All-trans retinoic acid upregulates the expression of p53 via Axin and inhibits the proliferation of glioma cells.

abstract：:Formation of cancer stem cells (CSCs) and increased cells proliferation are involved in tumorigenesis, tumour recurrence and therapy resistance and microRNA is essential for the development of the biological traits of CSCs and the increased cells proliferation. Studying molecular mechanism of tumorigenesis, tumour rec...

journal_title：Oncology reports

authors： Liu Y,Miao L,Ni R,Zhang H,Li L,Wang X,Li X,Wang J

更新日期：2016-12-01 00:00:00

abstract：:The authors of the above article drew to our attention that they had identified three instances of data overlapping between data panels, suggesting that data purportedly showing results obtained under different experimental conditions had been derived from the same original source. Comparing between the two figures, t...

journal_title：Oncology reports

authors： Ji CX,Fan YH,Xu F,Lv SG,Ye MH,Wu MJ,Zh XG,Wu L

更新日期：2020-11-01 00:00:00

abstract：:Esophageal cancer is one of the most aggressive cancers in the world. Novel preventive and therapeutic strategies tend to target the key molecules involved in the signaling transduction pathways for cell growth. It is known that FAK and mTOR are important controllers of cell growth. TAE226, a novel small molecule comp...

journal_title：Oncology reports

authors： Wang ZG,Fukazawa T,Nishikawa T,Watanabe N,Sakurama K,Motoki T,Takaoka M,Hatakeyama S,Omori O,Ohara T,Tanabe S,Fujiwara Y,Shirakawa Y,Yamatsuji T,Tanaka N,Naomoto Y

更新日期：2008-12-01 00:00:00

abstract：:Given the important role of CXCR4 in cancer metastasis, microenvironmental factors that modulate CXCR4 may have an impact on the process of tumor expansion. Hypoxia is a common feature of solid tumors and a significant microenvironmental factor that drives aggressive behavior. CXCR4...

journal_title：Oncology reports

authors： Oh YS,Kim HY,Song IC,Yun HJ,Jo DY,Kim S,Lee HJ

更新日期：2012-12-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) signaling has been shown to play a critical role in the development of epithelial-mesenchymal transition (EMT). PAI-1 is one of the most important target genes in the TGF-β/Smad signaling pathway, which can hinder the degradation of ECM composition and may promote cell invasion a...

journal_title：Oncology reports

authors： Wang X,Liu C,Wang J,Fan Y,Wang Z,Wang Y

更新日期：2017-02-01 00:00:00

abstract：:Lymph node metastases are responsible for shorter survival in oral squamous cell carcinoma (OSCC). The aim of the present study was to assess the node metastasis frequency and survival according to the node metastasis features in 121 neck dissections (NDs) performed for OSCC, identifying evidence-based correlations an...

journal_title：Oncology reports

authors： Contaldo M,Di Napoli A,Pannone G,Franco R,Ionna F,Feola A,De Rosa A,Santoro A,Sbordone C,Longo F,Pasquali D,Loreto C,Ricciardiello F,Esposito G,D'Angelo L,Itro A,Bufo P,Tombolini V,Serpico R,Di Domenico M

更新日期：2013-12-01 00:00:00

abstract：:Cisplatin (DDP), a cytotoxic antitumor drug, functions in a dose-dependent manner. However, the pursuit for high‑dose therapeutic effects leads to more serious side effects including kidney toxicity. Nephrotoxicity caused due to endothelial cell dysfunction and neutrophils infiltration in kidneys. Interleukin-8 (IL-8)...

journal_title：Oncology reports

authors： Li L,Khan MN,Li Q,Chen X,Wei J,Wang B,Cheng JW,Gordon JR,Li F

更新日期：2015-02-01 00:00:00

abstract：:Cell cycle analysis has become increasingly important in verifying the effect of anti-tumor drugs and cytokinetic research. In the early methods of cell cycle analysis, the flow cytometry relied on DNA content, and therefore, the cell cycle could be only broken into three stages: G(0)/G(1), S, and G(2)/M phase. It cou...

journal_title：Oncology reports

authors： Qin J,Tao D,Duan R,Leng Y,Shen M,Zhou H,Feng Y,Gao C,Yu Y,Li QQ,Hu J,Gong J

更新日期：2002-09-01 00:00:00

abstract：:In the present study, we investigated the role of lysyl oxidase‑like 2 (LOXL2), the correlation between LOXL2 and epithelial to mesenchymal transition (EMT) and the effects of using β‑aminopropionitrile (BAPN) to inhibit LOXL2 with the aim of reducing tumor progression in hepatocellular carcinoma (HCC). The expression...

journal_title：Oncology reports

authors： Ninomiya G,Yamada S,Hayashi M,Takeda S,Suenaga M,Takami H,Kanda M,Iwata N,Niwa Y,Tanaka C,Kobayashi D,Fujii T,Nakayama G,Sugimoto H,Koike M,Fujiwara M,Kodera Y

更新日期：2018-06-01 00:00:00

abstract：:The activation of receptor tyrosine kinases (RTKs) results in cellular effects including cell proliferation, survival, migration and invasion; RTKs also play an important role in tumourigenesis. It has been reported that EGFR signalling controls the migration of oral squamous cell carcinoma (OSCC) SAS and HSC3 cells b...

journal_title：Oncology reports

authors： Yasui H,Ohnishi Y,Nakajima M,Nozaki M

更新日期：2017-06-01 00:00:00

abstract：:Synovial sarcomas (SS) consistently show a characteristic chromosomal translocation, t(X;18)(p11;q11), which usually leads to the formation of 2 chimeric fusion transcripts, SYT-SSX1 and -SSX2. A recent multi-institutional retrospective study revealed that the SYT-SSX fusion type emerged as the only independent signif...

journal_title：Oncology reports

authors： Saito T,Oda Y,Kawaguchi K,Takahira T,Yamamoto H,Tanaka K,Matsuda S,Sakamoto A,Iwamoto Y,Tsuneyoshi M

更新日期：2004-05-01 00:00:00

abstract：:Tetraspanins are transmembrane adaptor proteins involved in the regulation of various fundamental cellular processes. For a number of malignant diseases, the level of expression of members of the tetraspanin family was found to correlate with tumor cell invasiveness, ability to form metastases, and poor clinical outco...

journal_title：Oncology reports

authors： Sauer G,Kurzeder C,Grundmann R,Kreienberg R,Zeillinger R,Deissler H

更新日期：2003-03-01 00:00:00

abstract：:A-kinase can inhibit RhoA activation through phosphorylating ser188 of RhoA. AKAP is a novel protein that can target PKA to different subcellular compartment. Evidence has been presented that PKA anchorage by AKAP is important for the kinase to exert its function. This study analyzed the role of PKA anchorage in PKA-i...

journal_title：Oncology reports

authors： Wang Y,Chen Y,Chen M,Xu W

更新日期：2006-10-01 00:00:00

abstract：:Fecal microRNAs (miRNAs) are increasingly explored as non-invasive markers of colorectal cancer (CRC). However, its holistic profile in Asian CRC patients remains elusive. In the present study, the global human fecal miRNAs in Asian Chinese CRC patients was assayed to elucidate novel diagnostic fecal markers. Addition...

journal_title：Oncology reports

authors： Phua LC,Chue XP,Koh PK,Cheah PY,Chan EC,Ho HK

更新日期：2014-07-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is the second most common hepatic cancer with high resistance to current chemotherapies and extremely poor prognosis. The present study aimed to examine the effects of schisandrin B (Sch B) on CCA cells both in vitro and in vivo and to examine its underlying mechanism. We found that Sch B inhi...

journal_title：Oncology reports

authors： Yang X,Wang S,Mu Y,Zheng Y

更新日期：2016-10-01 00:00:00

abstract：:Inflammasomes can identify endogenous danger signals as an inflammatory immune response. As the most common inflammasome, the NLR pyrin family domain containing 3 (NLRP3) inflammasome is associated with the pathogenesis of different tumors. However, the function of the NLRP3 inflammasome in esophageal cancer (EC) has ...

journal_title：Oncology reports

authors： Yu S,Yin JJ,Miao JX,Li SG,Huang CZ,Huang N,Fan TL,Li XN,Wang YH,Han SN,Zhang LR

更新日期：2020-04-01 00:00:00

abstract：:Extracellular matrix remodeling crucial to tumorigenesis involves proteolytic enzymes, primarily matrix metalloproteinases (MMPs). MMP production is stimulated by multiple factors, including the extracellular matrix metallo-proteinase inducer EMMPRIN/CD147. Overexpression of EMMPRIN...

journal_title：Oncology reports

authors： Takahashi M,Suzuki S,Ishikawa K

更新日期：2012-01-01 00:00:00

abstract：:MicroRNA-154 (miR-154) has been identified as a tumor suppressor in several types of human cancers; however, its clinical significance and function in human hepatocellular carcinoma (HCC) remain unclear. The aim of the present study was to analyze the clinical significance and cellular function of miR-154 in HCC patie...

journal_title：Oncology reports

authors： Pang X,Huang K,Zhang Q,Zhang Y,Niu J

更新日期：2015-12-01 00:00:00

abstract：:Multiple drug resistance (MDR) is considered a major challenge in the clinical treatment of non-small cell lung cancer (NSCLC). Both nitric oxide synthase (iNOS) and Wnt signaling pathway participate in the regulation of drug resistance, but the interaction between them remains unclear. In the present study, we detect...

journal_title：Oncology reports

authors： Li Y,Ma C,Shi X,Wen Z,Li D,Sun M,Ding H

更新日期：2014-10-01 00:00:00

abstract：:In order to investigate the involvement of the IER3/PP2A-B56γ/ERK-positive feedback loop, which leads to sustained phosphorylation/activation of ERK in carcinogenesis, we immunohistochemically examined the expression of IER3 and phosphorylated ERK in lung tumor tissues. IER3 was overexpressed in all cases of adenocarc...

journal_title：Oncology reports

authors： Ito T,Ozaki S,Chanasong R,Mizutani Y,Oyama T,Sakurai H,Matsumoto I,Takemura H,Kawahara E

更新日期：2016-05-01 00:00:00

abstract：:New therapeutic approaches are mandatory for anaplastic thyroid cancer. We investigated the ability of a new combined treatment using valproic acid (VPA), the only clinically available histone deacetylase inhibitor, and the tyrosine-kinase inhibitor imatinib mesylate to control the cell growth of anaplastic thyroid ca...

journal_title：Oncology reports

authors： Catalano MG,Pugliese M,Poli R,Bosco O,Bertieri R,Fortunati N,Boccuzzi G

更新日期：2009-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a leading cause of cancer‑related morbidity and mortality globally. Despite the remarkable improvements in comprehensive HCC treatment, the underlying mechanistic details of HCC remain elusive. We screened HCC patients for differentially expressed genes (DEGs) using the Gene Expressio...

journal_title：Oncology reports

authors： Li L,Huang K,Lu Z,Zhao H,Li H,Ye Q,Peng G

更新日期：2020-11-01 00:00:00

abstract：:Previous reports showed that breast and gastric cancers overexpressing c-erbB-2 protein have a greater metastatic potential and worse prognosis than tumors in which this protein is not overexpressed. The present study was undertaken to examine the significance of c-erbB-2 protein expression as a prognostic factor in c...

journal_title：Oncology reports

authors： Ishida H,Sadahiro S,Suzuki T,Ishikawa K,Tajima T,Makuuchi H

更新日期：2000-11-01 00:00:00

abstract：:Mechanisms of synergistic effect of thermotherapy and chemotherapy on human lung adenocarcinoma cell growth are unclear. The purpose of this study was to investigate these effects and explore the function of ROS, Akt and caspase-3 in relation to these. A549 cells were subjected to different thermochemotherapy treatmen...

journal_title：Oncology reports

authors： Wang L,Liu X,Wu Y,Wu W,Wu Y

更新日期：2012-10-01 00:00:00

abstract：:High expression of the 110 kDa catalytic subunit of the class IA PI3K (PI3Kp110α) may play an important role in cetuximab resistance exhibited by both colorectal cancer and head and neck squamous cell carcinoma. Therefore, the present study aimed to examine the association between the expression of proteins in the PI3...

journal_title：Oncology reports

authors： Tsuchihashi H,Naruse T,Yanamoto S,Okuyama K,Furukawa K,Omori K,Umeda M

更新日期：2020-09-01 00:00:00

abstract：:The decision to repeat transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) is based on correct evaluation of response to therapy. The purpose of this study was to investigate whether apparent diffusion coefficient (ADC), a quantitative parameter of diffusion-weighted imaging (DWI), can p...

journal_title：Oncology reports

authors： Kubota K,Yamanishi T,Itoh S,Murata Y,Miyatake K,Yasunami H,Morio K,Hamada N,Nishioka A,Ogawa Y

更新日期：2010-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) play a vital role in tumour biological and pathologic processes. In the present study, we aimed to detect the expression and biological role of miR-216b in glioma. Our data showed that miR-216b was significantly downregulated in human glioma tissues and cells. Ectopic expression of miR-216b inhibite...

journal_title：Oncology reports

authors： Zhang T,Ma G,Zhang Y,Huo H,Zhao Y

更新日期：2017-09-01 00:00:00

abstract：:Vitamin K2 (VK2) has been shown to have a potent anti-tumor effect against several cancer types including hepatocellular carcinoma (HCC), but the mechanisms remain to be elucidated. Matrix metalloproteinase (MMP) plays an important role in the invasion and metastasis of cancer cells, but it is not known whether VK2 re...

journal_title：Oncology reports

authors： Ide Y,Zhang H,Hamajima H,Kawaguchi Y,Eguchi Y,Mizuta T,Yamamoto K,Fujimoto K,Ozaki I

更新日期：2009-09-01 00:00:00

abstract：:Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited...

journal_title：Oncology reports

authors： Saiko P,Ozsvar-Kozma M,Graser G,Lackner A,Grusch M,Madlener S,Krupitza G,Jaeger W,Hidvegi M,Agarwal RP,Fritzer-Szekeres M,Szekeres T

更新日期：2009-03-01 00:00:00

abstract：:The expression of the DNA mismatch repair proteins hMSH2 and hMLH1 and p21(waf1) the cyclin G1 inhibitor, may determine response of adult cancers to anti-cancer drugs, that include alkylating agents and platinum-based drugs. The role of DNA mismatch repair proteins (hMSH2 and hMLH1) and p21(waf1) in pediatric tumor re...

journal_title：Oncology reports

authors： Idikio HA

更新日期：2001-09-01 00:00:00