N-myc downstream regulated gene 1 (NDRG1)/Cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma.

abstract：:Chromosome 13 presents frequent allelic loss in esophageal squamous cell carcinomas (ESCC). However, no ESCC suppressor gene has been identified from this chromosome. To define common deletion regions that possibly contain the ESCC suppressor gene(s), we performed a mapping of allelic loss in 50 esophageal squamous ce...

journal_title：Oncology reports

authors： Guo GM,Huang XP,Dong JT,Caia Y,Xu X,Han YL,Wu M,Zhan QM,Wang MR

更新日期：2005-12-01 00:00:00

abstract：:The current study characterized peripheral blood mononuclear cells (PBMC) obtained from leukapheresis products of patients with non-small cell lung cancer (NSCLC) for cytokine release, the ability to incorporate tritiated thymidine following stimulation using PHA as well as the levels of both CD4 and CD8 regulatory T ...

journal_title：Oncology reports

authors： Yannelli JR,Tucker JA,Hidalgo G,Perkins S,Kryscio R,Hirschowitz EA

更新日期：2009-12-01 00:00:00

abstract：:Histone acetylation is one of the key chromatin modifications that control gene transcription during development and tumorigenesis. Recently, it was reported that the histone deacetylase inhibitor, Trichostatin A (TSA), induces growth arrest and apoptosis in tumors. However, the mol...

journal_title：Oncology reports

authors： Anh TD,Ahn MY,Kim SA,Yoon JH,Ahn SG

更新日期：2012-02-01 00:00:00

abstract：:Apoptosis is a crucial event for anticancer drug efficacy. The signal pathways activated by anticancer drugs are classified as death receptor (DR) -dependent or -independent. The mechanisms by which anticancer drugs induce apoptosis via DR-dependent pathways are not fully understood. In the present study, we assessed ...

journal_title：Oncology reports

authors： Kim R,Tanabe K,Emi M,Uchida Y,Toge T

更新日期：2003-11-01 00:00:00

abstract：:We investigated the microsatellite alterations in mitochondrial DNA (mtDNA) and in TP53 in thoracic esophageal squamous cell carcinomas (TESCC). Using laser microdissection, 66 paired non-cancerous esophageal muscles, non-cancerous esophageal mucosa, cancerous TESCC nests plus 35 metastatic lymph nodes harvested from ...

journal_title：Oncology reports

authors： Lin CS,Wang LS,Chang SC,Chou TY,Hsu WH,Liu CS,Lee MH,Chung MY,Wei YH

更新日期：2012-07-01 00:00:00

abstract：:LKB1 encodes a serine/threonine kinase generally inactivated in human lung cancers, which mediates cancer cell proliferation, migration and differentiation, but its biological function has not been completely elucidated. In this study, we demonstrated that LKB1 was associated with a substantial reduction of c-myc expr...

journal_title：Oncology reports

authors： Liang X,Nan KJ,Li ZL,Xu QZ

更新日期：2009-04-01 00:00:00

abstract：:Three cases of benign pelvic tumors are presented (2 leiomyomas and 1 fibroma). All three tumors were suspected of being malignant neoplasms because they were visualized as heterogeneous high signal intensity on T2-weighted images, and thus they were difficult to diagnose preoperatively. One of the leiomyomas was loca...

journal_title：Oncology reports

authors： Kojima T,Ishiko O,Ichimura T,Nishimura S,Sumi T,Ueda J,Tsujimura T,Shimura K

更新日期：2001-07-01 00:00:00

abstract：:We investigated the effects of combined treatment with 5-fluorouracil and apigenin on proliferation and apoptosis, as well as the underlying mechanism, in human breast cancer MDA-MB-453 cells. The MDA-MB-453 cells, which have been shown to overexpress ErbB2, were resistant to 5-fluorouracil; 5-fluorouracil exhibited a...

journal_title：Oncology reports

authors： Choi EJ,Kim GH

更新日期：2009-12-01 00:00:00

abstract：:Cisplatin (DDP), a cytotoxic antitumor drug, functions in a dose-dependent manner. However, the pursuit for high‑dose therapeutic effects leads to more serious side effects including kidney toxicity. Nephrotoxicity caused due to endothelial cell dysfunction and neutrophils infiltration in kidneys. Interleukin-8 (IL-8)...

journal_title：Oncology reports

authors： Li L,Khan MN,Li Q,Chen X,Wei J,Wang B,Cheng JW,Gordon JR,Li F

更新日期：2015-02-01 00:00:00

abstract：:The growth of malignant tumors is associated with mechanisms of immune escape and inhibition of apoptosis. Livin is a novel member of the inhibitors of apoptosis (IAP) protein family that inhibits cell apoptosis. Livin is specifically expressed by the majority of tumor cells, but it is not expressed in normal adult ti...

journal_title：Oncology reports

authors： Chen H,Jin Y,Chen T,Zhang M,Ma W,Xiong X,Tao X

更新日期：2013-02-01 00:00:00

abstract：:MicroRNA-455 (miR-455) has been considered as a novel cancer-related miRNA and dysregulated expression frequently occurs in various human types of cancer. However, its clinical significance, its biological function and the underlying molecular signaling involved in hepatocellular carcinoma (HCC) remain to be elucidate...

journal_title：Oncology reports

authors： Qin L,Zhang Y,Lin J,Shentu Y,Xie X

更新日期：2016-12-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) cells are relatively resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis during culture. We investigated the role of a proteaosome inhibitor in the survival and apoptosis of these cells. We found that the proteasome inhibitor MG132 markedl...

journal_title：Oncology reports

authors： Yoshiba S,Iwase M,Kurihara S,Uchida M,Kurihara Y,Watanabe H,Shintani S

更新日期：2011-03-01 00:00:00

abstract：:Normal breast development is controlled by a balance between cell proliferation and apoptosis. The balance between the two parameters is crucial for determining the growth or regression of breast tumours in response to therapies and treatments. Therefore, it is necessary to understand the role of apoptosis in tumour p...

journal_title：Oncology reports

authors： Puertollano MA,Carrera MP,Puertollano E,Alvarez de Cienfuegos G,Ramirez-Expósito MJ,De Pablo MA,Martinez-Martos JM

更新日期：2008-09-01 00:00:00

abstract：:Although the human telomerase reverse transcriptase (hTERT) promoter can regulate cancer-specific genes, it is generally too weak to be effective. We therefore attempted to improve the potency of synthetic hTERT promoters by fusing the core element (E) of the hTERT promoter (H) and the tripartite leader sequence (T) f...

journal_title：Oncology reports

authors： Kim SJ,Lee HS,Shin JH,Kim CG,Jeong S,Park K,Choe H,Lee H

更新日期：2006-11-01 00:00:00

abstract：:Gene therapy mediated by murine leukemia virus (MLV)-based replicating retrovirus vector (RRV) was previously proven to be highly effective in tumor cell killing, resulting in significant suppression of tumor growth in vivo. Recently, we developed a different form of RRV which is derived from another retrovirus, gibbo...

journal_title：Oncology reports

authors： Lu YC,Chen YJ,Yu YR,Lai YH,Cheng JC,Li YF,Shen CH,Tai CK

更新日期：2012-07-01 00:00:00

abstract：:The advent of pathotropic (disease-seeking) targeting has transported genetic medicine across the threshold of history with the progressive clinical validation of Rexin-G, a tumor-targeted nanosized anti-cancer agent. Achieving noteworthy single-agent efficacy and survival benefits in otherwise intractable cancers, th...

journal_title：Oncology reports

authors： Hall FL,Levy JP,Reed RA,Petchpud WN,Chua VS,Chawla SP,Gordon EM

更新日期：2010-10-01 00:00:00

abstract：:Resistance to docetaxel, a chemotherapy drug for breast cancer (BC) treatment, occurs in ~50% of patients, and the underlying molecular mechanisms of drug resistance are not fully understood. Gene regulation through miR-141 has been proven to play an important role in cancer drug resistance. The present study investig...

journal_title：Oncology reports

authors： Yao YS,Qiu WS,Yao RY,Zhang Q,Zhuang LK,Zhou F,Sun LB,Yue L

更新日期：2015-05-01 00:00:00

abstract：:Tumour cell proliferation is an important biological prognostic parameter to be considered alongside clinical and histopathological parameters. It has been evaluated by immunohistochemistry using proliferative markers (PCNA, Ki67, etc.) and by flow cytometry considering DNA content, growth fraction (S + G2M) and S-pha...

journal_title：Oncology reports

authors： Tirelli G,Sidari L,Giacomarra V,Papanikolla L,Sasso F,Russolo M,Melato M

更新日期：2002-05-01 00:00:00

abstract：:Quercetin, a naturally occurring flavonoid abundant in fruits and vegetables, has been demonstrated as a multipotent bioflavonoid with great potential for the prevention and treatment of cancer. Apoptosis is thought to be an important response to most chemotherapeutic agents in leukemia cells. However, the underlying ...

journal_title：Oncology reports

authors： Lee WJ,Chen YR,Tseng TH

更新日期：2011-02-01 00:00:00

abstract：:Mechanisms of synergistic effect of thermotherapy and chemotherapy on human lung adenocarcinoma cell growth are unclear. The purpose of this study was to investigate these effects and explore the function of ROS, Akt and caspase-3 in relation to these. A549 cells were subjected to different thermochemotherapy treatmen...

journal_title：Oncology reports

authors： Wang L,Liu X,Wu Y,Wu W,Wu Y

更新日期：2012-10-01 00:00:00

abstract：:Luteolin was recently demonstrated to suppress tumor growth by interfering with nuclear factor (NF)‑κB activation. As the NF‑κB pathway plays a critical role in muscular atrophy associated with cancer cachexia, we aimed to investigate the potential of luteolin to alleviate cancer‑associated cachexia in a Lewis lung ca...

journal_title：Oncology reports

authors： Chen T,Li B,Xu Y,Meng S,Wang Y,Jiang Y

更新日期：2018-08-01 00:00:00

abstract：:Muscle atrophy F-Box (MAFbx)/atrogin-1 and muscle ring-finger-1 (MuRF-1) have been identified as two muscle-specific E3 ubiquitin ligases that are highly expressed in skeletal muscle during muscle atrophy. However, the role of muscle-specific E3 ubiquitin ligases during the process of muscle atrophy of cancer cachexia...

journal_title：Oncology reports

authors： Yuan L,Han J,Meng Q,Xi Q,Zhuang Q,Jiang Y,Han Y,Zhang B,Fang J,Wu G

更新日期：2015-05-01 00:00:00

abstract：:Withaferin A (Wit A), a steroidal lactone isolated from Withania somnifera, exhibits anti-inflammatory, immuno-modulatory and anti-angiogenic properties and antitumor activities. In the present study, we investigated the effects of Wit A on protease-mediated invasiveness of the human metastatic cancer cell lines Caski...

journal_title：Oncology reports

authors： Lee DH,Lim IH,Sung EG,Kim JY,Song IH,Park YK,Lee TJ

更新日期：2013-08-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most common malignancies, and is the second leading cause of cancer-related deaths worldwide. Macrophages infiltrated in the tumor microenvironment (TME) called tumor-associated macrophages (TAMs) are key orchestrators in TME. In GC, it has been reported that infiltration of TAMs is a...

journal_title：Oncology reports

authors： Guo J,Yan Y,Yan Y,Guo Q,Zhang M,Zhang J,Goltzman D

更新日期：2017-10-01 00:00:00

abstract：:The androgen receptor (AR) plays an essential role in the development and progression of prostate cancer. Castration-resistant prostate cancer (CRPC) is a consequence of androgen deprivation therapy. Unchecked CRPC followed by metastasis is lethal. Some CRPCs show decreased AR gene expression due to epigenetic mechani...

journal_title：Oncology reports

authors： Fialova B,Luzna P,Gursky J,Langova K,Kolar Z,Trtkova KS

更新日期：2016-10-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most aggressive human brain cancer. Little is known regarding how these cells adapt to the harsh tumor microenvironment, and consequently survive and resist various treatments. Myoglobin (MB), the oxygen‑binding hemoprotein, has been shown to be ectopically expressed in different h...

journal_title：Oncology reports

authors： El-Tohamy R,Elkholi I,Elsherbiny ME,Magdy M,Hammam O,Allalunis-Turner J,Emara M

更新日期：2020-03-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been widely accepted as critical molecules playing regulatory roles in various biological processes, including proliferation, differentiation and apoptotic/ferroptotic/necrotic cell death. Emerging evidence suggests that ROS may be involved in the induction of epithelial‑to‑mesenchym...

journal_title：Oncology reports

authors： Peng G,Tang Z,Xiang Y,Chen W

更新日期：2019-02-01 00:00:00

abstract：:Post‑transcriptional mechanisms are an important approach in the treatment of cancer, and may also be hijacked by tumor cells to help adapt to the local microenvironment. Filamin B (FLNB), an actin‑binding protein that provides crucial scaffolds for cell motility and signaling, has also been identified as an RNA‑bindi...

journal_title：Oncology reports

authors： Ma HR,Cao L,Wang F,Cheng C,Jiang R,Zhou H,Xie Z,Wuermanbieke S,Qian Z

更新日期：2020-05-01 00:00:00

abstract：:The present study aimed to investigate the effects of cold atmospheric plasma (CAP)‑activated Ringer's solution on osteosarcoma cell lines MG63 and U2OS, and to identify the molecular mechanism underlying these effects. CAP‑activated Ringer's solution was used to treat osteosarcoma cell lines MG63 and U2OS for 30 min....

journal_title：Oncology reports

authors： Xu S,Wang Y,Que Y,Ma C,Cai S,Wang H,Yang X,Yang C,Cheng C,Zhao G,Hu Y

更新日期：2020-05-01 00:00:00

abstract：:The thioredoxin (Trx) system is an important enzymatic complex involved in cellular redox homeostasis. Arsenic trioxide (ATO; As2O3) is known to trigger cell death in vascular smooth muscle cells (VSMCs) via oxidative stress. In the present study, the effects of changes in thioredoxin 1 (Trx1) and Trx reductase1 (TrxR...

journal_title：Oncology reports

authors： Park WH

更新日期：2020-01-01 00:00:00