Quercetin acts as an antioxidant and downregulates CYP1A1 and CYP1B1 against DMBA-induced oxidative stress in mice.

abstract：:Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries, and mainly originates from an accumulation of abnormal B cells caused by the dysregulation of cell proliferation and apoptosis rates. The aberration of apoptosis-related genes in CLL cells results in defective apoptosis of CLL cells i...

journal_title：Oncology reports

authors： Fu C,Gong Y,Shi X,Sun Z,Niu M,Sang W,Xu L,Zhu F,Wang Y,Xu K

更新日期：2016-09-01 00:00:00

abstract：:Frequent frameshift mutations in the DNA mismatch repair genes hMSH3, and hMSH6, have been reported in colorectal and endometrial cancers with microsatellite instability, however, it is unclear whether they are similarly altered in ovarian endometrioid carcinoma. In this study, we examined frequency of frameshift muta...

journal_title：Oncology reports

authors： Albarracin CT,Silva EG,Malpica A,Luthra R,Liu J

更新日期：2004-12-01 00:00:00

abstract：:Doxorubicin (Dox) is one of the most commonly used and highly effective antineoplastic agents, but the clinical application of this broad spectrum drug is largely hampered by its poor stability and serious toxicity to normal tissues. Hence, it is essential to improve the therapeutic effect and decrease the systematic ...

journal_title：Oncology reports

authors： Zheng L,Gou M,Zhou S,Yi T,Zhong Q,Li Z,He X,Chen X,Zhou L,Wei Y,Qian Z,Zhao X

更新日期：2011-06-01 00:00:00

abstract：:Elimination of leukoplakia is one of the strategies for prevention of oral cancer. However, the efficacy of reducing malignant transformation for the treated leukoplakia has rarely been reported despite a number of studies addressing its malignant transformation to oral cancer after intervention. The obstacle to do so...

journal_title：Oncology reports

authors： Shiu MN,Chen TH

更新日期：2003-11-01 00:00:00

abstract：:Cumulative evidence suggests that long non-coding RNAs (lncRNAs) may be good biomarkers in various types of tumors. In the present study, we mined lncRNA expression profiling in 739 lung cancer patients from Gene Expression Omnibus (GEO) datasets. A risk score model was constructed based on the expression data of thes...

journal_title：Oncology reports

authors： Tu Z,He D,Deng X,Xiong M,Huang X,Li X,Hao L,Ding Q,Zhang Q

更新日期：2016-07-01 00:00:00

abstract：:High mobility group box-B1 (HMGB1), an autophagy activator, is crucial in tumorigenesis. However, its extracellular role and signaling in gastric cancer remain unclear. Samples were collected from gastric cancer patients and healthy controls. Immunohistochemistry and immunocytochemistry were used to determine the loca...

journal_title：Oncology reports

authors： Zhang QY,Wu LQ,Zhang T,Han YF,Lin X

更新日期：2015-04-01 00:00:00

abstract：:A phase II trial of vinorelbine and low dose prednisone in hormone-refractory metastatic prostate cancer was conducted in order to investigate its safety, efficacy and impact on quality of life. Vinorelbine was administered at the dose of 25 mg/m(2) i.v. weekly for 12 weeks and then biweekly, along with 10 mg of daily...

journal_title：Oncology reports

authors： Robles C,Furst AJ,Sriratana P,Lai S,Chua L,Donnelly E,Solomon J,Sundaram M,Feun L,Savaraj N

更新日期：2003-07-01 00:00:00

abstract：:Elevated serum CA15‑3 assessed by enzyme‑linked immunosorbent assay (ELISA) has been considered a diagnostic marker of breast cancer. However, accumulating data indicate that the current ELISA system for detecting CA15‑3, which targets the peptide backbone of CA15‑3, is not sufficiently sensitive to detect early or lo...

journal_title：Oncology reports

authors： Choi JW,Moon BI,Lee JW,Kim HJ,Jin Y,Kim HJ

更新日期：2018-07-01 00:00:00

abstract：:We aimed to examine the relationship between the preoperative GSA index [uptake ratio of the liver to the liver plus heart at 15 min (LHL15) to uptake ratio of the heart at 15 min to that at 3 min (HH15) ratio] calculated from 99mTc‑labeled diethylene triamine pentaacetate-galactosyl human serum albumin (99mTc-GSA) sc...

journal_title：Oncology reports

authors： Nishikawa H,Osaki Y,Komekado H,Sakamoto A,Saito S,Nishijima N,Nasu A,Arimoto A,Kita R,Kimura T

更新日期：2015-03-01 00:00:00

abstract：:DNA damage sensor proteins are recognized as upstream components of the DNA damage checkpoint signaling pathway and are required for cell cycle control and the induction of apoptosis. hRad9 plays an important role as an upstream regulator of checkpoint signaling. In our previous studies, we confirmed the significant a...

journal_title：Oncology reports

authors： Yuki T,Maniwa Y,Doi T,Okada K,Nishio W,Hayashi Y,Okita Y

更新日期：2008-11-01 00:00:00

abstract：:The aim of this study was to evaluate the clinicopathological prognostic factors in patients with stage IVb cervical carcinoma (CC). All patients with stage IVb CC included in the study were diagnosed from 1997 to 2006 at the National Cancer Center Hospital. We retrospectively examined clinicopathological parameters i...

journal_title：Oncology reports

authors： Nishio S,Katsumata N,Matsumoto K,Tanabe H,Yonemori K,Kohno T,Shimizu C,Ando M,Kasamatsu T,Fujiwara Y

更新日期：2008-02-01 00:00:00

abstract：:Rab is a large subfamily of small GTPases which play an important role in multiple processes relating to cellular transportation and modulation of the cytoskeleton. Novel gene Rab-like 3 (Rabl3), which we originally reported as a new member belonging to this subfamily, may participate in other processes in human cance...

journal_title：Oncology reports

authors： Li Q,Wang L,Zeng L,Zhang Y,Li K,Jin P,Su B,Wang L

更新日期：2010-08-01 00:00:00

abstract：:Fecal microRNAs (miRNAs) are increasingly explored as non-invasive markers of colorectal cancer (CRC). However, its holistic profile in Asian CRC patients remains elusive. In the present study, the global human fecal miRNAs in Asian Chinese CRC patients was assayed to elucidate novel diagnostic fecal markers. Addition...

journal_title：Oncology reports

authors： Phua LC,Chue XP,Koh PK,Cheah PY,Chan EC,Ho HK

更新日期：2014-07-01 00:00:00

abstract：:Hypoxia was shown to increase tumor cell invasion into the extracellular matrix in vitro. This result suggests that heparanase (Hpa), one of the key enzymes involved in tumor invasion and metastasis, may be regulated by hypoxia. RT-PCR, Western blot and Matrigel invasive assays were used to study the regulation of Hpa...

journal_title：Oncology reports

authors： Wu W,Pan C,Meng K,Zhao L,Du L,Liu Q,Lin R

更新日期：2010-01-01 00:00:00

abstract：:No information is currently available regarding pancreatic cancer (PC) pattern of care in Italy. In the present study, a nationwide survey using a questionnaire was performed to enquire the local standards for PC diagnosis and radiotherapy treatment. Fifty-seven percent of 140 Italian centres completed questionnaire. ...

journal_title：Oncology reports

authors： Macchia G,Sainato A,Talamini R,Boz G,Bacigalupo A,Caravatta L,Fiore M,Friso ML,Fusco V,Lupattelli M,Mantello G,Mattiucci GC,Slim N,Sciacero P,Turri L,Valentini V,Morganti AG,Genovesi D

更新日期：2015-07-01 00:00:00

abstract：:We showed that the HER2/Grb2/Akt pathway induces all-trans retinoic acid (ATRA) resistance in breast cancer cells by suppressing the DNA binding activity of retinoic acid receptors (RAR). AP-1 activation was shown to induce ATRA resistance. Here, we determined whether AP-1 binding activity is correlated with ATRA resi...

journal_title：Oncology reports

authors： Mendoza-Gamboa E,Siwak DR,Tari AM

更新日期：2004-10-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations are frequently found in a variety of tumors. However, the role of mtDNA mutations in tumor behavior is poorly understood. We explored the effects of mtDNA mutations on tumor phenotype employing mtDNA-depleted SK-Hep1 rho0 hepatoma cells. Expression of hypoxia inducible factor (HIF)-...

journal_title：Oncology reports

authors： Cheon H,Moon HE,Lee MS,Kim SS

更新日期：2010-03-01 00:00:00

abstract：:Taxanes, a new class of antitumor drugs, are effective against a large number of human tumors, although there are problems with drug resistance. The novel taxane, IDN5109, is characterized by its high tolerability, antitumor efficacy, ability to overcome multidrug resistance, and oral bioavailabilty. We investigated t...

journal_title：Oncology reports

authors： Sano D,Matsuda H,Ishiguro Y,Nishimura G,Kawakami M,Tsukuda M

更新日期：2006-02-01 00:00:00

abstract：:The outcome of patients with advanced stage rhabdomyosarcoma (RMS) is still sobering. This outcome has not improved through conservative treatments. Therefore, novel treatment approaches such as immunotherapy need to be evaluated in human-adapted animal models. The aim of this study was to develop a humanized mouse mo...

journal_title：Oncology reports

authors： Seitz G,Pfeiffer M,Fuchs J,Warmann SW,Leuschner I,Vokuhl C,Lang P,Handgretinger R,Armeanu-Ebinger S

更新日期：2010-10-01 00:00:00

abstract：:SRY-box containing gene 17 (Sox17), a transcription factor, is considered as an antagonist to canonical Wnt/β‑catenin signaling in several types of malignant tumors. As the influence of Sox17 in the pathogenesis of human melanoma is still unknown, the investigation of Sox17 expression in melanoma is warranted and its ...

journal_title：Oncology reports

authors： Lu J,Zhang G,Cheng Y,Tang Y,Dong Z,McElwee KJ,Li G

更新日期：2014-12-01 00:00:00

abstract：:Human leukocyte antigen B (HLA-B), a novel member of the NF-kappaB signal pathway in laryngeal squamous cell carcinoma (LSCC), mediates immunological surveillance of tumor cells by presenting peptides to cytotoxic T-lymphocytes (CTLs) together with S100 calcium binding protein A8 (S100A8). The objective of this study ...

journal_title：Oncology reports

authors： Guo Y,Liu J,Xu Z,Sun K,Fu W

更新日期：2008-06-01 00:00:00

abstract：:Male breast cancer (MBC) is extremely rare, with an incidence in the general US population of <1%. It tends to be diagnosed at later stages than breast cancer in females, likely because of low awareness on the part of the patient and low suspicion by the physician. Risk factors include genetic predisposition, alterati...

journal_title：Oncology reports

authors： Johansen Taber KA,Morisy LR,Osbahr AJ 3rd,Dickinson BD

更新日期：2010-11-01 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is involved in malignant transformation and the biological aggressiveness of several human malignancies. Growing evidence indicates that EZH2 may be an appropriate therapeutic target for malignancies, including cholangiocarcinoma. Recently, an S-adenosyl-L-homocysteine hydrolase inhi...

journal_title：Oncology reports

authors： Nakagawa S,Sakamoto Y,Okabe H,Hayashi H,Hashimoto D,Yokoyama N,Tokunaga R,Sakamoto K,Kuroki H,Mima K,Beppu T,Baba H

更新日期：2014-02-01 00:00:00

abstract：:To study the role of the chemokine receptor CCR7 in the metastatic process, a murine CCR7 gene was transduced in two mammary cancer cell lines with different origins and molecular features; TS/A, derived from a spontaneous mammary cancer of BALB/c strain, and N202.1A, derived from a HER-2/neu transgenic mammary cancer...

journal_title：Oncology reports

authors： Croci S,Nicoletti G,Landuzzi L,Palladini A,Chiarini F,Nanni P,Lollini PL,De Giovanni C

更新日期：2007-08-01 00:00:00

abstract：:In this study, a total of 108 patients with primary colorectal cancer who underwent hybrid 2-port hand-assisted laparoscopic surgery (HALS) were classified as 58 patients with colon cancer and 50 patients with rectal cancer. The mean operating time, mean blood loss, postoperative complications, and mean postoperative ...

journal_title：Oncology reports

authors： Mukai M,Kishima K,Tajima T,Hoshikawa T,Yazawa N,Fukumitsu H,Okada K,Ogoshi K,Makuuchi H

更新日期：2009-10-01 00:00:00

abstract：:Migration and adhesion of tumor cells are essential prerequisites for the formation of metastases in malignant diseases. Chemokine receptor 7 (CCR7) has been shown to regulate integrin which can then facilitate adhesion of cancer cells to and/or migration through the extracellular matrix (ECM). In order to identify th...

journal_title：Oncology reports

authors： Li P,Zhao ZJ,Liu FY,Sun LY,Ding X,Zhang WZ,Shang DH,Sun CF

更新日期：2010-10-01 00:00:00

abstract：:Insulin resistance (IR) is reportedly involved in the progression of hepatocellular carcinoma (HCC). Since neovascularization plays an important role in hepatocarcinogenesis and IR, an angiostatic therapy may be considered as one of the promising approaches for chemoprevention again...

journal_title：Oncology reports

authors： Yoshiji H,Noguchi R,Ikenaka Y,Kaji K,Aihara Y,Yamazaki M,Yamao J,Toyohara M,Mitoro A,Sawai M,Yoshida M,Morioka C,Fujimoto M,Uemura M,Fukui H

更新日期：2011-12-01 00:00:00

abstract：:Breast cancer is the most common cancer type and the leading cause of cancer‑associated mortality in women across the majority of countries. In general, the incidence of breast cancer has been decreasing in developed countries over the previous 20 years, while it has increased in the other areas, such as the Asian‑Pac...

journal_title：Oncology reports

authors： Han R,Zhao J,Lu L

更新日期：2020-06-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related mortality worldwide. microRNAs (miRNAs) are small post-transcriptional regulatory non-coding RNAs that function as oncogenes or tumor suppressors in human cancers. Emerging evidence reveals that deregulation of miRNAs contributes to the progression of human lung cance...

journal_title：Oncology reports

authors： Jiang X,Chen X,Chen L,Ma Y,Zhou L,Qi Q,Liu Y,Zhang S,Luo J,Zhou X

更新日期：2015-02-01 00:00:00

abstract：:Colorectal cancer (CRC) is still one of the most important neoplasias causing human death. Multidisciplinary therapy has won consensus in the management of CRC, of which, radiotherapy occupies an important position. However, radioresistance is still a major obstacle in local control of CRC. Overexpression of long non-...

journal_title：Oncology reports

authors： Yang XD,Xu HT,Xu XH,Ru G,Liu W,Zhu JJ,Wu YY,Zhao K,Wu Y,Xing CG,Zhang SY,Cao JP,Li M

更新日期：2016-01-01 00:00:00