SETDB1 induces epithelial‑mesenchymal transition in breast carcinoma by directly binding with Snail promoter.

abstract：:Garlic and its constituents are reported to have a preventive effect against colorectal cancer in animal models. Aged garlic extract (AGE), which is produced by natural extraction from fresh garlic for more than 10 months in aqueous ethanol, also has reputed chemopreventive effects on colon carcinogenesis, but has nev...

journal_title：Oncology reports

authors： Jikihara H,Qi G,Nozoe K,Hirokawa M,Sato H,Sugihara Y,Shimamoto F

更新日期：2015-03-01 00:00:00

abstract：:Oncolytic viruses are genetically engineered viruses designed for the treatment of solid tumors, and are often coupled with the antitumor immunity of the host. The challenge of using oncolytic herpes simplex virus (oHSV) as an efficacious oncolytic agent is the potential host tissue damage caused by the production of ...

journal_title：Oncology reports

authors： Ren S,Chen X,Huang R,Zhou GG,Yuan Z

更新日期：2019-03-01 00:00:00

abstract：:Pancreatic cancer is usually diagnosed in the advanced stages and is sensitive to only few therapies. The forkhead box L1 (FOXL1) and protein phosphatase 2A (PP2A) have been recognized to be tumor suppressive in human pancreatic cancers. In the present study, we co-expressed the two tumor suppressive molecules with a ...

journal_title：Oncology reports

authors： Li Y,Yu D,Sheng W,Song H,Li Y,Dong M

更新日期：2016-04-01 00:00:00

abstract：:To clarify hepatocarcinogenesis by the heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), we investigated the global expression of genes in rat liver. Rats were continuously fed MeIQx 100 ppm in their diet, and were sacrificed at weeks 4 and 16 for early time points, and week 104 for tumor samp...

journal_title：Oncology reports

authors： Kang JS,Wanibuchi H,Murai T,Morimura K,Kinoshita A,Fukushima S

更新日期：2007-04-01 00:00:00

abstract：:Burkitt's lymphoma (BL) is a fast growing cancer of the human lymphatic system, and an extremely invasive B-cell non-Hodgkin's lymphoma. We explored the mechanism of apoptosis in Raji cells associated with the post-transcriptional regulation factors. To confirm that the predicted microRNA-520a (miR-520a) is matched wi...

journal_title：Oncology reports

authors： Wang X,Wang P,Zhu Y,Zhang Z,Zhang J,Wang H

更新日期：2016-09-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an important mediator of tumor angiogenesis. A high serum VEGF level has been shown to predict poor response to chemotherapy and poor survival in several cancers, but its prognostic value in hepatocellular carcinoma (HCC) remains unknown. We conducted a prospective study to...

journal_title：Oncology reports

authors： Poon RT,Lau C,Yu WC,Fan ST,Wong J

更新日期：2004-05-01 00:00:00

abstract：:The NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme is implicated in protection against oxidative stress and carcinogenesis. NQO1 C609T genetic polymorphism was reported to be associated with an increased risk for cancers, including breast cancer. However, there is still lack of evidence whether higher oxidative stress...

journal_title：Oncology reports

authors： Tseng LM,Yin PH,Tsai YF,Chi CW,Wu CW,Lee LM,Lee HC

更新日期：2009-05-01 00:00:00

abstract：:The long non-coding RNA MFI2 antisense RNA is overexpressed in human cancer tissues and its increased expression is associated with occurrence and metastasis of cancer. However, the underlying mechanism in evolution and progression of human osteosarcoma is not well known. In the present study, we aimed to evaluate the...

journal_title：Oncology reports

authors： Yin Z,Ding H,He E,Chen J,Li M

更新日期：2016-10-01 00:00:00

abstract：:The tumor microenvironment plays an important role in cancer growth, invasion and metastasis. The stroma surrounding a tumor is known to contain a variety of factors that can increase angiogenesis, cancer growth and tumor progression. The aim of the present study was to determine the role of fascin in cancer growth an...

journal_title：Oncology reports

authors： Zhang X,Cho IH,Park JH,Lee MK,Hwang YS

更新日期：2019-01-01 00:00:00

abstract：:The present study determined the anticancer activity and its mechanism of microRNA‑133b on cell proliferation of cisplatin-induced non-small cell lung cancer cells. The expression of microRNA-133b cisplatin‑induced non-small cell lung cancer (NSCLC) tissue was lower than that of para-carcinoma tissue in patients. Over...

journal_title：Oncology reports

authors： Li B,Ding CM,Li YX,Peng JC,Geng N,Qin WW

更新日期：2018-03-01 00:00:00

abstract：:MHC class I-related chain molecules A and B (MICA and B) expressed on the cell-surface of tumor cells are ligands for an activating receptor, NKG2D, expressed on natural killer (NK) cells and stimulate the NK cell-mediated cytotoxicity. On the other hand, the soluble form of MICA and B produced by proteolytic cleavage...

journal_title：Oncology reports

authors： Yamanegi K,Yamane J,Kobayashi K,Kato-Kogoe N,Ohyama H,Nakasho K,Yamada N,Hata M,Nishioka T,Fukunaga S,Futani H,Okamura H,Terada N

更新日期：2010-12-01 00:00:00

abstract：:Chemotherapy is one of the methods to treat patients with non-small cell lung cancer (NSCLC) developing resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib. Previous studies revealed that the sensitivity to chemotherapy may depend on different cellular mechanisms ...

journal_title：Oncology reports

authors： Zhou J,Hu Q,Zhang X,Zheng J,Xie B,Xu Z,Zhang W

更新日期：2018-04-01 00:00:00

abstract：:The long non‑coding RNA (lncRNA) PVT1 plays vital roles in the tumorigenesis and development of various types of cancer. However, the potential expression profiling, functions and pathways of PVT1 in HCC remain unknown. PVT1 was knocked down in SMMC‑7721 cells, and a miRNA microarray analysis was performed to detect t...

journal_title：Oncology reports

authors： Zhang Y,Mo WJ,Wang X,Zhang TT,Qin Y,Wang HL,Chen G,Wei DM,Dang YW

更新日期：2018-07-01 00:00:00

abstract：:Prostate and breast cancer overexpressed 1 (PBOV1) is significantly upregulated in prostate, breast and bladder cancer, while its expression status in ovarian cancer and its clinical significance are unclear. We examined the expression levels of PBOV1 mRNA and protein in ovarian cancer cell lines and primary tissues u...

journal_title：Oncology reports

authors： Wang L,Niu CH,Wu S,Wu HM,Ouyang F,He M,He SY

更新日期：2016-01-01 00:00:00

abstract：:Tetraarsenic oxide (As4O6, TAO) is a new arsenic compound that inhibits cell growth and induces apoptosis in human cervical cancer cell lines. In the present study, we report that the growth of tumor cells (CaSki) was inhibited by treatment with TAO alone or in combination with cisp...

journal_title：Oncology reports

authors： Byun JM,Jeong DH,Lee DS,Kim JR,Park SG,Kang MS,Kim YN,Lee KB,Sung MS,Kim KT

更新日期：2013-04-01 00:00:00

abstract：:Male breast cancer (MBC) is extremely rare, with an incidence in the general US population of <1%. It tends to be diagnosed at later stages than breast cancer in females, likely because of low awareness on the part of the patient and low suspicion by the physician. Risk factors include genetic predisposition, alterati...

journal_title：Oncology reports

authors： Johansen Taber KA,Morisy LR,Osbahr AJ 3rd,Dickinson BD

更新日期：2010-11-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) cells are relatively resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis during culture. We investigated the role of a proteaosome inhibitor in the survival and apoptosis of these cells. We found that the proteasome inhibitor MG132 markedl...

journal_title：Oncology reports

authors： Yoshiba S,Iwase M,Kurihara S,Uchida M,Kurihara Y,Watanabe H,Shintani S

更新日期：2011-03-01 00:00:00

abstract：:MicroRNA (miRNA) is a type of endogenous non‑coding RNA implicated in various cellular processes. Studies have shown that miR-124 is involved in the malignant progression of cancer, but little is known concerning its potential role in breast cancer. Therefore, the purpose of this study was to conduct a functional anal...

journal_title：Oncology reports

authors： Du S,Li H,Sun X,Li D,Yang Y,Tao Z,Li Q,Liu K

更新日期：2016-12-01 00:00:00

abstract：:miR-95 has been revealed to be aberrantly expressed in multiple types of cancer and to regulate tumor development. Moreover, miR-95 has been revealed to be downregulated in gastric cancer. However, the detailed function of miR-95 in gastric cancer has remained largely unknown. In the present study, we found that miR-9...

journal_title：Oncology reports

authors： Zhang W,Sun J,Chen J,Xu C,Zhang L

更新日期：2019-02-01 00:00:00

abstract：:We hypothesized that expression of multidrug resistance-associated protein 2 (MRP2), a major cisplatin transporter, may determine the efficacy of cisplatin as a treatment for patients with hepatocellular carcinoma (HCC). A prospective analysis was conducted of 49 consecutive patients who underwent resection for HCC (1...

journal_title：Oncology reports

authors： Korita PV,Wakai T,Shirai Y,Matsuda Y,Sakata J,Takamura M,Yano M,Sanpei A,Aoyagi Y,Hatakeyama K,Ajioka Y

更新日期：2010-04-01 00:00:00

abstract：:The presence of hypoxic regions within solid tumors is caused by an imbalance between cell proliferation and angiogenesis. Such regions may facilitate the onset of recurrence after radiation therapy and chemotherapy, as hypoxic cells show resistance to these treatments. We found that tempol, a nitroxide, strongly indu...

journal_title：Oncology reports

authors： Kagiya G,Ogawa R,Choudhuri R,Cook JA,Hatashita M,Tanaka Y,Koda K,Yamashita K,Kubo M,Kawakami F,Mitchell JB

更新日期：2015-08-01 00:00:00

abstract：:Tumor growth is accelerated by induction of angiogenesis regulated by many cytokines and growth factors. In a tumor mass, various angiogenic factors and their receptors are simultaneously expressed and the overlapped expressions of various factors may contribute to the aggressive growth of tumor. However, the possible...

journal_title：Oncology reports

authors： Lee YM,Bae MH,Lee OH,Moon EJ,Moon CK,Kim WH,Kim KW

更新日期：2004-10-01 00:00:00

abstract：:Chemotherapy plays a major role in cancer management; however, acquired drug resistance remains a significant problem for ovarian cancer treatment. Chemoresistance is regulated by the coordinated expression of a set of genes. Thus, the identification of genes specifically modulated in the process provides an important...

journal_title：Oncology reports

authors： Li L,Luan Y,Li X,Tang B,Zhang W,Li D,Zhao J,Wang G,Ding H,Reed E,Li QQ

更新日期：2005-05-01 00:00:00

abstract：:Bone morphogenetic protein 9 (BMP9) is a member of the BMP family, which is involved in the regulation of tumor biogenesis, development and metastasis. The present study aimed to investigate whether BMP9 inhibits the growth of MDA‑MB‑231 breast cancer cells via the phosphoinositide 3‑kinase (PI3K)/Akt signaling pathwa...

journal_title：Oncology reports

authors： Li S,Dai H,He Y,Peng S,Zhu T,Wu Y,Li C,Wang K

更新日期：2018-09-01 00:00:00

abstract：:Soft tissue sarcomas comprise a heterogeneous group of mesenchymal tumors with varying biological behavior ranging from indolent tumors with no or minimal metastatic risk to aggressive and frequently metastasizing tumors. Among the more common aggressive adult soft tissue sarcomas are malignant fibrous histiocytoma, s...

journal_title：Oncology reports

authors： Alford SH,Vrana MS,Waite L,Heim-Hall J,Sylvia VL,Williams RP

更新日期：2007-12-01 00:00:00

abstract：:Prostate cancer is a leading cause of cancer-related death among men. Early diagnosis and treatment are successful against prostate cancer, yet the clinical treatment of advanced prostate cancer remains a challenge. Gemcitabine is used to treat a broad spectrum of solid tumors; however, the clinical response of prosta...

journal_title：Oncology reports

authors： Guo Z,Zhang X,Li X,Xie F,Su B,Zhang M,Zhou L

更新日期：2015-03-01 00:00:00

abstract：:Non‑small cell lung cancer (NSCLC) accounts for over 80% of all diagnosed lung cancer cases. Lung cancer is the leading cause of cancer‑related deaths worldwide. Most NSCLC cells overexpress vascular endothelial growth factor‑A (VEGF‑A) which plays a pivotal role in tumour angiogenesis. Anti‑angiogenic therapies inclu...

journal_title：Oncology reports

authors： Eguchi R,Wakabayashi I

更新日期：2020-07-01 00:00:00

abstract：:Hypoxia was shown to increase tumor cell invasion into the extracellular matrix in vitro. This result suggests that heparanase (Hpa), one of the key enzymes involved in tumor invasion and metastasis, may be regulated by hypoxia. RT-PCR, Western blot and Matrigel invasive assays were used to study the regulation of Hpa...

journal_title：Oncology reports

authors： Wu W,Pan C,Meng K,Zhao L,Du L,Liu Q,Lin R

更新日期：2010-01-01 00:00:00

abstract：:Glioblastoma is the most common type of primary brain tumour in adults, and its pathogenesis is particularly complicated. Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic ...

journal_title：Oncology reports

authors： Xu PF,Yang JA,Liu JH,Yang X,Liao JM,Yuan FE,Liu BH,Chen QX

更新日期：2019-01-01 00:00:00

abstract：:Despite improvements in immunotherapy, little is known about dendritic cell (DC) subpopulations naturally occurring in the laryngeal cancer tissue (LCT) and peripheral blood (PB) of untreated laryngeal cancer (LC) patients. The purpose of the present study was to evaluate mature, im...

journal_title：Oncology reports

authors： Klatka J,Grywalska E,Tabarkiewicz J,Polak A,Rolinski J

更新日期：2012-07-01 00:00:00