Abstract:
:The modifying effect of dietary tuna (Thunnus thynnus orientalis) orbital oil rich in docosahexaenoic acid (DHA) and vitamin D3 (VD3) on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) was investigated in male F344 rats. Animals were given three weekly subcutaneous injections of AOM (15 mg/kg body weight) to induce ACF. The rats were fed the experimental diet containing 5% tuna orbital oil (low fish oil), 23.5% tuna orbital oil (high fish oil), 5% corn oil (low corn oil) or 23.5% corn oil (high corn oil) for 5 weeks, starting 1 week before the first dose of AOM. Animals were sacrificed 2 weeks after the last AOM injection to count colonic ACF and assay the expression of cyclooxygenase (COX)-1 and -2. High corn oil diet significantly increased the development of ACF, when compared with low corn oil diet (P<0.005). High fish oil diet also increased ACF formation compared with low fish oil diet (P<0.01), but the increase was smaller than high corn oil diet. The frequency of ACF was significantly lower in the rats fed high fish oil diet than high corn oil diet (P<0.02). Moreover, frequency of ACF consisted of 4 or more crypts in rats fed the high fish oil diet was significantly lower than that of rats given high corn oil diet. COX-1 and COX-2 expression did not significantly differ among the groups. These results suggest that fish oil derived from tuna, which contains high amounts of DHA and VD3, suppresses the formation and growth of ACF without affecting COX-1 and COX-2 expression, and may have a preventive effect on colon carcinogenesis.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Kohno H,Yamaguchi N,Ohdoi C,Nakajima S,Odashima S,Tanaka Tdoi
10.3892/or.7.5.1069keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
1069-74issue
5eissn
1021-335Xissn
1791-2431journal_volume
7pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Malignant pleural mesothelioma (MPM) is locally aggressive and challenging to quantitate non-invasively in vivo, particularly in orthotopic models of disease. We describe imaging of extracellular protease activity, typically elevated in locally aggressive tumors, as a novel method f...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1888
更新日期:2012-09-01 00:00:00
abstract::Resistance to chemotherapeutic agents is a major problem for successful cancer treatment. P-glycoprotein (Pgp), a product of the multidrug resistance (MDR)1 gene expressed in cancer cells, is one of the mechanism of MDR. However, there are few reports regarding the effects of Pgp on prognosis of colorectal cancer (CRC...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.4.815
更新日期:2001-07-01 00:00:00
abstract::The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas. Somatic mutations of Bcl10 were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other tumors. To clarify the actual frequency and spectrum of Bcl10 mutat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.6.1333
更新日期:2001-11-01 00:00:00
abstract::Androgen receptor (AR) expression in prostate cancer (CaP) cells varies due to the multiple changes including epigenetic modifications such as DNA methylation and histone deacetylation. DNA methyltransferase and histone deacetylase inhibitors are promising for the treatment of CaP. The aim of our study was to analyze ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2344
更新日期:2013-05-01 00:00:00
abstract::Resistance to docetaxel, a chemotherapy drug for breast cancer (BC) treatment, occurs in ~50% of patients, and the underlying molecular mechanisms of drug resistance are not fully understood. Gene regulation through miR-141 has been proven to play an important role in cancer drug resistance. The present study investig...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3866
更新日期:2015-05-01 00:00:00
abstract::The emergence of radioresistance is a significant issue in the treatment of squamous cell carcinoma. We recently demonstrated that post-radiogenic extracellular signal-regulated kinase (ERK) signaling might decrease radiosensitivity in this cancer type. To further elucidate how tumo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2180
更新日期:2013-02-01 00:00:00
abstract::Inhibitor of DNA-binding protein 1 (ID1) is commonly abnormally overexpressed in colorectal cancer (CRC); yet, the functional significance of ID1 in the growth and invasive properties of CRC cells remains largely unclear. The present study investigated the effects of ID1 downregulation on the cell growth and metastati...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3172
更新日期:2014-07-01 00:00:00
abstract::Complement system activation contributes to various immune and inflammatory diseases, as well as cancers.However, the role of complement activation in the proliferation of cancer cells is not clear. In the present study, we investigated the consequences of complement activation on the proliferation of breast cancer ce...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3489
更新日期:2014-12-01 00:00:00
abstract::This study was aimed to obtain additional information on the activity of a cyclized 9-amino acid peptide (cP) containing the active site of alpha fetoprotein, which inhibits the estrogen-stimulated proliferation of tumor cells in culture and of xenografts in immunodeficient mice. Breast cancer cells cultured in the pr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::5-Aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is a new ablation treatment for tumors, while its function mechanism in cervical cancer has not been elucidated. In this study, we investigated the effects of ALA-PDT on the cervical cancer cell line Me180, to search for optimal parameters of PDT. ALA-PDT o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000295
更新日期:2009-04-01 00:00:00
abstract::Gastric cancer is a common malignancy worldwide. The prognosis of early stage gastric cancer patients has significantly improved in recent years. However, in progressive stage gastric cancer patients, the prognosis remains relatively poor due to tumor metastases. In our previous study, we showed that the expression of...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6681
更新日期:2018-11-01 00:00:00
abstract::The aberrant expression of miR107‑5p is closely related to the development of several types of human cancers. However, the role of miR‑107‑5p in endometrial carcinoma (EC) has not been fully confirmed. In the present study, we aimed to explore the function of miR‑107‑5p in EC carcinogenesis. EC samples and normal endo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6936
更新日期:2019-03-01 00:00:00
abstract::The aim of the present study was to research the apoptosis of human hepatocellular carcinoma cell line HepG 2 induced by pitavastatin. HepG 2 cells were treated with increasing doses of pitavastatin or with mevalonic acid for 48 h. The proliferation of cells was detected with WST-8. The morphology of the nucleus was o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-08-01 00:00:00
abstract::The aim of this study was to assess the use of human papillomavirus (HPV) E6/E7 mRNA testing in the follow-up of women treated for cervical intraepithelial neoplasia (CIN) by conization and to compare the prognostic value of HPV E6/E7 mRNA to HPV L1 DNA and cytology. One hundred and...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1755
更新日期:2012-07-01 00:00:00
abstract::A phase II trial of vinorelbine and low dose prednisone in hormone-refractory metastatic prostate cancer was conducted in order to investigate its safety, efficacy and impact on quality of life. Vinorelbine was administered at the dose of 25 mg/m(2) i.v. weekly for 12 weeks and then biweekly, along with 10 mg of daily...
journal_title:Oncology reports
pub_type: 临床试验,杂志文章
doi:10.3892/or.10.4.885
更新日期:2003-07-01 00:00:00
abstract::Frequent invasion of oral cancers into the neighboring jaw bones is a major cause of increased mortality. Moreover, majority of patients with these oral cancers suffer from functional inconveniences and esthetic disadvantages during clinical course and after surgical treatments. Understanding of the mechanisms underly...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-02-01 00:00:00
abstract::The emerging role of microRNA-181A (miR-181A) in CRC patients with late liver metastases was studied. In the present study we investigated the association between expression and mechanism of miRNA-181A, liver metastasis and prognosis of colorectal cancer (CRC). The expression of miR-181A and PTEN in CRC patients with ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4546
更新日期:2016-03-01 00:00:00
abstract::The objective of the present study was to explore the in vitro and in vivo anticancer effects of Platycodin D (PD), derived from Platycodin grandiflorum, on highly metastatic MDA-MB-231 breast cancer cells. Using the MTT assay, we found that PD inhibited MDA-MB-231 cell growth in a concentration-dependent manner, with...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4935
更新日期:2016-09-01 00:00:00
abstract::Multigene-based combination therapy may be an effective practice in cancer gene therapy. Substantial studies have demonstrated that tumor suppressor p53 acetylation is indispensable for p53 activation. Inhibitor of growth 4 (ING4), as a novel tumor suppressor, is capable of remarkably enhancing p53 acetylation and its...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4385
更新日期:2016-01-01 00:00:00
abstract::Chemokine (C-C motif) ligand 2 (CCL2) has been shown to play an important role in the regulation of tumor cell growth, metastasis and host immune response. CCL2 preferentially binds to the C-C chemokine receptor type 2 (CCR2), which is expressed in various tissues. However, the role of the CCL2/CCR2 axis in hepatocell...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6069
更新日期:2018-01-01 00:00:00
abstract::The degradation of basement membranes by tumor cells involves secretion and activation of proteinases, such as the matrix metalloproteinases (MMPs), and results from an imbalance between their inhibitors and activators that are controlled by various growth factors or cytokines, among which TGF-β(1) may be the most int...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.2128
更新日期:2013-02-01 00:00:00
abstract::The clinical applications of Rhizoma paridis in traditional Chinese medicine are well known. However, the therapeutic potential of Rhizoma paridis and its active component such as Paris saponin I (polyphyllin D) and Paris saponin II (PSII) (formosanin C) in cancer treatments have not yet been fully explored. Recent st...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3836
更新日期:2015-05-01 00:00:00
abstract::The present study aimed to investigate the role of miR‑181a in multiple myeloma (MM) cell lines. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect the expression of microRNA (miR)‑181a. The MM cell line RPMI 8226 stably transduced with miR‑181a mimics or inhibitor was establishe...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7160
更新日期:2019-07-01 00:00:00
abstract::Trop2 is considered to have an important function in tumor metastasis and the promotion of epithelial‑mesenchymal transition (EMT). E‑cadherin is a crucial factor in intercellular adhesion and EMT transformation. In the present study, we detected the expression of Trop2 and E‑cadherin in breast cancer (BC) to better d...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6496
更新日期:2018-08-01 00:00:00
abstract::The aim of this study is to assess, in squamous cell carcinoma of the cervix, the expression of pan-ras, c-myc and tp53 at protein level using an immunohistochemical (IHC) staining method. One hundred and seven patients with squamous cell carcinoma of the cervix were recruited. Fifty-four patients were of stage 1B/2A ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::The aim of the present study was to search for an effective regimen among existing chemotherapies for head and neck squamous cell carcinoma (HNSCC). Among the tested drugs, we focused on combined SN-38, which is the active metabolite produced from irinotecan hydrochloride - a type I DNA topoisomerase inhibitor - after...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6105
更新日期:2018-01-01 00:00:00
abstract::Currently, various types of keratins have been reported to be highly expressed in cancer cells and to be associated with a malignant phenotype. In the present study, it was found that expression levels of keratin 6 (K6), keratin 16 (K16), and keratin 17 (K17) were highly elevated in SNU601 cells resistant to cisplatin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7201
更新日期:2019-08-01 00:00:00
abstract::Mutations in the epidermal growth factor receptor (EGFR) make lung adenocarcinoma cells sensitive to EGFR tyrosine kinase inhibitors (TKIs). Long-term cancer therapy may cause the occurrence of acquired resistance to EGFR TKIs. Long non-coding RNAs (lncRNAs) play important roles in tumor formation, tumor metastasis an...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4758
更新日期:2016-06-01 00:00:00
abstract::WNT5B is a member of the WNT family that has been reported to be overexpressed in a variety of cancer cell lines and tissues, including colorectal cancer (CRC). However, the potential roles of WNT5B in tumorigenesis have not been reported. In the present study, the WNT5B gene was transfected into CRC cells and generat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4772
更新日期:2016-07-01 00:00:00
abstract::Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer-related mortality worldwide. Aberrant expression of miRNAs play important roles in the development and progression of various types of cancers by modulating oncogenic and tumour-suppressor pathways. Therefore, exploring the ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6135
更新日期:2018-02-01 00:00:00