Abstract:
:We showed that the HER2/Grb2/Akt pathway induces all-trans retinoic acid (ATRA) resistance in breast cancer cells by suppressing the DNA binding activity of retinoic acid receptors (RAR). AP-1 activation was shown to induce ATRA resistance. Here, we determined whether AP-1 binding activity is correlated with ATRA resistance in HER2-overexpressing cells. Inhibition of HER2/Grb2/Akt decreased AP-1 binding activity in HER2-transfected cells, but increased AP-1 activity in cells that are naturally HER2-overexpressing. Since HER2/Grb2/Akt inhibition sensitized both cell types to ATRA, our results indicate that, unlike RAR, AP-1 binding activity is not correlated with ATRA sensitivity in HER2-overexpressing breast cancer cells.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Mendoza-Gamboa E,Siwak DR,Tari AMkeywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
903-8issue
4eissn
1021-335Xissn
1791-2431journal_volume
12pub_type
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