hRFI overexpressed in HCT116 cells modulates Bcl-2 family proteins when treated with 5-fluorouracil.

abstract：:The current study characterized peripheral blood mononuclear cells (PBMC) obtained from leukapheresis products of patients with non-small cell lung cancer (NSCLC) for cytokine release, the ability to incorporate tritiated thymidine following stimulation using PHA as well as the levels of both CD4 and CD8 regulatory T ...

journal_title：Oncology reports

authors： Yannelli JR,Tucker JA,Hidalgo G,Perkins S,Kryscio R,Hirschowitz EA

更新日期：2009-12-01 00:00:00

abstract：:Metastatic progression is the cause of most cancer deaths. Host tumour cell separation (fission) is accompanied by simultaneous acquisition of migrating capability of cancer cells, remodeling of cellular architecture and effective 'homing' in body host environment. Cell remodeling involves cytoskeletal protein-protein...

journal_title：Oncology reports

authors： Patra SK,Bettuzzi S

更新日期：2007-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) play crucial roles in the initiation and progression of various cancers, including melanoma. Recently, the genetic variants and deregulation of miR-605 have been reported to participate in carcinogenesis. However, the expression status of the miR-605 in melanoma tissues and its role in melanoma prog...

journal_title：Oncology reports

authors： Chen L,Cao Y,Rong D,Wang Y,Cao Y

更新日期：2017-08-01 00:00:00

abstract：:Multidrug resistance (MDR) to chemotherapeutic drugs is the main cause of chemotherapy failure in cancer treatment, and it generally results from expression of ATP-dependent efflux pump P-glycoprotein (P-gp). MDR reversal agents typically act by inhibiting the drug efflux activity of P-gp, thereby increasing intracell...

journal_title：Oncology reports

authors： Cao Z,Wright M,Cheng J,Huang X,Liu L,Wu L,Yang P

更新日期：2014-09-01 00:00:00

abstract：:Abnormal lymphangiogenesis is associated with several diseases such as tumor metastasis and lymphangioma. Human lymphangioma originated from the transformation of lymphatic endothelium is a benign malformation of lymphatic vessels and its pathogenesis has up to date not been illuminated and its cell model has also not...

journal_title：Oncology reports

authors： You L,Wu M,Chen Y,Xu G,Wei J,Li Q,Song A,Zhao L,Li S,Han Z,Zhou J,Lu Y,Wang S,Ma D,Meng L

更新日期：2010-01-01 00:00:00

abstract：:The aims of this study were to investigate the expression levels of beta-catenin, Pin1 and cyclin D1 in salivary adenoid cystic carcinomas (SACC ) and to evaluate its clinical importance, furthermore, to elucidate whether beta-catenin expression was aberrant in SACC and whether Pin1 was involved in aberrant beta-caten...

journal_title：Oncology reports

authors： Zhou CX,Gao Y

更新日期：2006-09-01 00:00:00

abstract：:Malignant peripheral nerve tumours (MPNT), e.g. malignant schwannoma, represent a relatively rare tumour entity which is usually regarded as a member of the group of soft-tissue sarcomas and treated accordingly. For chemotherapeutic approaches in metastasised disease, ifosfamide and doxorubicin have been identified as...

journal_title：Oncology reports

authors： Steins MB,Serve H,Zühlsdorf M,Senninger N,Semik M,Berdel WE

更新日期：2002-05-01 00:00:00

abstract：:The emerging role of microRNA-181A (miR-181A) in CRC patients with late liver metastases was studied. In the present study we investigated the association between expression and mechanism of miRNA-181A, liver metastasis and prognosis of colorectal cancer (CRC). The expression of miR-181A and PTEN in CRC patients with ...

journal_title：Oncology reports

authors： Li Z,Wang H,Xu Z,Sun Y,Han J

更新日期：2016-03-01 00:00:00

abstract：:The esophageal squamous cell carcinoma (ESCC) subtype with STMN1 overexpression has a high likelihood of lymphatic metastatic recurrence. However, the underlying mechanism remains to be further elucidated. We assessed the expression level of STMN1 and PTEN in 96 pN0 ESCC patient tissues using immunohistochemistry and ...

journal_title：Oncology reports

authors： Jiang W,Huang S,Song L,Wang Z

更新日期：2018-02-01 00:00:00

abstract：:Expression of neural differentiation-associated genes was examined by RT-PCR and macroarray analyses during neural differentiation of P19 embryonal carcinoma cells induced by cell aggregation and/or retinoic acid (RA) treatment. Results revealed that the neural genes examined could be classified into 4 groups based on...

journal_title：Oncology reports

authors： Teramoto S,Kihara-Negishi F,Sakurai T,Yamada T,Hashimoto-Tamaoki T,Tamura S,Kohno S,Oikawa T

更新日期：2005-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is highly resistant to chemotherapy, leading to a poor prognosis of advanced disease. Inhibitors of histone deacetylase (HDACi) induce re-differentiation in tumor cells and thereby re-establish sensitivity towards apoptotic stimuli. HDACi are entering the clinical stage of tumor treatmen...

journal_title：Oncology reports

authors： Schuchmann M,Schulze-Bergkamen H,Fleischer B,Schattenberg JM,Siebler J,Weinmann A,Teufel A,Wörns M,Fischer T,Strand S,Lohse AW,Galle PR

更新日期：2006-01-01 00:00:00

abstract：:Breast cancer is the most common cancer type and the leading cause of cancer‑associated mortality in women across the majority of countries. In general, the incidence of breast cancer has been decreasing in developed countries over the previous 20 years, while it has increased in the other areas, such as the Asian‑Pac...

journal_title：Oncology reports

authors： Han R,Zhao J,Lu L

更新日期：2020-06-01 00:00:00

abstract：:Retinoblastoma, a well-vascularized tumor that is dependent on a very robust angiogenic response, is the most common intraocular malignancy in children. Tissue factor (TF) is known to regulate tumor progression and in the present study we demonstrated that TF regulates tumor angioge...

journal_title：Oncology reports

authors： Song HB,Park KD,Kim JH,Kim DH,Yu YS,Kim JH

更新日期：2012-12-01 00:00:00

abstract：:The expression of CDR1‑AS, a representative circular RNA, is closely linked with poor prognosis in gastrointestinal cancers, such as colon, liver, and pancreatic cancers. Although it is well known that CDR1‑AS antagonizes microRNA‑7 function through its sequence similarities in the brain, its biological function and l...

journal_title：Oncology reports

authors： Tanaka E,Miyakawa Y,Kishikawa T,Seimiya T,Iwata T,Funato K,Odawara N,Sekiba K,Yamagami M,Suzuki T,Ishibashi R,Otsuka M,Koike K

更新日期：2019-10-01 00:00:00

abstract：:The development of drug resistance represents a major complication in the effective treatment of breast cancer. Epigenetic therapy, through the use of histone deacetylase inhibitors (HDACi) or demethylation agents, is an emerging area of therapeutic targeting in a number of ontologi...

journal_title：Oncology reports

authors： Rhodes LV,Nitschke AM,Segar HC,Martin EC,Driver JL,Elliott S,Nam SY,Li M,Nephew KP,Burow ME,Collins-Burow BM

更新日期：2012-01-01 00:00:00

abstract：:Benign prostatic hyperplasia (BPH) is a common chronic disease in older males. The pathogenesis of BPH remains elusive but may be associated with chronic inflammation. Chemokines and chemokine receptors have been implicated as critical mediators in the immune response and inflammatory processes. In the present study, ...

journal_title：Oncology reports

authors： Pang Y,Li H,Gong Y,Jing S,Peng C,Liu W,Zhao Y,Wang H,Kaushik D,Rodriguez R,Wang Z

更新日期：2019-04-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations are frequently found in a variety of tumors. However, the role of mtDNA mutations in tumor behavior is poorly understood. We explored the effects of mtDNA mutations on tumor phenotype employing mtDNA-depleted SK-Hep1 rho0 hepatoma cells. Expression of hypoxia inducible factor (HIF)-...

journal_title：Oncology reports

authors： Cheon H,Moon HE,Lee MS,Kim SS

更新日期：2010-03-01 00:00:00

abstract：:The immunohistochemical expression of type 1 blood group antigens (type 1 BGAs) was analyzed for 30 cases of testicular germ cell tumors (TGCTs), using monoclonal antibodies against DU-PAN-2, CA19-9, Lewis(a) (Le(a)), and Lewis(b) (Le(b)). DU-PAN-2 was expressed very frequently in all of the embryonal carcinomas (ECs)...

journal_title：Oncology reports

authors： Kamoshida S,Satoh Y,Yasuda M,Kajiwara H,Tsukinoki K,Osamura RY

更新日期：2002-07-01 00:00:00

abstract：:In this study, we investigated the sequence variation and different transcriptional activities of the upstream regulatory region (URR) in HPV 16 E7 variants in cervical cancer tissue from Korean women. Using PCR-directed sequencing, the presence of sequence variations in URRs were analyzed and the sites of sequence va...

journal_title：Oncology reports

authors： Kim YB,Song YS,Jeon YT,Park JS,Um SJ,Kim JW,Park NH,Kang SB,Lee HP

更新日期：2005-08-01 00:00:00

abstract：:Tanshinone IIA is known to induce apoptosis in several types of cancer cells. However, little is known about its activity in chemoresistant cells. The aim of this study was to investigate the anticancer properties of tanshinone IIA in cisplatin-resistant human ovarian cancer COC1/DDP cells in vitro. We used a variety ...

journal_title：Oncology reports

authors： Jiao JW,Wen F

更新日期：2011-03-01 00:00:00

abstract：:The expression levels of tissue factor (TF), the clotting initiator protein, have been correlated with angiogenesis and the histological grade of malignancy in glioma patients. The pro-tumor function of TF is linked to a family of G protein-coupled receptors known as protease-activated receptors (PARs), which may be a...

journal_title：Oncology reports

authors： Carneiro-Lobo TC,Lima MT,Mariano-Oliveira A,Dutra-Oliveira A,Oba-Shinjo SM,Marie SK,Sogayar MC,Monteiro RQ

更新日期：2014-02-01 00:00:00

abstract：:ABCG2 is a multidrug cellular transport protein that is associated with resistance to certain treatments in patients, particularly anticancer treatment. The tumor-protective properties of ABCG2 expression are reported to be a feature of a subset of stem cell-like tumor cells. While protection against chemotherapy has ...

journal_title：Oncology reports

authors： Zoernig I,Ziegelmeier C,Lahrmann B,Grabe N,Jäger D,Halama N

更新日期：2013-05-01 00:00:00

abstract：:Combined chemotherapy with 5-fluorouracil and leucovorin (LV) has been widely used for the treatment of patients with colorectal cancer. Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), whic...

journal_title：Oncology reports

authors： Tsukioka S,Sakamoto E,Tsujimoto H,Nakagawa F,Saito H,Uchida J,Kiniwa M,Fukushima M

更新日期：2011-05-01 00:00:00

abstract：:Garlic and its constituents are reported to have a preventive effect against colorectal cancer in animal models. Aged garlic extract (AGE), which is produced by natural extraction from fresh garlic for more than 10 months in aqueous ethanol, also has reputed chemopreventive effects on colon carcinogenesis, but has nev...

journal_title：Oncology reports

authors： Jikihara H,Qi G,Nozoe K,Hirokawa M,Sato H,Sugihara Y,Shimamoto F

更新日期：2015-03-01 00:00:00

abstract：:We have recently noticed an accidental error in part of a figure which appeared in the above‑mentioned article. In Fig. 3A, the image for the HGC27‑pEF, 15 h panel was mistakenly replicated as the HGC27‑KD, 0 h panel in the same figure, and the AGS‑pEF, 15 h and AGS KD, 0 h panels were mistakenly switched with each ot...

journal_title：Oncology reports

authors： Gao XY,Li L,Wang XH,Wen XZ,Ji K,Ye L,Cai J,Jiang WG,Ji JF

更新日期：2018-04-01 00:00:00

abstract：:Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein which plays multiple roles in different types of cancer. Our previous study showed that SPARC overexpression inhibited the growth and angiogenesis of tumors, and reduced expression of vascular endothelial growth factor (VEGF). However, the relation...

journal_title：Oncology reports

authors： Zhang J,Wang P,Zhu J,Wang W,Yin J,Zhang C,Chen Z,Sun L,Wan Y,Wang X,Chen G,Liu Y

更新日期：2014-05-01 00:00:00

abstract：:Subsequently to the publication of this paper, the authors have realized that the affilitation address omitted the name of the university at which this research was conducted (Capital Medical University). Therefore, the author affiliations for this paper should have appeared as follows (changes are highlighted in bold...

journal_title：Oncology reports

authors： Dong J,Xu M

更新日期：2019-12-01 00:00:00

abstract：:Invasiveness and metastasis may seriously affect the prognosis of small cell lung cancer (SCLC). In the present study, we analyzed the effects and inherent mechanisms of action of polysialic acid-modified neural cell adhesion molecule (NCAM) on the invasive and metastatic potential of SCLC. Gene transfection and short...

journal_title：Oncology reports

authors： Gong L,Zhou X,Yang J,Jiang Y,Yang H

更新日期：2017-01-01 00:00:00

abstract：:E1A binding protein P300 (EP300), tumor protein P53 (TP53) and BCL2 associated X, apoptosis regulator (BAX) genes encode proteins which cooperate to regulate important cellular processes. The present study aimed to determine the expression levels of EP300, TP53 and BAX in colorectal cancer (CRC) and to investigate the...

journal_title：Oncology reports

authors： Kowalczyk AE,Krazinski BE,Godlewski J,Kiewisz J,Kwiatkowski P,Sliwinska-Jewsiewicka A,Kiezun J,Sulik M,Kmiec Z

更新日期：2017-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) play an important role in the genesis and development of gastric cancer. In the present study, we determined whether miRNA-135a-5p expression was increased in gastric cancer compared with adjacent non-tumor tissues using 20 pairs of gastric cancer and para-carcinoma tissue samples which were assesse...

journal_title：Oncology reports

authors： Pan Y,Ren F,Zhang W,Liu G,Yang D,Hu J,Feng K,Feng Y

更新日期：2014-12-01 00:00:00