A preliminary study on the construction of double suicide gene delivery vectors by mesenchymal stem cells and the in vitro inhibitory effects on SKOV3 cells.

abstract：:Semaphorin 3A (SEMA3A), a secretory protein, is a founding member of the semaphorin family and functions in both the biological behavior of tumor cells and the modulation of tumor-associated macrophages. However, the role of SEMA3A in hepatocellular carcinoma (HCC) is still not well established. In the present study, ...

journal_title：Oncology reports

authors： Li X,Chen Q,Yin D,Shi S,Yu L,Zhou S,Chen E,Zhou Z,Shi Y,Fan J,Zhou J,Dai Z

更新日期：2017-06-01 00:00:00

abstract：:Angiogenesis is essential for the development, growth and advancement of solid tumors. Cyclooxygenase (cox)-2 is recognized as an angiogenic factor in various tumors. This prompted us to study the clinical implications of cox-2 expression and angiogenesis in ovarian cancer. There was a significant correlation between ...

journal_title：Oncology reports

authors： Fujimoto J,Toyoki H,Sakaguchi H,Jahan I,Alam SM,Tamaya T

更新日期：2006-01-01 00:00:00

abstract：:The emergence of radioresistance is a significant issue in the treatment of squamous cell carcinoma. We recently demonstrated that post-radiogenic extracellular signal-regulated kinase (ERK) signaling might decrease radiosensitivity in this cancer type. To further elucidate how tumo...

journal_title：Oncology reports

authors： Affolter A,Schmidtmann I,Mann WJ,Brieger J

更新日期：2013-02-01 00:00:00

abstract：:Resistance to chemotherapeutic agents is a major problem for successful cancer treatment. P-glycoprotein (Pgp), a product of the multidrug resistance (MDR)1 gene expressed in cancer cells, is one of the mechanism of MDR. However, there are few reports regarding the effects of Pgp on prognosis of colorectal cancer (CRC...

journal_title：Oncology reports

authors： Tokunaga Y,Hosogi H,Hoppou T,Nakagami M,Tokuka A,Ohsumi K

更新日期：2001-07-01 00:00:00

abstract：:The challenging possibility of selectively inducing mitotic death in tumor cells by combining genotoxic agents with the inhibition of G2 checkpoints of the cell cycle is the subject of intensive investigation. We show that very low concentrations (3.5 and 5 nM) of okadaic acid induce mitotic death in two glioblastoma ...

journal_title：Oncology reports

authors： Castigli E,Sciaccaluga M,Schiavoni G,Brozzi F,Fabiani R,Gorello P,Gianfranceschi GL

更新日期：2006-02-01 00:00:00

abstract：:Cancer cells in ascites are usually exposed to a hypoxia tumor microenvironment and utilize enhanced glycolysis which produces energy and metabolizes nutrients to support proliferation. Vesicular stomatitis virus (VSV) is an oncolytic virus that relies on the host cellular metabolism for replication. We tested the eff...

journal_title：Oncology reports

authors： Zhou Y,Wen F,Zhang P,Tang R,Li Q

更新日期：2016-03-01 00:00:00

abstract：:The thioredoxin (Trx) system is an important enzymatic complex involved in cellular redox homeostasis. Arsenic trioxide (ATO; As2O3) is known to trigger cell death in vascular smooth muscle cells (VSMCs) via oxidative stress. In the present study, the effects of changes in thioredoxin 1 (Trx1) and Trx reductase1 (TrxR...

journal_title：Oncology reports

authors： Park WH

更新日期：2020-01-01 00:00:00

abstract：:OCT4B1, a splice variant of OCT4, is a key regulator in maintaining the properties of pluripotency and self-renewal in embryonic stem (ES) cells. Recent results have shown that OCT4B1 is involved in tumorigenesis. However, the contribution of OCT4B1 in the tumorigenesis and drug resistance of colon cancer remains to b...

journal_title：Oncology reports

authors： Wen KM,Zhang GH,Li J,Chen ZQ,Cheng YL,Su X,Zeng QL

更新日期：2015-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that contribute to modulating signaling pathways after radiation exposure and have emerged as a potential therapeutic target or biomarker in the radiation response of cancer. Exposing breast cancer cells to single-dose (SD) or multifractionated (MF) radiation may affect the...

journal_title：Oncology reports

authors： Leung CM,Chen TW,Li SC,Ho MR,Hu LY,Liu WS,Wu TT,Hsu PC,Chang HT,Tsai KW

更新日期：2014-05-01 00:00:00

abstract：:Recently, overexpression of EphA2, a member of the Eph family of receptor tyrosine kinases, has been reported in several cancers. Reduced expression of E-cadherin, an intercellular adhesion molecule of epithelial cells, has been reported to be associated with aggressive clinicopathological phenotypes in various cancer...

journal_title：Oncology reports

authors： Saito T,Masuda N,Miyazaki T,Kanoh K,Suzuki H,Shimura T,Asao T,Kuwano H

更新日期：2004-03-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers worldwide. Long non-coding RNAs (lncRNAs) have been confirmed to play a critical regulatory role in various biological processes including carcinogenesis, which indicates that lncRNAs are valuable biomarkers and therapeutic targets. The novel lncRNA prostate ca...

journal_title：Oncology reports

authors： Yang L,Qiu M,Xu Y,Wang J,Zheng Y,Li M,Xu L,Yin R

更新日期：2016-01-01 00:00:00

abstract：:Chemokines have been reported to play crucial roles in tumor progression. Eotaxin-1 (CCL11), a member of the CC chemokine family, is elevated in many types of human cancer. Here, to reveal the molecular mechanisms of eotaxin-1 in prostate cancer cell invasion, the expression of eotaxin-1 receptors [CC chemokine recept...

journal_title：Oncology reports

authors： Zhu F,Liu P,Li J,Zhang Y

更新日期：2014-05-01 00:00:00

abstract：:Quercetin, a kind of flavonoid, is found in edible fruits and vegetables and has anti-tumorigenic activity. However, the mechanism of activity has not been elucidated. We show for the first time that gadd45 is a molecular target of quercetin, which inhibits growth of human cervical cancer HeLa cells. Apoptosis was det...

journal_title：Oncology reports

authors： Yoshida T,Maeda A,Horinaka M,Shiraishi T,Nakata S,Wakada M,Yogosawa S,Sakai T

更新日期：2005-11-01 00:00:00

abstract：:Pentoxifylline is commonly used in the treatment of peripheral vascular diseases. It improves microcirculatory flow and tissue perfusion. Moreover, pentoxifylline displays some immunomodulatory properties that presumably might affect the anticancer response. Therefore, the aim of the present study was to evaluate the ...

journal_title：Oncology reports

authors： Grzela T,Lazarczyk M,Niderla J,Golab J,Lazarczyk MA,Skopinski P

更新日期：2003-11-01 00:00:00

abstract：:N-myc downstream regulated gene 1 (NDRG1)/Cap43 is a 43 kDa protein that is widely distributed in the body. Its expression is regulated by nickel, cobalt, hypoxic condition and others; it is reported to be weaker in tumors than normal tissues; and NDRG1/Cap43 is considered to act suppressively to tumor metastasis. Thi...

journal_title：Oncology reports

authors： Akiba J,Ogasawara S,Kawahara A,Nishida N,Sanada S,Moriya F,Kuwano M,Nakashima O,Yano H

更新日期：2008-12-01 00:00:00

abstract：:Cancer immunotherapy is a promising new approach to cancer treatment. It has been demonstrated that a high number of tumor-specific cytotoxic T cells (CTLs) is associated with increased disease-specific survival in lung cancer patients. Identification of superior CTL epitopes from tumor antigens is essential for the d...

journal_title：Oncology reports

authors： Yoshimura M,Tada Y,Ofuzi K,Yamamoto M,Nakatsura T

更新日期：2014-07-01 00:00:00

abstract：:A 69-year-old woman presented to her local clinic with vomiting and abdominal distension. Since a bowel obstruction by left colon cancer was suspected due to a marked dilation of the transverse colon, she was referred to our hospital. On admission, an enema disclosed a complete obstruction at the splenic flexure of th...

journal_title：Oncology reports

authors： Mukai M,Tanaka A,Tajima T,Fukasawa M,Yamagiwa T,Okada K,Sato K,Tobita K,Oida Y,Makuuchi H

更新日期：2008-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly vascular tumor, and treatment options for patients of advanced-stage are limited. Nitric oxide (NO), which is derived from endothelial nitric oxide synthase (eNOS), provides crucial signals for angiogenesis in the tumor microenvironment. Tetrahydrobiopterin (BH4) is an essent...

journal_title：Oncology reports

authors： Dai Y,Cui J,Gan P,Li W

更新日期：2016-08-01 00:00:00

abstract：:Previous studies have shown decreased expression of repulsive guidance molecule member A (RGMa) in colorectal cancer. However, the relationship between the expression levels and promoter DNA methylation status of RGMa and the clinical characteristics of colorectal cancer has not bee...

journal_title：Oncology reports

authors： Zhao ZW,Lian WJ,Chen GQ,Zhou HY,Wang GM,Cao X,Yang HJ,Hou YP

更新日期：2012-05-01 00:00:00

abstract：:We have studied the effects of Saiboku-to, a traditional Chinese medicine having suppressive activities for leukotriene production and release, on the proliferation of the estrogen-responsive mouse Leydig tumor cell line B-1F. In our previous reports, it is shown that Saiboku-to promotes, but Scutellaria baicalensis, ...

journal_title：Oncology reports

authors： Murashima T,Katayama H,Shojiro K,Nishizawa Y

更新日期：2011-05-01 00:00:00

abstract：:The present study determined the anticancer activity and its mechanism of microRNA‑133b on cell proliferation of cisplatin-induced non-small cell lung cancer cells. The expression of microRNA-133b cisplatin‑induced non-small cell lung cancer (NSCLC) tissue was lower than that of para-carcinoma tissue in patients. Over...

journal_title：Oncology reports

authors： Li B,Ding CM,Li YX,Peng JC,Geng N,Qin WW

更新日期：2018-03-01 00:00:00

abstract：:Tumor invasion and migration are major causes of mortality in patients with cervical carcinoma. Tumors under hypoxic conditions are more invasive and have a higher metastasic activity. Lysyl oxidase (LOX) is a hypoxia-responsive gene. LOX has been shown to be essential for hypoxia-induced metastasis in breast cancer. ...

journal_title：Oncology reports

authors： Yang X,Li S,Li W,Chen J,Xiao X,Wang Y,Yan G,Chen L

更新日期：2013-02-01 00:00:00

abstract：:Daily vs. weekly dosing with EGFR inhibitors (gefitinib and lapatinib) and an AKT inhibitor (MK2206) were compared in two rodent breast cancer models. Female Sprague-Dawley rats were administered methylnitrosourea (MNU) at 50 days of age, and gefitinib (daily/weekly dosing at 10/70 mg/kg BW) or lapatinib (daily/weekly...

journal_title：Oncology reports

authors： Lubet RA,Steele VE,Juliana MM,Bode A,Moeinpour F,Grubbs CJ

更新日期：2018-09-01 00:00:00

abstract：:Colorectal cancer is the second most deadly cancer in the United States. When diagnosed early, current treatments bring a limited success; however, once metastasis occurs, radiation and chemotherapy are generally ineffective. Structural changes in the ECM are necessary for cell migration during tissue remodeling. Matr...

journal_title：Oncology reports

authors： Roomi MW,Ivanov V,Kalinovsky T,Niedzwiecki A,Rath M

更新日期：2005-03-01 00:00:00

abstract：:The deficiencies of nucleotide excision repair (NER) factors are involved in rare genetic diseases such as xeroderma pigmentosum (XP) with increased risk of developing cancer on sun-exposed areas of the skin. However, the abnormality of NER factors in human sporadic carcinoma remains unclear. Loss of heterozygosity (L...

journal_title：Oncology reports

authors： Miyashita H,Mori S,Tanda N,Nakayama K,Kanzaki A,Sato A,Morikawa H,Motegi K,Takebayashi Y,Fukumoto M

更新日期：2001-09-01 00:00:00

abstract：:The aim of the present study was to search for an effective regimen among existing chemotherapies for head and neck squamous cell carcinoma (HNSCC). Among the tested drugs, we focused on combined SN-38, which is the active metabolite produced from irinotecan hydrochloride - a type I DNA topoisomerase inhibitor - after...

journal_title：Oncology reports

authors： Nanbu T,Umemura N,Ohkoshi E,Nanbu K,Sakagami H,Shimada J

更新日期：2018-01-01 00:00:00

abstract：:Vascular endothelial growth factor C (VEGF-C), a member of VEGF gene family, is considered to induce both lymph node metastasis and lymphatic involvement in various cancers related to lymphangiogenesis. We examined the relationship between VEGF-C expression and clinicopathological features in 112 Japanese patients wit...

journal_title：Oncology reports

authors： Kimura Y,Watanabe M,Ohga T,Saeki H,Kakeji Y,Baba H,Maehara Y

更新日期：2003-11-01 00:00:00

abstract：:Breast cancer is one of the most malignant diseases world-wide and it ranks the first among female cancers. Masses of intrinsic and extrinsic factors, especially the inflammatory factors can lead to breast cancer. Aberrant activation and accumulation of key molecules can lead to inflammation associated carcinogenesis....

journal_title：Oncology reports

authors： Wang N,Wei L,Huang Y,Wu Y,Su M,Pang X,Wang N,Ji F,Zhong C,Chen T,Li B

更新日期：2017-03-01 00:00:00

abstract：:The human multidrug resistance gene 1 (MDR-1) encodes a plasma membrane P-glycoprotein (P-gp) that functions as the transmembrane efflux pump for various structurally unrelated anticancer agents and toxins. Polymorphisms in the MDR-1 gene may have an impact on the expression and function of P-gp, thereby influencing t...

journal_title：Oncology reports

authors： Zubor P,Lasabova Z,Hatok J,Stanclova A,Danko J

更新日期：2007-07-01 00:00:00

abstract：:VBP-1 has been isolated as a novel protein binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. The fundamental function of the gene was examined in the nematode, Caenorhabditis elegans (C. elegans). The C. elegans VBP-1 gene was expressed in adults only in the gonads and was also expressed in early s...

journal_title：Oncology reports

authors： Ichimiya H,Hino O,Kohara Y,Ishii N

更新日期：2003-03-01 00:00:00