Selective inhibition of PI3K110α as a novel therapeutic strategy for cetuximab‑resistant oral squamous cell carcinoma.

Abstract:

:High expression of the 110 kDa catalytic subunit of the class IA PI3K (PI3Kp110α) may play an important role in cetuximab resistance exhibited by both colorectal cancer and head and neck squamous cell carcinoma. Therefore, the present study aimed to examine the association between the expression of proteins in the PI3Kp110α pathway and cetuximab resistance, and the antitumor effects of alpelisib (PI3K inhibitor) and cetuximab in oral squamous cell carcinoma (OSCC) cells. The association between PI3Kp110α protein expression levels and the tumor response to cetuximab was determined using immunohistochemistry. OSCC cells were treated with alpelisib, cetuximab, or in combination, and the effects were examined in vitro and in vivo. PI3Kp110α protein expression was significantly associated with the tumor response to cetuximab (P<0.05) and 1‑year progression‑free survival and overall survival (P<0.05). Combined treatment of alpelisib and cetuximab resulted in enhanced antitumor effects in vitro compared with either agent administered alone. In particular, the expression level of N‑cadherin, an epithelial‑mesenchymal transition‑related protein, was decreased, suggesting that the invasion potential of cetuximab‑resistant cells decreased. Furthermore, the expression of proteins in the PI3K pathway were decreased in tumors from mice with OSCC xenografts treated with alpelisib and cetuximab in combination. These results indicate that novel regimens of systemic therapy (such as chemotherapy), with combinations of cetuximab and alpelisib, may be beneficial for patients with cetuximab‑resistant OSCC.

journal_name

Oncol Rep

journal_title

Oncology reports

authors

Tsuchihashi H,Naruse T,Yanamoto S,Okuyama K,Furukawa K,Omori K,Umeda M

doi

10.3892/or.2020.7674

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

863-872

issue

3

eissn

1021-335X

issn

1791-2431

journal_volume

44

pub_type

杂志文章
  • p16, MGMT, RARbeta2, CLDN3, CRBP and MT1G gene methylation in esophageal squamous cell carcinoma and its precursor lesions.

    abstract::Esophageal squamous cell carcinoma (ESCC) is a common cancer with a very poor prognosis. New methods are needed to screen high-risk populations and identify curable tumors and precursor lesions early. Molecular markers may be useful in such screening efforts. This study was designed to determine the prevalence of p16,...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Roth MJ,Abnet CC,Hu N,Wang QH,Wei WQ,Green L,D'Alelio M,Qiao YL,Dawsey SM,Taylor PR,Woodson K

    更新日期:2006-06-01 00:00:00

  • Umbilical cord-derived mesenchymal stem cells promote proliferation and migration in MCF-7 and MDA-MB-231 breast cancer cells through activation of the ERK pathway.

    abstract::Mesenchymal stem cells (MSCs) are known to migrate to tumor tissues and to play an important role in cancer progression. However, the effects of MSCs on tumor progression remain controversial. The purpose of the present study was to detect the effects of human umbilical cord-derived MSCs (hUC‑MSCs) on the human breast...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4109

    authors: Li T,Zhang C,Ding Y,Zhai W,Liu K,Bu F,Tu T,Sun L,Zhu W,Zhou F,Qi W,Hu J,Chen H,Sun X

    更新日期:2015-09-01 00:00:00

  • APOBEC3B is expressed in human glioma, and influences cell proliferation and temozolomide resistance.

    abstract::Highly malignant gliomas are characterized by pronounced intra‑ and intertumoral heterogeneity. On the genetic level, this heterogeneity may be caused by spontaneous mutation events, but recent studies have reported distinct mutational signatures that may be caused by an enzyme family with cytidine desaminase activity...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6698

    authors: Schmitt C,Lucius R,Synowitz M,Held-Feindt J,Hattermann K

    更新日期:2018-11-01 00:00:00

  • Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity.

    abstract::MHC class I-related chain molecules A and B (MICA and B) expressed on the cell-surface of tumor cells are ligands for an activating receptor, NKG2D, expressed on natural killer (NK) cells and stimulate the NK cell-mediated cytotoxicity. On the other hand, the soluble form of MICA and B produced by proteolytic cleavage...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or_00001026

    authors: Yamanegi K,Yamane J,Kobayashi K,Kato-Kogoe N,Ohyama H,Nakasho K,Yamada N,Hata M,Nishioka T,Fukunaga S,Futani H,Okamura H,Terada N

    更新日期:2010-12-01 00:00:00

  • The role of lncRNA MALAT1 in bone metastasis in patients with non-small cell lung cancer.

    abstract::lncRNA metastasis-associated lung adencarcinoma transcript 1 (MALAT1) plays an important role in the metastasis of lung cancer. Yet, its role in bone metastasis and the related mechanism remain unknown. The present study aimed to investigate the role of lncRNA MALAT1 in the bone metastasis of non-small cell lung cance...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.4909

    authors: Liu M,Sun W,Liu Y,Dong X

    更新日期:2016-09-01 00:00:00

  • Mutational analysis of Chk1, Chk2, Apaf1 and Rb1 in human malignant melanoma cell lines.

    abstract::Four tumour suppressor genes (Chk1, Chk2, Apaf1 and Rb1) in nine human malignant melanoma cell lines were screened for a loss of gene expression, point mutations and small deletions/insertions by cDNA-based DGGE/SCCP analysis. In two cell lines alterations of the investigated genes could be demonstrated. This result c...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Papp T,Niemetz A,Dosdahl N,Kumar K,Schiffmann D

    更新日期:2007-01-01 00:00:00

  • Evidence for in the appearance of mRNAs of nucleotide excision repair genes, in human ovarian cancer tissues.

    abstract::Nucleotide excision repair (NER) is the DNA repair pathway through which cisplatin-DNA intrastrand adduct is repaired. Clinical studies have shown that increased mRNA expression of selected genes involved in the rate-limiting step of NER, appear to be closely associated with clinical resistance to platinum agents. The...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.7.5.1123

    authors: Reed E,Dabholkar M,Thornton K,Thompson C,Yu JJ,Bostick-Bruton F

    更新日期:2000-09-01 00:00:00

  • DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma.

    abstract::DEK, a transcription factor, is involved in mRNA splicing, transcriptional control, cell division and differentiation. Recent studies suggest that DEK overexpression can promote tumorigenesis in a wide range of cancer cell types. However, little is known concerning the status of DEK in pancreatic ductal adenocarcinoma...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.5302

    authors: Sun J,Bi F,Yang Y,Zhang Y,Jin A,Li J,Lin Z

    更新日期:2017-02-01 00:00:00

  • Genome-wide profiling of long non-coding RNA expression patterns in the EGFR-TKI resistance of lung adenocarcinoma by microarray.

    abstract::Mutations in the epidermal growth factor receptor (EGFR) make lung adenocarcinoma cells sensitive to EGFR tyrosine kinase inhibitors (TKIs). Long-term cancer therapy may cause the occurrence of acquired resistance to EGFR TKIs. Long non-coding RNAs (lncRNAs) play important roles in tumor formation, tumor metastasis an...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.4758

    authors: Wu Y,Yu DD,Hu Y,Yan D,Chen X,Cao HX,Yu SR,Wang Z,Feng JF

    更新日期:2016-06-01 00:00:00

  • Tumor necrosis factor receptor associated factor-4: an adapter protein overexpressed in metastatic prostate cancer is regulated by microRNA-29a.

    abstract::The tumor necrosis factor receptor (TNFR)-associated factor 4 (TRAF4) is a member of TRAF family proteins that act as major signal transducers of the TNF receptor and the interleukin-1 receptor/Toll-like receptor (IL-1R/TLR) superfamily. TRAF4 has been reported to be overexpressed in various human cancers. However, th...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2789

    authors: Ahmed F,Shiraishi T,Vessella RL,Kulkarni P

    更新日期:2013-12-01 00:00:00

  • Death receptor-dependent and -independent pathways in anticancer drug-induced apoptosis of breast cancer cells.

    abstract::Apoptosis is a crucial event for anticancer drug efficacy. The signal pathways activated by anticancer drugs are classified as death receptor (DR) -dependent or -independent. The mechanisms by which anticancer drugs induce apoptosis via DR-dependent pathways are not fully understood. In the present study, we assessed ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Kim R,Tanabe K,Emi M,Uchida Y,Toge T

    更新日期:2003-11-01 00:00:00

  • Characterizing the molecular mechanisms of acquired temozolomide resistance in the U251 glioblastoma cell line by protein microarray.

    abstract::Acquired chemoresistance refers to tumor cells gradually losing their sensitivity to anticancer drugs during the course of treatment, resulting in tumor progression or recurrence. This phenomenon, which has deleterious outcomes for the patient, has long been observed in patients with glioblastoma receiving temozolomid...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6322

    authors: Lin J,Zuo J,Cui Y,Song C,Wu X,Feng H,Li J,Li S,Xu Q,Wei W,Qiu G,He H

    更新日期:2018-05-01 00:00:00

  • Inhibition of epithelial‑mesenchymal transition in gastric cancer cells by miR‑711‑mediated downregulation of CD44 expression.

    abstract::Gastric cancer is a common malignancy worldwide. The prognosis of early stage gastric cancer patients has significantly improved in recent years. However, in progressive stage gastric cancer patients, the prognosis remains relatively poor due to tumor metastases. In our previous study, we showed that the expression of...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6681

    authors: Xiao WS,Li DF,Tang YP,Chen YZ,Deng WB,Chen J,Zhou WW,Liao AJ

    更新日期:2018-11-01 00:00:00

  • TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation.

    abstract::Gastric cancer (GC), a type of gastric mucosal epithelium disease caused by common malignant tumors, has become a major threat to human health and survival. Tumor necrosis factor‑α‑induced protein‑8 like‑2 (TIPE2) is a negative immune regulatory factor that is selectively expressed in immune organs, immune cells and v...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6576

    authors: Lin Z,Liu W,Xiao C,Fan Y,Zhuang G,Qi Z

    更新日期:2018-09-01 00:00:00

  • Hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines with different radiothermosensitivity in vitro.

    abstract::We investigated cell susceptibility to hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines (RYSTs) and attempted to correlate this with the known potentially relevant molecular determinants of apoptosis, p53 protein status, Bcl-2 family of proteins and heat shock proteins (Hsp). Parent cell line, NMT-1...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.8.3.501

    authors: Islam MS,Mitsuhashi N,Akimoto T,Sakurai H,Hasegawa M,Ishikawa H,Niibe H

    更新日期:2001-05-01 00:00:00

  • EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.

    abstract::Esophageal cancer (EC) has a globally increasing incidence with poor curative treatment options and survival rates. Crucial risk factors are exposure to toxins or carcinogens. Microsomal epoxide hydrolase (mEH) is a biotransformation enzyme essential for the detoxification of xenobiotics. Polymorphisms in exon 3 and e...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.1734

    authors: Dura P,Bregitha CV,Te Morsche RH,Roelofs HM,Kristinsson JO,Wobbes T,Witteman BJ,Tan AC,Drenth JP,Peters WH

    更新日期:2012-06-01 00:00:00

  • Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1.

    abstract::Hepatocellular carcinoma is the most common type of liver cancer. The risk of hepatocellular carcinoma for type 2 diabetic patients is greater than that for non-diabetic individuals although the mechanism is unclear. The cancer suppressor resveratrol inhibits cancer cell proliferation partly through the STAT3 signalin...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2748

    authors: Li Y,Zhu W,Li J,Liu M,Wei M

    更新日期:2013-12-01 00:00:00

  • Morusin suppresses A549 cell migration and induces cell apoptosis by downregulating the expression of COX‑2 and VEGF genes.

    abstract::The present study aimed to examine the inhibitory effects of morusin on the human lung cancer cell line A549. Various doses of morusin were applied to A549 cells and the effects were assessed by wound‑healing and MTT assays, flow cytometry analysis of apoptosis, a mitochondrial membrane potential assay and RT‑PCR. The...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6431

    authors: Yin XL,Lv Y,Wang S,Zhang YQ

    更新日期:2018-07-01 00:00:00

  • 18F-fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts.

    abstract::We investigated whether 18F-fluorothymidine-positron-emission tomography/computed tomography (18F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1338

    authors: Takeuchi S,Zhao S,Kuge Y,Zhao Y,Nishijima K,Hatano T,Shimizu Y,Kinoshita I,Tamaki N,Dosaka-Akita H

    更新日期:2011-09-01 00:00:00

  • Primary carcinoid tumor of the common hepatic duct: A rare case with immunohistochemical and molecular findings.

    abstract::We report immunohistochemical (IHC) and molecular findings in a rare case of a carcinoid tumor of the extrahepatic bile ducts in a 33-year-old woman, who presented with a 3.9x2.8x2.6 cm mass within the right and common hepatic ducts. She underwent surgery and a carcinoid tumor was identified. This lesion is of interes...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Ligato S,Furmaga W,Cartun RW,Hull D,Tsongalis GJ

    更新日期:2005-03-01 00:00:00

  • S100P, a potential novel prognostic marker in colorectal cancer.

    abstract::Previous studies have shown that S100P contributes to the development of a number of tumors. However, its prognostic significance in colorectal cancer (CRC) has not been demonstrated. This study aimed to confirm the expression of S100P in colorectal cancer as well as the epigenetic mechanism underlying its gene expres...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.1794

    authors: Wang Q,Zhang YN,Lin GL,Qiu HZ,Wu B,Wu HY,Zhao Y,Chen YJ,Lu CM

    更新日期:2012-07-01 00:00:00

  • Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma.

    abstract::Casein kinase 2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is involved in regulating many processes such as cell proliferation, differentiation and apoptosis. CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma. In the present study, we found that...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.5233

    authors: Zhu X,Ouyang Y,Zhong F,Wang Q,Ding L,Zhang P,Chen L,Liu H,He S

    更新日期:2017-01-01 00:00:00

  • The inhibition of proliferation and migration of glioma spheroids exposed to temozolomide is less than additive if combined with irradiation.

    abstract::The aim of this study was to investigate the effect of temozolomide (TZM) in combination with X-rays on proliferation and migration in human glioma spheroids. Multicellular spheroids were derived from GaMg and U87 cell lines. Spheroids were treated with various concentrations of TZM (5 micromol, 0.025 mmol, 0.05 mmol)...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Fehlauer F,Muench M,Richter E,Rades D

    更新日期:2007-04-01 00:00:00

  • pseudo-G-Rh2 induces mitochondrial-mediated apoptosis in SGC-7901 human gastric cancer cells.

    abstract::This study was designed to investigate the effect of pseudo-G-Rh2, a novel metabolite of ginsenoside Rh2, on the apoptosis of SGC-7901 human gastric cancer cells. Pseudo-G-Rh2 demonstrated antitumor activity and significantly inhibited the proliferation of SGC-7901 cells in a concen...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1442

    authors: Qu X,Qu S,Yu X,Xu H,Chen Y,Ma X,Sui D

    更新日期:2011-12-01 00:00:00

  • Simvastatin protects Sertoli cells against cisplatin cytotoxicity through enhanced gap junction intercellular communication.

    abstract::Cisplatin, an important chemotherapeutic agent against testicular germ cell cancer, induces testicular toxicity on Leydig and Sertoli cells, leading to serious side-effects such as azoospermia and infertility. In a previous study, it was found that simvastatin enhanced the sensitivity of Leydig tumor cells to chemothe...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4192

    authors: Wang L,Peng J,Huang H,Wang Q,Yu M,Tao L

    更新日期:2015-10-01 00:00:00

  • Human papillomavirus predicts the outcome following concomitant chemoradiotherapy in patients with head and neck squamous cell carcinomas.

    abstract::We investigated the prevalence of human papillomavirus (HPV) in a clinical series of 72 patients with head and neck squamous cell carcinoma (HNSCC) using a retrospective and prospective study design. The majority of patients were smokers and/or drinkers and were treated with concomitant chemoradiotherapy (CCR). Furthe...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2415

    authors: Duray A,Descamps G,Decaestecker C,Sirtaine N,Gilles A,Khalifé M,Chantrain G,Depuydt CE,Delvenne P,Saussez S

    更新日期:2013-07-01 00:00:00

  • Induction of eEF2-specific antitumor CTL responses in vivo by vaccination with eEF2-derived 9mer-peptides.

    abstract::Eukaryotic elongation factor 2 (eEF2) is an essential factor for protein synthesis. Previous studies have shown that the eEF2 gene was overexpressed and plays an oncogenic role in various types of cancers and that eEF2 gene product elicited both humoral immune responses to produce eEF2-specific IgG autoantibody in can...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.4589

    authors: Nakajima H,Murakami Y,Morii E,Akao T,Tatsumi N,Odajima S,Fukuda M,Machitani T,Iwai M,Kawata S,Hojo N,Oka Y,Sugiyama H,Oji Y

    更新日期:2016-04-01 00:00:00

  • [Retracted] Long non-coding RNA MEG3 inhibits cell growth of gliomas by targeting miR-93 and inactivating PI3K/AKT pathway.

    abstract::Following the publication of this paper, it was drawn to the authors' attention by an interested reader that certain of the tumours featured in Fig. 6A of the above paper were strikingly similar to those featured in Fig. 8A of an article appearing in International Journal of Oncology (Fan F-Y, Deng R, Yi H, Sun H-P, Z...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2020.7828

    authors: Zhang L,Liang X,Li Y

    更新日期:2021-01-01 00:00:00

  • Optimal method for quantitative detection of plasma EGFR T790M mutation using droplet digital PCR system.

    abstract::Though patients with EGFR mutations are initially responsive to EGFR-tyrosine kinase inhibitors (TKIs), most tumors ultimately acquire resistance to EGFR-TKIs. The most frequently reported mechanism is EGFR T790M mutation. In this study, using a droplet digital PCR (ddPCR) system, we assessed optimal conditions for a ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.5567

    authors: Suzawa K,Yamamoto H,Ohashi K,Hashida S,Tomida S,Kubo T,Maki Y,Soh J,Tsukuda K,Kiura K,Miyoshi S,Toyooka S

    更新日期:2017-05-01 00:00:00

  • Cancer patients treated with the Banerji protocols utilising homoeopathic medicine: a Best Case Series Program of the National Cancer Institute USA.

    abstract::Although many studies have been conducted on the role of alternative medicine in the treatment of cancer, only a few reports have been published regarding the total regression of malignant tumors. At the PBH Research Foundation (PBHRF), two of the authors have used homoeopathic therapy to treat many patients with vari...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Banerji P,Campbell DR,Banerji P

    更新日期:2008-07-01 00:00:00