Efficacy of oral UFT plus leucovorin therapy for colon cancer with ovarian and multiple liver metastases: report of two cases.

abstract：:Hypoxic tumor cells are known to be more resistant to conventional chemotherapy and radiation than normoxic cells. However, the effects of 2-methoxyestradiol (2-ME), an anti-angiogenic, antiproliferative and pro-apoptotic drug, on hypoxic lung cancer cells are unknown. The aim of the present study was to compare the e...

journal_title：Oncology reports

authors： Aquino-Gálvez A,González-Ávila G,Delgado-Tello J,Castillejos-López M,Mendoza-Milla C,Zúñiga J,Checa M,Maldonado-Martínez HA,Trinidad-López A,Cisneros J,Torres-Espíndola LM,Hernández-Jiménez C,Sommer B,Cabello-Gutiérrez C,Guti

更新日期：2016-01-01 00:00:00

abstract：:We hypothesized that expression of multidrug resistance-associated protein 2 (MRP2), a major cisplatin transporter, may determine the efficacy of cisplatin as a treatment for patients with hepatocellular carcinoma (HCC). A prospective analysis was conducted of 49 consecutive patients who underwent resection for HCC (1...

journal_title：Oncology reports

authors： Korita PV,Wakai T,Shirai Y,Matsuda Y,Sakata J,Takamura M,Yano M,Sanpei A,Aoyagi Y,Hatakeyama K,Ajioka Y

更新日期：2010-04-01 00:00:00

abstract：:Following the publication of this paper, it was drawn to the authors' attention by an interested reader that certain of the tumours featured in Fig. 6A of the above paper were strikingly similar to those featured in Fig. 8A of an article appearing in International Journal of Oncology (Fan F-Y, Deng R, Yi H, Sun H-P, Z...

journal_title：Oncology reports

authors： Zhang L,Liang X,Li Y

更新日期：2021-01-01 00:00:00

abstract：:The immune suppression of sentinel lymph node (SN) is directly influenced by primary tumors. It has been reported that the T-helper type 1 (Th1) to T-helper type 2 (Th2) ratio or T-cytotoxic type 1 (Tc1) to T-cytotoxic type 2 (Tc2) ratio of lymph node lymphocytes could be used to evaluate direct immunological circumst...

journal_title：Oncology reports

authors： Ehi K,Ishigami S,Masamoto I,Uenosono Y,Natsugoe S,Arigami T,Arima H,Kijima Y,Yoshinaka H,Yanagita S,Kozono T,Funasako Y,Maruyama I,Aikou T

更新日期：2008-03-01 00:00:00

abstract：:We have previously demonstrated that gastric and intestinal endocrine cell (End-cell) marker expression is important for assessment of the histogenesis of endocrine cell tumors. However, the End-cell phenotypes of carcinoid tumors in the rectum remain largely unclear. We therefore examined marker expression of rectal ...

journal_title：Oncology reports

authors： Hirata Y,Mizoshita T,Mizushima T,Shimura T,Mori Y,Kubota E,Wada T,Ogasawara N,Tanida S,Kataoka H,Sasaki M,Kamiya T,Tsukamoto T,Tatematsu M,Joh T

更新日期：2009-01-01 00:00:00

abstract：:Four tumour suppressor genes (Chk1, Chk2, Apaf1 and Rb1) in nine human malignant melanoma cell lines were screened for a loss of gene expression, point mutations and small deletions/insertions by cDNA-based DGGE/SCCP analysis. In two cell lines alterations of the investigated genes could be demonstrated. This result c...

journal_title：Oncology reports

authors： Papp T,Niemetz A,Dosdahl N,Kumar K,Schiffmann D

更新日期：2007-01-01 00:00:00

abstract：:Bisphosphonates (BPs) inhibit bone resorption by preventing osteoclast maturation and apoptosis induction. Recently, BPs have also been shown to have antitumor effects against various types of carcinomas in vitro and in vivo. In this study, we investigated the antitumor effect of zoledronic acid (ZOL), a third generat...

journal_title：Oncology reports

authors： Tamura T,Shomori K,Nakabayashi M,Fujii N,Ryoke K,Ito H

更新日期：2011-04-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most commonly diagnosed malignancies, and 90% of advanced prostate cancer patients relapse after therapy. Trophinin associated protein (TROAP) is essential for centrosome integrity and proper bipolar organisation of spindle assembly during mitosis and plays an essential role in prol...

journal_title：Oncology reports

authors： Ye J,Chu C,Chen M,Shi Z,Gan S,Qu F,Pan X,Yang Q,Tian Y,Wang L,Yang W,Cui X

更新日期：2019-02-01 00:00:00

abstract：:Colon cancer is the main cause of cancer mortality worldwide. Its poor prognosis is mainly ascribed to high recurrence rates. Identifying novel prognostic biomarkers and therapeutic key points for management is crucial and important. Long non-coding RNAs (lncRNAs) are a class of RNAs, which have various roles in carci...

journal_title：Oncology reports

authors： Yang H,Wang S,Kang YJ,Wang C,Xu Y,Zhang Y,Jiang Z

更新日期：2018-07-01 00:00:00

abstract：:Aberrantly expressed miRNAs play a crucial role in the progression of lung adenocarcinoma. However, to date, the role of miR‑888 in lung adenocarcinoma progression is unclear. In the present study, the biological function of miR‑888 and its underlying mechanism in lung adenocarcinoma progression were explored. RT‑qPCR...

journal_title：Oncology reports

authors： Cao JX

更新日期：2019-06-01 00:00:00

abstract：:IncRNAs play an important role in the regulation of gene expression. The present study profiled differentially expressed lncRNAs (DELs) and mRNAs (DEMs) in myelodysplastic syndrome (MDS) to construct a 4‑aminobutyrate aminotransferase (ABAT)‑DEL‑DEM co‑expression network in MDS development using the Agilent human Bead...

journal_title：Oncology reports

authors： Chen Y,Zhao G,Li N,Luo Z,Wang X,Gu J

更新日期：2019-08-01 00:00:00

abstract：:In a screen for thoracic malignancy-associated markers, thyroid stimulating hormone receptor (TSHR) was identified as a candidate as it binds to the previously-characterized lung cancer marker NKX2-1. We screened for mutations in all coding regions of the TSHR gene in 96 lung adenoc...

journal_title：Oncology reports

authors： Kim JW,Lee S,Lui N,Choi H,Mulvihill M,Fang LT,Kang HC,Kwon YW,Jablons D,Kim IJ

更新日期：2012-10-01 00:00:00

abstract：:We investigated cell susceptibility to hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines (RYSTs) and attempted to correlate this with the known potentially relevant molecular determinants of apoptosis, p53 protein status, Bcl-2 family of proteins and heat shock proteins (Hsp). Parent cell line, NMT-1...

journal_title：Oncology reports

authors： Islam MS,Mitsuhashi N,Akimoto T,Sakurai H,Hasegawa M,Ishikawa H,Niibe H

更新日期：2001-05-01 00:00:00

abstract：:Expression of miR-365 has been reported to be downregulated in hepatocellular carcinoma (HCC). However, the biological function and underlying mechanism of miR-365 in HCC growth and metastasis remain unclear. The aim of the present study was to explore the role of miR-365 in HCC progression. We found that miR-365 expr...

journal_title：Oncology reports

authors： Liu Y,Zhang W,Liu S,Liu K,Ji B,Wang Y

更新日期：2017-03-01 00:00:00

abstract：:Emodin is an active ingredient derived from root and rhizome of Rheum palmatum L and many studies have reported that it exhibits anticancer effects in a number of human tumors. However, there is little information demonstrating the possible effects of emodin on the proliferation and apoptosis of hepatocellular carcino...

journal_title：Oncology reports

authors： Lin W,Zhong M,Yin H,Chen Y,Cao Q,Wang C,Ling C

更新日期：2016-08-01 00:00:00

abstract：:Few studies have examined apoptosis induced by low-voltage electric pulses (LVEPs). LVEP-induce changes in membrane potential that are below the membrane breakdown threshold and increase membrane permeability without electroporation (pore formation) through the transport of extracellular substances via phagocytosis. W...

journal_title：Oncology reports

authors： Matsuki N,Takeda M,Ishikawa T,Kinjo A,Hayasaka T,Imai Y,Yamaguchi T

更新日期：2010-05-01 00:00:00

abstract：:The advent of pathotropic (disease-seeking) targeting has transported genetic medicine across the threshold of history with the progressive clinical validation of Rexin-G, a tumor-targeted nanosized anti-cancer agent. Achieving noteworthy single-agent efficacy and survival benefits in otherwise intractable cancers, th...

journal_title：Oncology reports

authors： Hall FL,Levy JP,Reed RA,Petchpud WN,Chua VS,Chawla SP,Gordon EM

更新日期：2010-10-01 00:00:00

abstract：:The clinicopathological significance of cell-cycle proteins has remained unclear in oral tongue squamous cell carcinomas (OTSCC). In the current study, we evaluated several cell-cycle proteins in relation to clinicopathological parameters and disease outcome for OTSCC. A total of 123 previously untreated patients with...

journal_title：Oncology reports

authors： Goto M,Tsukamoto T,Inada K,Mizoshita T,Ogawa T,Terada A,Hyodo I,Shimozato K,Hasegawa Y,Tatematsu M

更新日期：2005-10-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is one of the most malignant and aggressive tumors, and has a very poor prognosis with a mean survival time of <2 years, despite intensive treatment using chemo-radiation. Therefore, novel therapeutic approaches including immunotherapy have been developed against GBM. For the purpose of i...

journal_title：Oncology reports

authors： Akiyama Y,Komiyama M,Miyata H,Yagoto M,Ashizawa T,Iizuka A,Oshita C,Kume A,Nogami M,Ito I,Watanabe R,Sugino T,Mitsuya K,Hayashi N,Nakasu Y,Yamaguchi K

更新日期：2014-04-01 00:00:00

abstract：:The long non‑coding RNA (lncRNA) PVT1 plays vital roles in the tumorigenesis and development of various types of cancer. However, the potential expression profiling, functions and pathways of PVT1 in HCC remain unknown. PVT1 was knocked down in SMMC‑7721 cells, and a miRNA microarray analysis was performed to detect t...

journal_title：Oncology reports

authors： Zhang Y,Mo WJ,Wang X,Zhang TT,Qin Y,Wang HL,Chen G,Wei DM,Dang YW

更新日期：2018-07-01 00:00:00

abstract：:Prostate cancer is one of the most common age-related malignancies. The occurrence frequency of prostate cancer is very different according to prostate zones. The prostate stroma is an important element in growth and differentiation of the normal prostate and also has a close relationship to the occurrence of benign p...

journal_title：Oncology reports

authors： Zhang Y,Nojima S,Nakayama H,Jin Y,Enza H

更新日期：2003-01-01 00:00:00

abstract：:The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present study included 81 consecutive patients with confirmed diagnoses of r...

journal_title：Oncology reports

authors： Shoji H,Motegi M,Takakusagi Y,Asao T,Kuwano H,Takahashi T,Ogoshi K

更新日期：2017-02-01 00:00:00

abstract：:The novel tumor suppressor RASSF1A is frequently inactivated during human tumorigenesis by promoter methylation. In this study, we detected the RASSF1A promoter methylation by methylated-specific PCR and investigated RASSF1A gene expression by semi-quantitative RT-PCR and immunohistochemical staining in 36 cases of br...

journal_title：Oncology reports

authors： Li Y,Wei Q,Cao F,Cao X

更新日期：2008-05-01 00:00:00

abstract：:We report immunohistochemical (IHC) and molecular findings in a rare case of a carcinoid tumor of the extrahepatic bile ducts in a 33-year-old woman, who presented with a 3.9x2.8x2.6 cm mass within the right and common hepatic ducts. She underwent surgery and a carcinoid tumor was identified. This lesion is of interes...

journal_title：Oncology reports

authors： Ligato S,Furmaga W,Cartun RW,Hull D,Tsongalis GJ

更新日期：2005-03-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) signaling has been shown to play a critical role in the development of epithelial-mesenchymal transition (EMT). PAI-1 is one of the most important target genes in the TGF-β/Smad signaling pathway, which can hinder the degradation of ECM composition and may promote cell invasion a...

journal_title：Oncology reports

authors： Wang X,Liu C,Wang J,Fan Y,Wang Z,Wang Y

更新日期：2017-02-01 00:00:00

abstract：:In the present study, to evaluate the role of Ku80 in thyroid carcinoma (TC), 86 thyroid tissue samples from patients with a spectrum of thyroid disorders were examined for protein levels of Ku80, nuclear factor‑κB (NF‑κB) and RET/TC by immunohistochemistry. Furthermore, in TC cells, Ku80 mRNA was detected by reverse ...

journal_title：Oncology reports

authors： Fan Y,Li J,Wei W,Fang H,Duan Y,Li N,Zhang Y,Yu J,Wang J

更新日期：2019-12-01 00:00:00

abstract：:The pathogenic mechanisms responsible for inflammatory bowel disease (IBD) are poorly understood. In an IBD animal model, the oral administration of polysaccharides such as dextran sulfate sodium (DSS) induced colitis, which exhibited several clinical and histological features similar to IBD. However, pathogenic facto...

journal_title：Oncology reports

authors： Araki Y,Mukaisyo K,Sugihara H,Hattori T

更新日期：2008-07-01 00:00:00

abstract：:Thymic epithelial tumors (TETs) consist of a series of neoplasm that differ morphologically and biologically. Due to its rarity and indolent natural history, large-scale prospective trials have been lacking. This study aimed to evaluate long-term clinical outcomes and clinicopathologic features for TET after surgical ...

journal_title：Oncology reports

authors： Kim BK,Cho BC,Choi HJ,Sohn JH,Park MS,Chang J,Kim SK,Kim DJ,Chung KY,Lee CG,Kim JH,Yoo NC

更新日期：2008-06-01 00:00:00

abstract：:The inhibitor of differentiation/DNA binding 1 (Id-1), a negative regulator of basic helix-loop-helix transcription factors, plays an important role in the regulation of cell proliferation and differentiation. We examined the Id-1 expression by immunohistochemistry in 9 adenomas, 79 primary colorectal adenocarcinomas ...

journal_title：Oncology reports

authors： Zhao ZR,Zhang ZY,Zhang H,Jiang L,Wang MW,Sun XF

更新日期：2008-02-01 00:00:00

abstract：:The aim of this study was to verify whether histopathological features of extratumoral and of primary tumor breast tissue could play a role in identifying patients with familial characteristics. We examined the clinicopathological features of 504 patients with sporadic or familial breast cancer stratified for risk of ...

journal_title：Oncology reports

authors： Mangia A,Tommasi S,Bruno M,Malfettone A,D'Amico C,Zito FA,Paradiso A,Simone G

更新日期：2010-06-01 00:00:00