Angiogenesis in breast cancer: how should we measure this? (Review).

abstract：:The present study demonstrated that chaetocin, a natural small-molecule product produced by Chaetomium fungal species and a potential anticancer agent, inhibited the viability and invasive ability of the human intrahepatic cholangio-carcinoma cell line CCLP-1 in vivo and in vitro as revealed by CCK-8 and Transwell inv...

journal_title：Oncology reports

authors： He J,Chen X,Li B,Zhou W,Xiao J,He K,Zhang J,Xiang G

更新日期：2017-10-01 00:00:00

abstract：:Polysaccharides derived from Inonotus obliquus (PIO) are known to possess multiple pharmacological activities including antitumor activity. However, the possible molecular mechanisms of these activities are unknown. In the present study, we determined the anti-metastatic potential and signaling pathways of PIO in the ...

journal_title：Oncology reports

authors： Lee KR,Lee JS,Kim YR,Song IG,Hong EK

更新日期：2014-05-01 00:00:00

abstract：:Glucocorticoids such as dexamethasone are widely used as comedication in the treatment of head and neck cancer, e.g., to improve appetite and decrease weight loss and fatigue in patients with advanced disease or as antiallergic and antiemetic prophylaxis during anti-EGFR therapy. However, the literature suggests that ...

journal_title：Oncology reports

authors： Wagenblast J,Baghi M,Mörtel S,Hirth D,Thron L,Arnoldner C,Gstöttner W,May A,Hambek M

更新日期：2009-07-01 00:00:00

abstract：:The present study aimed to examine the inhibitory effects of morusin on the human lung cancer cell line A549. Various doses of morusin were applied to A549 cells and the effects were assessed by wound‑healing and MTT assays, flow cytometry analysis of apoptosis, a mitochondrial membrane potential assay and RT‑PCR. The...

journal_title：Oncology reports

authors： Yin XL,Lv Y,Wang S,Zhang YQ

更新日期：2018-07-01 00:00:00

abstract：:We previously reported that chromosome arm 10q is one of the target regions of allelic loss in human endometrial cancer. To identify the gene in this region responsible for endometrial cancer, we further characterized this region and localized the hBRAG gene. The function of hBRAG has not yet been fully studied, and t...

journal_title：Oncology reports

authors： Yuki M,Yoshinaga K,Yamakawa H,Sakurada K,Sato S,Yajima A,Horii A

更新日期：2000-11-01 00:00:00

abstract：:In order to clarify the molecular mechanism involved in renal carcinogenesis, and to identify molecular targets for development of novel treatments of renal cell carcinoma (RCC), we previously analyzed genome-wide gene expression profiles of clear-cell types of RCC by cDNA microarray. Among the transcativated genes, w...

journal_title：Oncology reports

authors： Dobashi S,Katagiri T,Hirota E,Ashida S,Daigo Y,Shuin T,Fujioka T,Miki T,Nakamura Y

更新日期：2009-02-01 00:00:00

abstract：:Human gonadotropin-releasing hormone receptor (GnRHR) and its natural ligand human gonadotropin-releasing hormone (GnRH) were initially described as signaling complexes that play a key role in reproductive functions. By binding to specific receptors present on pituitary gonadotropes, GnRH regulates the sperm and ovum ...

journal_title：Oncology reports

authors： Aguilar-Rojas A,Huerta-Reyes M

更新日期：2009-11-01 00:00:00

abstract：:In this study 10(7) peripheral blood mononuclear cells including on average 78.56% CD19+/CD5+ lymphocytes were irradiated, and then administered intradermally as an anti-cancer vaccine to seventeen patients with B-cell chronic lymphocytic leukemia (B-CLL) at early stages (twelve injections, four at a weekly interval f...

journal_title：Oncology reports

authors： Hus I,Kawiak J,Tabarkiewicz J,Radej S,Hoser G,Bojarska-Junak A,Schmitt M,Giannopoulos K,Dmoszynska A,Rolinski J

更新日期：2008-08-01 00:00:00

abstract：:Survivin, an anti-apoptotic protein, is abundantly expressed in a variety of cancer cells, including hepatoma cells, resulting in the resistance of these cells to various apoptotic stimuli. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known to induce cancer cell-specific apoptosis, but hepa...

journal_title：Oncology reports

authors： Nakao K,Hamasaki K,Ichikawa T,Arima K,Eguchi K,Ishii N

更新日期：2006-08-01 00:00:00

abstract：:Lysyl oxidase is an important extracellular matrix remodeling enzyme and plays critical roles in tumor progression and development. Its tumor-suppressor activity has been shown to depend on the propeptide region. Previous studies have reported that the expression levels of lysyl oxidase propeptide (LOX-PP) are associa...

journal_title：Oncology reports

authors： Zheng Y,Wang X,Wang H,Yan W,Zhang Q,Chang X

更新日期：2014-04-01 00:00:00

abstract：:Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. Various physiological and pathological conditions such as glucose starvation, inhibition of protein glycosylat...

journal_title：Oncology reports

authors： Coker-Gürkan A,Arisan ED,Obakan P,Akalın K,Özbey U,Palavan-Unsal N

更新日期：2015-06-01 00:00:00

abstract：:The present study investigated the expression and potential influence of SHC SH2 domain‑binding protein 1 (SHCBP1) in gastric cancer (GC) cells. SHCBP1 is closely related to cell proliferation and cell cycle progression, but its role in GC remains unclear. The TCGA database revealed that SHCBP1 is highly expressed in ...

journal_title：Oncology reports

authors： Dong YD,Yuan YL,Yu HB,Tian GJ,Li DY

更新日期：2019-03-01 00:00:00

abstract：:Aberrant nuclear factor-erythroid 2 (NRF2) expression correlates with tumor development. We investigated NRF2 expression in ovarian epithelial carcinoma (OEC), aiming to identify associations with clinicopathological factors, hormones and induced reactive oxygen species (ROS). Immun...

journal_title：Oncology reports

authors： Liao H,Zhou Q,Zhang Z,Wang Q,Sun Y,Yi X,Feng Y

更新日期：2012-06-01 00:00:00

abstract：:Recent studies suggest that latexin (Lxn) expression is involved in stem cell regulation and that it plays significant roles in tumor cell migration and invasion. The clinicopathological significance of Lxn expression and its possible correlation with CD133 expression in pancreatic ductal adenocarcinoma (PDAC) is curr...

journal_title：Oncology reports

authors： Xue Z,Zhou Y,Wang C,Zheng J,Zhang P,Zhou L,Wu L,Shan Y,Ye M,He Y,Cai Z

更新日期：2016-01-01 00:00:00

abstract：:The t(8;21) translocation is one of the most frequent chromosome abnormalities associated with acute myeloid leukaemia (AML). This abberation deregulates numerous molecular pathways including the ERK signalling pathway among others. Therefore, the aim of the present study was to investigate the gene expression pattern...

journal_title：Oncology reports

authors： Bashanfer SAA,Saleem M,Heidenreich O,Moses EJ,Yusoff NM

更新日期：2019-03-01 00:00:00

abstract：:The present study determined the anticancer activity and its mechanism of microRNA‑133b on cell proliferation of cisplatin-induced non-small cell lung cancer cells. The expression of microRNA-133b cisplatin‑induced non-small cell lung cancer (NSCLC) tissue was lower than that of para-carcinoma tissue in patients. Over...

journal_title：Oncology reports

authors： Li B,Ding CM,Li YX,Peng JC,Geng N,Qin WW

更新日期：2018-03-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is an oncogene that promotes cell survival, proliferation, and motility. In the present study, we explored the mechanism involved in the inhibition by epigallocatechin-3-gallate (EGCG) of STAT3 signaling as detected by surface plasmon resonance (SPR)-binding a...

journal_title：Oncology reports

authors： Wang Y,Ren X,Deng C,Yang L,Yan E,Guo T,Li Y,Xu MX

更新日期：2013-12-01 00:00:00

abstract：:Thymidylate synthase (TS) is the rate-limiting enzyme in the synthesis of pyrimidine nucleotides, required for DNA synthesis, and is also a critical target for fluoropyrimidines, which are widely used in the treatment of gastrointestinal tumours. We examined TS expression in tumours from 86 patients with advanced colo...

journal_title：Oncology reports

authors： Bendardaf R,Lamlum H,Elzagheid A,Ristamäki R,Pyrhönen S

更新日期：2005-09-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) families are receptors for ligands that initiate extracellular or intracellular signaling, such as lipopolysaccharides (LPS). It has been reported that TLR4 activation resulted in the upregulation of a coordinated set of proinflammatory mediators and inhibition of matrix expression in the i...

journal_title：Oncology reports

authors： Zhang Q,Weng Y,Jiang Y,Zhao S,Zhou D,Xu N

更新日期：2018-08-01 00:00:00

abstract：:Although antiestrogens significantly improve the survival of patients with ER-positive breast cancer, therapeutic resistance remains a major limitation. The combinatorial use of antiestrogen with other therapies was proposed to increase their efficiency and more importantly, to prevent or delay the resistance phenomen...

journal_title：Oncology reports

authors： Maynadier M,Basile I,Gallud A,Gary-Bobo M,Garcia M

更新日期：2016-08-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, and only 15% of lung cancer patients live more than 5 years. microRNAs (miRNAs) are endogenously expressed non-coding RNAs, and dysregulation of miRNAs is a common feature in human cancers including lung cancer. In this study, w...

journal_title：Oncology reports

authors： Chen Y,Min L,Zhang X,Hu S,Wang B,Liu W,Wang R,Gu X,Shen W,Lv H,Zou J,Chen Y,Xu X,Chen L

更新日期：2013-10-01 00:00:00

abstract：:The molecular mechanisms underlying the biological effects of carbon ions are unclear. The aim of this study was to explore the Wnt/β‑catenin pathway in regulating carbon ion (12C6+) radiation‑induced cellular toxicity. HLY78 is a Wnt‑specific small molecular modulator, whose effects on 12C6+ radiation‑induced damage ...

journal_title：Oncology reports

authors： Si J,Zhang J,Gan L,Guo M,Xie Y,Di C,Sun C,Wang F,Yan J,Zhang H

更新日期：2020-07-01 00:00:00

abstract：:The gene Nm23, which encodes for a nucleoside diphosphate kinase, has been defined as a metastasis-suppressor gene because of the inverse correlation between its expression and the metastatic capacity of the tumor cells. For colorectal cancer, however, the findings are equivocal. The aim of our study was to assess, in...

journal_title：Oncology reports

authors： Dusonchet L,Corsale S,Migliavacca M,Calò V,Bazan V,Amato A,Cammareri P,Totaro MS,Agnese V,Cascio S,La Rocca G,Sisto PS,Dardanoni G,Valerio MR,Grassi N,Latteri S,Cajozzo M,Buscemi M,Castorina S,Morello V,Tomasino R

更新日期：2003-09-01 00:00:00

abstract：:Lapatinib, an inhibitor of human epidermal growth factor receptor 2 (HER2) phosphorylation, has been reported to inhibit several types of tumors such as HER2-overexpressing breast cancer. However, the effect of lapatinib on the malignant phenotype of human osteosarcoma (OS) cells and the potential molecular mechanisms...

journal_title：Oncology reports

authors： Long XH,Zhang GM,Peng AF,Luo QF,Zhang L,Wen HC,Zhou RP,Gao S,Zhou Y,Liu ZL

更新日期：2014-01-01 00:00:00

abstract：:The present study investigated the effect of macrophage colony-stimulating factor (M-CSF) on the immune functions and blood cell counts of patients with ovarian carcinoma receiving cytotoxic chemotherapy (CTX). Seventy-five consecutive patients with white blood cell counts less than 3,000/microl after CTX were randoml...

journal_title：Oncology reports

authors： Shimizu Y,Utsugi K,Umezawa S,Shimizu K,Hasumi K,Suzuki M,Takaku F

更新日期：2001-07-01 00:00:00

abstract：:Acquisition of resistance to paclitaxel is a major obstacle to successful treatment of breast cancer patients, but the molecular mechanisms underlying the development of drug resistance remain largely unclear. The aim of the present study was to investigate the role and mechanism of action of miR‑200c‑3p in the resist...

journal_title：Oncology reports

authors： Chen J,Tian W,He H,Chen F,Huang J,Wang X,Chen Z

更新日期：2018-12-01 00:00:00

abstract：:Zinc finger protein 403 (ZFP403), located on human chromosome 17q12‑21, is closely associated with the development of cancer. However, to date, there are a limited number of studies on the biological functions of this gene, particularly in prostate cancer (PCa). The results of the present study demonstrated that compa...

journal_title：Oncology reports

authors： Xu X,Zhu Z,Xu Y,Tian S,Jiang Y,Zhao H

更新日期：2020-12-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a highly lethal malignant tumor arising from the biliary tract epithelium. Chronic inflammatory conditions, including primary sclerosing cholangitis, liver fluke infestation, and hepatolithiasis, are considered risk factors, but the cause is still unknown in most cases. Recent advances in m...

journal_title：Oncology reports

authors： Isomoto H

更新日期：2009-08-01 00:00:00

abstract：:Epigenetic changes as well as genetic changes are mechanisms of tumorigenesis. We aimed to identify novel genes that are silenced by DNA hypermethylation in hepatocellular carcinoma (HCC). We screened for genes with promoter DNA hypermethylation using a genome-wide methylation microarray analysis in primary HCC (the d...

journal_title：Oncology reports

authors： Yamada N,Yasui K,Dohi O,Gen Y,Tomie A,Kitaichi T,Iwai N,Mitsuyoshi H,Sumida Y,Moriguchi M,Yamaguchi K,Nishikawa T,Umemura A,Naito Y,Tanaka S,Arii S,Itoh Y

更新日期：2016-04-01 00:00:00

abstract：:Telomere-associated proteins function as survival factors in telomere maintenance, which are major contributors to radiosensitivity in human cancers. The aim of this study was to investigate the association of telomere-associated gene expression and radiation resistance in human larynx squamous carcinoma. The changes ...

journal_title：Oncology reports

authors： Tang T,Zhou FX,Lei H,Yu HJ,Xie CH,Zhou YF,Liu SQ

更新日期：2009-06-01 00:00:00