Abstract:
:ABCG2 is a multidrug cellular transport protein that is associated with resistance to certain treatments in patients, particularly anticancer treatment. The tumor-protective properties of ABCG2 expression are reported to be a feature of a subset of stem cell-like tumor cells. While protection against chemotherapy has been well analyzed, the role of ABCG2 in the treatment with tyrosine kinase inhibitors is only partially understood. Tyrosine kinase inhibitors are currently the main treatment option in irresectable renal cell carcinomas. To investigate possible underlying sequence variations in the ABCG2 gene with relevance to the functional properties of the protein, 36 patient samples were analyzed. Using sequence analysis and single-nucleotide polymorphism databases, sequence variations in the highly conserved domains of the binding pocket of ABCG2 were analyzed. The resulting variations were used for computational protein prediction algorithms to identify conformational alterations. A relevant shift from A to G at position 1376 (resulting in Y→C at 459 aa) was identified and found to be present in 8.3% of the patients. These patients are currently in follow-up after resection, thus, further analysis will reveal whether this mutation has relevance to treatment efficacy.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Zoernig I,Ziegelmeier C,Lahrmann B,Grabe N,Jäger D,Halama Ndoi
10.3892/or.2013.2324subject
Has Abstractpub_date
2013-05-01 00:00:00pages
1697-700issue
5eissn
1021-335Xissn
1791-2431journal_volume
29pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::The aim of this study was to assess the ability of a new magnetic resonance (MR) angiography technique that does not use contrast enhancement medium to depict the vascularity of musculoskeletal neoplasms, and evaluate its clinical utility. We performed 3D fresh blood imaging (FBI) MR angiography in 57 patients with bo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract::The aim of the present study was to investigate the role of miR‑203a‑3p in colorectal cancer (CRC) and identify the target gene of microRNA (miR)‑203a‑3p. A total of 59 sets of cancer tissues and corresponding adjacent non‑tumor tissues were collected from CRC patients (aged 31‑78 years) between October 2016 and May 2...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7310
更新日期:2019-11-01 00:00:00
abstract::Erythropoietin (Epo) is a key regulator of erythroid cell proliferation, differentiation and apoptosis. In the form of the recombinant protein, it is widely used to treat various types of anemias, including that associated with cancer and with the myelosuppressive effects of chemotherapy, particularly platinum-based r...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2566
更新日期:2013-09-01 00:00:00
abstract::Circulating microRNAs (miRNAs) exist stably in body fluids and are potential biomarkers for hepatocellular carcinoma (HCC). Twenty-five patients with cirrhosis that evolved into HCC, who were treated at The Third Hospital of Zhenjiang Affiliated to Jiangsu University between January 2005 and December 2012, were enroll...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3924
更新日期:2015-06-01 00:00:00
abstract::MicroRNA (miRNA) is a type of endogenous non‑coding RNA implicated in various cellular processes. Studies have shown that miR-124 is involved in the malignant progression of cancer, but little is known concerning its potential role in breast cancer. Therefore, the purpose of this study was to conduct a functional anal...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5163
更新日期:2016-12-01 00:00:00
abstract::No information is currently available regarding pancreatic cancer (PC) pattern of care in Italy. In the present study, a nationwide survey using a questionnaire was performed to enquire the local standards for PC diagnosis and radiotherapy treatment. Fifty-seven percent of 140 Italian centres completed questionnaire. ...
journal_title:Oncology reports
pub_type: 杂志文章,多中心研究
doi:10.3892/or.2015.3955
更新日期:2015-07-01 00:00:00
abstract::The isothiocyanates (ITCs) have long been known to possess chemopreventive activities for a variety of neoplasms including breast cancer, but the molecular mechanism by which ITCs prevent breast cancer development has not been established. In this study, we investigated the effects of benzyl and phenethyl isothiocyana...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Benign prostatic hyperplasia (BPH) is a common chronic disease in older males. The pathogenesis of BPH remains elusive but may be associated with chronic inflammation. Chemokines and chemokine receptors have been implicated as critical mediators in the immune response and inflammatory processes. In the present study, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7002
更新日期:2019-04-01 00:00:00
abstract::Chemotherapeutic drug resistance is correlated with treatment failure and poor prognosis among lung cancer patients. Numerous studies indicate the relevance of miRNAs in inducing certain drug resistance. In the course of the study, we unexpectedly found that miR‑144‑3p could regulate the cisplatin resistance of lung c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6772
更新日期:2018-12-01 00:00:00
abstract::It has been demonstrated that homozygous mutations at the L(2)gl locus in Drosophila result in the development of tumor in the presumptive adult optic centers of the larval brain and of the imaginal discs. We previously cloned an L(2)gl homologue, Rgl-1, in the rat brain. In this study, we analyzed the capability of R...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00
abstract::9-Oxo-10, 11-dehydroageraphorone (euptox A), a cadenine sesquiterpene, is the main toxin from Eupatorium adenophorum. The aim of the present study was to examine the induction and mechanism of HeLa cell apoptosis by euptox A. The apoptosis‑inducing effect of the euptox A on HeLa cells was examined by MTT assay. The un...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3778
更新日期:2015-04-01 00:00:00
abstract::Zinc finger protein 403 (ZFP403), located on human chromosome 17q12‑21, is closely associated with the development of cancer. However, to date, there are a limited number of studies on the biological functions of this gene, particularly in prostate cancer (PCa). The results of the present study demonstrated that compa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7786
更新日期:2020-12-01 00:00:00
abstract::Despite the high response rates of small cell lung cancer (SCLC) to first-line cisplatin-based chemotherapies, most patients with SCLC will eventually experience disease progression. Accordingly, novel chemotherapeutic regimens are desired. This in vitro study was carried out in order to develop novel chemotherapeutic...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract::The development and characterization of effective anticancer drugs against colorectal cancer (CRC) is of urgent need since it is the second most common cause of cancer death. The study was designed to evaluate the effects of two IGF-1R antagonists, MK-0646, a recombinant fully humanized monoclonal antibody and OSI-906...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2819
更新日期:2014-01-01 00:00:00
abstract::Novel agents need to be developed to overcome the limitations of the current melanoma therapeutics. Atractylenolide I (AT-I) is a sesquiterpene compound isolated from atractylodis macrocephalae rhizoma. Previous findings demonstrated that AT-I exhibited cytotoxic action in melanoma cells. However, the molecular mechan...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4111
更新日期:2015-09-01 00:00:00
abstract::The signal transducer and activator of transcription 3 (STAT3) are ideal targets for ovarian cancer. Previous studies showed that downregulation of STAT3 using specific short hairpin RNAs (shRNA) can significantly reduce ovarian tumor growth. However, RNA interference does not fully ablate target gene expression due t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3623
更新日期:2015-02-01 00:00:00
abstract::MicroRNA-154 (miR-154) has been identified as a tumor suppressor in several types of human cancers; however, its clinical significance and function in human hepatocellular carcinoma (HCC) remain unclear. The aim of the present study was to analyze the clinical significance and cellular function of miR-154 in HCC patie...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4321
更新日期:2015-12-01 00:00:00
abstract::Deferoxamine (DFO), an iron chelator, has numerous clinical applications for patients presenting with iron overload in regards to the improvement in the quality of life and overall survival. In addition, experimental iron chelators have demonstrated potent anticancer properties. The present study investigated the effe...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3676
更新日期:2015-03-01 00:00:00
abstract::Bufalin, a major digoxin-like immunoreactive component of the Chinese medicine Chansu, is prepared from toad venom. This compound has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro. However, the detailed molecular mechanisms ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1451
更新日期:2012-01-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs), which belong to the transforming growth factor-β superfamily, are multifunctional signaling molecules that have become of increasing interest in cancer research. Recent observations suggest that alterations in BMPs and BMP signaling are associated...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1548
更新日期:2012-03-01 00:00:00
abstract::Bcl-2 is overexpressed in various types of human tumors, including Burkitt's lymphoma, and it is involved in tumorigenesis and chemoresistance, therefore, it is regarded as a potential target of gene therapy. In this study, RNA interference using short hairpin RNA (shRNA)-mediated R...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2081
更新日期:2013-01-01 00:00:00
abstract::Temozolomide (TMZ), as a kind of alkylating agent, is widely utilized for the treatment of glioblastoma (GBM). However, temozolomide resistance (TR) often develops quickly and results in tumor recurrence and poor outcome. Recent advances have demonstrated that miRNAs exert critical roles in chemoresistance. Downregula...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5970
更新日期:2017-11-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are associated with invasion and metastasis of several human malignant tumors. Especially so MMP-7, as it is mainly produced by the actual cancer cells. However, the expression of MMP-7 in transitional cell carcinoma (TCC) of the urinary bladder has not been previously investigated. We...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::Sesquiterpene lactones have been confirmed to have potential antitumor activity. Here, we demonstrated that Eupalinolide O (EO), a novel sesquiterpene lactone isolated from Eupatorium lindleyanum DC., showed significant anticancer activity against human MDA-MB-468 breast cancer cells. The cytotoxicity induced by EO wa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5115
更新日期:2016-11-01 00:00:00
abstract::A small subset of cells within a malignant neoplasm, named cancer stem cells (CSCs) or tumour initiating cells, are thought to be capable of initiating the neoplasm itself, and of driving its growth and recurrence after treatment. It is unclear whether CSCs can be identified and experimentally induced within oral squa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1299
更新日期:2011-08-01 00:00:00
abstract::Ribonucleotide reductase M2 subunit (RRM2) is one of the two subunits of human ribonucleotide reductase which plays a critical role in tumor progression. The aim of the present study was to analyze its expression, clinical significance and biological functions in gastric adenocarcinoma. We observed the upregulation of...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3148
更新日期:2014-06-01 00:00:00
abstract::Colorectal cancer (CRC) is one of the most common cancers worldwide. Long non-coding RNAs (lncRNAs) have been confirmed to play a critical regulatory role in various biological processes including carcinogenesis, which indicates that lncRNAs are valuable biomarkers and therapeutic targets. The novel lncRNA prostate ca...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4364
更新日期:2016-01-01 00:00:00
abstract::In preclinical studies, antagonists of growth hormone-releasing hormone (GHRH) have demonstrated inhibitory effects on the growth of various types of cancers expressing the pituitary type of GHRH receptors (pGHRH-R) and/or its active splice variant 1 (SV1). In this study, we investigated the effectiveness of the treat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2435
更新日期:2013-07-01 00:00:00
abstract::Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3918
更新日期:2015-06-01 00:00:00
abstract::Garlic and its constituents are reported to have a preventive effect against colorectal cancer in animal models. Aged garlic extract (AGE), which is produced by natural extraction from fresh garlic for more than 10 months in aqueous ethanol, also has reputed chemopreventive effects on colon carcinogenesis, but has nev...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3705
更新日期:2015-03-01 00:00:00