Abstract:
:In a screen for thoracic malignancy-associated markers, thyroid stimulating hormone receptor (TSHR) was identified as a candidate as it binds to the previously-characterized lung cancer marker NKX2-1. We screened for mutations in all coding regions of the TSHR gene in 96 lung adenocarcinoma samples and their matched adjacent normal lung samples. We found one patient with a somatic mutation at codon 458 (exon 10), which is located at the transmembrane domain where most TSHR mutations have been found in thyroid-related diseases. This patient had lung adenocarcinoma with BAC (bronchioloalveolar carcinoma) features in the setting of a prior medical history significant for carotid stenosis and severe chronic obstructive pulmonary disease (COPD). In order to characterize the genetic features of TSHR in lung cancer, we checked for TSHR expression and copy number in the 96 lung cancer tissues. TSHR protein expression was generally overexpressed in multiple thoracic malignancies (adenocarcinoma, squamous cell carcinoma and malignant pleural mesothelioma) by immunohistochemistry. Our data suggest that aberrant TSHR function may contribute to lung cancer development or a subgroup of lung cancer with specific clinical phenotypes.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Kim JW,Lee S,Lui N,Choi H,Mulvihill M,Fang LT,Kang HC,Kwon YW,Jablons D,Kim IJdoi
10.3892/or.2012.1938subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1225-30issue
4eissn
1021-335Xissn
1791-2431journal_volume
28pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::The novel gene human Biot2 (hBiot2) was first reported by our laboratory. Previously, we indicated its function of proliferation and carcinogenesis in human endometrial cancer. In the present study, we aimed to investigate whether hBiot2 played a similar role in human cervical cancer. We tested hBiot2 expression profi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Survivin, an anti-apoptotic protein, is abundantly expressed in a variety of cancer cells, including hepatoma cells, resulting in the resistance of these cells to various apoptotic stimuli. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known to induce cancer cell-specific apoptosis, but hepa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
abstract::Peroxiredoxin 1 (Prdx1) is an antioxidant and plays an important role in H2O2-mediated cell signaling. We previously found that the expression level of Prdx1 was elevated in esophagus squamous cell carcinoma (ESCC) tissue using a proteomics approach. Since overexpressed protein can induce an autoimmune response, to fu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2714
更新日期:2013-11-01 00:00:00
abstract::The aim of the study was to estimate the long-term results and the prognostic value of clinical and pathological factors following R0 anterior resection with total mesorectal excision (TME). Ninety-eight consecutive patients with histologically confirmed rectal cancer were studied prospectively with five-year follow-u...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00
abstract::Tumor metastasis is considered the main cause of mortality in cancer patients, thus it is important to investigate the differences between high- and low-metastatic cancer cells. Our previous study showed that the highly metastatic breast cancer cell line MDA-MB-231 released higher levels of ATP and exhibited higher P2...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.3972
更新日期:2015-07-01 00:00:00
abstract::The present study was designed to retrospectively examine the efficacy of postoperative adjuvant chemotherapy in 107 patients with stage II primary colorectal cancer who underwent curative resection. The chemotherapy regimen was intravenous 5FU/LV in 30 patients (FL-IV group) and oral UFT/PSK in 77 patients (oral grou...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
abstract::Colorectal carcinoma (CRC) is a major type of malignancy worldwide. Ellagic acid (EA), a natural phenolic constituent, has been shown to exhibit anticancer effects. In our previous study, it was shown that EA inhibited proliferation of CRC cells. Additionally, microarray analysis revealed 4,738 differentially expresse...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7617
更新日期:2020-08-01 00:00:00
abstract::Transforming growth factor-β1 (TGF-β1) signaling has been shown to play a critical role in the development of epithelial-mesenchymal transition (EMT). PAI-1 is one of the most important target genes in the TGF-β/Smad signaling pathway, which can hinder the degradation of ECM composition and may promote cell invasion a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5292
更新日期:2017-02-01 00:00:00
abstract::Activating mutations of Ras gene families have been found in a variety of human malignancies, including lung cancer, suggesting their dominant role in tumorigenesis. Many studies have showed that the Kras gene is activated by point mutations in approximately 15-20% of non-small cell lung cancers (NSCLCs), however, the...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract::Melanoma is a malignant tumor of the melanocytes. microRNAs (miRNAs) are emerging as important regulators of cancer-related processes. A thorough understanding of miRNAs in melanoma progression is important for developing new therapeutic targets. miRNA expression was detected by quantitative PCR. In vitro, MTT assay, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2451
更新日期:2013-07-01 00:00:00
abstract::Bmi-1, a member of the polycomb family, it is involved in self renewal of stem cells and functions as an oncogene in many malignant human cancer types. Recent studies have demonstrated that Bmi-1 is a predictive factor for poor patient prognosis. However, the underlying mechanisms o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1615
更新日期:2012-04-01 00:00:00
abstract::The present study aimed to assess the in vitro and in vivo magnetic resonance imaging (MRI) features of chlorotoxin (CTX)-conjugated superparamagnetic iron oxide (SPIO) nanoprobes. CTX-conjugated nanoprobes were composed of SPIO coated with polyethylene glycol (PEG) and conjugated with CTX. The nanoprobes were termed ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4629
更新日期:2016-05-01 00:00:00
abstract::Isocitrate dehydrogenase 2 (IDH2) is a mitochondrial NADP-dependent isocitrate dehydrogenase. It is considered to be a novel tumor suppressor in several types of tumors. However, the role and related mechanism of IDH2 in osteosarcoma remain unknown. The expression and significance of IDH2 were investigated by immunohi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4553
更新日期:2016-04-01 00:00:00
abstract::To ascertain the implications of loss of imprinting (LOI) of the insulin-like growth factor II gene (IGF2) for carcinogenesis, the precise frequency of LOI in colorectal carcinoma was examined using a laser capture microdissection method, and compared to the matched normal colorectal mucosa. LOI was examined by PCR-re...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00
abstract::Low-intensity ultrasound (LIUS) combined with chemotherapy is an innovative modality for cancer treatment, but its effect on orthotopic carcinoma remains unknown. Our previous study revealed that LIUS enhanced the growth inhibitory effects of several chemotherapeutic drugs in nude mice with transplanted tumors. In the...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6262
更新日期:2018-04-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of highly conserved, small endogenous single-strand non-coding RNAs. They are aberrantly expressed in the circulation and tissue of patients with cancer. Therefore, it has been suggested that they may act as key regulators of carcinogenesis. The aim of the present study was to examine th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.2971
更新日期:2014-03-01 00:00:00
abstract::As one of the most common malignancies, esophageal squamous cell carcinoma (ESCC) is ranked as the sixth leading cause of cancer-related death worldwide. In our previous study, by employing cDNA microarray analysis, semaphorin 3B (SEMA3B) was found to be significantly downregulated in ESCC. In the present study, SEMA3...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4901
更新日期:2016-08-01 00:00:00
abstract::The inhibitor of differentiation/DNA binding 1 (Id-1), a negative regulator of basic helix-loop-helix transcription factors, plays an important role in the regulation of cell proliferation and differentiation. We examined the Id-1 expression by immunohistochemistry in 9 adenomas, 79 primary colorectal adenocarcinomas ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract::Lung cancer remains the leading cause of cancer-related mortality worldwide and non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all cases of lung cancer. Cisplatin plays a significant role in the management of human lung cancer. Translesion DNA synthesis (TLS) is involved in DNA damage repair. ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4121
更新日期:2015-09-01 00:00:00
abstract::MicroRNAs (miRNAs) that negatively regulate gene expression play a key role in the development and progression of cancer. Aberrant expression of hsa-miR-187 (miR-187) has been reported in various malignancies. However, the function of miR-187 in tumor progression remains controversial and its role in non-small cell lu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5548
更新日期:2017-05-01 00:00:00
abstract::Prostate cancer (PCa) growth initially depends on circulating androgens. Gonadotropin-releasing hormone (GnRH) agonists are currently used for the treatment of PCa. However, after an initial responsiveness to hormonal deprivation, PCa progresses and metastasizes. Recently, also GnRH antagonists have been used for clin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.15.2.393
更新日期:2006-02-01 00:00:00
abstract::Soft tissue sarcomas comprise a heterogeneous group of mesenchymal tumors with varying biological behavior ranging from indolent tumors with no or minimal metastatic risk to aggressive and frequently metastasizing tumors. Among the more common aggressive adult soft tissue sarcomas are malignant fibrous histiocytoma, s...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00
abstract::Mitochondrial DNA (mtDNA) mutations occur in a variety of human cancers, suggesting a possible role for mitochondrial respiratory functions in tumorigenesis. Recent studies have demonstrated that SDHD, a nuclear gene encoding one of the mitochondrial complex II subunits, acts as a tumor-suppressor for hereditary parag...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::The aim of the present study was to search for an effective regimen among existing chemotherapies for head and neck squamous cell carcinoma (HNSCC). Among the tested drugs, we focused on combined SN-38, which is the active metabolite produced from irinotecan hydrochloride - a type I DNA topoisomerase inhibitor - after...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6105
更新日期:2018-01-01 00:00:00
abstract::Sanguinarine (SAN), an alkaloid isolated from plants of the Papaveraceae family, is a compound with multiple biological activities. In the present study, we explored the anticancer properties of SAN in lung cancer using the human lung adenocarcinoma cell line SPC-A1. Our results revealed that SAN inhibited SPC-A1 cell...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4054
更新日期:2015-08-01 00:00:00
abstract::Esculetin, a phenolic compound, has been shown to inhibit the growth of colon tumors in animal studies. However, the roles of signaling pathways and cell cycle regulation in the esculetin-induced inhibition of cancer cell growth, remain to be elucidated. The present study suggests a novel mechanism for the Ras/ERK1/2 ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer, and numerous oncogenes are associated with this disease. Oxysterol‑binding protein‑related protein 8 (ORP8) is essential for cell growth, migration and the modulation of mitochondrial respiration and morphology. However, the underlying role of ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2020.7517
更新日期:2020-05-01 00:00:00
abstract::Soft tissue sarcomas are rare and aggressive tumors arising from connective tissues. Adjuvant radiotherapy is a commonly used treatment approach for the majority of sarcomas. We attempted to identify a gene signature that can predict radiosensitive patients who are most likely to have a better treatment response from ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5999
更新日期:2017-11-01 00:00:00
abstract::MicroRNAs (miRNAs), as gene expression regulators, have been identified to be closely associated with tumorigenesis. Thus a loss-of-function study is more likely to reveal the biological roles of endogenous miRNAs. Genetic knockout, antisense oligonucleotide inhibitors, and miRNA sponge (miR‑SP) are usually performed ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3517
更新日期:2014-12-01 00:00:00
abstract::Cyclooxygenase-2 (Cox-2) is an inducible enzyme that converts arachidonic acid to prostaglandins, and it is hypothesized to induce carcinogenesis and metastasis in colorectal cancer. Our previous data also indicated that a higher expression level of Cox-2 was correlated with colorec...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2012.1867
更新日期:2012-09-01 00:00:00