Abstract:
:The adenovirus vector-based cancer gene therapy is controversial. Low transduction efficacy is believed to be one of the main barriers for the decreased expression of coxsackie and adenovirus receptor (CAR) on tumor cells. However, the expression of CAR on primary tumor tissue and tumor tissue survived from treatment has still been not extensively studied. The present study analyzed the adenovirus infection rates and CAR expression in human lung adenocarcinoma cell line A549 and its cisplatin-resistant subline A549/DDP. The results showed that although the CAR expression in A549 and A549/DDP was not different, compared with the A549, A549/DDP appeared obviously to reject adenovirus infection. Moreover, we modified CAR expression in the two cell lines with proteasome inhibitor MG-132 and histone deacetylase inhibitor trichostatin A (TSA), and analyzed the adenovirus infection rates after modifying agent treatments. Both TSA and MG-132 pretreatments could increase the CAR expression in the two cell lines, but the drug pretreatments could only make A549 cells more susceptible to adenovirus infectivity.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Zhang NH,Peng RQ,Ding Y,Zhang XSdoi
10.3892/or.2016.4870subject
Has Abstractpub_date
2016-08-01 00:00:00pages
715-20issue
2eissn
1021-335Xissn
1791-2431journal_volume
36pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Sentinel lymph node (SLN) biopsy is a useful way of assessing axillary nodal status and obviates unnecessary axillary lymph node dissection for patients with node-negative breast cancer. However, SLN can also be located in the internal mammary lymph node (IMN) chain or elsewhere. The practicability and relevance of in...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:
更新日期:2002-05-01 00:00:00
abstract::ONECUT1 (HNF-6) is the prototype of a new class of homeodomain transcription factors, that controls the development of pancreatic ducts during mouse development. In the present study, the role of ONECUT1 and its targeted genes TCF2, PKHD1 and CYS1 was analyzed in human pancreatic ductal adenocarcinoma (PDAC). mRNA lev...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::The targeting of receptor activator of nuclear factor-κB ligand (RANKL) is being increasingly investigated as a potential therapeutic strategy in several types of cancers. However, the exact function and mechanism of RANKL in human endometrial cancer (EC), particularly in progesterone-resistant and aggressive EC, rema...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3651
更新日期:2015-02-01 00:00:00
abstract::Gastroenteropancreatic neuroendocrine tumors (GEP‑NETs) are relatively uncommon. Unfortunately, epidemiological studies on the incidence of GEP‑NETs worldwide have reported a marked increase in the detection of these tumors. Although they often exhibit relatively indolent clinical courses, GEP‑NETs have the potential ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5170
更新日期:2016-12-01 00:00:00
abstract::Tripartite motif containing 28 (TRIM28) is a universal corepressor for Kruppel‑associated box zinc finger proteins. In our previous study, it was shown that expression of TRIM28 is upregulated in non‑small cell lung cancer (NSCLC) cell lines and tissues. Here, we demonstrated that the stable silencing of TRIM28 expres...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5638
更新日期:2017-06-01 00:00:00
abstract::The objective of the present study was to explore the in vitro and in vivo anticancer effects of Platycodin D (PD), derived from Platycodin grandiflorum, on highly metastatic MDA-MB-231 breast cancer cells. Using the MTT assay, we found that PD inhibited MDA-MB-231 cell growth in a concentration-dependent manner, with...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4935
更新日期:2016-09-01 00:00:00
abstract::Telomerase activation is prevalent in most epithelial tumors, and may be a critical step in cellular immortalization and carcinogenesis. However, telomerase activity in tumors of mesenchymal origin is not well understood. In the present study, we examined telomerase activity in clinical samples from osteosarcoma and s...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-06-01 00:00:00
abstract::The modifying effect of dietary tuna (Thunnus thynnus orientalis) orbital oil rich in docosahexaenoic acid (DHA) and vitamin D3 (VD3) on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) was investigated in male F344 rats. Animals were given three weekly subcutaneous injections of AOM (15...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.7.5.1069
更新日期:2000-09-01 00:00:00
abstract::The aim of the present study was to investigate the efficacy of using human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) as gene delivery vectors in the treatment of ovarian cancer. Lentivectors overexpressing cytosine deaminase (CD) and herpes simplex virus thymidine kinase (HSV-tk) (pGC-FU-CD-TK) ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2898
更新日期:2014-02-01 00:00:00
abstract::Fecal microRNAs (miRNAs) are increasingly explored as non-invasive markers of colorectal cancer (CRC). However, its holistic profile in Asian CRC patients remains elusive. In the present study, the global human fecal miRNAs in Asian Chinese CRC patients was assayed to elucidate novel diagnostic fecal markers. Addition...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3193
更新日期:2014-07-01 00:00:00
abstract::The MTA1 gene has been identified as metastasis-associated gene and has been seen to correlate with the degree of invasion and lymphatic metastasis in gastric, colorectal, and esophageal carcinomas. We investigated the possible role of MTA1 gene expression in hepatocellular carcinoma (HCC). The mRNA expression level o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::Bisphosphonates (BPs) inhibit bone resorption by preventing osteoclast maturation and apoptosis induction. Recently, BPs have also been shown to have antitumor effects against various types of carcinomas in vitro and in vivo. In this study, we investigated the antitumor effect of zoledronic acid (ZOL), a third generat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1152
更新日期:2011-04-01 00:00:00
abstract::Human telomerase reverse transcriptase (hTERT) plays an important role in the development of tumors and has been investigated as a potent target for anticancer therapy. In the present study, we constructed a recombinant adenovirus, Ad-EGFP-C197 which was capable of expressing COOH‑terminal polypeptide of hTERT (amino ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4298
更新日期:2015-12-01 00:00:00
abstract::Burkitt's lymphoma (BL) is a fast growing cancer of the human lymphatic system, and an extremely invasive B-cell non-Hodgkin's lymphoma. We explored the mechanism of apoptosis in Raji cells associated with the post-transcriptional regulation factors. To confirm that the predicted microRNA-520a (miR-520a) is matched wi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4975
更新日期:2016-09-01 00:00:00
abstract::Fluoroquinolones affect the proliferation and apoptotic cell death of several human malignancies. Therefore, we investigated whether new 6-aminoquinolone derivatives, initially synthesized as anti-HIV agents, could affect the proliferation and apoptotic cell death of human prostate cancer cell lines. PC3 and LNCaP cel...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract::Alterations in DNA methylation have a central role in the development and outcome of most human malignancies. Non‑small cell lung cancer (NSCLC), the most common lung cancer, leads to the largest number of cancer‑related deaths worldwide. FBJ murine osteosarcoma viral oncogene homolog B (FOSB) is a key component of th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7431
更新日期:2020-02-01 00:00:00
abstract::Vitamin K2 (VK2) has been shown to have a potent anti-tumor effect against several cancer types including hepatocellular carcinoma (HCC), but the mechanisms remain to be elucidated. Matrix metalloproteinase (MMP) plays an important role in the invasion and metastasis of cancer cells, but it is not known whether VK2 re...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000478
更新日期:2009-09-01 00:00:00
abstract::The long non‑coding RNA (lncRNA) PVT1 plays vital roles in the tumorigenesis and development of various types of cancer. However, the potential expression profiling, functions and pathways of PVT1 in HCC remain unknown. PVT1 was knocked down in SMMC‑7721 cells, and a miRNA microarray analysis was performed to detect t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6410
更新日期:2018-07-01 00:00:00
abstract::Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. No mutation could be found. Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.6.1375
更新日期:2001-11-01 00:00:00
abstract::We established a new cell line (ACCNS) from human adenoid cystic carcinoma (AdCC) of the maxilla, using tissue culture techniques and it has been successfully subcultured for more than 100 passages during 2 years. The population doubling time was approximately 39.2 h on a plastic dish. In type I collagen gel culture, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00
abstract::Esculetin, a phenolic compound, has been shown to inhibit the growth of colon tumors in animal studies. However, the roles of signaling pathways and cell cycle regulation in the esculetin-induced inhibition of cancer cell growth, remain to be elucidated. The present study suggests a novel mechanism for the Ras/ERK1/2 ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Recently, overexpression of EphA2, a member of the Eph family of receptor tyrosine kinases, has been reported in several cancers. Reduced expression of E-cadherin, an intercellular adhesion molecule of epithelial cells, has been reported to be associated with aggressive clinicopathological phenotypes in various cancer...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract::Apoptin, a small protein derived from chicken anemia virus, possesses the capacity to specifically kill tumor cells while leaving normal cells intact. Previous studies have indicated that the subcellular localization of apoptin appears to be crucial for this tumor-selective activity. Apoptin resides in the cytoplasm o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2399
更新日期:2013-06-01 00:00:00
abstract::Ubiquitin specific protease 22 (USP22) is an oncogene that is upregulated in many cancer types, and aberrant expression of USP22 correlates with clinical outcome. However, its potential functional impact in epithelial ovarian cancer (EOC) has not been determined. Here, we report that USP22 was upregulated in EOC speci...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3580
更新日期:2015-01-01 00:00:00
abstract::Primarily through in vitro studies, the Rho-family of small GTPases and their effector proteins have been implicated in mediating oncogenic properties of cancer cells. We sought to determine if pharmacological inhibition of the RhoA effector proteins known as Rho-kinases (ROCK) with the small molecule inhibitor Y-2763...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
abstract::CXC chemokine receptor 7 (CXCR7) has been implicated in tumor development and metastasis in multiple malignancies. Yet, the function and molecular mechanisms of CXCR7 in human osteosarcoma (OS) are still unclear. The aim of the present study was to investigate the role of CXCR7 in human OS. The expression of CXCR7 was...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3290
更新日期:2014-09-01 00:00:00
abstract::Exogenous overexpression of hRFI, originally isolated in our laboratory, inhibits not only death receptor-mediated apoptosis but also the mitochondrial apoptosis induced by several chemotherapeutic agents including 5-fluorouracil (5-FU). Recently, it has become clear that hRFI targets and degradates caspase-8 and -10 ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.15.5.1293
更新日期:2006-05-01 00:00:00
abstract::The monoterpene perillyl alcohol (POH) is a naturally occurring compound derived from citrus fruits, mint and herbs. It exhibited chemotherapeutic potential against various malignant tumors in preclinical models and is currently being tested in clinical trials in patients with refractory advanced cancers. POH inhibits...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2167
更新日期:2013-02-01 00:00:00
abstract::Inflammation is regarded as one of the major hallmarks of tumors, and has a very close relationship with gastric cancer. Interleukin-33 (IL-33), a new member of the IL-1 family, plays an important role in both inflammatory disease and tumors. The present study was designed to explore the effects of IL-33 on the prolif...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3898
更新日期:2015-06-01 00:00:00
abstract::Cancer cells in ascites are usually exposed to a hypoxia tumor microenvironment and utilize enhanced glycolysis which produces energy and metabolizes nutrients to support proliferation. Vesicular stomatitis virus (VSV) is an oncolytic virus that relies on the host cellular metabolism for replication. We tested the eff...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4522
更新日期:2016-03-01 00:00:00