Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells.

abstract：:Splenic metastasis from a lung cancer is infrequently noted, however, the pattern of the metastasis has not been studied, thus we conducted a retrospective study. Twelve of the consecutive 997 patients with lung cancer, who were admitted to our division, developed splenic metastasis. The pattern of splenic metastasis ...

journal_title：Oncology reports

authors： Satoh H,Watanabe K,Ishikawa H,Yamashita YT,Ohtsuka M,Sekizawa K

更新日期：2001-11-01 00:00:00

abstract：:Prostate specific antigen (PSA) is still the best available tumour marker in prostate cancer (PCa), but presents some limits. Therefore, there is a need for novel markers in the detection and management of PCa. The 80-kDa soluble form of E-cadherin (sE-cad) and the cytokine IL-6 are being discussed as supplemental ser...

journal_title：Oncology reports

authors： Iacopino F,Pinto F,Bertaccini A,Calarco A,Proietti G,Totaro A,Martorana G,Bassi P,Sica G

更新日期：2012-07-01 00:00:00

abstract：:Honokiol (HNK), a potential antitumor compound, has been widely studied in recent years. It induces apoptosis and affects autophagy in cancer cells, yet the mechanism of its antitumor efficacy remains obscure. Chloroquine (CQ), an autophagy inhibitor, is often applied to sensitize antitumor drugs in clinical trials. H...

journal_title：Oncology reports

authors： Lv X,Liu F,Shang Y,Chen SZ

更新日期：2015-09-01 00:00:00

abstract：:Aberrant glycosylation, a common feature of malignant alteration, is partly due to changes in the expression of glycosyltransferases, including β1,3-N-acetyl-glucosaminyltrans-ferase 8 (β3Gn‑T8), which synthesizes poly-N-acetyllactosamine (poly-LacNAc) chains on β1,6 branched N‑glycans. Although the role of β3Gn‑T8 in...

journal_title：Oncology reports

authors： Jiang Z,Liu Z,Zou S,Ni J,Shen L,Zhou Y,Hua D,Wu S

更新日期：2016-09-01 00:00:00

abstract：:During the last decade, microRNAs (miRNAs) have been identified as potential biomarkers and therapeutic targets for multiple malignancies; yet, few studies exist on intrahepatic cholangiocarcinoma (ICC). In the present study, a miRNA microarray was applied to determine the significant miRNAs involved in ICC. miR-150 w...

journal_title：Oncology reports

authors： Wang S,Yin J,Li T,Yuan L,Wang D,He J,Du X,Lu J

更新日期：2015-02-01 00:00:00

abstract：:IFN-alpha regulates tumor cell growth at least through induction of apoptosis. We have recently demonstrated that IFN-alpha causes apoptosis through upregulation of TNF-related apoptosis-inducing ligand (TRAIL) in Daudi B lymphoma and U266 myeloma cells. However, other cell lines such as Ramos and RPMI 8226 underwent ...

journal_title：Oncology reports

authors： Yanase N,Kanetaka Y,Mizuguchi J

更新日期：2007-10-01 00:00:00

abstract：:Human papillomavirus (HPV) L1 capsid protein is only produced during a productive HPV infection at the end of the natural viral life cycle and is a major target of the immune response in women with HPV-related squamous intraepithelial lesions. We evaluated the usefulness of L1 detection by immunocytochemistry in high-...

journal_title：Oncology reports

authors： Norman I,Hjerpe A,Andersson S

更新日期：2013-08-01 00:00:00

abstract：:Progestin and adipoQ receptor family member III (PAQR3) is a regulator that negatively modulates the Ras/Raf/MEK/ERK signaling cascade and the GPCR Gβγ subunit signaling pathway. The role of PAQR3 in hepatocellular carcinoma (HCC) has not been elucidated. The present study investigated the expression of PAQR3 and its ...

journal_title：Oncology reports

authors： Wu HG,Zhang WJ,Ding Q,Peng G,Zou ZW,Liu T,Cao RB,Fei SJ,Li PC,Yang KY,Hu JL,Dai XF,Wu G,Li PD

更新日期：2014-12-01 00:00:00

abstract：:Ovarian cancer (OC) is one of the most lethal gynecological malignancies in the world. The aim of the present study was to examine the role of microRNA (miR)-134-3p in OC. Reverse transcription-quantitative PCR was used to measure the expression levels of miR-134-3p. Cell Counting Kit-8, TUNEL, flow cytometric and col...

journal_title：Oncology reports

authors： Zhao M,Ji H,Fu Q,Cheng Q,Zhang Y,Yang Y

更新日期：2021-01-01 00:00:00

abstract：:Autophagy is an intracellular multi-step catabolic degradation process that involves the degradation and recycling of cellular proteins and cytoplasmic damaged organelles to maintain cellular homeostasis and reduction of metabolic stress. Numerous studies have indicated the importance of autophagy in cancer, but the r...

journal_title：Oncology reports

authors： Zhang L,Zhang J,Chen L,Wang J

更新日期：2015-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence in males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation with regard to sex factors affecting disease progression. In the present stud...

journal_title：Oncology reports

authors： Wu Y,Yao N,Feng Y,Tian Z,Yang Y,Zhao Y

更新日期：2019-09-01 00:00:00

abstract：:WNT signaling pathway networks with Hedgehog, Notch and FGF signaling pathways during carcinogenesis and embryogenesis. FZD8 is up-regulated in HeLa S3 and A549 cells. Here we identified and characterized rat Fzd8 gene by using bioinformatics. Rat Fzd8 gene was identified within AC131883.2 genome sequence. Rat Fzd8 (6...

journal_title：Oncology reports

authors： Katoh Y,Katoh M

更新日期：2005-05-01 00:00:00

abstract：:Breast cancer metastasizes to the bone in a majority of patients with advanced disease resulting in bone destruction. The underlying mechanisms are complex, and both processes are controlled by an interaction between locally and systemically derived signals. Clinically, breast cancer patients with depression have a hi...

journal_title：Oncology reports

authors： Zong JC,Wang X,Zhou X,Wang C,Chen L,Yin LJ,He BC,Deng ZL

更新日期：2016-02-01 00:00:00

abstract：:Emodin is an active ingredient derived from root and rhizome of Rheum palmatum L and many studies have reported that it exhibits anticancer effects in a number of human tumors. However, there is little information demonstrating the possible effects of emodin on the proliferation and apoptosis of hepatocellular carcino...

journal_title：Oncology reports

authors： Lin W,Zhong M,Yin H,Chen Y,Cao Q,Wang C,Ling C

更新日期：2016-08-01 00:00:00

abstract：:Low-intensity ultrasound (LIUS) combined with chemotherapy is an innovative modality for cancer treatment, but its effect on orthotopic carcinoma remains unknown. Our previous study revealed that LIUS enhanced the growth inhibitory effects of several chemotherapeutic drugs in nude mice with transplanted tumors. In the...

journal_title：Oncology reports

authors： Li HX,Zheng JH,Ji L,Liu GY,Lv YK,Yang D,Hu Z,Chen H,Zhang FM,Cao W

更新日期：2018-04-01 00:00:00

abstract：:Ras-association domain family of proteins (RASSF) is characterized by the Ras-association (RA) domain at the C-terminal. Frequent inactivation of RASSF1A gene in human cancers suggests that other members of the family may also play an important role in tumorigenesis. By in silico gene searches, the number of RASSF fam...

journal_title：Oncology reports

authors： Chow LS,Lo KW,Kwong J,Wong AY,Huang DP

更新日期：2004-10-01 00:00:00

abstract：:We investigated whether or not the mitochondrial genotypes affect radiation-induced micronucleus (MN) formation. For that purpose, the rho+, KT1 and rho0 human osteosarcoma cell lines were used, which carry the wild-type mitochondrial DNA (mtDNA), the tRNALys mutant mtDNA and no mtDNA, respectively. Despite no signifi...

journal_title：Oncology reports

authors： Yoshida K,Yamazaki H,Ozeki S,Inoue T,Yoshioka Y,Yoneda M,Fujiwara Y,Inoue T

更新日期：2001-05-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) in exosomes play crucial roles in the onset, progression and metastasis of cancer by regulating the stability of target mRNAs or by inhibiting translation. In the present study, differentially expressed miRNAs were identified in exosomes of 27 breast cancer patients and 3 healthy controls using...

journal_title：Oncology reports

authors： Wu H,Wang Q,Zhong H,Li L,Zhang Q,Huang Q,Yu Z

更新日期：2020-01-01 00:00:00

abstract：:Iodine-125 (125I) seed irradiation can be used as an important supplementary treatment for unresectable advanced gastric cancer. However, the radiobiological mechanism underlying brachytherapy remains unclear. Therefore, we investigated the influence of continuous and low-energy 125I irradiation on the cell cycle dist...

journal_title：Oncology reports

authors： Zhang WF,Jin WD,Li B,Wang MC,Li XG,Mao WY,Luo KY

更新日期：2014-08-01 00:00:00

abstract：:The activation of receptor tyrosine kinases (RTKs) results in cellular effects including cell proliferation, survival, migration and invasion; RTKs also play an important role in tumourigenesis. It has been reported that EGFR signalling controls the migration of oral squamous cell carcinoma (OSCC) SAS and HSC3 cells b...

journal_title：Oncology reports

authors： Yasui H,Ohnishi Y,Nakajima M,Nozaki M

更新日期：2017-06-01 00:00:00

abstract：:The goal of this study was to evaluate the effect of the Na+/H+ exchanger-1 (NHE-1) antisense gene on drug-resistant human small cell lung cancer (SCLC) cell proliferation and apoptosis. A recombinant NHE-1 antisense gene was transfected into drug-resistant human SCLC H446/CDDP cells. Intracellular pH (pHi) was measur...

journal_title：Oncology reports

authors： Li S,Bao P,Li Z,Ouyang H,Wu C,Qian G

更新日期：2009-05-01 00:00:00

abstract：:The role of vascular endothelial growth factor (VEGF) during peritoneal dissemination of ovarian carcinoma and the association with tumor microvessel density (MVD) and matrix metalloproteinase (MMP) activity was investigated. To this end, MVD, tumor tissue and ascitic fluid levels of VEGF, and MMP activity of ascitic ...

journal_title：Oncology reports

authors： Yabushita H,Shimazu M,Noguchi M,Kishida T,Narumiya H,Sawaguchi K,Noguchi M

更新日期：2003-01-01 00:00:00

abstract：:miR-95 has been revealed to be aberrantly expressed in multiple types of cancer and to regulate tumor development. Moreover, miR-95 has been revealed to be downregulated in gastric cancer. However, the detailed function of miR-95 in gastric cancer has remained largely unknown. In the present study, we found that miR-9...

journal_title：Oncology reports

authors： Zhang W,Sun J,Chen J,Xu C,Zhang L

更新日期：2019-02-01 00:00:00

abstract：:Pin-1 has been shown to regulate several phases of the cell cycle and is strikingly overexpressed in many human cancers. Vascular endothelial growth factor (VEGF)-C is a potent lymphangiogenic factor produced by tumor and stromal cells. However, little is known about the roles of Pin-1 and VEGF-C in breast carcinoma. ...

journal_title：Oncology reports

authors： Kim BC,Han SI,Lim SC

更新日期：2009-12-01 00:00:00

abstract：:Chromosome 13 presents frequent allelic loss in esophageal squamous cell carcinomas (ESCC). However, no ESCC suppressor gene has been identified from this chromosome. To define common deletion regions that possibly contain the ESCC suppressor gene(s), we performed a mapping of allelic loss in 50 esophageal squamous ce...

journal_title：Oncology reports

authors： Guo GM,Huang XP,Dong JT,Caia Y,Xu X,Han YL,Wu M,Zhan QM,Wang MR

更新日期：2005-12-01 00:00:00

abstract：:Emerging evidence suggests that cancer cells present profound epigenetic alterations in addition to featuring classic genetic mutations. Valproic acid (VPA), a histone deacetylase inhibitor, can potently inhibit tumor growth and induce differentiation. However, the effect and underlying mechanism of VPA on head and ne...

journal_title：Oncology reports

authors： Lee SH,Nam HJ,Kang HJ,Samuels TL,Johnston N,Lim YC

更新日期：2015-10-01 00:00:00

abstract：:We have studied the effects of Saiboku-to, a traditional Chinese medicine having suppressive activities for leukotriene production and release, on the proliferation of the estrogen-responsive mouse Leydig tumor cell line B-1F. In our previous reports, it is shown that Saiboku-to promotes, but Scutellaria baicalensis, ...

journal_title：Oncology reports

authors： Murashima T,Katayama H,Shojiro K,Nishizawa Y

更新日期：2011-05-01 00:00:00

abstract：:Cyclooxygenase-2 (Cox-2) is an inducible enzyme that converts arachidonic acid to prostaglandins, and it is hypothesized to induce carcinogenesis and metastasis in colorectal cancer. Our previous data also indicated that a higher expression level of Cox-2 was correlated with colorec...

journal_title：Oncology reports

authors： Li ZG,Wang XY,Chang JL,Xie WB,Liu TF,Zhang QL,Deng YJ,Ding YQ

更新日期：2012-09-01 00:00:00

abstract：:The aim of this study was to verify whether histopathological features of extratumoral and of primary tumor breast tissue could play a role in identifying patients with familial characteristics. We examined the clinicopathological features of 504 patients with sporadic or familial breast cancer stratified for risk of ...

journal_title：Oncology reports

authors： Mangia A,Tommasi S,Bruno M,Malfettone A,D'Amico C,Zito FA,Paradiso A,Simone G

更新日期：2010-06-01 00:00:00

abstract：:Mother-to-infant transmission of hepatitis B virus (HBV) can occur as an intrauterine, intrapartum or postpartum infection. In the present study, we induced a multifunctional viral regulator of HBV gene products, HBx, and its different fragments to overexpress in a tropho-blast cell line, HTR-8/SVneo. We then identifi...

journal_title：Oncology reports

authors： Cui H,Li QL,Chen J,Na Q,Liu CX

更新日期：2015-10-01 00:00:00