L,Qiu M,Xu Y,Wang J,Zheng Y,Li M,Xu L,Yin R

更新日期：2016-01-01 00:00:00