Loss of imprinting in IGF2 in colorectal carcinoma assessed by microdissection.

Abstract:

:To ascertain the implications of loss of imprinting (LOI) of the insulin-like growth factor II gene (IGF2) for carcinogenesis, the precise frequency of LOI in colorectal carcinoma was examined using a laser capture microdissection method, and compared to the matched normal colorectal mucosa. LOI was examined by PCR-restriction fragment length polymorphism in combination with direct sequencing. The status was assigned as imprinting when PCR-RFLP showed only one band or sequence with a single peak, otherwise cases were classified as LOI. LOI was found in 13 of 24 informative cases of carcinoma (54%), which was higher than the ratios reported previously. LOI was also found in the normal colorectal mucosae in 14 cases (58%). The LOIs in carcinomas and in the normal mucosae were closely correlated: 10 of 13 LOI-positive carcinomas showed LOI in the matched normal mucosae. These results suggest that LOI of IGF2 in colorectal carcinoma and LOI in the background mucosa play important roles in carcinogenesis.

journal_name

Oncol Rep

journal_title

Oncology reports

authors

Maenaka S,Hikichi T,Imai MA,Minamoto T,Kawahara E

keywords:

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

791-5

issue

4

eissn

1021-335X

issn

1791-2431

journal_volume

15

pub_type

杂志文章
  • Effect of hepatocyte growth factor on invasion of prostate cancer cell lines.

    abstract::Hepatocyte growth factor (HGF) was suggested to play an important role in the regulation of mitogenesis, motogenesis, angiogenesis, migration and invasion for various types of cells, and acts through a specific membrane receptor encoded by c-met proto-oncogene. However, the mechanism of the effect of HGF on tumor inva...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Fujiuchi Y,Nagakawa O,Murakami K,Fuse H,Saiki I

    更新日期:2003-07-01 00:00:00

  • C5a promotes the proliferation of human nasopharyngeal carcinoma cells through PCAF-mediated STAT3 acetylation.

    abstract::The anaphylatoxin C5a is a chemoattractant that can induce various inflammatory responses in vivo via the C5a receptor (C5aR). There is emerging evidence that C5a is generated in the cancer microenvironment. However, the role of C5a in human nasopharyngeal carcinoma (NPC) remains largely unclear. Thus, the present stu...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3420

    authors: Cai K,Wan Y,Wang Z,Wang Y,Zhao X,Bao X

    更新日期:2014-11-01 00:00:00

  • Expression of transglutaminases in human breast cancer and their possible clinical significance.

    abstract::Implicated in several physiologic processes, including tumour-host, some transglutaminases (TGase) have been noted to play a regulatory role in the extracellular matrix in cell adhesion and migration of cancer cells. This study sought to determine the level of expression of TGases and their possible clinical significa...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Jiang WG,Ablin R,Douglas-Jones A,Mansel RE

    更新日期:2003-11-01 00:00:00

  • Curcumin and paclitaxel induce cell death in breast cancer cell lines.

    abstract::Breast cancer is one of the major health issues confronting women; however, treatment with conventional chemotherapeutic drugs is limited. Currently, paclitaxel is used as a therapeutic clinical agent to treat breast cancer that exerts antitumor activity in numerous types of cancer cell. Curcumin (diferuloylmethane), ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6603

    authors: Calaf GM,Ponce-Cusi R,Carrión F

    更新日期:2018-10-01 00:00:00

  • Ascorbate (vitamin C) induces cell death through the apoptosis-inducing factor in human breast cancer cells.

    abstract::Although ascorbate (Vitamin C) has been shown to inhibit cell growth and induce cell death in variety of cancer cells, results reported in other studies are inconsistent with this conclusion. It was previously reported that ascorbate induces apoptosis in human breast cancer cells. However, the molecular mechanism for ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Hong SW,Jin DH,Hahm ES,Yim SH,Lim JS,Kim KI,Yang Y,Lee SS,Kang JS,Lee WJ,Lee WK,Lee MS

    更新日期:2007-10-01 00:00:00

  • Predictive factors in patients with advanced and metastatic squamous cell carcinoma of the head and neck: a study based on SWOG protocol S0420.

    abstract::To evaluate the prognostic values of different protein expression in the progression of squamous cell carcinoma of the head and neck (SCCHN) patients, we conducted immunohistochemical (IHC) analysis in tissue samples of different patients enrolled on SWOG protocol S0420. S0420 was a phase II trial to evaluate the effi...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2374

    authors: Mehta S,Moon J,Hashmi M,Leblanc M,Huang CH,Rinehart E,Wolf GT,Urba SG,Banerjee SK,Williamson S

    更新日期:2013-06-01 00:00:00

  • Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells.

    abstract::Quercetin, a naturally occurring flavonoid abundant in fruits and vegetables, has been demonstrated as a multipotent bioflavonoid with great potential for the prevention and treatment of cancer. Apoptosis is thought to be an important response to most chemotherapeutic agents in leukemia cells. However, the underlying ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2010.1097

    authors: Lee WJ,Chen YR,Tseng TH

    更新日期:2011-02-01 00:00:00

  • Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma.

    abstract::In the development and progression of cancer, tumor suppressor genes may be silenced by mechanisms such as methylation. Thus the discovery of new genes silenced by methylation may uncover new tumor suppressor genes, and improve our understanding of cancer biology. In this study we investigated the methylation of 19 ge...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or_00000325

    authors: Tsunoda S,Smith E,De Young NJ,Wang X,Tian ZQ,Liu JF,Jamieson GG,Drew PA

    更新日期:2009-04-01 00:00:00

  • Gastric-and-intestinal mixed endocrine cell phenotypic expression of carcinoid tumors in the rectum.

    abstract::We have previously demonstrated that gastric and intestinal endocrine cell (End-cell) marker expression is important for assessment of the histogenesis of endocrine cell tumors. However, the End-cell phenotypes of carcinoid tumors in the rectum remain largely unclear. We therefore examined marker expression of rectal ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Hirata Y,Mizoshita T,Mizushima T,Shimura T,Mori Y,Kubota E,Wada T,Ogasawara N,Tanida S,Kataoka H,Sasaki M,Kamiya T,Tsukamoto T,Tatematsu M,Joh T

    更新日期:2009-01-01 00:00:00

  • Inhibition of autophagy enhances the targeted therapeutic effect of sorafenib in thyroid cancer.

    abstract::The multi-target kinase inhibitor sorafenib has been approved for the treatment of patients with advanced differentiated thyroid cancer. However, different sensitivities to sorafenib have been observed, and few patients have benefited from sorafenib treatment in the long term. In the event of acquired resistance to so...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.6118

    authors: Yi H,Ye T,Ge M,Yang M,Zhang L,Jin S,Ye X,Long B,Li L

    更新日期:2018-02-01 00:00:00

  • Muscle-specific E3 ubiquitin ligases are involved in muscle atrophy of cancer cachexia: an in vitro and in vivo study.

    abstract::Muscle atrophy F-Box (MAFbx)/atrogin-1 and muscle ring-finger-1 (MuRF-1) have been identified as two muscle-specific E3 ubiquitin ligases that are highly expressed in skeletal muscle during muscle atrophy. However, the role of muscle-specific E3 ubiquitin ligases during the process of muscle atrophy of cancer cachexia...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.3845

    authors: Yuan L,Han J,Meng Q,Xi Q,Zhuang Q,Jiang Y,Han Y,Zhang B,Fang J,Wu G

    更新日期:2015-05-01 00:00:00

  • Extracellular protease imaging for cell mass tracking of xenografted human malignant pleural mesothelioma.

    abstract::Malignant pleural mesothelioma (MPM) is locally aggressive and challenging to quantitate non-invasively in vivo, particularly in orthotopic models of disease. We describe imaging of extracellular protease activity, typically elevated in locally aggressive tumors, as a novel method f...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.1888

    authors: Zhou L,El-Deiry W,Wang W,Ingram ME,Katz SI

    更新日期:2012-09-01 00:00:00

  • Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model.

    abstract::Solid tumors are abnormal tissues containing tumor and non-tumor cells, also known as tumor stromal cells. However, the malignant potential of tumor stromal cells remains largely unknown. The aim of the present study was to investigate the malignant potential of host bone marrow‑derived stroma cells in transplanted su...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4281

    authors: Dai X,Chen H,Chen Y,Wu J,Wang H,Shi J,Fei X,Wang Z,Wang A,Dong J,Lan Q,Huang Q

    更新日期:2015-12-01 00:00:00

  • The bacterial polysaccharide tecogalan blocks growth of breast cancer cells in vivo.

    abstract::The growth of supportive tissue during the progression of solid tumors is an absolute requirement for the nourishment of the tumor. The blockade of this proliferative response of normal tissues to the growing tumor should hence inhibit tumor progression. We have shown earlier, that the heparinoid pentosan polysulfate ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Yunmbam MK,Wellstein A

    更新日期:2001-01-01 00:00:00

  • Compound K-induced apoptosis of human hepatocellular carcinoma MHCC97-H cells in vitro.

    abstract::An intestinal bacterial metabolite of ginseng protopanaxadiol saponin, 20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol (compound K), has been reported to induce apoptosis in a variety of cancer cells. However, the precise mechanisms induced by compound K in human hepatocellular carcinoma (HCC) cells remain unclear. In...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3171

    authors: Zheng ZZ,Ming YL,Chen LH,Zheng GH,Liu SS,Chen QX

    更新日期:2014-07-01 00:00:00

  • E26 transformation (ETS)‑specific related transcription factor‑3 (ELF3) orchestrates a positive feedback loop that constitutively activates the MAPK/Erk pathway to drive thyroid cancer.

    abstract::Thyroid cancer is the most commonly diagnosed malignancy of the endocrine system, the incidence of which has increased rapidly in the last 30 years. Genetic alterations in pathways, including the mitogen‑activated protein kinase (MAPK)/extracellular signal‑regulated kinase (Erk) and phosphatidylinositol‑3‑kinase (PI3K...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6807

    authors: Chen H,Chen W,Zhang X,Hu L,Tang G,Kong J,Wang Z

    更新日期:2019-01-01 00:00:00

  • The histone methyltransferase EZH2 promotes mammary stem and luminal progenitor cell expansion, metastasis and inhibits estrogen receptor-positive cellular differentiation in a model of basal breast cancer.

    abstract::Mammary stem cells (MSCs) are the progenitor population for human breast epithelia. MSCs give rise during mammary gland development to estrogen receptor (ER)-negative basal cells and the ER- luminal progenitor (LP) population which maintains ER+ and ER- luminal cells. The MSC population is expanded and tumorigenic in ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4003

    authors: Wu J,Crowe DL

    更新日期:2015-07-01 00:00:00

  • Expression of CXCL12 and CXCR4 in pT3-stage gastric cancer does not correlate with peritoneal metastasis.

    abstract::CXCR4, a chemokine receptor, is considered to be involved in the metastastic formation of various types of cancer and could influence survival. More recently, CXCR4 was reported to be associated with peritoneal metastasis in gastric cancer, and CXCL12, its ligand, as a prognostic determinant among gastric cancer of va...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Tsuboi K,Kodera Y,Nakanishi H,Ito S,Mochizuki Y,Nakayama G,Koike M,Fujiwara M,Yamamura Y,Nakao A

    更新日期:2008-11-01 00:00:00

  • Downregulation of MDC1 and 53BP1 by short hairpin RNA enhances radiosensitivity in laryngeal carcinoma cells.

    abstract::DNA double-strand breaks (DSBs) induced by ionizing radiation (IR) are among the most cytotoxic types of DNA damage. The DNA damage response (DDR) may be a reason for the cancer cell resistance to radiotherapy using IR. Identified as critical upstream mediators of the phosphorylation of ataxia telangiectasia-mutated (...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.3980

    authors: Gou Q,Xie Y,Liu L,Xie K,Wu Y,Wang Q,Wang Z,Li P

    更新日期:2015-07-01 00:00:00

  • Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non‑small cell lung cancer.

    abstract::Gasdermin D (GSDMD) is a newly discovered pyroptosis executive protein, which can be cleaved by inflammatory caspases and is essential for secretion of IL‑1β, making it a critical mediator of inflammation. However, the precise role of GSDMD in carcinogenesis remains nearly unknown. Considering the vital role of inflam...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6634

    authors: Gao J,Qiu X,Xi G,Liu H,Zhang F,Lv T,Song Y

    更新日期:2018-10-01 00:00:00

  • 18F-fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts.

    abstract::We investigated whether 18F-fluorothymidine-positron-emission tomography/computed tomography (18F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1338

    authors: Takeuchi S,Zhao S,Kuge Y,Zhao Y,Nishijima K,Hatano T,Shimizu Y,Kinoshita I,Tamaki N,Dosaka-Akita H

    更新日期:2011-09-01 00:00:00

  • Activation of caspases and apoptosis in response to low-voltage electric pulses.

    abstract::Few studies have examined apoptosis induced by low-voltage electric pulses (LVEPs). LVEP-induce changes in membrane potential that are below the membrane breakdown threshold and increase membrane permeability without electroporation (pore formation) through the transport of extracellular substances via phagocytosis. W...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or_00000780

    authors: Matsuki N,Takeda M,Ishikawa T,Kinjo A,Hayasaka T,Imai Y,Yamaguchi T

    更新日期:2010-05-01 00:00:00

  • Forced downregulation of RACK1 inhibits glioma development by suppressing Src/Akt signaling activity.

    abstract::Glioma is the most common primary brain malignant tumor. Receptor for activated C-kinase 1 (RACK1) is widely expressed in the central nervous system, and regulates multiple cellular processes including cell survival, proliferation, migration and metastasis. However, the role of RACK1 in glioma has never been revealed....

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2723

    authors: Peng R,Jiang B,Ma J,Ma Z,Wan X,Liu H,Chen Z,Cheng Q,Chen R

    更新日期:2013-11-01 00:00:00

  • Chemotherapy-induced modification of microRNA expression in esophageal cancer.

    abstract::Neoadjuvant chemotherapy is often used in the treatment of advanced esophageal cancer. In this study, we determined the impact of chemotherapy on microRNA (miRNA) expression in esophageal cancer cells, and whether identified changes might have biological relevance. Two esophageal carcinoma cell lines (one adenocarcino...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1381

    authors: Hummel R,Wang T,Watson DI,Michael MZ,Van der Hoek M,Haier J,Hussey DJ

    更新日期:2011-10-01 00:00:00

  • TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation.

    abstract::Gastric cancer (GC), a type of gastric mucosal epithelium disease caused by common malignant tumors, has become a major threat to human health and survival. Tumor necrosis factor‑α‑induced protein‑8 like‑2 (TIPE2) is a negative immune regulatory factor that is selectively expressed in immune organs, immune cells and v...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6576

    authors: Lin Z,Liu W,Xiao C,Fan Y,Zhuang G,Qi Z

    更新日期:2018-09-01 00:00:00

  • A phase II study of the combination of endocrine treatment and bortezomib in patients with endocrine-resistant metastatic breast cancer.

    abstract::The majority of patients with hormone receptor-positive metastatic breast cancer die from disease progression despite different types of anti-hormonal treatments. Preclinical studies have indicated that resistance to anti-hormonal therapies may be the result of an activated NF-κB si...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1562

    authors: Trinh XB,Sas L,Van Laere SJ,Prové A,Deleu I,Rasschaert M,Van de Velde H,Vinken P,Vermeulen PB,Van Dam PA,Wojtasik A,De Mesmaeker P,Tjalma WA,Dirix LY

    更新日期:2012-03-01 00:00:00

  • Overexpression of orotate phosphoribosyl transferase in hormone-refractory prostate cancer.

    abstract::Orotate phosphoribosyl transferase (OPRT) is the initial enzyme of 5-fluorouracil (5-FU) activation, in which 5-FU is converted to 5-fluorouridinemonophosphate. Dihydropyrimidine dehydrogenase (DPD) is a degrading enzyme that catabolizes 5-FU. In this study, we investigated the expression of these enzymes in normal pr...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Tanaka T,Kawashima H,Matsumura K,Yamashita-Hosono T,Yoshimura R,Kuratsukuri K,Harimoto K,Nakatani T

    更新日期:2009-01-01 00:00:00

  • Type III TGF-β receptor inhibits cell proliferation and migration in salivary glands adenoid cystic carcinoma by suppressing NF-κB signaling.

    abstract::It is known that the TGF-β superfamily receptors act as master regulators of cancer progression. However, alteration and role of type III TGF-β receptor (TβRIII, or betaglycan) as the most abundant of the TGF-β receptor has not been explored in salivary gland adenoid cystic carcinoma (ACC). Here, we reported that tumo...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4390

    authors: Xu D,Li D,Lu Z,Dong X,Wang X

    更新日期:2016-01-01 00:00:00

  • Frequent CYP1A1 expression in gastric cancers and their related lesions.

    abstract::CYP1A1 expression in various tissues of 43 gastric cancer cases was analyzed with frozen tissue array-based immunohistochemical staining (IHC), RT-PCR, Western blot analysis and EROD (7-ethoxyresourfin-O-deethylase) assay. CYP1A1 was detected immunohistochemically in 86% (37/43) of gastric cancers, in both 57% (4/7) o...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Zhang KL,Ma JX,Chen XY,Sun Y,Kong QY,Liu J,Li H

    更新日期:2004-12-01 00:00:00

  • Genetic progression and divergence in superficial esophageal squamous cell carcinoma by loss of heterozygosity analysis.

    abstract::Esophageal squamous cell carcinoma (SCC) is one of the most common fatal carcinomas worldwide and has some of the most malignant characteristics among gastrointestinal tumors. Although a high frequency of loss of heterozygosity (LOH) for various genes has been observed in esophageal SCCs, these findings do not provide...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Shima H,Hiyama T,Tanaka S,Yoshihara M,Arihiro K,Chayama K

    更新日期:2006-10-01 00:00:00