Abstract:
:The isothiocyanates (ITCs) have long been known to possess chemopreventive activities for a variety of neoplasms including breast cancer, but the molecular mechanism by which ITCs prevent breast cancer development has not been established. In this study, we investigated the effects of benzyl and phenethyl isothiocyanate (BITC and PEITC) on the estrogen-stimulated growth of estrogen receptor alpha (ERalpha)-positive breast cancer MCF7 and T-47D cells. BITC and PEITC inhibited estrogen-stimulated cell growth and reduced the expression levels of ERalpha in MCF7 and T-47D cells in a dose- and time-dependent and reversible manner. In addition, BITC and PEITC also abrogated the transcriptional activity of ERalpha and hence inhibited estrogen-stimulated expression of the estrogen responsive gene, pS2. These results demonstrated that BITC and PEITC function as potent ERalpha disruptors to abrogate mitogenic estrogen signaling in ER-positive breast cancer cells, which provides a molecular explanation for the growth inhibitory function of ITCs in breast cancer development, and a rational for further exploration of ITCs as chemopreventive agents for human mammary carcinogenesis.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Kang L,Ding L,Wang ZYsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
185-92issue
1eissn
1021-335Xissn
1791-2431journal_volume
21pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Complement system activation contributes to various immune and inflammatory diseases, as well as cancers.However, the role of complement activation in the proliferation of cancer cells is not clear. In the present study, we investigated the consequences of complement activation on the proliferation of breast cancer ce...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3489
更新日期:2014-12-01 00:00:00
abstract::Luteolin was recently demonstrated to suppress tumor growth by interfering with nuclear factor (NF)‑κB activation. As the NF‑κB pathway plays a critical role in muscular atrophy associated with cancer cachexia, we aimed to investigate the potential of luteolin to alleviate cancer‑associated cachexia in a Lewis lung ca...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6453
更新日期:2018-08-01 00:00:00
abstract::The ING1 gene is involved in the regulation of the cell cycle, senescence, and apoptosis and is a novel candidate tumor suppressor gene. ING2, another gene in the ING family, was identified and cloned. The functions of ING1 and ING2 largely depend on the activity of p53. To determine whether an alteration in these gen...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract::Mammary small cell carcinoma (SmCC) is a very rare neoplasm with a poor prognosis compared with other invasive carcinomas. We studied the histological and immunohistochemical profiles of two cases of mammary SmCC, and compared them with those of five cases of carcinoma with endocrine features (CEF) and five cases of i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-04-01 00:00:00
abstract::Recently, gene fusions between the androgen responsive gene TMPRSS2 and members of the ETS-family of DNA-binding transcription factor genes were found in prostate cancer. Recurrent fusions were identified between the 5'-noncoding region of TMPRSS2 and ERG, or less frequently ETV1 or ETV4, resulting in overexpression o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
abstract::Miconazole (MIC), an antifungal agent, diplays anti‑tumorigenic activity in various types of human cancers, including bladder cancer, yet its mechanism of antitumor action is not well understood. In the present study, we demonstrated that, in a cell viability assay, MIC had a cytotoxic effect on human T24, J82 and TSG...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5608
更新日期:2017-06-01 00:00:00
abstract::The gene Nm23, which encodes for a nucleoside diphosphate kinase, has been defined as a metastasis-suppressor gene because of the inverse correlation between its expression and the metastatic capacity of the tumor cells. For colorectal cancer, however, the findings are equivocal. The aim of our study was to assess, in...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::Bmi-1, a member of the polycomb family, it is involved in self renewal of stem cells and functions as an oncogene in many malignant human cancer types. Recent studies have demonstrated that Bmi-1 is a predictive factor for poor patient prognosis. However, the underlying mechanisms o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1615
更新日期:2012-04-01 00:00:00
abstract::Sunitinib is a novel, multi-targeted receptor tyrosine kinase inhibitor, which has demonstrated evidence of improved survival when compared to interferon (IFN)-alpha in patients with metastatic renal cell carcinoma (RCC). Recently published National Institute for Health and Clinical Excellence guidance recommends suni...
journal_title:Oncology reports
pub_type: 临床试验,杂志文章
doi:10.3892/or_00000886
更新日期:2010-08-01 00:00:00
abstract::SET domain bifurcated 1 (SETDB1) is a histone H3 lysine 9 methyltransferase that is highly expressed in various tumor types, including breast cancer. However, how SETDB1 functions in breast cancer is unclear. In the present study, proliferation, migration and invasion assays were performed to explore the role of SETDB...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6871
更新日期:2019-02-01 00:00:00
abstract::Identification of safe, effective radiosensitizing agents is urgently needed to improve the outcome of radiotherapy in nasopharyngeal cancer (NPC). In this study, we assessed the ability of the polyphenol resveratrol to act as a radiosensitizer in vitro and in vivo. CNE-1 cells were treated with 50 µM resveratrol for ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5413
更新日期:2017-03-01 00:00:00
abstract::Primary and metastatic cancers that affect bones are frequently associated with severe and intractable pain. The mechanisms underlying the development of bone cancer pain are largely unknown. In the present study, we investigated whether inhibition of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3718
更新日期:2015-03-01 00:00:00
abstract::Thrombospondin-1 (TSP1) is known to possess tumor suppressor functions. In contradiction, TSP1 enhances the stromal vascularization and growth of certain cancers. A cell adhesion receptor, CD36, has been shown to interact with a ligand TSP1. We studied how CD36 affects the growth of the osteosarcoma cell line (HOS) ex...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
abstract::PFN2 is an invasion promoter in several cancers including lung cancer. However, the probable effects and underlying mechanisms of PFN2 in tumor cell epithelial-mesenchymal-transition (EMT) of non-small cell lung cancer (NSCLC) remain poorly understood. The protein and mRNA levels of PFN2 in human bronchial epithelial ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5566
更新日期:2017-05-01 00:00:00
abstract::Resistance to chemotherapeutic agents is a major problem for successful cancer treatment. P-glycoprotein (Pgp), a product of the multidrug resistance (MDR)1 gene expressed in cancer cells, is one of the mechanism of MDR. However, there are few reports regarding the effects of Pgp on prognosis of colorectal cancer (CRC...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.4.815
更新日期:2001-07-01 00:00:00
abstract::We conducted a study to determine whether the expression levels of genes in tumors were correlated with the survival of patients after complete resection of non-small cell lung cancer (NSCLC). The expression levels of 1176 genes in resected tumor specimens from 28 patients were analyzed using the Atlastrade mark Human...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract::Tamoxifen and raloxifene are widely used in clinical practice. It has been found that tamoxifen treatment increases the risk of development of endometrial cancer. The effects of tamoxifen and raloxifene on endometrium might be caused by different estrogen receptor expression. The aim of the present study was immunohis...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract::An arsenical compound, As2O3 has been reported to be effective for treating acute leukemia and induce apoptosis in many different tumor cell types. In this study we designed a novel arsenical compound, As4O6, and compared its ability to induce cell growth inhibition as well as gene expression profiles along with As2O3...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract::Colorectal carcinoma (CRC) is a major type of malignancy worldwide. Ellagic acid (EA), a natural phenolic constituent, has been shown to exhibit anticancer effects. In our previous study, it was shown that EA inhibited proliferation of CRC cells. Additionally, microarray analysis revealed 4,738 differentially expresse...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7617
更新日期:2020-08-01 00:00:00
abstract::As part of the efforts to drug repurposing, some HIV drugs have recently been identified to exert anticancer effects. Selected nucleoside analogues of nucleosidic reverse-transcriptase inhibitors (NRTIs) have been shown to interfere with RNA transcription of HI viruses as well as with the replication of DNA in cancer ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5243
更新日期:2017-01-01 00:00:00
abstract::The growth of malignant tumors is associated with mechanisms of immune escape and inhibition of apoptosis. Livin is a novel member of the inhibitors of apoptosis (IAP) protein family that inhibits cell apoptosis. Livin is specifically expressed by the majority of tumor cells, but it is not expressed in normal adult ti...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2133
更新日期:2013-02-01 00:00:00
abstract::Despite significant homology between IRS-1 and IRS-2, recent studies have revealed distinct functions for these adaptor proteins in regulating breast cancer progression. Thus far, most of the studies on breast cancer have focused upon IRS-1, the biological pattern of IRS-2 is limited. We demonstrated that depletion of...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00001016
更新日期:2010-12-01 00:00:00
abstract::The aim of the present study was to investigate the expression, function and underlying molecular mechanism of the long non‑coding (lnc) RNA RP1‑163G9.1 in patients with gastric adenocarcinoma (GA). The expression levels of lncRNA RP1‑163G9.1 were determined in 112 paired clinical GA tissues by reverse transcription‑q...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7127
更新日期:2019-06-01 00:00:00
abstract::Nuclear factor (NF)-κB is the key transcription factor involved in the inflammatory responses, and its activation aggravates tumors. Peptidoglycan (PGN), a main cell wall component of Gram-positive bacteria, stimulates Toll-like receptor 2 (TLR-2) and activates a number of inflammat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1937
更新日期:2012-10-01 00:00:00
abstract::To estimate the incidence of Epstein-Barr virus-associated gastric carcinoma (EBV-GC) in Colombia and to clarify its clinicopathological features, we examined 178 consecutive gastric carcinoma cases, diagnosed during the period from 1996 to 1998, at Hospital Universitario del Valle in Cali, Colombia. The mean age of t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::Abnormal lymphangiogenesis is associated with several diseases such as tumor metastasis and lymphangioma. Human lymphangioma originated from the transformation of lymphatic endothelium is a benign malformation of lymphatic vessels and its pathogenesis has up to date not been illuminated and its cell model has also not...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::The mechanisms leading to squamous cell carcinoma of head and neck (SCCHN) metastasis are not fully understood. Although evidence shows that the chemokine receptor 7 (CCR7) and its ligand CCL19 may regulate tumor dissemination, their role is not clearly defined in SCCHN. Matrix metalloproteinases break consisting of t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3242
更新日期:2014-08-01 00:00:00
abstract::The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present study included 81 consecutive patients with confirmed diagnoses of r...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5300
更新日期:2017-02-01 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) are the most common genetic variation in mammalian cells with prognostic potential. Anillin‑actin binding protein (ANLN) has been identified as being involved in PI3K/PTEN signaling, which is critical in cell life/death control, and kinase insert domain receptor (KDR) encodes a k...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7332
更新日期:2019-12-01 00:00:00
abstract::The incidence and associated mortality of melanoma continues to increase worldwide. At present, there is no curative therapy for advanced stage of melanoma. It is necessary to find new indicators of prognosis and therapeutic targets. Increasing evidence shows that miRNA can provide potential candidate biomarkers for m...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5020
更新日期:2016-10-01 00:00:00