Abstract:
:The immunohistochemical expression of type 1 blood group antigens (type 1 BGAs) was analyzed for 30 cases of testicular germ cell tumors (TGCTs), using monoclonal antibodies against DU-PAN-2, CA19-9, Lewis(a) (Le(a)), and Lewis(b) (Le(b)). DU-PAN-2 was expressed very frequently in all of the embryonal carcinomas (ECs). CA19-9 expression was demonstrated in 53% of ECs, but the number of positive cells was generally smaller than that for DU-PAN-2. CA19-9-negative ECs tended to show a higher number of DU-PAN-2-positive cells compared to CA19-9-positive ECs, and ECs in which DU-PAN-2 was more strongly expressed showed a relatively frequent expression of CA19-9. In 36% of seminomas and 56% of yolk sac tumors (YSTs), DU-PAN-2 was weakly expressed, and the positive cells were few in number. Little or no expression of CA19-9 was demonstrated in seminomas and YSTs. Regarding Le(a) and Le(b), the expressions were found to be limited to teratomas at a frequency of 57% and 86%, respectively, with the exception of one EC positive for Lea and one YST positive for Leb. Eighty-six percent of teratomas showed expressions of DU-PAN-2 and CA19-9. DU-PAN-2 was also seen in some intratubular malignant germ cells. The antibodies used were all negative for choriocarcinomas, syncytiotrophoblastic giant cells, and normal testicular tissues. The antigen expressions were predominantly observed on the surface of tumor cells developing luminal structures. In conclusion, although CA19-9 was relatively specific for ECs, it should be emphasized that ECs were rather characteristic of extensive DU-PAN-2 expression. Particularly in CA19-9-negative ECs, a combined analysis of DU-PAN-2 and CA19-9 would be helpful in confirming the histopathologic diagnosis of TGCTs. The clinical significance of DU-PAN-2 in ECs as a tumor marker remains to be clarified. Le(a) and Le(b) expressions were thought to be related to the differentiation or maturation rather than to the malignant transformation in TGCTs.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Kamoshida S,Satoh Y,Yasuda M,Kajiwara H,Tsukinoki K,Osamura RYdoi
10.3892/or.9.4.845keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
845-51issue
4eissn
1021-335Xissn
1791-2431journal_volume
9pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::The aim of this study was to determine genetic alterations in mucoepidermoid carcinomas of the salivary gland in association with clinical and histopathological parameters. Nineteen formalin-fixed, paraffin-embedded tumors were analysed by using comparative genomic hybridization (CGH), fluorescence in situ hybridizati...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2009-08-01 00:00:00
abstract::Daily vs. weekly dosing with EGFR inhibitors (gefitinib and lapatinib) and an AKT inhibitor (MK2206) were compared in two rodent breast cancer models. Female Sprague-Dawley rats were administered methylnitrosourea (MNU) at 50 days of age, and gefitinib (daily/weekly dosing at 10/70 mg/kg BW) or lapatinib (daily/weekly...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6313
更新日期:2018-09-01 00:00:00
abstract::Gastric cancer (GC) is one of the most lethal malignancies worldwide. To reduce its high mortality, sensitive and specific biomarkers for early detection are urgently needed. Recent studies have reported that tumor-specific long non-coding RNAs (lncRNAs) seem to be potential biomarkers for the early diagnosis and trea...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4531
更新日期:2016-03-01 00:00:00
abstract::Hereditary multiple exostoses (HME) is an autosomal dominant bone disorder characterized by the presence of multiple benign cartilage-capped tumors. EXT1 located on chromosome 8q23-q24 and EXT2 located on 11p11-p12 are the main disease-causing genes which are responsible for ~90% of HME cases. Mutations of EXT1 or EXT...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2891
更新日期:2014-02-01 00:00:00
abstract::Histone acetylation is one of the key chromatin modifications that control gene transcription during development and tumorigenesis. Recently, it was reported that the histone deacetylase inhibitor, Trichostatin A (TSA), induces growth arrest and apoptosis in tumors. However, the mol...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1496
更新日期:2012-02-01 00:00:00
abstract::Several investigators have demonstrated that TGF-beta stimulated clone-22 (TSC-22) regulates cell growth and differentiation, and cell death. TSC-22 is a putative transcriptional regulator containing a leucine zipper-like structure and a nuclear export signal. We previously showed the cytoplasmic localization of TSC-2...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::Histone deacetylase inhibitors (HDIs) as well as non-steroidal anti-inflammatory drugs including aspirin show promise as antineoplastic agents. The treatment with both HDIs and aspirin can result in hyperacetylation of proteins. In this study, we investigated whether HDIs and aspirin interacted in inducing anticancer ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
abstract::Investigations into extracellular vesicles (EVs) have significantly increased since their role in physiological and pathological processes has become more clearly understood. Furthermore, it has become increasingly clear that several subpopulations of EVs exist, such as exosomes (EXOs) and microvesicles (MVs). Various...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4199
更新日期:2015-11-01 00:00:00
abstract::Antineoplastons are naturally occurring peptides and amino acid derivatives found in human blood and urine. antineoplastons have been shown to control neoplastic growth. In the present study, we investigated demethylation effect of the antineoplaston AS2-1 (a mixture of phenylacetylglutamine and phenylacetate in the r...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2839
更新日期:2014-01-01 00:00:00
abstract::Angiogenesis is essential for the development, growth and advancement of solid tumors. Cyclooxygenase (cox)-2 is recognized as an angiogenic factor in various tumors. This prompted us to study the clinical implications of cox-2 expression and angiogenesis in ovarian cancer. There was a significant correlation between ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::External abdomino-pelvic irradiation after primary surgery in early stages of epithelial ovarian carcinoma has been used as adjuvant therapy. The aims of this study were to evaluate efficacy and tolerability of abdomino-pelvic radiotherapy in ovarian carcinomas and to find predictive factors for recurrent disease. Fro...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-08-01 00:00:00
abstract::Thymidine kinase-1 (TK-1) and thymidylate synthase (TS) are key enzymes for salvage and de novo pyrimidine synthesis, respectively. Numerous studies have suggested that increased TS levels are associated closely with resistance to fluoropyrimidine-based chemotherapy. TAS-102 is a novel drug containing trifluorothymidi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000770
更新日期:2010-05-01 00:00:00
abstract::Chemokines have been reported to play crucial roles in tumor progression. Eotaxin-1 (CCL11), a member of the CC chemokine family, is elevated in many types of human cancer. Here, to reveal the molecular mechanisms of eotaxin-1 in prostate cancer cell invasion, the expression of eotaxin-1 receptors [CC chemokine recept...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3060
更新日期:2014-05-01 00:00:00
abstract::Depressed and flat surface lesions are not easy to identify with routine colonoscopies during screening for colorectal cancer (CRC). Identifying clinically relevant genes that influence tumor shape could be useful when screening for the presence of depressed lesions. Total RNA was extracted from tumor cells collected ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3251
更新日期:2014-08-01 00:00:00
abstract::Oxymatrine, the main alkaloid component in the traditional Chinese herbal medicine Sophora japonica (Sophora flavescens Ait), has been reported to have antitumor properties. However, the mechanisms of action in human pancreatic cancer are not well established to date. In the present study, we investigated the antiangi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2529
更新日期:2013-08-01 00:00:00
abstract::Cachexia accompanied by muscle wasting is a key determinant of poor prognosis in cancer patients and cancer‑related death. Previous studies have demonstrated that inflammatory cytokines such as interleukin‑6 (IL‑6), tumor necrosis factor‑α (TNF‑α), IL‑1 and interferon‑γ (IFN‑γ) secreted from host cells and tumor cells...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2015.4527
更新日期:2016-03-01 00:00:00
abstract::Numerous human chemoprevention studies have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) possess chemopreventive effects against a variety of malignant tumors. However, there have been many clinical studies on aspirin, but not ibuprofen, even though ibuprofen is one of the most clinically and safel...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2713
更新日期:2013-11-01 00:00:00
abstract::B7-H1 is a co-inhibitory molecule belonging to the B7 family. The B7-H1 protein is only expressed on macrophage lineage of cells in normal tissues, but is overexpressed in most types of tumor. The aberrant expression of cell surface B7-H1 on cancer cells is generally associated with high-risk prognostic factors. The t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2686
更新日期:2013-11-01 00:00:00
abstract::The mechanisms of drug resistance in cancer are not fully elucidated. To study the drug resistance of gastric cancer, we analyzed gene expression and DNA methylation profiles of 5-fluorouracil (5-FU)- and cisplatin (CDDP)-resistant gastric cancer cells and biopsy specimens. Drug-resistant gastric cancer cells were est...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3014
更新日期:2014-04-01 00:00:00
abstract::Eicosapentaenoic acid (EPA) is a dietary polyunsaturated fatty acid (PUFA) that is found abundantly in fish oils and induces apoptosis in human promyelocytic leukemia HL-60 cells. Cyclooxygenase (COX) converts EPA intracellularly into various inflammatory mediators that may affect the bioavailability of this fatty aci...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::All-trans retinoic acid (ATRA) is a potent chemopreventive and therapeutic agent and exerts its effects by inducing growth arrest. In the present study, we demonstrated that ATRA activated the expression of p53 via Axin and induced cell cycle arrest at the G1/S phase and apoptosis of glioma cells. Briefly, C6 cells we...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2391
更新日期:2013-06-01 00:00:00
abstract::Podoplanin is a 38 kDa mucin-type transmembrane glycoprotein that was first identified in rat glomerular epithelial cells (podocytes). It is expressed in normal lymphatic endothelium, but is absent from vascular endothelial cells. D2-40 is a commercially available mouse monoclonal antibody which binds to an epitope on...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1141
更新日期:2011-03-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is one of the most malignant and aggressive tumors, and has a very poor prognosis with a mean survival time of <2 years, despite intensive treatment using chemo-radiation. Therefore, novel therapeutic approaches including immunotherapy have been developed against GBM. For the purpose of i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3049
更新日期:2014-04-01 00:00:00
abstract::Prostate cancer (PCa) growth initially depends on circulating androgens. Gonadotropin-releasing hormone (GnRH) agonists are currently used for the treatment of PCa. However, after an initial responsiveness to hormonal deprivation, PCa progresses and metastasizes. Recently, also GnRH antagonists have been used for clin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.15.2.393
更新日期:2006-02-01 00:00:00
abstract::To elucidate the mechanism of resistance to 5-fluorouracil (5-FU) in human gastric cancer cells, we established a cell line MKN45/F2R, which acquired 5-FU resistance as a result of continuous exposure to increasing dosages of 5-FU over a year. The cell line showed 157-fold elevated 5-FU resistance compared to the MKN4...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-12-01 00:00:00
abstract::Frequent invasion of oral cancers into the neighboring jaw bones is a major cause of increased mortality. Moreover, majority of patients with these oral cancers suffer from functional inconveniences and esthetic disadvantages during clinical course and after surgical treatments. Understanding of the mechanisms underly...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-02-01 00:00:00
abstract::MicroRNA-455 (miR-455) has been considered as a novel cancer-related miRNA and dysregulated expression frequently occurs in various human types of cancer. However, its clinical significance, its biological function and the underlying molecular signaling involved in hepatocellular carcinoma (HCC) remain to be elucidate...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5139
更新日期:2016-12-01 00:00:00
abstract::The effects of a novel oral fluoropyrimidine derivative S-1 on peritoneal metastasis from gastric cancer were investigated. OCUM-2MD3 cells, a highly peritoneal-metastatic cell line, were injected intraperitoneally in nude mice. These mice were allocated to the following three groups (each group, n=10): the S-1 group,...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00
abstract::Currently, there are emerging multiple studies on human epididymis protein 4 (HE4) in ovarian cancer. HE4 possesses higher sensitivity and specificity than CA125 in the confirmative early diagnosis for ovarian cancer. Although much attention has been given to explore its clinical application, research of the basic mec...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4926
更新日期:2016-09-01 00:00:00
abstract::Breast cancer is the worldwide leading cause of cancer incidence among women. Night shift work exposure has been recently considered one of the significant breast cancer risk factors in industrialized countries. The mechanisms by which this work exposure may be responsible for cance...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2012.1839
更新日期:2012-08-01 00:00:00