Replicating retroviral vectors for oncolytic virotherapy of experimental hepatocellular carcinoma.

abstract：:Bone morphogenetic proteins (BMPs), which belong to the transforming growth factor-β superfamily, are multifunctional signaling molecules that have become of increasing interest in cancer research. Recent observations suggest that alterations in BMPs and BMP signaling are associated...

journal_title：Oncology reports

authors： Hashida Y,Nemoto Y,Imajoh M,Murakami M,Taniguchi A,Komatsu N,Yokoyama A,Daibata M

更新日期：2012-03-01 00:00:00

abstract：:Arginine and nitric oxide (NO) are important mediators of tumorigenesis in various types of cancer. Dysregulation of NO content by argininosuccinate lyase (ASL) has been previously demonstrated to inhibit the proliferation of liver and breast cancer cells. However, the function of ASL in colon cancer is not well defin...

journal_title：Oncology reports

authors： Huang HL,Chen WC,Hsu HP,Cho CY,Hung YH,Wang CY,Lai MD

更新日期：2017-01-01 00:00:00

abstract：:Vasohibin-1 (VASH1) has recently been isolated as a novel inhibitor of angiogenesis. Several studies have demonstrated that VASH1 plays important roles in tumor angiogenesis but the role of this angiogenic inhibitor in renal cell carcinoma (RCC) has not been elucidated. We previously reported that VASH1 expression is ...

journal_title：Oncology reports

authors： Zhao G,Na R,Li L,Xiao H,Ding N,Sun Y,Han R

更新日期：2017-08-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) is a potent chemopreventive and therapeutic agent and exerts its effects by inducing growth arrest. In the present study, we demonstrated that ATRA activated the expression of p53 via Axin and induced cell cycle arrest at the G1/S phase and apoptosis of glioma cells. Briefly, C6 cells we...

journal_title：Oncology reports

authors： Lu J,Zhang F,Yuan Y,Ding C,Zhang L,Li Q

更新日期：2013-06-01 00:00:00

abstract：:Patients with autosomal recessive primary microcephaly have a small but architecturally normal brain containing a reduced number of neurons. Microcephalin and ASPM are two of the genes causing this disease. Both are centrosomal proteins involved in cell cycle regulation. Whereas microcephalin is a component of the DNA...

journal_title：Oncology reports

authors： Hagemann C,Anacker J,Gerngras S,Kühnel S,Said HM,Patel R,Kämmerer U,Vordermark D,Roosen K,Vince GH

更新日期：2008-08-01 00:00:00

abstract：:In the present study, we analyzed the influence of brefeldin A (BFA) and castanospermine (CAS) on the activity, stability and localization of P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in various resistant cell lines. The impact of BFA and CAS on cell viability was assessed using the MTT test. We...

journal_title：Oncology reports

authors： Wojtowicz K,Januchowski R,Sosińska P,Nowicki M,Zabel M

更新日期：2016-05-01 00:00:00

abstract：:Histone deacetylase (HDAC) 4 is an emerging target in cancer therapeutics, but little is known about the function of HDAC4 in gynecologic malignancies. Therefore we investigated the mechanism of HDAC4 promoting the proliferation of epithelial ovarian cancer cells (OV). In this study, we observed that the proliferation...

journal_title：Oncology reports

authors： Shen YF,Wei AM,Kou Q,Zhu QY,Zhang L

更新日期：2016-02-01 00:00:00

abstract：:Breast cancer is one of the most common malignancies diagnosed in women and it is increasing in incidence. Siegesbeckia glabrescens (SG) has been used in traditional oriental medicine to treat cardiovascular diseases such as hypertension and angina pectoris. This study examined whether or not SG could induce apoptosis...

journal_title：Oncology reports

authors： Jun SY,Choi YH,Shin HM

更新日期：2006-06-01 00:00:00

abstract：:VBP-1 has been isolated as a novel protein binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. The fundamental function of the gene was examined in the nematode, Caenorhabditis elegans (C. elegans). The C. elegans VBP-1 gene was expressed in adults only in the gonads and was also expressed in early s...

journal_title：Oncology reports

authors： Ichimiya H,Hino O,Kohara Y,Ishii N

更新日期：2003-03-01 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) caused by NF1 gene mutation is a commonly inherited autosomal dominant disorder. Malignant peripheral nerve sheath tumors (MPNSTs), a type of aggressive sarcoma, are a major cause of mortality in NF1 patients. The malignant transformation of benign plexiform neurofibromas (PNs) to MPNSTs...

journal_title：Oncology reports

authors： Park GH,Lee SJ,Yim H,Han JH,Kim HJ,Sohn YB,Ko JM,Jeong SY

更新日期：2014-10-01 00:00:00

abstract：:To determine whether immunohistochemistry can identify BRCA1 mutations, immunohistochemical (IH) analysis was undertaken on paraffin sections of paired ovarian cancer and normal tissue using antibodies against both terminal regions of the BRCA1 protein. Ten patients at risk for BRCA1 mutations were studied. The result...

journal_title：Oncology reports

authors： Byrne TJ,Reece MT,Adams LA,Lane MA,Cohn GM

更新日期：2000-09-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and cancer. Among the pathogenic factors of HBV, HBV X protein (HBx) is attracting increased attention. Although it is documented that HBx is a multifunctional regulator that modulates cell inflammation and apoptosis, the exact mechanism r...

journal_title：Oncology reports

authors： Gao WY,Li D,Cai DE,Huang XY,Zheng BY,Huang YH,Chen ZX,Wang XZ

更新日期：2017-01-01 00:00:00

abstract：:We investigated whether or not the mitochondrial genotypes affect radiation-induced micronucleus (MN) formation. For that purpose, the rho+, KT1 and rho0 human osteosarcoma cell lines were used, which carry the wild-type mitochondrial DNA (mtDNA), the tRNALys mutant mtDNA and no mtDNA, respectively. Despite no signifi...

journal_title：Oncology reports

authors： Yoshida K,Yamazaki H,Ozeki S,Inoue T,Yoshioka Y,Yoneda M,Fujiwara Y,Inoue T

更新日期：2001-05-01 00:00:00

abstract：:Splenic metastasis from a lung cancer is infrequently noted, however, the pattern of the metastasis has not been studied, thus we conducted a retrospective study. Twelve of the consecutive 997 patients with lung cancer, who were admitted to our division, developed splenic metastasis. The pattern of splenic metastasis ...

journal_title：Oncology reports

authors： Satoh H,Watanabe K,Ishikawa H,Yamashita YT,Ohtsuka M,Sekizawa K

更新日期：2001-11-01 00:00:00

abstract：:Tumor size indicates the extent of cell proliferation in most cases of colorectal cancer (CRC), although there are some advanced small tumors with metastases. Lymph node metastasis is a significant factor that greatly impacts disease prognosis in CRC cases. The underlying factors that cause lymph node metastasis in CR...

journal_title：Oncology reports

authors： Takahashi Y,Sawada G,Sato T,Kurashige J,Mima K,Matsumura T,Uchi R,Ueo H,Ishibashi M,Takano Y,Akiyoshi S,Eguchi H,Sudo T,Sugimachi K,Tanaka J,Kudo SE,Doki Y,Mori M,Mimori K

更新日期：2013-09-01 00:00:00

abstract：:Although chemotherapy is initially effective in debulking tumor mass in a number of different types of malignancy, tumor cells gradually acquire chemoresistance and frequently progress to advanced clinical stage. Accumulating evidence has indicated that the tumor sensitivity to several chemotherapeutic drugs is regula...

journal_title：Oncology reports

authors： Tomita R,Sasabe E,Tomomura A,Yamamoto T

更新日期：2020-11-01 00:00:00

abstract：:The usefulness of diagnostic ultrasound in gene transfer was investigated. The hepatocellular carcinoma cell lines PRL/PRF/5 and Hep3B, and the pancreatic carcinoma Panc-1 cells were transfected with lipofectin or irradiated with a linear probe with a frequency of 8 MHz at a mechani...

journal_title：Oncology reports

authors： Tomizawa M,Shinozaki F,Sugiyama T,Yamamoto S,Sueishi M,Yoshida T

更新日期：2012-05-01 00:00:00

abstract：:Pin-1 has been shown to regulate several phases of the cell cycle and is strikingly overexpressed in many human cancers. Vascular endothelial growth factor (VEGF)-C is a potent lymphangiogenic factor produced by tumor and stromal cells. However, little is known about the roles of Pin-1 and VEGF-C in breast carcinoma. ...

journal_title：Oncology reports

authors： Kim BC,Han SI,Lim SC

更新日期：2009-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is a major cause of cancer-related mortality in the world. Recently, a number of studies have demonstrated that cancer stem cells (CSCs) present in colorectal cancer tissues, are responsible for resistance to conventional therapies. Therefore, effective recog...

journal_title：Oncology reports

authors： Wang C,Xie J,Guo J,Manning HC,Gore JC,Guo N

更新日期：2012-10-01 00:00:00

abstract：:No information is currently available regarding pancreatic cancer (PC) pattern of care in Italy. In the present study, a nationwide survey using a questionnaire was performed to enquire the local standards for PC diagnosis and radiotherapy treatment. Fifty-seven percent of 140 Italian centres completed questionnaire. ...

journal_title：Oncology reports

authors： Macchia G,Sainato A,Talamini R,Boz G,Bacigalupo A,Caravatta L,Fiore M,Friso ML,Fusco V,Lupattelli M,Mantello G,Mattiucci GC,Slim N,Sciacero P,Turri L,Valentini V,Morganti AG,Genovesi D

更新日期：2015-07-01 00:00:00

abstract：:miR-95 has been revealed to be aberrantly expressed in multiple types of cancer and to regulate tumor development. Moreover, miR-95 has been revealed to be downregulated in gastric cancer. However, the detailed function of miR-95 in gastric cancer has remained largely unknown. In the present study, we found that miR-9...

journal_title：Oncology reports

authors： Zhang W,Sun J,Chen J,Xu C,Zhang L

更新日期：2019-02-01 00:00:00

abstract：:Chemokines have been reported to play crucial roles in tumor progression. Eotaxin-1 (CCL11), a member of the CC chemokine family, is elevated in many types of human cancer. Here, to reveal the molecular mechanisms of eotaxin-1 in prostate cancer cell invasion, the expression of eotaxin-1 receptors [CC chemokine recept...

journal_title：Oncology reports

authors： Zhu F,Liu P,Li J,Zhang Y

更新日期：2014-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence in males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation with regard to sex factors affecting disease progression. In the present stud...

journal_title：Oncology reports

authors： Wu Y,Yao N,Feng Y,Tian Z,Yang Y,Zhao Y

更新日期：2019-09-01 00:00:00

abstract：:Metastasis-associated protein 1 (MTA1) is highly upregulated in cancer cells with metastatic potential; however, the molecular mechanism by which MTA1 increases the metastatic potential of cancer cells is far from clear. We characterized the functional consequences of MTA1 overexpression on p53-induced apoptosis of ca...

journal_title：Oncology reports

authors： Moon HE,Cheon H,Lee MS

更新日期：2007-11-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) families are receptors for ligands that initiate extracellular or intracellular signaling, such as lipopolysaccharides (LPS). It has been reported that TLR4 activation resulted in the upregulation of a coordinated set of proinflammatory mediators and inhibition of matrix expression in the i...

journal_title：Oncology reports

authors： Zhang Q,Weng Y,Jiang Y,Zhao S,Zhou D,Xu N

更新日期：2018-08-01 00:00:00

abstract：:Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, ...

journal_title：Oncology reports

authors： Akagi J,Baba H

更新日期：2019-01-01 00:00:00

abstract：:The present study was designed to retrospectively examine the efficacy of postoperative adjuvant chemotherapy in 107 patients with stage II primary colorectal cancer who underwent curative resection. The chemotherapy regimen was intravenous 5FU/LV in 30 patients (FL-IV group) and oral UFT/PSK in 77 patients (oral grou...

journal_title：Oncology reports

authors： Ito I,Mukai M,Ninomiya H,Kishima K,Tsuchiya K,Tajima T,Oida Y,Nakamura M,Makuuchi H

更新日期：2008-11-01 00:00:00

abstract：:The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present study included 81 consecutive patients with confirmed diagnoses of r...

journal_title：Oncology reports

authors： Shoji H,Motegi M,Takakusagi Y,Asao T,Kuwano H,Takahashi T,Ogoshi K

更新日期：2017-02-01 00:00:00

abstract：:The incidence of well‑differentiated thyroid cancer (WDTC) is rapidly increasing. Poor survival follows distant metastasis (DM) and recurrence. In the present study, we aimed to analyze the expression alterations in different stages of WDTC and the regulatory mechanism of DM and the recurrence of DM. A male patient di...

journal_title：Oncology reports

authors： Zhang YJ,Ma YS,Xia Q,Yu F,Lv ZW,Jia CY,Jiang XX,Zhang L,Shao YC,Xie WT,Lu GX,Yv XQ,Zhong P,Fu D,Wang XF

更新日期：2018-12-01 00:00:00

abstract：:The purpose of this study was to examine the effects of irradiation by 125I seeds in human lung cancer xenograft model and to determine the underlying mechanisms involved, with a focus on angiogenesis. A group of 40 mice bearing A549 lung adenocarcinoma xenografts was randomly separated into 4 groups: control group (n...

journal_title：Oncology reports

authors： Xiang GL,Zhu XH,Lin CZ,Wang LJ,Sun Y,Cao YW,Wang FF

更新日期：2017-05-01 00:00:00