Isolation and characterization of lymphatic endothelial cells from human glossal lymphangioma.

abstract：:Recently, gene fusions between the androgen responsive gene TMPRSS2 and members of the ETS-family of DNA-binding transcription factor genes were found in prostate cancer. Recurrent fusions were identified between the 5'-noncoding region of TMPRSS2 and ERG, or less frequently ETV1 or ETV4, resulting in overexpression o...

journal_title：Oncology reports

authors： Winnes M,Lissbrant E,Damber JE,Stenman G

更新日期：2007-05-01 00:00:00

abstract：:In the present study, we analyzed the influence of brefeldin A (BFA) and castanospermine (CAS) on the activity, stability and localization of P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in various resistant cell lines. The impact of BFA and CAS on cell viability was assessed using the MTT test. We...

journal_title：Oncology reports

authors： Wojtowicz K,Januchowski R,Sosińska P,Nowicki M,Zabel M

更新日期：2016-05-01 00:00:00

abstract：:Agaricus blazei is well known as a traditional medicinal mushroom and it has been shown to exhibit immunostimulatory and anti-cancer activity. However, the cellular and molecular mechanism of cell cycle arrest and apoptosis of cancer cells is poorly understood. In this study, we have investigated whether A. blazei ext...

journal_title：Oncology reports

authors： Jin CY,Choi YH,Moon DO,Park C,Park YM,Jeong SC,Heo MS,Lee TH,Lee JD,Kim GY

更新日期：2006-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is highly resistant to chemotherapy, leading to a poor prognosis of advanced disease. Inhibitors of histone deacetylase (HDACi) induce re-differentiation in tumor cells and thereby re-establish sensitivity towards apoptotic stimuli. HDACi are entering the clinical stage of tumor treatmen...

journal_title：Oncology reports

authors： Schuchmann M,Schulze-Bergkamen H,Fleischer B,Schattenberg JM,Siebler J,Weinmann A,Teufel A,Wörns M,Fischer T,Strand S,Lohse AW,Galle PR

更新日期：2006-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) and pancreatic cancer are at the forefront of chemotherapy-resistant tumors with poor prognosis. Even with innovative treatment regimens, response rates remain low and the duration of response is short. We examined whether the suppression of DNA methylation was capable of enhancing the s...

journal_title：Oncology reports

authors： Kanda T,Tada M,Imazeki F,Yokosuka O,Nagao K,Saisho H

更新日期：2005-10-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is locally aggressive and challenging to quantitate non-invasively in vivo, particularly in orthotopic models of disease. We describe imaging of extracellular protease activity, typically elevated in locally aggressive tumors, as a novel method f...

journal_title：Oncology reports

authors： Zhou L,El-Deiry W,Wang W,Ingram ME,Katz SI

更新日期：2012-09-01 00:00:00

abstract：:Human glioblastoma is a malignant and aggressive primary human brain solid tumor characterized by severe hypoxia. Hypoxia can induce autophagy, which may result in chemoresistance and malignant progression of cancer cells. MicroRNAs (miRNAs) have been reported to modulate hypoxia‑induced autophagy in various types of ...

journal_title：Oncology reports

authors： Huang S,Qi P,Zhang T,Li F,He X

更新日期：2019-03-01 00:00:00

abstract：:The purpose of this study was to examine the effects of irradiation by 125I seeds in human lung cancer xenograft model and to determine the underlying mechanisms involved, with a focus on angiogenesis. A group of 40 mice bearing A549 lung adenocarcinoma xenografts was randomly separated into 4 groups: control group (n...

journal_title：Oncology reports

authors： Xiang GL,Zhu XH,Lin CZ,Wang LJ,Sun Y,Cao YW,Wang FF

更新日期：2017-05-01 00:00:00

abstract：:Bmal1 is a core factor in the regulation of circadian rhythms. Previous studies have shown that Bmal1 suppresses tumor growth in cell culture and animal models and is downregulated in certain types of cancer. The aim of the present study was to investigated whether Bmal1 influences the invasiveness of cancer cells. We...

journal_title：Oncology reports

authors： Jung CH,Kim EM,Park JK,Hwang SG,Moon SK,Kim WJ,Um HD

更新日期：2013-06-01 00:00:00

abstract：:Insulin resistance (IR) is reportedly involved in the progression of hepatocellular carcinoma (HCC). Since neovascularization plays an important role in hepatocarcinogenesis and IR, an angiostatic therapy may be considered as one of the promising approaches for chemoprevention again...

journal_title：Oncology reports

authors： Yoshiji H,Noguchi R,Ikenaka Y,Kaji K,Aihara Y,Yamazaki M,Yamao J,Toyohara M,Mitoro A,Sawai M,Yoshida M,Morioka C,Fujimoto M,Uemura M,Fukui H

更新日期：2011-12-01 00:00:00

abstract：:Ligularia fischeri (LF) has been used as an edible herb and traditional medicine for the treatment of inflammatory and infectious diseases. In the present study, we report the effects and molecular mechanism of the ethanolic extract of LF on cell proliferation, invasion and tube formation in human umbilical vein endot...

journal_title：Oncology reports

authors： Kim JH,Kim HJ,Kim JK,Ahn EK,Ko HJ,Cho YR,Lee SJ,Bae GU,Kim YK,Park JW,Oh JS,Seo DW

更新日期：2015-07-01 00:00:00

abstract：:Resistance to docetaxel, a chemotherapy drug for breast cancer (BC) treatment, occurs in ~50% of patients, and the underlying molecular mechanisms of drug resistance are not fully understood. Gene regulation through miR-141 has been proven to play an important role in cancer drug resistance. The present study investig...

journal_title：Oncology reports

authors： Yao YS,Qiu WS,Yao RY,Zhang Q,Zhuang LK,Zhou F,Sun LB,Yue L

更新日期：2015-05-01 00:00:00

abstract：:We investigated the effects of combined treatment with 5-fluorouracil and apigenin on proliferation and apoptosis, as well as the underlying mechanism, in human breast cancer MDA-MB-453 cells. The MDA-MB-453 cells, which have been shown to overexpress ErbB2, were resistant to 5-fluorouracil; 5-fluorouracil exhibited a...

journal_title：Oncology reports

authors： Choi EJ,Kim GH

更新日期：2009-12-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients with epithelial growth factor receptor (EGFR) mutations and bone metastases are often concurrently administered tyrosine kinase inhibitors (TKIs) and bisphosphonates. Yet, the effects and mechanisms of these agents are unclear. In the present study, we aimed to ascertain whe...

journal_title：Oncology reports

authors： Feng C,Liu X,Li X,Guo F,Huang C,Qin Q,Wang Y

更新日期：2016-06-01 00:00:00

abstract：:A crucial step in the path to the malignant transformation of cells and tumor formation is immortalization, which essentially depends on telomere maintenance. The aim of this study was to investigate the role of telomerase in the progression of Barrett's esophagus. Telomerase activi...

journal_title：Oncology reports

authors： Qin X,Qi B,Zhao B

更新日期：2013-04-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most commonly diagnosed malignancies, and 90% of advanced prostate cancer patients relapse after therapy. Trophinin associated protein (TROAP) is essential for centrosome integrity and proper bipolar organisation of spindle assembly during mitosis and plays an essential role in prol...

journal_title：Oncology reports

authors： Ye J,Chu C,Chen M,Shi Z,Gan S,Qu F,Pan X,Yang Q,Tian Y,Wang L,Yang W,Cui X

更新日期：2019-02-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a highly lethal malignant tumor arising from the biliary tract epithelium. Chronic inflammatory conditions, including primary sclerosing cholangitis, liver fluke infestation, and hepatolithiasis, are considered risk factors, but the cause is still unknown in most cases. Recent advances in m...

journal_title：Oncology reports

authors： Isomoto H

更新日期：2009-08-01 00:00:00

abstract：:Tumor invasion, angiogenesis and metastasis involve secretion of proteolytic enzymes and cell migration into blood vessels. Tumor cells are capable of degrading the extracellular matrix via a proteolytic cascade that includes urokinase-type plasminogen activator (uPA) and matrix metalloproteases (MMPs). We have invest...

journal_title：Oncology reports

authors： Farina HG,Pomies M,Alonso DF,Gomez DE

更新日期：2006-10-01 00:00:00

abstract：:Hydrogen sulfide (H2S), regarded as the third gaseous transmitter, mediates and induces various biological effects. The present study investigated the effects of H2S on multiple myeloma cell progression via amplifying the activation of Akt pathway in multiple myeloma cells. The level of H2S produced in multiple myelom...

journal_title：Oncology reports

authors： Zheng D,Chen Z,Chen J,Zhuang X,Feng J,Li J

更新日期：2016-10-01 00:00:00

abstract：:Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylat...

journal_title：Oncology reports

authors： Coker-Gürkan A,Arisan ED,Obakan P,Akalın K,Özbey U,Palavan-Unsal N

更新日期：2015-06-01 00:00:00

abstract：:The efficacy of chemotherapy for hepatocellular carcinoma (HCC) remains unsatisfactory, primarily due to inherent self‑defense mechanisms (e.g., mitophagy and autophagy). In the present study, we aimed to explore the pro‑apoptotic effects of targeting mitophagy to potentiate the efficacy of chemotherapy for HCC. HCC c...

journal_title：Oncology reports

authors： Ma M,Lin XH,Liu HH,Zhang R,Chen RX

更新日期：2020-03-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (SCC) is one of the most common fatal carcinomas worldwide and has some of the most malignant characteristics among gastrointestinal tumors. Although a high frequency of loss of heterozygosity (LOH) for various genes has been observed in esophageal SCCs, these findings do not provide...

journal_title：Oncology reports

authors： Shima H,Hiyama T,Tanaka S,Yoshihara M,Arihiro K,Chayama K

更新日期：2006-10-01 00:00:00

abstract：:Peroxiredoxin 1 (Prdx1) is an antioxidant and plays an important role in H2O2-mediated cell signaling. We previously found that the expression level of Prdx1 was elevated in esophagus squamous cell carcinoma (ESCC) tissue using a proteomics approach. Since overexpressed protein can induce an autoimmune response, to fu...

journal_title：Oncology reports

authors： Ren P,Ye H,Dai L,Liu M,Liu X,Chai Y,Shao Q,Li Y,Lei N,Peng B,Yao W,Zhang J

更新日期：2013-11-01 00:00:00

abstract：:Previous studies have shown that S100P contributes to the development of a number of tumors. However, its prognostic significance in colorectal cancer (CRC) has not been demonstrated. This study aimed to confirm the expression of S100P in colorectal cancer as well as the epigenetic mechanism underlying its gene expres...

journal_title：Oncology reports

authors： Wang Q,Zhang YN,Lin GL,Qiu HZ,Wu B,Wu HY,Zhao Y,Chen YJ,Lu CM

更新日期：2012-07-01 00:00:00

abstract：:Despite significant advances in micro-metastasis detection methods, little is known about the relationship between micro-metastasis and primary tumors. The purpose of this study was to assess the ability of expression of the breast cancer-related markers, HER-2/neu, COX-2, VEGF and PDGF-B, as a predictor for micro-met...

journal_title：Oncology reports

authors： Zhu L,Loo WT,Cheng CW,Chow LW

更新日期：2006-05-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. It has poor clinical outcome due to intrinsic or acquired drug resistance. Deregulation of both apoptosis and autophagy contributes to chemotherapy resistance and disease progression. A new member of the inhibitors of ...

journal_title：Oncology reports

authors： Frassanito MA,Saltarella I,Vinella A,Muzio LL,Pannone G,Fumarulo R,Vacca A,Mariggiò MA

更新日期：2019-05-01 00:00:00

abstract：:TRIM58 (tripartite motif containing 58) has been reported as a novel methylated gene in hepatocellular carcinoma (HCC) by methylation microarrays. However, its associations with mRNA expression and clinicopathological characteristics have not been evaluated. In this study, we explored the potential clinical implicatio...

journal_title：Oncology reports

authors： Qiu X,Huang Y,Zhou Y,Zheng F

更新日期：2016-08-01 00:00:00

abstract：:In breast cancer, neuregulin-1 (NRG1) is known as a ligand for the HER3 receptor, which has no intrinsic tyrosine kinase activity. When activated by NRG1 binding, the HER3 receptor forms a heterodimer with other HER family receptors and mediates downstream signaling pathways, leading to multiple effects including grow...

journal_title：Oncology reports

authors： Jeong H,Kim J,Lee Y,Seo JH,Hong SR,Kim A

更新日期：2014-09-01 00:00:00

abstract：:Bufalin, a major digoxin-like immunoreactive component of the Chinese medicine Chansu, is prepared from toad venom. This compound has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro. However, the detailed molecular mechanisms ...

journal_title：Oncology reports

authors： Hong SH,Choi YH

更新日期：2012-01-01 00:00:00

abstract：:The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we dis...

journal_title：Oncology reports

authors： Malas S,Harrasser M,Lacy KE,Karagiannis SN

更新日期：2014-09-01 00:00:00