Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer.

abstract：:Esophageal cancer (EC) has a globally increasing incidence with poor curative treatment options and survival rates. Crucial risk factors are exposure to toxins or carcinogens. Microsomal epoxide hydrolase (mEH) is a biotransformation enzyme essential for the detoxification of xenobiotics. Polymorphisms in exon 3 and e...

journal_title：Oncology reports

authors： Dura P,Bregitha CV,Te Morsche RH,Roelofs HM,Kristinsson JO,Wobbes T,Witteman BJ,Tan AC,Drenth JP,Peters WH

更新日期：2012-06-01 00:00:00

abstract：:Significance of expression of cytokine induced nitric oxide synthase (iNOS) in colorectal carcinoma remains controversial. The aim of the current study was to elucidate the significance of immunohistochemical expression of iNOS in colorectal carcinoma. The subjects were the 54 patients with colorectal carcinoma, inclu...

journal_title：Oncology reports

authors： Nozoe T,Yasuda M,Honda M,Inutsuka S,Korenaga D

更新日期：2002-05-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, capable of degrading all the molecular components of extracellular matrix. MMPs have been shown to play critical roles in tumor cell invasion and metastasis. We verified the activity of MMPs in the sera ...

journal_title：Oncology reports

authors： Di Carlo A

更新日期：2012-09-01 00:00:00

abstract：:Chemokine (C-C motif) ligand 2 (CCL2) has been shown to play an important role in the regulation of tumor cell growth, metastasis and host immune response. CCL2 preferentially binds to the C-C chemokine receptor type 2 (CCR2), which is expressed in various tissues. However, the role of the CCL2/CCR2 axis in hepatocell...

journal_title：Oncology reports

authors： Zhuang H,Cao G,Kou C,Liu T

更新日期：2018-01-01 00:00:00

abstract：:With the ever-increasing number of drugs approved to treat cancers, selection of the optimal treatment regimen for an individual patient is challenging. Breast cancer complexity requires novel predictive methods and tools. In the present study, we set up experimental conditions to obtain an 'ex vivo' organotypic cultu...

journal_title：Oncology reports

authors： Vesci L,Carollo V,Roscilli G,Aurisicchio L,Ferrara FF,Spagnoli L,De Santis R

更新日期：2015-09-01 00:00:00

abstract：:We examined pathomorphologically small nodular lesions in hepatitis C virus-related cirrhosis (type C cirrhosis). Small nodular lesions seen in the non-cancerous areas of 128 consecutively resected hepatocellular carcinomas (HCCs) associated with type C cirrhosis were selected for the study. From these, 18 large regen...

journal_title：Oncology reports

authors： Miyaaki H,Fujimoto M,Kurogi M,Nakashima O,Eguchi K,Kojiro M

更新日期：2005-12-01 00:00:00

abstract：:The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we dis...

journal_title：Oncology reports

authors： Malas S,Harrasser M,Lacy KE,Karagiannis SN

更新日期：2014-09-01 00:00:00

abstract：:In the present study, effectiveness of topical vidarabine or subsequent 5-fluorouracil (5-FU) administration was examined against persistent genital human papillomavirus (HPV) infection after local surgery. Thirty patients underwent local eradication treatment of uterine cervical intra-epithelial neoplasia (CIN) and s...

journal_title：Oncology reports

authors： Niwa K,Tagami K,Lian Z,Gao J,Mori H,Tamaya T

更新日期：2003-09-01 00:00:00

abstract：:The clinical applications of Rhizoma paridis in traditional Chinese medicine are well known. However, the therapeutic potential of Rhizoma paridis and its active component such as Paris saponin I (polyphyllin D) and Paris saponin II (PSII) (formosanin C) in cancer treatments have not yet been fully explored. Recent st...

journal_title：Oncology reports

authors： Yang M,Zou J,Zhu H,Liu S,Wang H,Bai P,Xiao X

更新日期：2015-05-01 00:00:00

abstract：:Gastric cancer rich in stromal tissue, such as diffuse-type disease, carries a poor prognosis. In some cancers, expression of vimentin, a mesenchymal maker, is associated with poor survival. The expression of mesenchymal markers such as vimentin is observed after epithelial-mesenchymal transition (EMT), an important i...

journal_title：Oncology reports

authors： Otsuki S,Inokuchi M,Enjoji M,Ishikawa T,Takagi Y,Kato K,Yamada H,Kojima K,Sugihara K

更新日期：2011-05-01 00:00:00

abstract：:The challenging possibility of selectively inducing mitotic death in tumor cells by combining genotoxic agents with the inhibition of G2 checkpoints of the cell cycle is the subject of intensive investigation. We show that very low concentrations (3.5 and 5 nM) of okadaic acid induce mitotic death in two glioblastoma ...

journal_title：Oncology reports

authors： Castigli E,Sciaccaluga M,Schiavoni G,Brozzi F,Fabiani R,Gorello P,Gianfranceschi GL

更新日期：2006-02-01 00:00:00

abstract：:In 72 patients without occult neoplastic cells (ONCs) in their lymph node sinuses, the 5-year relapse-free survival (RFS) rate and overall survival (OS) rate were 71.3% and 69.2%, respectively. In 33 patients with ONCs, the 5-year RFS rate and OS rate were 33.9% and 31.3%, respectively. There was a marked difference o...

journal_title：Oncology reports

authors： Mukai M,Sato S,Ninomiya H,Wakui K,Komatsu N,Tsuchiya K,Nakasaki H,Makuuchi H

更新日期：2005-11-01 00:00:00

abstract：:The estrogen receptor (ER) expression and HER2 amplification are important factors in determining the prognosis and therapy of breast cancer. Interactions between the two signaling pathways for example resulted in ERalpha-dependent regulation of HER2 expression in breast cancer cells. In this study, we investigated to...

journal_title：Oncology reports

authors： Lattrich C,Juhasz-Boess I,Ortmann O,Treeck O

更新日期：2008-03-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, and only 15% of lung cancer patients live more than 5 years. microRNAs (miRNAs) are endogenously expressed non-coding RNAs, and dysregulation of miRNAs is a common feature in human cancers including lung cancer. In this study, w...

journal_title：Oncology reports

authors： Chen Y,Min L,Zhang X,Hu S,Wang B,Liu W,Wang R,Gu X,Shen W,Lv H,Zou J,Chen Y,Xu X,Chen L

更新日期：2013-10-01 00:00:00

abstract：:S-1 is an oral antitumor agent that contains tegafur, which is converted to fluorouracil (5-FU) in the human body. Cytochrome P450 2A6 (CYP2A6) is the principal enzyme responsible for bioconversion of tegafur to 5-FU. A number of CYP2A6 polymorphisms have been associated with variat...

journal_title：Oncology reports

authors： Fang WJ,Mou HB,Jin DZ,Zheng YL,Zhao P,Mao CY,Peng L,Huang MZ,Xu N

更新日期：2012-05-01 00:00:00

abstract：:Agaricus blazei is well known as a traditional medicinal mushroom and it has been shown to exhibit immunostimulatory and anti-cancer activity. However, the cellular and molecular mechanism of cell cycle arrest and apoptosis of cancer cells is poorly understood. In this study, we have investigated whether A. blazei ext...

journal_title：Oncology reports

authors： Jin CY,Choi YH,Moon DO,Park C,Park YM,Jeong SC,Heo MS,Lee TH,Lee JD,Kim GY

更新日期：2006-12-01 00:00:00

abstract：:Telomerase activation is prevalent in most epithelial tumors, and may be a critical step in cellular immortalization and carcinogenesis. However, telomerase activity in tumors of mesenchymal origin is not well understood. In the present study, we examined telomerase activity in clinical samples from osteosarcoma and s...

journal_title：Oncology reports

authors： Terasaki T,Kyo S,Takakura M,Maida Y,Tsuchiya H,Tomita K,Inoue M

更新日期：2004-06-01 00:00:00

abstract：:MicroRNA-154 (miR-154) has been identified as a tumor suppressor in several types of human cancers; however, its clinical significance and function in human hepatocellular carcinoma (HCC) remain unclear. The aim of the present study was to analyze the clinical significance and cellular function of miR-154 in HCC patie...

journal_title：Oncology reports

authors： Pang X,Huang K,Zhang Q,Zhang Y,Niu J

更新日期：2015-12-01 00:00:00

abstract：:Tumor growth is accelerated by induction of angiogenesis regulated by many cytokines and growth factors. In a tumor mass, various angiogenic factors and their receptors are simultaneously expressed and the overlapped expressions of various factors may contribute to the aggressive growth of tumor. However, the possible...

journal_title：Oncology reports

authors： Lee YM,Bae MH,Lee OH,Moon EJ,Moon CK,Kim WH,Kim KW

更新日期：2004-10-01 00:00:00

abstract：:c‑mesenchymal‑epithelial transition (Met) is a transmembrane tyrosine kinase receptor of hepatocyte growth factor (HGF). HGF/Met signaling stimulates numerous pathways, including the Ras/mitogenactivated protein kinase (MAPK), phosphatidylinositol 3‑kinase/protein kinase B and Wnt/β‑catenin pathways, which serve impor...

journal_title：Oncology reports

authors： Liu D,Zhong M,Zhan D,Zhang Y,Liu S

更新日期：2020-12-01 00:00:00

abstract：:Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) treatment is effective for the treatment of primary tumors, but not sufficient for the treatment of metastatic tumors, likely owing to the effects of the tumor microenvironment. In this study, we aimed to determine the therapeutic effects of combined treatment with a matr...

journal_title：Oncology reports

authors： Li M,Xing S,Zhang H,Shang S,Li X,Ren B,Li G,Chang X,Li Y,Li W

更新日期：2016-03-01 00:00:00

abstract：:Lymph node metastases are responsible for shorter survival in oral squamous cell carcinoma (OSCC). The aim of the present study was to assess the node metastasis frequency and survival according to the node metastasis features in 121 neck dissections (NDs) performed for OSCC, identifying evidence-based correlations an...

journal_title：Oncology reports

authors： Contaldo M,Di Napoli A,Pannone G,Franco R,Ionna F,Feola A,De Rosa A,Santoro A,Sbordone C,Longo F,Pasquali D,Loreto C,Ricciardiello F,Esposito G,D'Angelo L,Itro A,Bufo P,Tombolini V,Serpico R,Di Domenico M

更新日期：2013-12-01 00:00:00

abstract：:The progress of the application of adenovirus in cancer gene therapy is hindered by the lack of expression of native adenovirus receptor on a variety of cancer types. Hence, strategies are needed to retarget the adenoviral vector to non-native cellular surface receptors. In the present study, a new peptide SWDIAWPPLKV...

journal_title：Oncology reports

authors： Wang D,Li W,Zhang H,Mao Q,Xia H

更新日期：2014-05-01 00:00:00

abstract：:Gene therapy mediated by murine leukemia virus (MLV)-based replicating retrovirus vector (RRV) was previously proven to be highly effective in tumor cell killing, resulting in significant suppression of tumor growth in vivo. Recently, we developed a different form of RRV which is derived from another retrovirus, gibbo...

journal_title：Oncology reports

authors： Lu YC,Chen YJ,Yu YR,Lai YH,Cheng JC,Li YF,Shen CH,Tai CK

更新日期：2012-07-01 00:00:00

abstract：:Resistance to docetaxel, a chemotherapy drug for breast cancer (BC) treatment, occurs in ~50% of patients, and the underlying molecular mechanisms of drug resistance are not fully understood. Gene regulation through miR-141 has been proven to play an important role in cancer drug resistance. The present study investig...

journal_title：Oncology reports

authors： Yao YS,Qiu WS,Yao RY,Zhang Q,Zhuang LK,Zhou F,Sun LB,Yue L

更新日期：2015-05-01 00:00:00

abstract：:The transmembrane (TM) receptor encoded by the HER-2 proto-oncogene (HER-2) is amplified in several types of human carcinomas and premalignant states and provides an important target for cancer therapy. While overexpression of HER-2 should lead to increased CTL epitope formation due to the attendant increase in higher...

journal_title：Oncology reports

authors： Castilleja A,Ward NE,Epstein RB,Kudelka AP,Gershenson DM,Efferson CL,O'Brian CA,Ioannides CG

更新日期：2002-09-01 00:00:00

abstract：:Pentoxifylline (PTX) is commonly used in peripheral blood vessel diseases, however it has also been found to decrease the level of proinflammatory cytokines such as IL-12, TNF-alpha and IFN-gamma. Moreover, some authors reported that PTX suppresses spontaneous cytotoxicity of peripheral blood mononuclear cells (PBMC) ...

journal_title：Oncology reports

authors： Lazarczyk M,Grzela T,Korczak-Kowalska G,Niderla J,Oldak M,Jozwiak J,Skopinski P

更新日期：2002-03-01 00:00:00

abstract：:Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore explored the effects of (-)-oleocanthal (OC) on the three processes in melanoma and investigated underlying mechanisms. In vitro, OC suppressed proliferation, migration, invasion and induced apoptosis in melanoma cells. In addi...

journal_title：Oncology reports

authors： Gu Y,Wang J,Peng L

更新日期：2017-01-01 00:00:00

abstract：:High-mobility group protein box 1 (HMGB1) released from dying tumor cells promotes tumor progression, on the other hand HMGB1 activates dendritic cells and triggers anti-neoplastic response of T-cells in chemotherapy and radiotherapy. HMGB1 expression is up-regulated in many kinds of tumors. To investigate HMGB1 expre...

journal_title：Oncology reports

authors： Shen X,Hong L,Sun H,Shi M,Song Y

更新日期：2009-09-01 00:00:00

abstract：:Monoclonal antibody therapy for immune checkpoint blockade has achieved promising results for several types of malignant tumors. For the future treatment of gastrointestinal stromal tumors (GISTs) by immune checkpoint blockade, expression of immune checkpoint-related molecules that suppress antitumor immunity in GISTs...

journal_title：Oncology reports

authors： Komita H,Koido S,Hayashi K,Kan S,Ito M,Kamata Y,Suzuki M,Homma S

更新日期：2015-10-01 00:00:00