Proteasome inhibitor sensitizes oral squamous cell carcinoma cells to TRAIL-mediated apoptosis.

abstract：:microRNAs (miRNAs), small non-coding RNAs, have emerged as key regulators of a large number of genes. The present study aimed to explore novel biological functions of miR-330 in the human prostate cancer cell lines DU145 and PC3. We confirmed that miR-330 was downregulated and inversely correlated with specificity pro...

journal_title：Oncology reports

authors： Mao Y,Chen H,Lin Y,Xu X,Hu Z,Zhu Y,Wu J,Xu X,Zheng X,Xie L

更新日期：2013-07-01 00:00:00

abstract：:Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylat...

journal_title：Oncology reports

authors： Coker-Gürkan A,Arisan ED,Obakan P,Akalın K,Özbey U,Palavan-Unsal N

更新日期：2015-06-01 00:00:00

abstract：:Antineoplastons are naturally occurring peptides and amino acid derivatives found in human blood and urine. antineoplastons have been shown to control neoplastic growth. In the present study, we investigated demethylation effect of the antineoplaston AS2-1 (a mixture of phenylacetylglutamine and phenylacetate in the r...

journal_title：Oncology reports

authors： Ushijima M,Ogata Y,Tsuda H,Akagi Y,Matono K,Shirouzu K

更新日期：2014-01-01 00:00:00

abstract：:The authors of the above article drew to our attention that they had identified three instances of data overlapping between data panels, suggesting that data purportedly showing results obtained under different experimental conditions had been derived from the same original source. Comparing between the two figures, t...

journal_title：Oncology reports

authors： Ji CX,Fan YH,Xu F,Lv SG,Ye MH,Wu MJ,Zh XG,Wu L

更新日期：2020-11-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs), which belong to the transforming growth factor-β superfamily, are multifunctional signaling molecules that have become of increasing interest in cancer research. Recent observations suggest that alterations in BMPs and BMP signaling are associated...

journal_title：Oncology reports

authors： Hashida Y,Nemoto Y,Imajoh M,Murakami M,Taniguchi A,Komatsu N,Yokoyama A,Daibata M

更新日期：2012-03-01 00:00:00

abstract：:Despite the established importance of angiogenesis in the pathogenesis of solid tumours, there is still no consensus on how this is best measured or which method is the most appropriate in the determination of prognosis. Here we review the pros and cons of current methods of assessing angiogenesis, both clinical and i...

journal_title：Oncology reports

authors： Pollitt MJ,Hanby AM,Horgan K,Murphy CE,Jones PF,Speirs V

更新日期：2005-05-01 00:00:00

abstract：:We investigated the correlation between BAG-1 expression and sensitivity to platinum-based chemotherapeutics in patients with non-small cell lung cancer (NSCLC). mRNA and protein expression of BAG-1 in lung tissue of NSCLC postoperative patients (I-IIIA stage) or healthy subjects were detected using reverse transcript...

journal_title：Oncology reports

authors： Wang YD,Ha MW,Cheng J,Zhang WL,Cong X,Tong CY,Sun J

更新日期：2012-04-01 00:00:00

abstract：:Apoptosis repressor with caspase recruitment domain (ARC), an inhibitor of apoptosis, is primarily expressed in terminally differentiated tissues. Recent studies have revealed that ARC is highly expressed in a variety of human cancer cell lines and epithelial-derived cancers, which suggests that ARC plays an important...

journal_title：Oncology reports

authors： Wu P,Tang Y,He J,Qi L,Jiang W,Zhao S

更新日期：2013-10-01 00:00:00

abstract：:This study assessed the prediction of gastric cancer recurrence based on detection of occult neoplastic cells (ONCs) in lymph nodes, and by using criteria that were developed to identify patients with a high risk of recurrence/metastasis. The subjects were 60 patients of stage II or III gastric cancer with lymph node ...

journal_title：Oncology reports

authors： Mukai M,Sato S,Komatsu N,Kimura T,Ninomiya H,Kawada M,Nakasaki H,Ogoshi K,Makuuchi H

更新日期：2004-07-01 00:00:00

abstract：:Oncolytic viruses are genetically engineered viruses designed for the treatment of solid tumors, and are often coupled with the antitumor immunity of the host. The challenge of using oncolytic herpes simplex virus (oHSV) as an efficacious oncolytic agent is the potential host tissue damage caused by the production of ...

journal_title：Oncology reports

authors： Ren S,Chen X,Huang R,Zhou GG,Yuan Z

更新日期：2019-03-01 00:00:00

abstract：:LKB1 encodes a serine/threonine kinase generally inactivated in human lung cancers, which mediates cancer cell proliferation, migration and differentiation, but its biological function has not been completely elucidated. In this study, we demonstrated that LKB1 was associated with a substantial reduction of c-myc expr...

journal_title：Oncology reports

authors： Liang X,Nan KJ,Li ZL,Xu QZ

更新日期：2009-04-01 00:00:00

abstract：:The human Igf-1 gene not only produces insulin‑like growth factor-I (IGF-I), but also different carboxy‑terminal extensions, known as E peptides, through alternative splicing. We and others have shown that human Eb peptide (hEb) derived from Igf-1 has intrinsic biological activity and is localized to nuclei of transfe...

journal_title：Oncology reports

authors： Durzyńska J,Barton E

更新日期：2014-09-01 00:00:00

abstract：:The antitumor effect of the human umbilical vein endothelial cell (HUVEC) vaccine has been well documented; however, its anti‑angiogenic effects on human esophageal squamous cell carcinoma (ESCC) have yet to be studied. In the present study, a 'humanized' mouse model was established by transplanting NOD/SCID mice with...

journal_title：Oncology reports

authors： Liu H,Zhao J,Yang Y,Jin G,Zhang X,Wang D,Xie C,Liu K,Chen X,Li X,Tian F,Dong Z,Lu J

更新日期：2018-11-01 00:00:00

abstract：:Few studies have examined apoptosis induced by low-voltage electric pulses (LVEPs). LVEP-induce changes in membrane potential that are below the membrane breakdown threshold and increase membrane permeability without electroporation (pore formation) through the transport of extracellular substances via phagocytosis. W...

journal_title：Oncology reports

authors： Matsuki N,Takeda M,Ishikawa T,Kinjo A,Hayasaka T,Imai Y,Yamaguchi T

更新日期：2010-05-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) plays a key role in the transformation of normal cells to cancerous cells. Although inhibitors of STAT3 have been shown to suppress the growth of multiple cancer types in vitro and in vivo, such agents are of particular interest for the prevention of breast ca...

journal_title：Oncology reports

authors： Shoemaker RH,Fox JT,Juliana MM,Moeinpour FL,Grubbs CJ

更新日期：2019-09-01 00:00:00

abstract：:The TP53 mutation (R175H) is one of the most common mutations in human cancer. It is a highly attractive strategy for cancer therapy to find the genes that lead the R175H-expressing cancer cells. The aim of this study was to identify the synthetic sick/lethal gene interacting with R175H. Using lentiviral bar-coded com...

journal_title：Oncology reports

authors： Imai H,Kato S,Sakamoto Y,Kakudo Y,Shimodaira H,Ishioka C

更新日期：2014-03-01 00:00:00

abstract：:Subsequently to the publication of this paper, the authors have realized that the affilitation address omitted the name of the university at which this research was conducted (Capital Medical University). Therefore, the author affiliations for this paper should have appeared as follows (changes are highlighted in bold...

journal_title：Oncology reports

authors： Dong J,Xu M

更新日期：2019-12-01 00:00:00

abstract：:We investigated the prevalence of human papillomavirus (HPV) in a clinical series of 72 patients with head and neck squamous cell carcinoma (HNSCC) using a retrospective and prospective study design. The majority of patients were smokers and/or drinkers and were treated with concomitant chemoradiotherapy (CCR). Furthe...

journal_title：Oncology reports

authors： Duray A,Descamps G,Decaestecker C,Sirtaine N,Gilles A,Khalifé M,Chantrain G,Depuydt CE,Delvenne P,Saussez S

更新日期：2013-07-01 00:00:00

abstract：:We investigated the effects of quercetin on 7,12-dimethylbenz(a)anthracene (DMBA)-induced oxidative stress and the expression of CYP1A1 and CYP1B1 in mice. Quercetin was administered orally to mice at 100 or 250 mg/kg BW for 18 days, after which DMBA (34 mg/kg BW) was administered intragastrically twice. Quercetin sho...

journal_title：Oncology reports

authors： Choi EJ,Kim T,Kim GH

更新日期：2012-07-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) was suggested to play an important role in the regulation of mitogenesis, motogenesis, angiogenesis, migration and invasion for various types of cells, and acts through a specific membrane receptor encoded by c-met proto-oncogene. However, the mechanism of the effect of HGF on tumor inva...

journal_title：Oncology reports

authors： Fujiuchi Y,Nagakawa O,Murakami K,Fuse H,Saiki I

更新日期：2003-07-01 00:00:00

abstract：:The aim of this study was to evaluate variations of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and protein expression after adjuvant treatment in glioblastoma patients. Sixteen patients with a glioblastoma underwent 34 microsurgeries including 18 re-operations. After surgery, patients underwent...

journal_title：Oncology reports

authors： Jung TY,Jung S,Moon KS,Kim IY,Kang SS,Kim YH,Park CS,Lee KH

更新日期：2010-05-01 00:00:00

abstract：:Paired box 6 (PAX6) is a transcription factor that has oncogenic features. In breast cancer, PAX6 facilitates tumor progression; however, the underlying mechanism is largely unknown. The majority of breast cancer‑related mortalities are associated with metastasis of cancer cells. Therefore, the present study aimed to ...

journal_title：Oncology reports

authors： Jin M,Gao D,Wang R,Sik A,Liu K

更新日期：2020-08-01 00:00:00

abstract：:The aim of this study was to verify whether histopathological features of extratumoral and of primary tumor breast tissue could play a role in identifying patients with familial characteristics. We examined the clinicopathological features of 504 patients with sporadic or familial breast cancer stratified for risk of ...

journal_title：Oncology reports

authors： Mangia A,Tommasi S,Bruno M,Malfettone A,D'Amico C,Zito FA,Paradiso A,Simone G

更新日期：2010-06-01 00:00:00

abstract：:Cell cycle analysis has become increasingly important in verifying the effect of anti-tumor drugs and cytokinetic research. In the early methods of cell cycle analysis, the flow cytometry relied on DNA content, and therefore, the cell cycle could be only broken into three stages: G(0)/G(1), S, and G(2)/M phase. It cou...

journal_title：Oncology reports

authors： Qin J,Tao D,Duan R,Leng Y,Shen M,Zhou H,Feng Y,Gao C,Yu Y,Li QQ,Hu J,Gong J

更新日期：2002-09-01 00:00:00

abstract：:The targeting of receptor activator of nuclear factor-κB ligand (RANKL) is being increasingly investigated as a potential therapeutic strategy in several types of cancers. However, the exact function and mechanism of RANKL in human endometrial cancer (EC), particularly in progesterone-resistant and aggressive EC, rema...

journal_title：Oncology reports

authors： Wang J,Sun X,Zhang H,Wang Y,Li Y

更新日期：2015-02-01 00:00:00

abstract：:Iodine-125 (125I) seed irradiation can be used as an important supplementary treatment for unresectable advanced gastric cancer. However, the radiobiological mechanism underlying brachytherapy remains unclear. Therefore, we investigated the influence of continuous and low-energy 125I irradiation on the cell cycle dist...

journal_title：Oncology reports

authors： Zhang WF,Jin WD,Li B,Wang MC,Li XG,Mao WY,Luo KY

更新日期：2014-08-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. It has poor clinical outcome due to intrinsic or acquired drug resistance. Deregulation of both apoptosis and autophagy contributes to chemotherapy resistance and disease progression. A new member of the inhibitors of ...

journal_title：Oncology reports

authors： Frassanito MA,Saltarella I,Vinella A,Muzio LL,Pannone G,Fumarulo R,Vacca A,Mariggiò MA

更新日期：2019-05-01 00:00:00

abstract：:Tropomodulin 3 (TMOD3) is a member of the pointed‑end capping protein family that contributes to invasion and metastasis in several types of malignancies. TMOD3 has been found to be crucial for membranous skeleton and embryonic development; however, little is known regarding the role of TMOD3 in liver cancer progressi...

journal_title：Oncology reports

authors： Jin C,Chen Z,Shi W,Lian Q

更新日期：2019-05-01 00:00:00

abstract：:Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, ...

journal_title：Oncology reports

authors： Akagi J,Baba H

更新日期：2019-01-01 00:00:00

abstract：:In order to clarify the molecular mechanism involved in renal carcinogenesis, and to identify molecular targets for development of novel treatments of renal cell carcinoma (RCC), we previously analyzed genome-wide gene expression profiles of clear-cell types of RCC by cDNA microarray. Among the transcativated genes, w...

journal_title：Oncology reports

authors： Dobashi S,Katagiri T,Hirota E,Ashida S,Daigo Y,Shuin T,Fujioka T,Miki T,Nakamura Y

更新日期：2009-02-01 00:00:00