miR-154 targeting ZEB2 in hepatocellular carcinoma functions as a potential tumor suppressor.


:MicroRNA-154 (miR-154) has been identified as a tumor suppressor in several types of human cancers; however, its clinical significance and function in human hepatocellular carcinoma (HCC) remain unclear. The aim of the present study was to analyze the clinical significance and cellular function of miR-154 in HCC patients. The data showed that miR-154 expression was consistently lower in HCC tissues and cell lines compared to that in matched tumor-adjacent tissues and a normal hepatic cell line, and its expression was negatively correlated with tumor differentiation (P<0.01), TNM stage (P<0.01) and lymph node metastasis (P<0.01). Restoration of miR-154 expression in HepG2 cells inhibited cell proliferation, migration and invasion, and induced apoptosis and cell arrest at the G1 phase in vitro, as well as suppressed tumor growth in a nude mouse model. Using a luciferase assay, we identified that miR-154 was able to target the 3'-untranslated region (3'UTR) of ZEB2 mRNA. Then, we revealed that miR-154 was able to reduce ZEB2 expression at the levels of mRNA and protein using qRT-PCR and western blot analysis. Notably, restoration of expression of ZEB2 weakened miR-154-mediated suppression of tumor progression. In conclusion, these results indicate that miR-154 functions as a tumor suppressor in HCC by suppressing ZEB2, suggesting that miR-154 may serve as a potential target for HCC.


Oncol Rep


Oncology reports


Pang X,Huang K,Zhang Q,Zhang Y,Niu J




Has Abstract


2015-12-01 00:00:00












  • Efficacy of hybrid 2-port hand-assisted laparoscopic surgery (Mukai's operation) for patients with primary colorectal cancer.

    abstract::In this study, a total of 108 patients with primary colorectal cancer who underwent hybrid 2-port hand-assisted laparoscopic surgery (HALS) were classified as 58 patients with colon cancer and 50 patients with rectal cancer. The mean operating time, mean blood loss, postoperative complications, and mean postoperative ...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Mukai M,Kishima K,Tajima T,Hoshikawa T,Yazawa N,Fukumitsu H,Okada K,Ogoshi K,Makuuchi H

    更新日期:2009-10-01 00:00:00

  • Dynamics of circadian fluctuations in serum concentration of cortisol and TNF-alpha soluble receptors in gastrointestinal cancer patients.

    abstract::The objective of the study was to investigate the dynamic changes of cortisol and soluble TNF-alpha p-55 and p-75 receptors in serum of advanced cancer patients during 24 h. The examined group consisted of 42 patients suffering from advanced gastrointestinal neoplasms (colorectal, gastric and pancreatic cancer). Serum...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Zubelewicz-Szkodzinska B,Muc-Wierzgon M,Wierzgon J,Brodziak A

    更新日期:2001-01-01 00:00:00

  • Effects of triple therapy with octreotide, galanin and serotonin on a human colon cancer cell line.

    abstract::Human colon cancer cells were implanted subcutaneously into nude mice. After 12 days, the animals were divided into two groups. The first group received 40 microg/kg body weight of octreotide, galanin and serotonin via an intraperitoneally implanted pump. The second group received sterile saline only. Treatment lasted...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: El-Salhy M

    更新日期:2005-01-01 00:00:00

  • Improved sensitivity and specificity for prostate cancer diagnosis based on the urine PCA3/PSA ratio acquired by sequence‑specific RNA capture.

    abstract::Prostate cancer antigen 3 (PCA3) is a non-coding RNA fragment that is overexpressed in prostate cancer cells. However, the clinical applications of PCA3 are highly limited due to the instability of RNA and the lack of reliable and efficient RNA extraction and purification methods. Thus, in the present study, we compar...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Zheng K,Dou Y,He L,Li H,Zhang Z,Chen Y,Ye A,Liu W,Kong L

    更新日期:2015-11-01 00:00:00

  • Effects of ephrinB2 gene siRNA on the biological behavior of human colorectal cancer cells.

    abstract::Colorectal cancer (CRC) is a common gastrointestinal malignancy worldwide and is a lethal and aggressive malignancy with a dismal prognosis. EphrinB2 is a membrane-bound ligand and has an intracellular domain that also possesses an intrinsic signaling capacity called 'reverse signaling'. In the present study, CRC cell...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Li P,Chen W,Wang Y,Fu X,Wen K,Qian J,Huang C,Fu Z

    更新日期:2015-02-01 00:00:00

  • Combination of branched-chain amino acids and angiotensin-converting enzyme inhibitor suppresses the cumulative recurrence of hepatocellular carcinoma: a randomized control trial.

    abstract::Insulin resistance (IR) is reportedly involved in the progression of hepatocellular carcinoma (HCC). Since neovascularization plays an important role in hepatocarcinogenesis and IR, an angiostatic therapy may be considered as one of the promising approaches for chemoprevention again...

    journal_title:Oncology reports

    pub_type: 杂志文章,随机对照试验


    authors: Yoshiji H,Noguchi R,Ikenaka Y,Kaji K,Aihara Y,Yamazaki M,Yamao J,Toyohara M,Mitoro A,Sawai M,Yoshida M,Morioka C,Fujimoto M,Uemura M,Fukui H

    更新日期:2011-12-01 00:00:00

  • MicroRNA-302a enhances 5-fluorouracil-induced cell death in human colon cancer cells.

    abstract::New therapeutic strategies are needed for colorectal cancer (CRC) treatment. MicroRNAs are involved in cancer‑pertinent cellular processes, including chemoresistance. As miR‑302a is an embryonic stem cell‑specific microRNA, studies on miR‑302a have focused on its role in human stem cells. Studies analyzing miR‑302 fun...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Liu N,Li J,Zhao Z,Han J,Jiang T,Chen Y,Hou N,Huang C

    更新日期:2017-01-01 00:00:00

  • Role of regenerative mucosa in primary gastric cancer treated by chemotherapy.

    abstract::We radiographically evaluated the response of primary lesions to chemotherapy in 101 patients with inoperable advanced gastric cancer. The median survival time in the 50 responders (49.5%) was 379 days, as compared with only 210 days in the 51 non-responders (50.1%) (p<0. 001). Morphologic changes of the gastric mucos...

    journal_title:Oncology reports

    pub_type: 临床试验,杂志文章


    authors: Yamazaki I,Koizumi W,Kondo I,Saigenji K

    更新日期:2000-11-01 00:00:00

  • Aberrant methylation of TRIM58 in hepatocellular carcinoma and its potential clinical implication.

    abstract::TRIM58 (tripartite motif containing 58) has been reported as a novel methylated gene in hepatocellular carcinoma (HCC) by methylation microarrays. However, its associations with mRNA expression and clinicopathological characteristics have not been evaluated. In this study, we explored the potential clinical implicatio...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Qiu X,Huang Y,Zhou Y,Zheng F

    更新日期:2016-08-01 00:00:00

  • Nicotine enhances store‑operated calcium entry by upregulating HIF‑1α and SOCC components in non‑small cell lung cancer cells.

    abstract::Store‑operated calcium entry (SOCE) is critical for regulating the proliferation and metastasis of various cancer types. The present study aimed to investigate the role of SOCE on nicotine‑promoted proliferation of non‑small cell lung cancer (NSCLC) A549 cells. Cell proliferation was evaluated by BrdU incorporation as...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Wang Y,He J,Jiang H,Zhang Q,Yang H,Xu X,Zhang C,Xu C,Wang J,Lu W

    更新日期:2018-10-01 00:00:00

  • miR-194 is a negative regulator of GEF-H1 pathway in melanoma.

    abstract::The incidence and associated mortality of melanoma continues to increase worldwide. At present, there is no curative therapy for advanced stage of melanoma. It is necessary to find new indicators of prognosis and therapeutic targets. Increasing evidence shows that miRNA can provide potential candidate biomarkers for m...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Guo B,Hui Q,Zhang Y,Chang P,Tao K

    更新日期:2016-10-01 00:00:00

  • Differential effects of raloxifene and tamoxifen on the expression of estrogen receptors and antigen Ki-67 in human endometrial adenocarcinoma cell line.

    abstract::Tamoxifen and raloxifene are widely used in clinical practice. It has been found that tamoxifen treatment increases the risk of development of endometrial cancer. The effects of tamoxifen and raloxifene on endometrium might be caused by different estrogen receptor expression. The aim of the present study was immunohis...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Koda M,Jarzabek K,Haczynski J,Knapp P,Sulkowski S,Wolczynski S

    更新日期:2004-09-01 00:00:00

  • Peptides and small molecules blocking the CXCR4/CXCL12 axis overcome bone marrow‑induced chemoresistance in acute leukemias.

    abstract::Notable advances in treatment have been made and increases in the cure rates of pediatric leukemia have been achieved. However, the majority of children with relapsed disease are not expected to survive, with chemotherapy resistance acting as the principal cause of treatment failure. Interaction between leukemic cells...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Pillozzi S,Bernini A,Spiga O,Lelli B,Petroni G,Bracci L,Niccolai N,Arcangeli A

    更新日期:2019-01-01 00:00:00

  • MicroRNA-100 promotes migration and invasion through mammalian target of rapamycin in esophageal squamous cell carcinoma.

    abstract::Esophageal squamous cell carcinoma (ESCC) is the predominant histologic subtype of esophageal cancer and is characterized by a high mortality rate and geographic differences in incidence. microRNAs (miRNAs) are small, non-coding RNAs that play important roles in the regulation of genes associated with cancer developme...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Zhang N,Fu H,Song L,Ding Y,Wang X,Zhao C,Zhao Y,Jiao F,Zhao Y

    更新日期:2014-10-01 00:00:00

  • Antiproliferative effects of β-blockers on human colorectal cancer cells.

    abstract::Colon cancer is the fourth and third most common cancer, respectively in men and women worldwide and its incidence is on the increase. Stress response has been associated with the incidence and development of cancer. The catecholamines (CA), adrenaline (AD) and noradrenaline (NA), are crucial mediators of stress respo...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Coelho M,Moz M,Correia G,Teixeira A,Medeiros R,Ribeiro L

    更新日期:2015-05-01 00:00:00

  • Biological comparison of ovarian cancer resistant cell lines to cisplatin and Taxol by two different administrations.

    abstract::Drug resistance is one of the major obstacles to chemotherapy of ovarian cancer. Studies with cell lines can serve as an initial screen for agents that might modulate drug resistance. To establish more appropriate models of drug resistance and explore whether the differences exist in the different drug resistant subli...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Yan XD,Li M,Yuan Y,Mao N,Pan LY

    更新日期:2007-05-01 00:00:00

  • The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer.

    abstract::Orotate phosphoribosyl transferase (OPRT) is an enzyme playing an important role in exertion of the effect of 5-fluorouracil (5-FU). A type of gene polymorphism, single nucleotide polymorphism (SNP), is considered to be a factor affecting individual differences in exertion of drug effects, and its analysis has recentl...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Kitajima M,Takita N,Hata M,Maeda T,Sakamoto K,Kamano T,Ochiai T

    更新日期:2006-01-01 00:00:00

  • Low dose carboplatin (AUC 4.5) combined with vinorelbine in the treatment of advanced non-small cell lung cancer: a single institution phase II study.

    abstract::Platinum compounds and vinorelbine (VNB) are active in the treatment of non-small cell lung cancer (NSCLC), but moderate toxicity has been reported. The aims of the present study were to assess activity and tolerability of low dose carboplatin (CBDCA): 4.5 AUC according to Calvert formula on day 1, combined with vinor...

    journal_title:Oncology reports

    pub_type: 临床试验,杂志文章


    authors: Bretti S,Manzin E,Celano A,Ritorto G,Loddo C,Berruti A

    更新日期:2001-03-01 00:00:00

  • Pathotropic targeting advances clinical oncology: tumor-targeted localization of therapeutic gene delivery.

    abstract::The advent of pathotropic (disease-seeking) targeting has transported genetic medicine across the threshold of history with the progressive clinical validation of Rexin-G, a tumor-targeted nanosized anti-cancer agent. Achieving noteworthy single-agent efficacy and survival benefits in otherwise intractable cancers, th...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Hall FL,Levy JP,Reed RA,Petchpud WN,Chua VS,Chawla SP,Gordon EM

    更新日期:2010-10-01 00:00:00

  • PI3Kβ inhibitor AZD6482 exerts antiproliferative activity and induces apoptosis in human glioblastoma cells.

    abstract::Glioblastoma is the most common type of primary brain tumour in adults, and its pathogenesis is particularly complicated. Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic ...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Xu PF,Yang JA,Liu JH,Yang X,Liao JM,Yuan FE,Liu BH,Chen QX

    更新日期:2019-01-01 00:00:00

  • Cross-validation of genes potentially associated with overall survival and drug resistance in ovarian cancer.

    abstract::Ovarian cancer is the leading cause of death among malignancies of the female reproductive system. The 5-year survival rates of ovarian cancer (OC) patients are very poor as a result of recurrent disease and emergence of drug resistance; thus, studies to find predictive markers and factors for drug resistance are ongo...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Gao Y,Liu X,Li T,Wei L,Yang A,Lu Y,Zhang J,Li L,Wang S,Yin F

    更新日期:2017-05-01 00:00:00

  • Antitumor effect of photodynamic therapy with a novel targeted photosensitizer on cervical carcinoma.

    abstract::The antitumor effect of photodynamic therapy (PDT) mediated by a novel photosensitizer I (Ps I; {γ-[N-poly(ethyleneglycol)]folic acid}-5,10,15-tris(3-hydroxyphenyl)-20-(4-carboxyphenyl)chlorin), in which chlorin was used as a photoactive unit, folic acid as a tumor‑targeting warhead, and polyethylene glycol as a linke...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Li PX,Mu JH,Xiao HL,Li DH

    更新日期:2015-01-01 00:00:00

  • HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo.

    abstract::Hyperplasia suppressor gene (HSG) is a novel gene that markedly suppresses the mitogenetic stimuli or injury mediated by vascular smooth muscle cell proliferation. Herein we provide experimental evidence to show that HSG can also play a key role in tumor proliferation. Down-regulation of HSG protein in hepatocellular ...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Wang W,Zhu F,Wang S,Wei J,Jia C,Zhang Y,Zhou L,Xie H,Zheng S

    更新日期:2010-07-01 00:00:00

  • Transcriptional changes induced by epigenetic therapy with hydralazine and magnesium valproate in cervical carcinoma.

    abstract::Aberrant DNA methylation and histone deacetylation participate in cancer development and progression; hence, their reversal by inhibitors of DNA methylation and histone deacetylases is a promising cancer therapy. Experimental data demonstrate that these inhibitors in combination do not only show synergy in antitumor e...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: De la Cruz-Hernández E,Perez-Plasencia C,Pérez-Cardenas E,Gonzalez-Fierro A,Trejo-Becerril C,Chávez-Blanco A,Taja-Chayeb L,Vidal S,Gutiérrez O,Dominguez GI,Trujillo JE,Duenas-González A

    更新日期:2011-02-01 00:00:00

  • miR-141 confers docetaxel chemoresistance of breast cancer cells via regulation of EIF4E expression.

    abstract::Resistance to docetaxel, a chemotherapy drug for breast cancer (BC) treatment, occurs in ~50% of patients, and the underlying molecular mechanisms of drug resistance are not fully understood. Gene regulation through miR-141 has been proven to play an important role in cancer drug resistance. The present study investig...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Yao YS,Qiu WS,Yao RY,Zhang Q,Zhuang LK,Zhou F,Sun LB,Yue L

    更新日期:2015-05-01 00:00:00

  • 5-Fluorouracil combined with apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells.

    abstract::We investigated the effects of combined treatment with 5-fluorouracil and apigenin on proliferation and apoptosis, as well as the underlying mechanism, in human breast cancer MDA-MB-453 cells. The MDA-MB-453 cells, which have been shown to overexpress ErbB2, were resistant to 5-fluorouracil; 5-fluorouracil exhibited a...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Choi EJ,Kim GH

    更新日期:2009-12-01 00:00:00

  • Plumbagin reduces chronic lymphocytic leukemia cell survival by downregulation of Bcl-2 but upregulation of the Bax protein level.

    abstract::Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries, and mainly originates from an accumulation of abnormal B cells caused by the dysregulation of cell proliferation and apoptosis rates. The aberration of apoptosis-related genes in CLL cells results in defective apoptosis of CLL cells i...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Fu C,Gong Y,Shi X,Sun Z,Niu M,Sang W,Xu L,Zhu F,Wang Y,Xu K

    更新日期:2016-09-01 00:00:00

  • Molecular and clinical characteristics of MSH6 germline variants detected in colorectal cancer patients.

    abstract::The MSH6 gene is one of the mismatch repair genes involved in Lynch syndrome and its mutations account for 10-20% of Lynch syndrome. Although previous studies suggested that the difference of the geographical region affects the clinical phenotype of Lynch syndrome, there has been no report on the detailed features of ...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Terui H,Tachikawa T,Kakuta M,Nishimura Y,Yatsuoka T,Yamaguchi K,Yura K,Akagi K

    更新日期:2013-12-01 00:00:00

  • Ultrasound-targeted microbubble destruction-mediated downregulation of CD133 inhibits epithelial-mesenchymal transition, stemness and migratory ability of liver cancer stem cells.

    abstract::Hepatocellular carcinoma (HCC) is an aggressive disease with a poor outcome due to the high incidence of metastasis. Cancer stem cells (CSCs) have been identified to be responsible for tumor progression and may be generated by epithelial-mesenchymal transition (EMT) characteristics. CD133 is a specific surface marker ...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Liu YM,Li XF,Liu H,Wu XL

    更新日期:2015-12-01 00:00:00

  • IGF expression in HPV-related and HPV-unrelated human cancer cells.

    abstract::The human Igf-1 gene not only produces insulin‑like growth factor-I (IGF-I), but also different carboxy‑terminal extensions, known as E peptides, through alternative splicing. We and others have shown that human Eb peptide (hEb) derived from Igf-1 has intrinsic biological activity and is localized to nuclei of transfe...

    journal_title:Oncology reports

    pub_type: 杂志文章


    authors: Durzyńska J,Barton E

    更新日期:2014-09-01 00:00:00