miR-154 targeting ZEB2 in hepatocellular carcinoma functions as a potential tumor suppressor.

abstract：:Paired box 6 (PAX6) is a transcription factor that has oncogenic features. In breast cancer, PAX6 facilitates tumor progression; however, the underlying mechanism is largely unknown. The majority of breast cancer‑related mortalities are associated with metastasis of cancer cells. Therefore, the present study aimed to ...

journal_title：Oncology reports

authors： Jin M,Gao D,Wang R,Sik A,Liu K

更新日期：2020-08-01 00:00:00

abstract：:Leptin may be involved in the pathogenesis of numerous cancer types by activation of cellular signal-transduction pathways. In this study, we analyzed the role of leptin and the mechanism(s) underlying its action in cervical carcinoma cells. Firstly, we examined the expression of leptin in 80 cases of cervical carcino...

journal_title：Oncology reports

authors： Yuan Y,Zhang J,Cai L,Ding C,Wang X,Chen H,Wang X,Yan J,Lu J

更新日期：2013-06-01 00:00:00

abstract：:c‑mesenchymal‑epithelial transition (Met) is a transmembrane tyrosine kinase receptor of hepatocyte growth factor (HGF). HGF/Met signaling stimulates numerous pathways, including the Ras/mitogenactivated protein kinase (MAPK), phosphatidylinositol 3‑kinase/protein kinase B and Wnt/β‑catenin pathways, which serve impor...

journal_title：Oncology reports

authors： Liu D,Zhong M,Zhan D,Zhang Y,Liu S

更新日期：2020-12-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the function and mechanism of lncRNA NEAT1 in oral squamous cell carcinoma (OSCC) are unclear. In the present study, NEAT1 was significantly upregulated in OSCC cells and tissues. High expression of NEAT1 was correlated w...

journal_title：Oncology reports

authors： Huang G,He X,Wei XL

更新日期：2018-04-01 00:00:00

abstract：:The aim of the present study was to discover the signaling pathways associated with 2-(3-hydroxy-5-methoxy-phenyl)-6,7-methylenedioxyquinolin-4-one (YYK1)-induced apoptosis in HL-60 human leukemia cells. YYK1 induced cytotoxic effects, cell morphological changes, decreased the cell ...

journal_title：Oncology reports

authors： Cheng YY,Yang JS,Tsai SC,Liaw CC,Chung JG,Huang LJ,Lee KH,Lu CC,Chien HC,Tsuzuki M,Kuo SC

更新日期：2012-10-01 00:00:00

abstract：:Signal transducer and activator of transcription (STAT) 5, including STAT 5a and STAT 5b, was reported to play important roles in the malignant biological behaviors of tumors. However, their roles in gastric cancer, especially for STAT 5b remain unknown. This study aimed to detect the expression of STAT 5b in gastric ...

journal_title：Oncology reports

authors： Sun T,Jia Y,Xiao D

更新日期：2015-07-01 00:00:00

abstract：:The emerging role of microRNA-181A (miR-181A) in CRC patients with late liver metastases was studied. In the present study we investigated the association between expression and mechanism of miRNA-181A, liver metastasis and prognosis of colorectal cancer (CRC). The expression of miR-181A and PTEN in CRC patients with ...

journal_title：Oncology reports

authors： Li Z,Wang H,Xu Z,Sun Y,Han J

更新日期：2016-03-01 00:00:00

abstract：:Progesterone has a potential protective effect against ovarian carcinoma induced by estrogen. Progesterone is also known to cause apoptosis while tamoxifen induces growth arrest. Therefore, we attempted to determine whether combined treatment with progesterone and tamoxifen has a sy...

journal_title：Oncology reports

authors： Lee JY,Shin JY,Kim HS,Heo JI,Kho YJ,Kang HJ,Park SH,Lee JY

更新日期：2012-01-01 00:00:00

abstract：:The novel tumor suppressor RASSF1A is frequently inactivated during human tumorigenesis by promoter methylation. In this study, we detected the RASSF1A promoter methylation by methylated-specific PCR and investigated RASSF1A gene expression by semi-quantitative RT-PCR and immunohistochemical staining in 36 cases of br...

journal_title：Oncology reports

authors： Li Y,Wei Q,Cao F,Cao X

更新日期：2008-05-01 00:00:00

abstract：:Cell cycle control is a promising target in cancer treatments, and some small-molecule cyclin-dependent kinase (CDK) inhibitors have exhibited clinical effectiveness. However, no biomarkers predictive of efficacy have been developed. Recent studies have revealed that CDK inhibitor (CKI) proteins, such as p27 and p16, ...

journal_title：Oncology reports

authors： Okada Y,Kato S,Sakamoto Y,Oishi T,Ishioka C

更新日期：2017-07-01 00:00:00

abstract：:Soft tissue sarcomas are rare and aggressive tumors arising from connective tissues. Adjuvant radiotherapy is a commonly used treatment approach for the majority of sarcomas. We attempted to identify a gene signature that can predict radiosensitive patients who are most likely to have a better treatment response from ...

journal_title：Oncology reports

authors： Tang Z,Zeng Q,Li Y,Zhang X,Suto MJ,Xu B,Yi N

更新日期：2017-11-01 00:00:00

abstract：:We have recently noticed an accidental error in part of a figure which appeared in the above‑mentioned article. In Fig. 3A, the image for the HGC27‑pEF, 15 h panel was mistakenly replicated as the HGC27‑KD, 0 h panel in the same figure, and the AGS‑pEF, 15 h and AGS KD, 0 h panels were mistakenly switched with each ot...

journal_title：Oncology reports

authors： Gao XY,Li L,Wang XH,Wen XZ,Ji K,Ye L,Cai J,Jiang WG,Ji JF

更新日期：2018-04-01 00:00:00

abstract：:We investigated cell susceptibility to hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines (RYSTs) and attempted to correlate this with the known potentially relevant molecular determinants of apoptosis, p53 protein status, Bcl-2 family of proteins and heat shock proteins (Hsp). Parent cell line, NMT-1...

journal_title：Oncology reports

authors： Islam MS,Mitsuhashi N,Akimoto T,Sakurai H,Hasegawa M,Ishikawa H,Niibe H

更新日期：2001-05-01 00:00:00

abstract：:The effects of a novel oral fluoropyrimidine derivative S-1 on peritoneal metastasis from gastric cancer were investigated. OCUM-2MD3 cells, a highly peritoneal-metastatic cell line, were injected intraperitoneally in nude mice. These mice were allocated to the following three groups (each group, n=10): the S-1 group,...

journal_title：Oncology reports

authors： Yamagata S,Nakata B,Hirakawa K

更新日期：2004-11-01 00:00:00

abstract：:The Nemo‑like kinase (NLK), a conserved serine/threonine kinase, plays a critical role in the regulation of a variety of transcription factors, with important roles in determining cell fate. Although recent studies have demonstrated decreased expression patterns of NLK in various types of human cancer, the functional ...

journal_title：Oncology reports

authors： Chen J,Lin Q,Ni T,Zhao J,Lin F,Lu X,Lv Y,Ren S,Liu Z,Zhang T,He S,Shen D,Mao W

更新日期：2020-06-01 00:00:00

abstract：:Low-intensity ultrasound (LIUS) combined with chemotherapy is an innovative modality for cancer treatment, but its effect on orthotopic carcinoma remains unknown. Our previous study revealed that LIUS enhanced the growth inhibitory effects of several chemotherapeutic drugs in nude mice with transplanted tumors. In the...

journal_title：Oncology reports

authors： Li HX,Zheng JH,Ji L,Liu GY,Lv YK,Yang D,Hu Z,Chen H,Zhang FM,Cao W

更新日期：2018-04-01 00:00:00

abstract：:Tumor metastasis is considered the main cause of mortality in cancer patients, thus it is important to investigate the differences between high- and low-metastatic cancer cells. Our previous study showed that the highly metastatic breast cancer cell line MDA-MB-231 released higher levels of ATP and exhibited higher P2...

journal_title：Oncology reports

authors： Eun SY,Ko YS,Park SW,Chang KC,Kim HJ

更新日期：2015-07-01 00:00:00

abstract：:The long-term effort in investigating chemical methods to eliminate only cancer cells has improved our knowledge and has led to the development of new drugs. The targets for cancer treatment may be large polymeric molecules such as DNA or microtubules as well as regulatory pathways for tumor development and cell survi...

journal_title：Oncology reports

authors： Stathopoulos GP

更新日期：2002-11-01 00:00:00

abstract：:9-Oxo-10, 11-dehydroageraphorone (euptox A), a cadenine sesquiterpene, is the main toxin from Eupatorium adenophorum. The aim of the present study was to examine the induction and mechanism of HeLa cell apoptosis by euptox A. The apoptosis‑inducing effect of the euptox A on HeLa cells was examined by MTT assay. The un...

journal_title：Oncology reports

authors： Liao F,Hu Y,Wu L,Tan H,Luo B,He Y,Qiao Y,Mo Q,Wang Y,Zuo Z,Deng J,Wei Y

更新日期：2015-04-01 00:00:00

abstract：:The objective of our study was to define a neural network for predicting recurrence and progression-free probability in patients affected by recurrent pTaG3 urothelial bladder cancer to use in everyday clinical practice. Among all patients who had undergone transurethral resection for bladder tumors, 143 were finally ...

journal_title：Oncology reports

authors： Cai T,Conti G,Nesi G,Lorenzini M,Mondaini N,Bartoletti R

更新日期：2007-10-01 00:00:00

abstract：:Increased production of reactive oxygen species (ROS) is a distinct feature of various types of cancer. ROS drive tumor progression and render cancer cells vulnerable to additional oxidative insult. The various natural herb compounds have been shown to induce additional production of ROS in cancer cells, although the ...

journal_title：Oncology reports

authors： Chen X,Song L,Hou Y,Li F

更新日期：2019-02-01 00:00:00

abstract：:Human glioblastoma is a malignant and aggressive primary human brain solid tumor characterized by severe hypoxia. Hypoxia can induce autophagy, which may result in chemoresistance and malignant progression of cancer cells. MicroRNAs (miRNAs) have been reported to modulate hypoxia‑induced autophagy in various types of ...

journal_title：Oncology reports

authors： Huang S,Qi P,Zhang T,Li F,He X

更新日期：2019-03-01 00:00:00

abstract：:Melanoma is the seventh most common malignancy in females and the fifth most common cancer in males worldwide. An increasing number of studies have reported that microRNA (miRNA) dysregulation is frequently observed in various types of human cancers, including melanoma. Abnormally expressed miRNAs play an important ro...

journal_title：Oncology reports

authors： Kang K,Zhang J,Zhang X,Chen Z

更新日期：2018-01-01 00:00:00

abstract：:There has been increasing evidence that numerous bioactive dietary agents can hamper the process of carcinogenesis by targeting epigenetic alterations including DNA methylation. This therapeutic approach is considered as a significant goal for cancer therapy due to the reversible nature of epigenetic-mediated gene sil...

journal_title：Oncology reports

authors： Khan MA,Hussain A,Sundaram MK,Alalami U,Gunasekera D,Ramesh L,Hamza A,Quraishi U

更新日期：2015-04-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant intracranial tumor. Although the affected patients are usually treated with surgery combined with radiotherapy and chemotherapy, the median survival time for GBM patients is still approximately 12‑14 months. Identifying the key molecular mechanisms and targets of GBM...

journal_title：Oncology reports

authors： Miao L,Jiang Z,Wang J,Yang N,Qi Q,Zhou W,Feng Z,Li W,Zhang Q,Huang B,Chen A,Zhang D,Zhao P,Li X

更新日期：2019-08-01 00:00:00

abstract：:The aim of this study was to assess the use of human papillomavirus (HPV) E6/E7 mRNA testing in the follow-up of women treated for cervical intraepithelial neoplasia (CIN) by conization and to compare the prognostic value of HPV E6/E7 mRNA to HPV L1 DNA and cytology. One hundred and...

journal_title：Oncology reports

authors： Persson M,Brismar Wendel S,Ljungblad L,Johansson B,Weiderpass E,Andersson S

更新日期：2012-07-01 00:00:00

abstract：:Complement system activation contributes to various immune and inflammatory diseases, as well as cancers.However, the role of complement activation in the proliferation of cancer cells is not clear. In the present study, we investigated the consequences of complement activation on the proliferation of breast cancer ce...

journal_title：Oncology reports

authors： Lu Y,Hu XB

更新日期：2014-12-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor, which was confirmed as a tumor suppressor gene in colorectal cancers. KLF4 inhibits colorectal cancer cells proliferation through upregulating p21WAF1/Cip1 and downregulating cyclin D1. We firstly reported that N-Myc downstream regulated gene 2 (NDRG2...

journal_title：Oncology reports

authors： Ma Y,Wu L,Liu X,Xu Y,Shi W,Liang Y,Yao L,Zheng J,Zhang J

更新日期：2017-08-01 00:00:00

abstract：:Gastric cancer (GC) is a severe public health problem worldwide, particularly in China. Radiotherapy is the main locoregional treatment for various types of unresectable tumor, including GC. However, many patients fail to respond to radiotherapy due to the intrinsic radioresistance of cancer cells. This study was desi...

journal_title：Oncology reports

authors： Geng W,Tian D,Wang Q,Shan S,Zhou J,Xu W,Shan H

更新日期：2019-08-01 00:00:00

abstract：:The inhibitor of differentiation/DNA binding 1 (Id-1), a negative regulator of basic helix-loop-helix transcription factors, plays an important role in the regulation of cell proliferation and differentiation. We examined the Id-1 expression by immunohistochemistry in 9 adenomas, 79 primary colorectal adenocarcinomas ...

journal_title：Oncology reports

authors： Zhao ZR,Zhang ZY,Zhang H,Jiang L,Wang MW,Sun XF

更新日期：2008-02-01 00:00:00