Emodin inhibits epithelial to mesenchymal transition in epithelial ovarian cancer cells by regulation of GSK-3β/β-catenin/ZEB1 signaling pathway.

abstract：:In recent years an extensive series of synthetic combretastatin A-4 (CA-4)-azetidinone (β-lactam) hybrids were designed and synthesised with a view to improve the stability, therapeutic efficacy and aqueous solubility of CA-4. Lead compounds containing a 3,4,5-trimethoxy aromatic ring at position 1 and a variety of su...

journal_title：Oncology reports

authors： Greene LM,Wang S,O'Boyle NM,Bright SA,Reid JE,Kelly P,Meegan MJ,Zisterer DM

更新日期：2013-06-01 00:00:00

abstract：:The blood‑brain barrier (BBB) constitutes an efficient organization of tight junctions that limits the delivery of tumor to the brain. The principal tight junction protein in BBB is claudin‑5 (CLDN5), but its mechanism of action remains largely unknown. Long non‑coding RNAs (lncRNAs) are aberrantly expressed in many c...

journal_title：Oncology reports

authors： Ma SC,Li Q,Peng JY,Zhouwen JL,Zhang DN,Zhang CB,Jiang WG,Jia W

更新日期：2018-03-01 00:00:00

abstract：:In the present study, we analyzed the influence of brefeldin A (BFA) and castanospermine (CAS) on the activity, stability and localization of P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in various resistant cell lines. The impact of BFA and CAS on cell viability was assessed using the MTT test. We...

journal_title：Oncology reports

authors： Wojtowicz K,Januchowski R,Sosińska P,Nowicki M,Zabel M

更新日期：2016-05-01 00:00:00

abstract：:Lymph node metastasis is one of the most important prognostic factors for cancer patients. There are few animal models of lymph node metastasis. The purpose of this study was to develop a simple animal model without surgical trauma. B16F10 melanoma (1 x 10(6) cells in 0.1 ml phosphate-buffered saline) were slowly inje...

journal_title：Oncology reports

authors： Ishibashi S,Sonoda K,Fujii K,Ishikawa K,Shiraishi N,Kitano S

更新日期：2004-07-01 00:00:00

abstract：:The MTA1 gene has been identified as metastasis-associated gene and has been seen to correlate with the degree of invasion and lymphatic metastasis in gastric, colorectal, and esophageal carcinomas. We investigated the possible role of MTA1 gene expression in hepatocellular carcinoma (HCC). The mRNA expression level o...

journal_title：Oncology reports

authors： Hamatsu T,Rikimaru T,Yamashita Y,Aishima S,Tanaka S,Shirabe K,Shimada M,Toh Y,Sugimachi K

更新日期：2003-05-01 00:00:00

abstract：:The androgen receptor (AR) plays an essential role in the development and progression of prostate cancer. Castration-resistant prostate cancer (CRPC) is a consequence of androgen deprivation therapy. Unchecked CRPC followed by metastasis is lethal. Some CRPCs show decreased AR gene expression due to epigenetic mechani...

journal_title：Oncology reports

authors： Fialova B,Luzna P,Gursky J,Langova K,Kolar Z,Trtkova KS

更新日期：2016-10-01 00:00:00

abstract：:The global rising incidence of hepatocellular carcinoma (HCC), which parallels the increase of hepatitis C virus (HCV) prevalence, has sparked a renewed interest in discovering additional HCC serum markers. In this study, we investigated the clinical use of serum E-cadherin, ICAM, MMP-2, VEGF, OPN and β-catenin as pot...

journal_title：Oncology reports

authors： Zekri AR,Bahnassy AA,Alam El-Din HM,Morsy HM,Shaarawy S,Moharram NZ,Daoud SS

更新日期：2011-10-01 00:00:00

abstract：:The emergence of radioresistance is a significant issue in the treatment of squamous cell carcinoma. We recently demonstrated that post-radiogenic extracellular signal-regulated kinase (ERK) signaling might decrease radiosensitivity in this cancer type. To further elucidate how tumo...

journal_title：Oncology reports

authors： Affolter A,Schmidtmann I,Mann WJ,Brieger J

更新日期：2013-02-01 00:00:00

abstract：:Large‑scale projects, such as The Cancer Genome Atlas (TCGA), Human Epigenome Project (HEP) and Human Epigenome Atlas (HEA), provide an insight into DNA methylation and histone modification markers. Changes in the epigenome significantly contribute to the initiation and progression of cancer. The goal of the present s...

journal_title：Oncology reports

authors： Kamińska K,Białkowska A,Kowalewski J,Huang S,Lewandowska MA

更新日期：2019-07-01 00:00:00

abstract：:In a screen for thoracic malignancy-associated markers, thyroid stimulating hormone receptor (TSHR) was identified as a candidate as it binds to the previously-characterized lung cancer marker NKX2-1. We screened for mutations in all coding regions of the TSHR gene in 96 lung adenoc...

journal_title：Oncology reports

authors： Kim JW,Lee S,Lui N,Choi H,Mulvihill M,Fang LT,Kang HC,Kwon YW,Jablons D,Kim IJ

更新日期：2012-10-01 00:00:00

abstract：:During the initial emergency operation, a temporary loop colostomy (TLC) was constructed at the oral border of the region for subsequent radical resection. Then, radical surgery was performed by hybrid 2-port HALS (Mukai's operation) using the TLC as the hand access site. Left hemicolectomy was done in three patients,...

journal_title：Oncology reports

authors： Mukai M,Sekido Y,Hoshikawa T,Yazawa N,Fukumitsu H,Okada K,Tajima T,Nakamura M,Ogoshi K

更新日期：2010-07-01 00:00:00

abstract：:Breast cancer is the most common type of cancer among women worldwide. Research using breast cancer cell lines derived from primary tumors may provide valuable additional knowledge regarding this type of cancer. Therefore, the aim of this study was to investigate the phenotypic prof...

journal_title：Oncology reports

authors： Corrêa NC,Kuasne H,Faria JA,Seixas CC,Santos IG,Abreu FB,Nonogaki S,Rocha RM,Aparecida Borges Silva G,Gobbi H,Rogatto SR,Goes AM,Gomes DA

更新日期：2013-04-01 00:00:00

abstract：:ABCG2 is a multidrug cellular transport protein that is associated with resistance to certain treatments in patients, particularly anticancer treatment. The tumor-protective properties of ABCG2 expression are reported to be a feature of a subset of stem cell-like tumor cells. While protection against chemotherapy has ...

journal_title：Oncology reports

authors： Zoernig I,Ziegelmeier C,Lahrmann B,Grabe N,Jäger D,Halama N

更新日期：2013-05-01 00:00:00

abstract：:Cyclooxygenase-2 (Cox-2) is an inducible enzyme that converts arachidonic acid to prostaglandins, and it is hypothesized to induce carcinogenesis and metastasis in colorectal cancer. Our previous data also indicated that a higher expression level of Cox-2 was correlated with colorec...

journal_title：Oncology reports

authors： Li ZG,Wang XY,Chang JL,Xie WB,Liu TF,Zhang QL,Deng YJ,Ding YQ

更新日期：2012-09-01 00:00:00

abstract：:Several investigators have demonstrated that TGF-beta stimulated clone-22 (TSC-22) regulates cell growth and differentiation, and cell death. TSC-22 is a putative transcriptional regulator containing a leucine zipper-like structure and a nuclear export signal. We previously showed the cytoplasmic localization of TSC-2...

journal_title：Oncology reports

authors： Hino S,Kawamata H,Omotehara F,Uchida D,Begum NM,Yoshida H,Sato M,Fujimori T

更新日期：2002-03-01 00:00:00

abstract：:Numerous studies have suggested that increased sialylation and fucosylation levels are signs of cancer progression. The majority of studies have focused on cell surface and bloodstream glycosylation changes associated with cancer progression, while little attention has been paid to changes in the glycosylation of cyto...

journal_title：Oncology reports

authors： Kim HJ,Kim SC,Ju W,Kim YH,Yin SY,Kim HJ

更新日期：2014-03-01 00:00:00

abstract：:Genetically modified tumour cells producing cytokines such as interleukin 12 (IL-12) are potent activators of the antitumour immune responses and represent a promising therapeutic modality when combined with chemotherapy. The objective of this study was to examine whether IL-12-producing cellular vaccines can augment ...

journal_title：Oncology reports

authors： Mikyšková R,Indrová M,Símová J,Bieblová J,Bubeník J,Reiniš M

更新日期：2011-06-01 00:00:00

abstract：:Activating mutations of Ras gene families have been found in a variety of human malignancies, including lung cancer, suggesting their dominant role in tumorigenesis. Many studies have showed that the Kras gene is activated by point mutations in approximately 15-20% of non-small cell lung cancers (NSCLCs), however, the...

journal_title：Oncology reports

authors： Sasaki H,Okuda K,Kawano O,Endo K,Yukiue H,Yokoyama T,Yano M,Fujii Y

更新日期：2007-09-01 00:00:00

abstract：:Circulating microRNAs (miRNAs) exist stably in body fluids and are potential biomarkers for hepatocellular carcinoma (HCC). Twenty-five patients with cirrhosis that evolved into HCC, who were treated at The Third Hospital of Zhenjiang Affiliated to Jiangsu University between January 2005 and December 2012, were enroll...

journal_title：Oncology reports

authors： Tan Y,Lin B,Ye Y,Wen D,Chen L,Zhou X

更新日期：2015-06-01 00:00:00

abstract：:The high affinity nerve growth factor (NGF) NGF receptor, p75NTR, is a member of the tumor necrosis factor (TNF) receptor superfamily that shares a conserved intracellular death domain capable of inducing apoptosis and suppressing growth in prostate epithelial cells. Expression of this receptor is lost as prostate can...

journal_title：Oncology reports

authors： Gravina GL,Marampon F,Sanità P,Mancini A,Colapietro A,Scarsella L,Jitariuc A,Biordi L,Ficorella C,Festuccia C

更新日期：2016-07-01 00:00:00

abstract：:Overexpression or amplification of G1 cyclins has been demonstrated in various types of human cancers. Overexpression of cyclin D1, an accelerator of cell cycle, is thought to be an early event in colonic multistage carcinogenesis, but its expression at transformation from benign to neoplastic foci is not clear. We an...

journal_title：Oncology reports

authors： Izawa H,Yamamoto H,Ikeda M,Ikeda K,Fukunaga H,Yasui M,Ikenaga M,Sekimoto M,Monden T,Matsuura N,Monden M

更新日期：2002-11-01 00:00:00

abstract：:Nucleostemin (NS) plays an important role in tumorigenesis and progression. Most studies consider that NS plays its role through combining with p53 and inhibiting it, however our previous studies revealed that NS could also function without the existence of p53. To date, few studies have focused on the p53-independent...

journal_title：Oncology reports

authors： Sun X,Jia Y,Wei Y,Liu S,Yue B

更新日期：2014-08-01 00:00:00

abstract：:The number of new lung cancer cases diagnosed yearly is high, and the mortality rate has not substantially declined. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, and adenocarcinoma accounts for the largest proportion of NSCLC. Currently, platinum-based combined chemotherapy, particularly ...

journal_title：Oncology reports

authors： Cheng R,Lu C,Zhang G,Zhang G,Zhao G

更新日期：2017-04-01 00:00:00

abstract：:Colorectal carcinoma (CRC) is a major type of malignancy worldwide. Ellagic acid (EA), a natural phenolic constituent, has been shown to exhibit anticancer effects. In our previous study, it was shown that EA inhibited proliferation of CRC cells. Additionally, microarray analysis revealed 4,738 differentially expresse...

journal_title：Oncology reports

authors： Zhao J,Li G,Wei J,Dang S,Yu X,Ding L,Shang C,Zhang H,Zhang Z,Chen H,Liu M

更新日期：2020-08-01 00:00:00

abstract：:Tumor invasion and migration are major causes of mortality in patients with cervical carcinoma. Tumors under hypoxic conditions are more invasive and have a higher metastasic activity. Lysyl oxidase (LOX) is a hypoxia-responsive gene. LOX has been shown to be essential for hypoxia-induced metastasis in breast cancer. ...

journal_title：Oncology reports

authors： Yang X,Li S,Li W,Chen J,Xiao X,Wang Y,Yan G,Chen L

更新日期：2013-02-01 00:00:00

abstract：:The precise mechanism through which the two estrogen receptor subtypes, ERα and ERβ, are linked to endometrial malignant progression is not fully understood. The aim of the present study was to examine their role in endometrial carcinoma cell migration, invasion and proliferation. We also explored the correlation betw...

journal_title：Oncology reports

authors： Hou X,Zhao M,Wang T,Zhang G

更新日期：2014-03-01 00:00:00

abstract：:Analysis of HER-2/neu gene amplification by fluorescence in situ hybridization was performed in 40 patients with invasive bladder cancer in order to evaluate the potential for molecular targeted therapy of HER-2 as a tailor-made treatment for patients with invasive bladder cancer. This study included 40 patients seen ...

journal_title：Oncology reports

authors： Yamada Y,Naruse K,Nakamura K,Aoki S,Taki T,Tobiume M,Zennami K,Katsuda R,Hirano M,Hayashida K,Mizumukai E,Nanaura H,Honda N

更新日期：2007-11-01 00:00:00

abstract：:We investigated the microsatellite alterations in mitochondrial DNA (mtDNA) and in TP53 in thoracic esophageal squamous cell carcinomas (TESCC). Using laser microdissection, 66 paired non-cancerous esophageal muscles, non-cancerous esophageal mucosa, cancerous TESCC nests plus 35 metastatic lymph nodes harvested from ...

journal_title：Oncology reports

authors： Lin CS,Wang LS,Chang SC,Chou TY,Hsu WH,Liu CS,Lee MH,Chung MY,Wei YH

更新日期：2012-07-01 00:00:00

abstract：:Currently, there are emerging multiple studies on human epididymis protein 4 (HE4) in ovarian cancer. HE4 possesses higher sensitivity and specificity than CA125 in the confirmative early diagnosis for ovarian cancer. Although much attention has been given to explore its clinical application, research of the basic mec...

journal_title：Oncology reports

authors： Zhu L,Guo Q,Jin S,Feng H,Zhuang H,Liu C,Tan M,Liu J,Li X,Lin B

更新日期：2016-09-01 00:00:00

abstract：:Previous studies have shown that S100 calcium-binding protein A8 (S100A8) contributes to the survival and migration of colorectal cancer (CRC) cells. However, whether S100A8 participates in the progression and metastasis of CRC via the regulation of macrophages in the tumor inflammatory microenvironment remains unknow...

journal_title：Oncology reports

authors： Zha H,Sun H,Li X,Duan L,Li A,Gu Y,Zeng Z,Zhao J,Xie J,Yuan S,Li H,Zhou L

更新日期：2016-07-01 00:00:00