A single institutional experience of surgically resected thymic epithelial tumors over 10 years: clinical outcomes and clinicopathologic features.

abstract：:Adoptive immunotherapy requires the isolation of CD8+ T cells specific for tumor-associated antigens, their expansion in vitro and their transfusion to the patient to mediate a therapeutic effect. MUC1 is an important adenocarcinoma antigen immunogenic for T cells. The MUC1-derived SAPDTRPA (MUC1-8-mer) peptide is a p...

journal_title：Oncology reports

authors： Atzin-Méndez JA,López-González JS,Báez R,Arenas-Del Angel MC,Montaño LF,Silva-Adaya D,Lascurain R,Gorocica P

更新日期：2016-01-01 00:00:00

abstract：:Histone deacetylase inhibitors are currently being evaluated for their therapeutic potential and have shown considerable promise as adjuvant therapies for a number of cancers. This study compared the effects of 2 hydroxamic acid based inhibitors, CG-1521 and SAHA, on gene expression...

journal_title：Oncology reports

authors： Knutson AK,Welsh J,Taylor T,Roy S,Wang WL,Tenniswood M

更新日期：2012-03-01 00:00:00

abstract：:In the development and progression of cancer, tumor suppressor genes may be silenced by mechanisms such as methylation. Thus the discovery of new genes silenced by methylation may uncover new tumor suppressor genes, and improve our understanding of cancer biology. In this study we investigated the methylation of 19 ge...

journal_title：Oncology reports

authors： Tsunoda S,Smith E,De Young NJ,Wang X,Tian ZQ,Liu JF,Jamieson GG,Drew PA

更新日期：2009-04-01 00:00:00

abstract：:Minimal residual disease (MRD) is derived from tumor-initiating cells (TICs) and is responsible for tumor relapse. Neuroblastoma is characterized by extreme tumor heterogeneity, and more than half of high-risk patients experience tumor relapse. To overcome tumor heterogeneity and ac...

journal_title：Oncology reports

authors： Hartomo TB,Kozaki A,Hasegawa D,Van Huyen Pham T,Yamamoto N,Saitoh A,Ishida T,Kawasaki K,Kosaka Y,Ohashi H,Yamamoto T,Morikawa S,Hirase S,Kubokawa I,Mori T,Yanai T,Hayakawa A,Takeshima Y,Iijima K,Matsuo M,Nishio H

更新日期：2013-04-01 00:00:00

abstract：:Human leukocyte antigen B (HLA-B), a novel member of the NF-kappaB signal pathway in laryngeal squamous cell carcinoma (LSCC), mediates immunological surveillance of tumor cells by presenting peptides to cytotoxic T-lymphocytes (CTLs) together with S100 calcium binding protein A8 (S100A8). The objective of this study ...

journal_title：Oncology reports

authors： Guo Y,Liu J,Xu Z,Sun K,Fu W

更新日期：2008-06-01 00:00:00

abstract：:Prostate cancer is the second most commonly diagnosed cancer in men in Poland after lung cancer and the third leading cause of cancer-related mortality after lung and colon cancer. The etiology of most cases of prostate cancer are not fully known, and therefore it is essential to search for the molecular basis of pros...

journal_title：Oncology reports

authors： Nowacka-Zawisza M,Wiśnik E

更新日期：2017-11-01 00:00:00

abstract：:Lymph node metastases are responsible for shorter survival in oral squamous cell carcinoma (OSCC). The aim of the present study was to assess the node metastasis frequency and survival according to the node metastasis features in 121 neck dissections (NDs) performed for OSCC, identifying evidence-based correlations an...

journal_title：Oncology reports

authors： Contaldo M,Di Napoli A,Pannone G,Franco R,Ionna F,Feola A,De Rosa A,Santoro A,Sbordone C,Longo F,Pasquali D,Loreto C,Ricciardiello F,Esposito G,D'Angelo L,Itro A,Bufo P,Tombolini V,Serpico R,Di Domenico M

更新日期：2013-12-01 00:00:00

abstract：:Improvements in detection, treatment and prognosis for patients with non-small cell lung cancer (NSCLC) depend on the molecular understanding of tumor development and progression. Using Affymetrix GeneChips comprising 59,620 elements, we determined the gene expression profiles of 89 NSCLC and 15 normal lung samples. W...

journal_title：Oncology reports

authors： Hofmann HS,Bartling B,Simm A,Murray R,Aziz N,Hansen G,Silber RE,Burdach S

更新日期：2006-09-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) families are receptors for ligands that initiate extracellular or intracellular signaling, such as lipopolysaccharides (LPS). It has been reported that TLR4 activation resulted in the upregulation of a coordinated set of proinflammatory mediators and inhibition of matrix expression in the i...

journal_title：Oncology reports

authors： Zhang Q,Weng Y,Jiang Y,Zhao S,Zhou D,Xu N

更新日期：2018-08-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor, which was confirmed as a tumor suppressor gene in colorectal cancers. KLF4 inhibits colorectal cancer cells proliferation through upregulating p21WAF1/Cip1 and downregulating cyclin D1. We firstly reported that N-Myc downstream regulated gene 2 (NDRG2...

journal_title：Oncology reports

authors： Ma Y,Wu L,Liu X,Xu Y,Shi W,Liang Y,Yao L,Zheng J,Zhang J

更新日期：2017-08-01 00:00:00

abstract：:The advent of pathotropic (disease-seeking) targeting has transported genetic medicine across the threshold of history with the progressive clinical validation of Rexin-G, a tumor-targeted nanosized anti-cancer agent. Achieving noteworthy single-agent efficacy and survival benefits in otherwise intractable cancers, th...

journal_title：Oncology reports

authors： Hall FL,Levy JP,Reed RA,Petchpud WN,Chua VS,Chawla SP,Gordon EM

更新日期：2010-10-01 00:00:00

abstract：:B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi1) is directly involved in cell growth, proliferation and self-renewal of cancer stem cells (CSCs). The aim of the present study was to assess the role of Bmi1 in the maintenance of stemness properties and tumorigenicity of human bladder CSC-like side ...

journal_title：Oncology reports

authors： Zhu D,Wan X,Huang H,Chen X,Liang W,Zhao F,Lin T,Han J,Xie W

更新日期：2014-02-01 00:00:00

abstract：:Recent research indicates that the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway may play an important role in chronic inflammation which promotes cancer progression, yet the mechanism is not clear. The present study aimed to investigate the role of the JAK/STAT3 pathway in the gr...

journal_title：Oncology reports

authors： Fang J,Chu L,Li C,Chen Y,Hu F,Zhang X,Zhao H,Liu Z,Xu Q

更新日期：2015-01-01 00:00:00

abstract：:Recent studies have shown that miRNAs have potent abilities to activate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa). In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal...

journal_title：Oncology reports

authors： Li S,Wang C,Yu X,Wu H,Hu J,Wang S,Ye Z

更新日期：2017-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) play a vital role in tumour biological and pathologic processes. In the present study, we aimed to detect the expression and biological role of miR-216b in glioma. Our data showed that miR-216b was significantly downregulated in human glioma tissues and cells. Ectopic expression of miR-216b inhibite...

journal_title：Oncology reports

authors： Zhang T,Ma G,Zhang Y,Huo H,Zhao Y

更新日期：2017-09-01 00:00:00

abstract：:The promigratory molecule L1CAM is overexpressed in various tumors, often representing an unfavorable prognostic marker. Recently, we identified L1CAM expression in pancreatic ductal adenocarcinoma (PDAC) cells accounting for chemoresistance and increased cell migration. Thus, the present study aims at further elucida...

journal_title：Oncology reports

authors： Bergmann F,Wandschneider F,Sipos B,Moldenhauer G,Schniewind B,Welsch T,Schirrmacher P,Klöppel G,Altevogt P,Schäfer H,Sebens Müerköster S

更新日期：2010-10-01 00:00:00

abstract：:Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and vegetables. Quercetin prevents tumor proliferation by inducing cell cycle arrest and is a well known cancer therapeutic agent and autophagy mediator. We investigated whether quercetin enhances TRAIL-induced tumor cell death and...

journal_title：Oncology reports

authors： Moon JH,Eo SK,Lee JH,Park SY

更新日期：2015-07-01 00:00:00

abstract：:Reactive oxygen species (ROS) can drive the de‑differentiation of tumor cells leading to the process of epithelial-to-mesenchymal transition (EMT) to enhance invasion and metastasis. The invasive and metastatic phenotype of malignant cells is often linked to loss of E-cadherin expression, a hallmark of EMT. Recent stu...

journal_title：Oncology reports

authors： Wang Y,Ma J,Shen H,Wang C,Sun Y,Howell SB,Lin X

更新日期：2014-11-01 00:00:00

abstract：:In this study, a total of 108 patients with primary colorectal cancer who underwent hybrid 2-port hand-assisted laparoscopic surgery (HALS) were classified as 58 patients with colon cancer and 50 patients with rectal cancer. The mean operating time, mean blood loss, postoperative complications, and mean postoperative ...

journal_title：Oncology reports

authors： Mukai M,Kishima K,Tajima T,Hoshikawa T,Yazawa N,Fukumitsu H,Okada K,Ogoshi K,Makuuchi H

更新日期：2009-10-01 00:00:00

abstract：:Flavonoids exhibit chemopreventive and chemotherapeutic effects. Butein, a bioactive flavonoid isolated from numerous native plants, has been shown to induce apoptosis in human cancer cells. In the current study, the molecular mechanisms of butein action on cell proliferation and apoptosis of neuroblastoma cells were ...

journal_title：Oncology reports

authors： Chen YH,Yeh CW,Lo HC,Su SL,Hseu YC,Hsu LS

更新日期：2012-04-01 00:00:00

abstract：:Abnormal lymphangiogenesis is associated with several diseases such as tumor metastasis and lymphangioma. Human lymphangioma originated from the transformation of lymphatic endothelium is a benign malformation of lymphatic vessels and its pathogenesis has up to date not been illuminated and its cell model has also not...

journal_title：Oncology reports

authors： You L,Wu M,Chen Y,Xu G,Wei J,Li Q,Song A,Zhao L,Li S,Han Z,Zhou J,Lu Y,Wang S,Ma D,Meng L

更新日期：2010-01-01 00:00:00

abstract：:A phase II trial was conducted to evaluate the tolerability and efficacy of incorporating cetuximab and simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) into a well-described 5-fluorouracil (5-FU) and hydroxyurea (HU)-based chemoradiation regimen. Patients with stage IVa-IVb or high-risk ...

journal_title：Oncology reports

authors： Tong CC,Lau KH,Rivera M,Cannan D,Aguirre-Ghiso J,Sikora AG,Gupta V,Forsythe K,Ko EC,Misiukiewicz K,Gurudutt V,Teng MS,Packer SH,Genden EM,Kao J

更新日期：2012-05-01 00:00:00

abstract：:The aim of this study was to evaluate the clinicopathological prognostic factors in patients with stage IVb cervical carcinoma (CC). All patients with stage IVb CC included in the study were diagnosed from 1997 to 2006 at the National Cancer Center Hospital. We retrospectively examined clinicopathological parameters i...

journal_title：Oncology reports

authors： Nishio S,Katsumata N,Matsumoto K,Tanabe H,Yonemori K,Kohno T,Shimizu C,Ando M,Kasamatsu T,Fujiwara Y

更新日期：2008-02-01 00:00:00

abstract：:Peroxiredoxin 1 (Prdx1) is an antioxidant and plays an important role in H2O2-mediated cell signaling. We previously found that the expression level of Prdx1 was elevated in esophagus squamous cell carcinoma (ESCC) tissue using a proteomics approach. Since overexpressed protein can induce an autoimmune response, to fu...

journal_title：Oncology reports

authors： Ren P,Ye H,Dai L,Liu M,Liu X,Chai Y,Shao Q,Li Y,Lei N,Peng B,Yao W,Zhang J

更新日期：2013-11-01 00:00:00

abstract：:Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore explored the effects of (-)-oleocanthal (OC) on the three processes in melanoma and investigated underlying mechanisms. In vitro, OC suppressed proliferation, migration, invasion and induced apoptosis in melanoma cells. In addi...

journal_title：Oncology reports

authors： Gu Y,Wang J,Peng L

更新日期：2017-01-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors exert potent inhibitory effects on various types of human cancer. The pioneer drug suberoylanilide hydroxamic acid (SAHA) is currently used in the clinic for cancer treatment. However, the effect of SAHA on tumor lymphangiogenesis is unclear. We recently showed that SAHA suppresse...

journal_title：Oncology reports

authors： Cheng HT,Hung WC

更新日期：2013-08-01 00:00:00

abstract：:Cancer represents a significant challenge for humankind, as early diagnosis and treatment are difficult to achieve. To systemically investigate the effect of sex, body mass index (BMI) and age on cancer incidence and prognosis, the data from 14,504 cases of cancer were downloaded from The Cancer Genome Atlas (TCGA). B...

journal_title：Oncology reports

authors： Huang X,Shu C,Chen L,Yao B

更新日期：2018-09-01 00:00:00

abstract：:Isocitrate dehydrogenase 2 (IDH2) is a mitochondrial NADP-dependent isocitrate dehydrogenase. It is considered to be a novel tumor suppressor in several types of tumors. However, the role and related mechanism of IDH2 in osteosarcoma remain unknown. The expression and significance of IDH2 were investigated by immunohi...

journal_title：Oncology reports

authors： Yi WR,Li ZH,Qi BW,Ernest ME,Hu X,Yu AX

更新日期：2016-04-01 00:00:00

abstract：:The NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme is implicated in protection against oxidative stress and carcinogenesis. NQO1 C609T genetic polymorphism was reported to be associated with an increased risk for cancers, including breast cancer. However, there is still lack of evidence whether higher oxidative stress...

journal_title：Oncology reports

authors： Tseng LM,Yin PH,Tsai YF,Chi CW,Wu CW,Lee LM,Lee HC

更新日期：2009-05-01 00:00:00

abstract：:Pancreatic cancer is one of the most lethal cancers, with an incidence equaling mortality. It is a heterogeneous group of neoplasms in which pancreatic ductal adenocarcinoma is most common. Pancreatic cancer cannot be cured even if detected early. When treatment is initiated, a suit...

journal_title：Oncology reports

authors： Takata T,Ishigaki Y,Shimasaki T,Tsuchida H,Motoo Y,Hayashi A,Tomosugi N

更新日期：2012-12-01 00:00:00