An eight-long non-coding RNA signature as a candidate prognostic biomarker for lung cancer.

abstract：:With the ever-increasing number of drugs approved to treat cancers, selection of the optimal treatment regimen for an individual patient is challenging. Breast cancer complexity requires novel predictive methods and tools. In the present study, we set up experimental conditions to obtain an 'ex vivo' organotypic cultu...

journal_title：Oncology reports

authors： Vesci L,Carollo V,Roscilli G,Aurisicchio L,Ferrara FF,Spagnoli L,De Santis R

更新日期：2015-09-01 00:00:00

abstract：:Lung cancer is one of the most common cancers worldwide and accounts for 28% of all cancer-related deaths. The expression of the β2‑adrenergic receptor (β2‑AR), one of the stress‑inducible receptors, has been reported to be closely correlated with malignant tumors. However, the role of β2‑AR activation in human lung e...

journal_title：Oncology reports

authors： Hu P,He J,Liu S,Wang M,Pan B,Zhang W

更新日期：2016-09-01 00:00:00

abstract：:MicroRNAs (miRNAs or miRs) contribute to the development of various malignant neoplasms, including glioblastoma multiforme (GBM). The present study aimed to explore the pathogenesis of GBM and to identify latent therapeutic agents for patients with GBM, based on an in silico analysis. Gene chips that provide miRNA exp...

journal_title：Oncology reports

authors： Xiong DD,Xu WQ,He RQ,Dang YW,Chen G,Luo DZ

更新日期：2019-04-01 00:00:00

abstract：:The aim of the study was to compare cross sections with longitudinal sections in histopathological examination of the rat heart after irradiation, to find the most optimal method for the detection of cardiac radiation injuries. For this purpose, rats were irradiated locally on the heart with a single dose of 0 or 20 G...

journal_title：Oncology reports

authors： Boerma M,Zurcher C,Esveldt I,Schutte-Bart CI,Wondergem J

更新日期：2004-08-01 00:00:00

abstract：:Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Frequent metastasis and recurrence are the main reasons for the poor prognosis of PC patients. Thus, the discovery of new biomarkers and wider insights into the mechanisms involved in pancreatic tumorigenesis and metastasis is cruc...

journal_title：Oncology reports

authors： Ma D,Jing X,Shen B,Liu X,Cheng X,Wang B,Fu Z,Peng C,Qiu W

更新日期：2016-08-01 00:00:00

abstract：:Perylenequinones that generate reactive oxygen species (ROS) when illuminated with visible light have been recommended as photodynamic chemotherapeutic agents. One of these is calphostin C (CalC), the action of the photo-activated derivative of which, CalCphiE, has been ascribed to its ability to selectively and irrev...

journal_title：Oncology reports

authors： Chiarini A,Whitfield JF,Pacchiana R,Marconi M,Armato U,Dal Prà I

更新日期：2010-04-01 00:00:00

abstract：:It has been revealed by our previous proteomic study that the expression profile is different between well‑differentiated and poorly differentiated hepatocellular carcinoma (HCC). Among those differently expressed proteins, peroxiredoxin2 (PRDX2) was our protein of interest. The present study aimed to further investig...

journal_title：Oncology reports

authors： Bai B,Lin Y,Hu J,Wang H,Li L,Zhao S,Zhang J,Meng W,Yue P,Bai Z,Li X

更新日期：2019-03-01 00:00:00

abstract：:The current study characterized peripheral blood mononuclear cells (PBMC) obtained from leukapheresis products of patients with non-small cell lung cancer (NSCLC) for cytokine release, the ability to incorporate tritiated thymidine following stimulation using PHA as well as the levels of both CD4 and CD8 regulatory T ...

journal_title：Oncology reports

authors： Yannelli JR,Tucker JA,Hidalgo G,Perkins S,Kryscio R,Hirschowitz EA

更新日期：2009-12-01 00:00:00

abstract：:Tobacco smoke is one of the serious risk factors of gastric cancer. Epithelial‑mesenchymal transition (EMT) has been shown to be associated with the initiation and carcinogenesis of gastric cancer. The role of Notch pathway in regulating tobacco smoke-induced EMT has not been investigated. β‑carotene, a carotenoid pre...

journal_title：Oncology reports

authors： Lu L,Chen J,Li M,Tang L,Wu R,Jin L,Liang Z

更新日期：2018-04-01 00:00:00

abstract：:Accumulating evidence has shown that aberrantly expressed microRNAs (miRNAs) are associated with tumor development and progression. Our previous study found that microRNA-375 (miR-375) was downregulated in colorectal cancer (CRC), but little is known concerning the role of miR-375 and the related mechanism in CRC deve...

journal_title：Oncology reports

authors： Cui F,Wang S,Lao I,Zhou C,Kong H,Bayaxi N,Li J,Chen Q,Zhu T,Zhu H

更新日期：2016-07-01 00:00:00

abstract：:We investigated the effects of combined treatment with 5-fluorouracil and apigenin on proliferation and apoptosis, as well as the underlying mechanism, in human breast cancer MDA-MB-453 cells. The MDA-MB-453 cells, which have been shown to overexpress ErbB2, were resistant to 5-fluorouracil; 5-fluorouracil exhibited a...

journal_title：Oncology reports

authors： Choi EJ,Kim GH

更新日期：2009-12-01 00:00:00

abstract：:Antimycin A (AMA) inhibits the mitochondrial electron transport between cytochromes b and c. However, the relationship between AMA and lung cancer cells is poorly understood. In this study, we investigated the involvement of reactive oxygen species (ROS) and glutathione (GSH) in AMA-treated lung cancer Calu-6 cell dea...

journal_title：Oncology reports

authors： Han YH,Park WH

更新日期：2009-01-01 00:00:00

abstract：:Esculetin, a phenolic compound, has been shown to inhibit the growth of colon tumors in animal studies. However, the roles of signaling pathways and cell cycle regulation in the esculetin-induced inhibition of cancer cell growth, remain to be elucidated. The present study suggests a novel mechanism for the Ras/ERK1/2 ...

journal_title：Oncology reports

authors： Park SS,Park SK,Lim JH,Choi YH,Kim WJ,Moon SK

更新日期：2011-01-01 00:00:00

abstract：:Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis. The present study was performed to characterize the role of Fzd2 in the migration and invasion of oral squamous cell carcinomas (OSCC) in...

journal_title：Oncology reports

authors： Zhang E,Li Z,Xu Z,Duan W,Sun C,Lu L

更新日期：2015-12-01 00:00:00

abstract：:Although ascorbate (Vitamin C) has been shown to inhibit cell growth and induce cell death in variety of cancer cells, results reported in other studies are inconsistent with this conclusion. It was previously reported that ascorbate induces apoptosis in human breast cancer cells. However, the molecular mechanism for ...

journal_title：Oncology reports

authors： Hong SW,Jin DH,Hahm ES,Yim SH,Lim JS,Kim KI,Yang Y,Lee SS,Kang JS,Lee WJ,Lee WK,Lee MS

更新日期：2007-10-01 00:00:00

abstract：:The identification of large numbers of genetic mutations in immature myeloid cells has made it difficult to identify specific targets for acute myeloid leukemia (AML) therapy. Although current pharmacological targets for controlling cancer are focused on identifying genetic mutations, it is hard to develop the specifi...

journal_title：Oncology reports

authors： Ryu I,Ryu MJ,Han J,Kim SJ,Lee MJ,Ju X,Yoo BH,Lee YL,Jang Y,Song IC,Chung W,Oh E,Heo JY,Kweon GR

更新日期：2018-12-01 00:00:00

abstract：:Few studies on sarcomas have examined the relationships between microsatellite alterations in particular loci, tumor prognosis and tumorigenesis, because sarcomas are uncommon and those prognoses can be confounded by coexisting factors, such as tumor site. We studied the relationship between microsatellite alterations...

journal_title：Oncology reports

authors： Iyoda A,Hiroshima K,Toyozaki T,Baba M,Fujisawa T,Yusa T,Ohwada H

更新日期：2001-07-01 00:00:00

abstract：:Pin-1 has been shown to regulate several phases of the cell cycle and is strikingly overexpressed in many human cancers. Vascular endothelial growth factor (VEGF)-C is a potent lymphangiogenic factor produced by tumor and stromal cells. However, little is known about the roles of Pin-1 and VEGF-C in breast carcinoma. ...

journal_title：Oncology reports

authors： Kim BC,Han SI,Lim SC

更新日期：2009-12-01 00:00:00

abstract：:In this study, a total of 108 patients with primary colorectal cancer who underwent hybrid 2-port hand-assisted laparoscopic surgery (HALS) were classified as 58 patients with colon cancer and 50 patients with rectal cancer. The mean operating time, mean blood loss, postoperative complications, and mean postoperative ...

journal_title：Oncology reports

authors： Mukai M,Kishima K,Tajima T,Hoshikawa T,Yazawa N,Fukumitsu H,Okada K,Ogoshi K,Makuuchi H

更新日期：2009-10-01 00:00:00

abstract：:The modifying effect of dietary tuna (Thunnus thynnus orientalis) orbital oil rich in docosahexaenoic acid (DHA) and vitamin D3 (VD3) on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) was investigated in male F344 rats. Animals were given three weekly subcutaneous injections of AOM (15...

journal_title：Oncology reports

authors： Kohno H,Yamaguchi N,Ohdoi C,Nakajima S,Odashima S,Tanaka T

更新日期：2000-09-01 00:00:00

abstract：:Photodynamic therapy (PDT) using photosensitizer can induce diverse cellular responses, including apoptosis. Recently, it has been reported that PDT using methylaminolaevulinate may be effective in basal cell carcinoma. However, it is largely unknown whether PDT using a natural product such as curcumin can induce apop...

journal_title：Oncology reports

authors： Park K,Lee JH

更新日期：2007-03-01 00:00:00

abstract：:The model animal of renal cell carcinoma (RCC), the Eker rat, has a germline mutation in the tuberous sclerosis 2 (Tsc2) gene. Heterozygous mutants develop RCCs by second hit in the wild-type Tsc2 allele, whereas homozygous mutants are embryonic lethal. In the present study, a new cell differentiation model was develo...

journal_title：Oncology reports

authors： Kawano H,Ito Y,Kanai F,Nakamura E,Tada N,Takai S,Horie S,Kobayashi T,Hino O

更新日期：2015-11-01 00:00:00

abstract：:The antitumor effect of the human umbilical vein endothelial cell (HUVEC) vaccine has been well documented; however, its anti‑angiogenic effects on human esophageal squamous cell carcinoma (ESCC) have yet to be studied. In the present study, a 'humanized' mouse model was established by transplanting NOD/SCID mice with...

journal_title：Oncology reports

authors： Liu H,Zhao J,Yang Y,Jin G,Zhang X,Wang D,Xie C,Liu K,Chen X,Li X,Tian F,Dong Z,Lu J

更新日期：2018-11-01 00:00:00

abstract：:Histone deacetylases (HDACs) have been shown to play important roles in the regulation of chromatin remodeling by histone deacetylation, and their expression is induced in several types of cancer. In addition, they are known to be associated with resistance to anticancer drugs. However, the relevance of HDAC4 in chemo...

journal_title：Oncology reports

authors： Yu SL,Lee DC,Son JW,Park CG,Lee HY,Kang J

更新日期：2013-09-01 00:00:00

abstract：:Inhibitor of DNA-binding protein 1 (ID1) is commonly abnormally overexpressed in colorectal cancer (CRC); yet, the functional significance of ID1 in the growth and invasive properties of CRC cells remains largely unclear. The present study investigated the effects of ID1 downregulation on the cell growth and metastati...

journal_title：Oncology reports

authors： Lai X,Liao J,Lin W,Huang C,Li J,Lin J,Chen Q,Ye Y

更新日期：2014-07-01 00:00:00

abstract：:The tumour suppressor protein p53 (wild-type = wt-p53) is of major importance in the genetic integrity of the cell. Mutations of the p53-gene (mt-p53) are the most frequent genetic aberrations identified in different tumour entities. As analyzed in a wide variety of human malignomas, mt-p53 evokes a specific immune re...

journal_title：Oncology reports

authors： Cordes C,Von Lingen J,Görögh T,Ambrosch P,Gottschlich S,Hoffmann M

更新日期：2009-12-01 00:00:00

abstract：:While Taxol has been reported to improve the clinical survival of breast cancer patients, subsequently developed drug-resistance of the cancer cells limits its final efficacy and applications. Previous studies suggested that Aurora A is involved in the development of the Taxol-resistance of breast cancer. We establish...

journal_title：Oncology reports

authors： Li Y,Zhou W,Tang K,Chen X,Feng Z,Chen J

更新日期：2017-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common tumors in the world. At present, the details of the mechanism responsible for HCC formation and maintenance remain unclear. However, the cancer stem cell (CSC) theory suggests that liver cancer stem cells (LCSCs) may be respon...

journal_title：Oncology reports

authors： Song K,Wu J,Jiang C

更新日期：2013-01-01 00:00:00

abstract：:Ras-association domain family of proteins (RASSF) is characterized by the Ras-association (RA) domain at the C-terminal. Frequent inactivation of RASSF1A gene in human cancers suggests that other members of the family may also play an important role in tumorigenesis. By in silico gene searches, the number of RASSF fam...

journal_title：Oncology reports

authors： Chow LS,Lo KW,Kwong J,Wong AY,Huang DP

更新日期：2004-10-01 00:00:00

abstract：:The cancer stem cell hypothesis suggests that mutated melanocyte stem cells are present in skin as precursors of melanoma cells. Nestin and CD133 have been described as markers of melanocytic stem cells. The aim of this study was to establish if melanocytic stem cells could have a prognostic significance in melanoma p...

journal_title：Oncology reports

authors： Piras F,Perra MT,Murtas D,Minerba L,Floris C,Maxia C,Demurtas P,Ugalde J,Ribatti D,Sirigu P

更新日期：2010-01-01 00:00:00