EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.

abstract：:MAP kinase signaling proteins have major implications in the molecular oncogenesis of breast cancers and have been extensively investigated as putative targets for therapy. This study reports the investigation of the expression of P38 MAPK and its phosphorylated form (p-P38 MAPK) in clinical specimens of invasive brea...

journal_title：Oncology reports

authors： Merlin JL,Harlé A,Lion M,Ramacci C,Leroux A

更新日期：2013-10-01 00:00:00

abstract：:In the present study, a novel signaling pathway of microRNA-141 (miR-141)/fused in sarcoma (FUS) was investigated in neuroblastoma (NB). Gene expression of miR-141 was evaluated in 6 NB cell lines. IMR-32 and SH-SY5Y cells were transduced with the miR-141 mimic lentivirus. The effects of miR-141 upregulation on cell p...

journal_title：Oncology reports

authors： Wang Z,Lei H,Sun Q

更新日期：2016-05-01 00:00:00

abstract：:microRNAs (miRNAs) are known to be involved in the pathogenesis of hepatocellular carcinoma (HCC). miR-128-3p was recently reported to be deregulated in several types of cancer. However, the biological function and potential mechanisms of miR-128-3p in HCC remain unknown. In the present study, we found that miR-128-3p...

journal_title：Oncology reports

authors： Huang CY,Huang XP,Zhu JY,Chen ZG,Li XJ,Zhang XH,Huang S,He JB,Lian F,Zhao YN,Wu GB

更新日期：2015-06-01 00:00:00

abstract：:Breast cancer is one of the most common malignancies diagnosed in women and it is increasing in incidence. Siegesbeckia glabrescens (SG) has been used in traditional oriental medicine to treat cardiovascular diseases such as hypertension and angina pectoris. This study examined whether or not SG could induce apoptosis...

journal_title：Oncology reports

authors： Jun SY,Choi YH,Shin HM

更新日期：2006-06-01 00:00:00

abstract：:A phase I study of S-1 and biweekly docetaxel (DOC) combination therapy was conducted to determine the maximum tolerated dose (MTD) and pharmacokinetic parameters. Fourteen patients with advanced or recurrent gastric cancer were analyzed. The treatment consisted of S-1 [body surface area (BSA) <1.25 m2:80 mg/day, 1.25...

journal_title：Oncology reports

authors： Takahashi I,Emi Y,Kakeji Y,Tokunaga E,Ushiro S,Oki E,Watanabe M,Baba H,Maehara Y

更新日期：2006-04-01 00:00:00

abstract：:Tumor metastasis is considered the main cause of mortality in cancer patients, thus it is important to investigate the differences between high- and low-metastatic cancer cells. Our previous study showed that the highly metastatic breast cancer cell line MDA-MB-231 released higher levels of ATP and exhibited higher P2...

journal_title：Oncology reports

authors： Eun SY,Ko YS,Park SW,Chang KC,Kim HJ

更新日期：2015-07-01 00:00:00

abstract：:P5, which is a member of the protein disulfide isomerase family, possesses isomerase and chaperone activity in vitro; however, the physiological functions of this enzyme in cells remain unclear. To understand the important roles of P5 in cancer cells, the present study examined its expression on the surface of normal ...

journal_title：Oncology reports

authors： Horibe T,Torisawa A,Masuda Y,Kawakami K

更新日期：2019-02-01 00:00:00

abstract：:Daily vs. weekly dosing with EGFR inhibitors (gefitinib and lapatinib) and an AKT inhibitor (MK2206) were compared in two rodent breast cancer models. Female Sprague-Dawley rats were administered methylnitrosourea (MNU) at 50 days of age, and gefitinib (daily/weekly dosing at 10/70 mg/kg BW) or lapatinib (daily/weekly...

journal_title：Oncology reports

authors： Lubet RA,Steele VE,Juliana MM,Bode A,Moeinpour F,Grubbs CJ

更新日期：2018-09-01 00:00:00

abstract：:The clinicopathological significance of cell-cycle proteins has remained unclear in oral tongue squamous cell carcinomas (OTSCC). In the current study, we evaluated several cell-cycle proteins in relation to clinicopathological parameters and disease outcome for OTSCC. A total of 123 previously untreated patients with...

journal_title：Oncology reports

authors： Goto M,Tsukamoto T,Inada K,Mizoshita T,Ogawa T,Terada A,Hyodo I,Shimozato K,Hasegawa Y,Tatematsu M

更新日期：2005-10-01 00:00:00

abstract：:Cancer research is currently focused on blocking the metastatic process at its early steps. Some particularly attractive targets are metastasis suppressor genes, which control cancer cell dissemination. The aim of this study was to clarify the relationship between the expression of KiSS1, a metastasis suppressor gene,...

journal_title：Oncology reports

authors： Okugawa Y,Inoue Y,Tanaka K,Toiyama Y,Shimura T,Okigami M,Kawamoto A,Hiro J,Saigusa S,Mohri Y,Uchida K,Kusunoki M

更新日期：2013-09-01 00:00:00

abstract：:Spindle-cell ameloblastic carcinoma is a classification proposed for a group of rare odontogenic carcinomas with sarcomatoid components and is distinguished from odontogenic carcinosarcoma. We report a case of spindle-cell ameloblastic carcinoma of the right mandible that occurred in a 67-year-old Japanese man. Growth...

journal_title：Oncology reports

authors： Kawauchi S,Hayatsu Y,Takahashi M,Furuya T,Oga A,Niwa S,Sasaki K

更新日期：2003-01-01 00:00:00

abstract：:Frequent invasion of oral cancers into the neighboring jaw bones is a major cause of increased mortality. Moreover, majority of patients with these oral cancers suffer from functional inconveniences and esthetic disadvantages during clinical course and after surgical treatments. Understanding of the mechanisms underly...

journal_title：Oncology reports

authors： Kitagawa Y,Hiraga T,Yura Y,Yoneda T

更新日期：2005-02-01 00:00:00

abstract：:The targeting of receptor activator of nuclear factor-κB ligand (RANKL) is being increasingly investigated as a potential therapeutic strategy in several types of cancers. However, the exact function and mechanism of RANKL in human endometrial cancer (EC), particularly in progesterone-resistant and aggressive EC, rema...

journal_title：Oncology reports

authors： Wang J,Sun X,Zhang H,Wang Y,Li Y

更新日期：2015-02-01 00:00:00

abstract：:In the present study, we investigated the antitumor activity of caudatin in the human hepatoma cell line SMMC‑7721 by analysis of cell viability, cell cycle distribution, apoptosis and metastasis. The results showed that caudatin impaired the cell viability and inhibited the growth of SMMC-7721 cells in a time- and do...

journal_title：Oncology reports

authors： Luo Y,Sun Z,Li Y,Liu L,Cai X,Li Z

更新日期：2013-12-01 00:00:00

abstract：:This study investigated the prognostic significance of thymidine phosphorylase (TP) and p53 expression in 96 surgically resected primary esophageal squamous cell carcinomas. Expression was assessed using immunohistochemical staining methods. Prognostic values were determined by multivariate analysis using Cox's propor...

journal_title：Oncology reports

authors： Makoto O,Takeda A,Ting-Leig L,Shinnichi O,Hisahiro M,Yutaka F,Yoshihiro N,Kobayashi S,Gunji Y,Suzuki T,Takenori O,Hideaki S

更新日期：2002-01-01 00:00:00

abstract：:Neuroblastoma is the most common inheritable, solid neoplasm in children found under the age of 7 and accounts for approximately 7% of childhood cancers. A common treatment that has been prescribed for over a decade is retinoid therapy [using all‑trans retinoic acid (RA)]. Treatment with this differentiating agent has...

journal_title：Oncology reports

authors： Illendula A,Fultang N,Peethambaran B

更新日期：2020-09-01 00:00:00

abstract：:After having carefully checked the original data of Fig. 3, the authors noted that the student in their research group had inadvertently selected incorrect images for the 10 and 20 µM lycorine experiments to show the effect of lycorine on the migration of HepG2 cells during the figure compilation process. The correcte...

journal_title：Oncology reports

authors： Liu W,Zhang Q,Tang Q,Hu C,Huang J,Liu Y,Lu Y,Wang Q,Li G,Zhang R

更新日期：2019-12-01 00:00:00

abstract：:The Houttuynia cordata Thunb (HCT) extract has been used as a traditional Chinese herb medicine and as well as an effective drug for treating allergic inflammation for thousands of years. In this study, we investigated the anti-cancer activity of HCT and its molecular mechanisms in the human colon adenocarcinoma cell ...

journal_title：Oncology reports

authors： Tang YJ,Yang JS,Lin CF,Shyu WC,Tsuzuki M,Lu CC,Chen YF,Lai KC

更新日期：2009-11-01 00:00:00

abstract：:For deveplopment and function of the lung, progesterone (Prog) fulfils important roles. In a recent report, immunolocalization of Prog and estrogen receptors in non-small cell lung carcinomas were examined and it was shown that the Prog receptor might be a potent prognostic factor. In the present study, a cell line wi...

journal_title：Oncology reports

authors： Nishizawa Y,Yamasaki M,Katayama H,Amakata Y,Fushiki S,Nishizawa Y

更新日期：2007-09-01 00:00:00

abstract：:Sentinel lymph node (SLN) biopsy is a useful way of assessing axillary nodal status and obviates unnecessary axillary lymph node dissection for patients with node-negative breast cancer. However, SLN can also be located in the internal mammary lymph node (IMN) chain or elsewhere. The practicability and relevance of in...

journal_title：Oncology reports

authors： Noguchi M

更新日期：2002-05-01 00:00:00

abstract：:The antitumor effect of the human umbilical vein endothelial cell (HUVEC) vaccine has been well documented; however, its anti‑angiogenic effects on human esophageal squamous cell carcinoma (ESCC) have yet to be studied. In the present study, a 'humanized' mouse model was established by transplanting NOD/SCID mice with...

journal_title：Oncology reports

authors： Liu H,Zhao J,Yang Y,Jin G,Zhang X,Wang D,Xie C,Liu K,Chen X,Li X,Tian F,Dong Z,Lu J

更新日期：2018-11-01 00:00:00

abstract：:The challenging possibility of selectively inducing mitotic death in tumor cells by combining genotoxic agents with the inhibition of G2 checkpoints of the cell cycle is the subject of intensive investigation. We show that very low concentrations (3.5 and 5 nM) of okadaic acid induce mitotic death in two glioblastoma ...

journal_title：Oncology reports

authors： Castigli E,Sciaccaluga M,Schiavoni G,Brozzi F,Fabiani R,Gorello P,Gianfranceschi GL

更新日期：2006-02-01 00:00:00

abstract：:We investigated the correlation between BAG-1 expression and sensitivity to platinum-based chemotherapeutics in patients with non-small cell lung cancer (NSCLC). mRNA and protein expression of BAG-1 in lung tissue of NSCLC postoperative patients (I-IIIA stage) or healthy subjects were detected using reverse transcript...

journal_title：Oncology reports

authors： Wang YD,Ha MW,Cheng J,Zhang WL,Cong X,Tong CY,Sun J

更新日期：2012-04-01 00:00:00

abstract：:The aim of the present study was to evaluate the antitumor effects of the curcumin analogue GL63 on radioresistant nasopharyngeal carcinoma (NPC) CNE2R cells and parental CNE2 cells. The cell viability and proliferation of NPC cells were detected by MTT assay and colony formation assay. The suppressive effect on tumor...

journal_title：Oncology reports

authors： Pan Y,Xiao J,Liang G,Wang M,Wang D,Wang S,Yang H

更新日期：2013-07-01 00:00:00

abstract：:Bcl-2 is overexpressed in various types of human tumors, including Burkitt's lymphoma, and it is involved in tumorigenesis and chemoresistance, therefore, it is regarded as a potential target of gene therapy. In this study, RNA interference using short hairpin RNA (shRNA)-mediated R...

journal_title：Oncology reports

authors： Liu Y,Shen Y,Qin C,Shi Y,Rong G,Yu X

更新日期：2013-01-01 00:00:00

abstract：:In recent years an extensive series of synthetic combretastatin A-4 (CA-4)-azetidinone (β-lactam) hybrids were designed and synthesised with a view to improve the stability, therapeutic efficacy and aqueous solubility of CA-4. Lead compounds containing a 3,4,5-trimethoxy aromatic ring at position 1 and a variety of su...

journal_title：Oncology reports

authors： Greene LM,Wang S,O'Boyle NM,Bright SA,Reid JE,Kelly P,Meegan MJ,Zisterer DM

更新日期：2013-06-01 00:00:00

abstract：:Owing to aggressiveness and chemoresistance, pancreatic ductal adenocarcinoma (PDAC) is characterised by a poor prognosis. To address this disease-spe-cific dilemma we aimed to establish animal models, which can be used for identifying new specific tumor markers, as well as serving ...

journal_title：Oncology reports

authors： Eyol E,Murtaga A,Zhivkova-Galunska M,Georges R,Zepp M,Djandji D,Kleeff J,Berger MR,Adwan H

更新日期：2012-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most prevalent types of cancer worldwide and a common cause of morbidity and mortality in humans. The garlic-derived organosulfur compound diallyl trisulfide (DATS) has been shown to induce apoptosis in many human cancer cell lines in vitro and ...

journal_title：Oncology reports

authors： Yu CS,Huang AC,Lai KC,Huang YP,Lin MW,Yang JS,Chung JG

更新日期：2012-09-01 00:00:00

abstract：:Carboxypeptidase X, M14 family member 2 (CPXM2), has been associated with several human disorders such as developmental diseases. However, whether CPXM2 is involved in oncogenesis or tumor progression remains unclear. In the present study, we used clinical samples from gastric cancer (GC) patients to investigate poten...

journal_title：Oncology reports

authors： Niu G,Yang Y,Ren J,Song T,Hu Z,Chen L,Hong R,Xia J,Ke C,Wang X

更新日期：2019-10-01 00:00:00

abstract：:Transitional cell carcinomas (TCCs) of the urinary bladder are common malignancies with a high recurrence rate. Since microRNA-21 (miR-21) may contribute to tumorigenesis and chemoresistance in many cancer types, we aimed to investigate its efficacy in TCCs. The expression of miR-21 and its target PTEN was determined ...

journal_title：Oncology reports

authors： Tao J,Lu Q,Wu D,Li P,Xu B,Qing W,Wang M,Zhang Z,Zhang W

更新日期：2011-06-01 00:00:00