AKAPs competing peptide HT31 disrupts the inhibitory effect of PKA on RhoA activity.

abstract：:Chemotherapy plays a major role in cancer management; however, acquired drug resistance remains a significant problem for ovarian cancer treatment. Chemoresistance is regulated by the coordinated expression of a set of genes. Thus, the identification of genes specifically modulated in the process provides an important...

journal_title：Oncology reports

authors： Li L,Luan Y,Li X,Tang B,Zhang W,Li D,Zhao J,Wang G,Ding H,Reed E,Li QQ

更新日期：2005-05-01 00:00:00

abstract：:The aim of the present study was to research the apoptosis of human hepatocellular carcinoma cell line HepG 2 induced by pitavastatin. HepG 2 cells were treated with increasing doses of pitavastatin or with mevalonic acid for 48 h. The proliferation of cells was detected with WST-8. The morphology of the nucleus was o...

journal_title：Oncology reports

authors： Wang J,Xu Z,Zhang M

更新日期：2007-08-01 00:00:00

abstract：:Eicosapentaenoic acid (EPA) is a dietary polyunsaturated fatty acid (PUFA) that is found abundantly in fish oils and induces apoptosis in human promyelocytic leukemia HL-60 cells. Cyclooxygenase (COX) converts EPA intracellularly into various inflammatory mediators that may affect the bioavailability of this fatty aci...

journal_title：Oncology reports

authors： Chiu LC,Tong KF,Ooi VE

更新日期：2004-01-01 00:00:00

abstract：:Prostate cancer (PCa) is the second most common type of male malignancy worldwide. The transcription factor zinc finger E‑box binding homeobox 1 (ZEB1) is associated with epithelial‑mesenchymal transition and is also involved in regulation of androgen receptor (AR) expression, the main ligands of which are testosteron...

journal_title：Oncology reports

authors： Herrera D,Orellana-Serradell O,Villar P,Torres MJ,Paciucci R,Castellón EA,Contreras HR

更新日期：2019-02-01 00:00:00

abstract：:This study was mainly focused on the development of a dual-ligand liposomal delivery system for targeting the delivery of paclitaxel (PTX) to lung cancer. The specific ligand peptide HAIYPRH (T7) and the cationic cell-penetrating peptide TAT were connected with phospholipid via a polyethylene glycol (PEG) spacer to pr...

journal_title：Oncology reports

authors： Wang RH,Cao HM,Tian ZJ,Jin B,Wang Q,Ma H,Wu J

更新日期：2015-02-01 00:00:00

abstract：:Targeted gene therapy needs to be implemented for future therapies to ensure efficient activity at the site of patient primary tumors or metastases without causing intolerable side-effects. One of the elements of gene therapy is vector, which includes viral and non-viral vector. In the present study, we constructed a ...

journal_title：Oncology reports

authors： Zuo Y,Liao S,Xu Z,Xie J,Huang W,Yu Z

更新日期：2014-12-01 00:00:00

abstract：:Esculetin, a phenolic compound, has been shown to inhibit the growth of colon tumors in animal studies. However, the roles of signaling pathways and cell cycle regulation in the esculetin-induced inhibition of cancer cell growth, remain to be elucidated. The present study suggests a novel mechanism for the Ras/ERK1/2 ...

journal_title：Oncology reports

authors： Park SS,Park SK,Lim JH,Choi YH,Kim WJ,Moon SK

更新日期：2011-01-01 00:00:00

abstract：:Oral cancer is one of the leading types of cancer and remains the most common cause of cancer‑related mortality in Asia. The pathogenesis of oral cancer is complicated and, due to lack of accurate diagnostic methods and efficient treatment strategies, oral cancer is responsible for a large number of deaths. Therefore,...

journal_title：Oncology reports

authors： Wang J,Lv N,Lu X,Yuan R,Chen Z,Yu J

更新日期：2021-01-01 00:00:00

abstract：:The presence of hypoxic regions within solid tumors is caused by an imbalance between cell proliferation and angiogenesis. Such regions may facilitate the onset of recurrence after radiation therapy and chemotherapy, as hypoxic cells show resistance to these treatments. We found that tempol, a nitroxide, strongly indu...

journal_title：Oncology reports

authors： Kagiya G,Ogawa R,Choudhuri R,Cook JA,Hatashita M,Tanaka Y,Koda K,Yamashita K,Kubo M,Kawakami F,Mitchell JB

更新日期：2015-08-01 00:00:00

abstract：:Lung cancer is still the leading cause of cancer-related deaths worldwide. Identifying new oncogenic drivers and developing efficient inhibitors through molecular targeting approaches are crucial for improving therapies. The aim of this study was to investigate whether targeting fibroblast growth factor receptor 1 (FG...

journal_title：Oncology reports

authors： Ren M,Hong M,Liu G,Wang H,Patel V,Biddinger P,Silva J,Cowell J,Hao Z

更新日期：2013-06-01 00:00:00

abstract：:Muscle atrophy F-Box (MAFbx)/atrogin-1 and muscle ring-finger-1 (MuRF-1) have been identified as two muscle-specific E3 ubiquitin ligases that are highly expressed in skeletal muscle during muscle atrophy. However, the role of muscle-specific E3 ubiquitin ligases during the process of muscle atrophy of cancer cachexia...

journal_title：Oncology reports

authors： Yuan L,Han J,Meng Q,Xi Q,Zhuang Q,Jiang Y,Han Y,Zhang B,Fang J,Wu G

更新日期：2015-05-01 00:00:00

abstract：:Analysis of HER-2/neu gene amplification by fluorescence in situ hybridization was performed in 40 patients with invasive bladder cancer in order to evaluate the potential for molecular targeted therapy of HER-2 as a tailor-made treatment for patients with invasive bladder cancer. This study included 40 patients seen ...

journal_title：Oncology reports

authors： Yamada Y,Naruse K,Nakamura K,Aoki S,Taki T,Tobiume M,Zennami K,Katsuda R,Hirano M,Hayashida K,Mizumukai E,Nanaura H,Honda N

更新日期：2007-11-01 00:00:00

abstract：:The WHO clearly identifies tumors as a curable or a chronic disease. The use of natural agents in cancer prevention and therapy is currently playing an important role. Our laboratory has been investigating various natural phenolic compounds, including grifolin, neoalbaconol and epigallocatechin-3-gallate (EGCG). In th...

journal_title：Oncology reports

authors： Luo X,Yu X,Liu S,Deng Q,Liu X,Peng S,Li H,Liu J,Cao Y

更新日期：2015-08-01 00:00:00

abstract：:Resolvins, an endogenous lipid mediator derived from eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) of fish oil, has been reported to have anti-inflammatory and antitumor effect in various pathogenic processes. However, there are no studies about the effects of resolvin D1 and E1 on concanavalin A-induced h...

journal_title：Oncology reports

authors： Kuang H,Hua X,Zhou J,Yang R

更新日期：2016-01-01 00:00:00

abstract：:Photodynamic therapy (PDT) using photosensitizer can induce diverse cellular responses, including apoptosis. Recently, it has been reported that PDT using methylaminolaevulinate may be effective in basal cell carcinoma. However, it is largely unknown whether PDT using a natural product such as curcumin can induce apop...

journal_title：Oncology reports

authors： Park K,Lee JH

更新日期：2007-03-01 00:00:00

abstract：:Thyroid cancer (TC) is the most frequent endocrine malignancy, accounting however for only 1-2% of all human cancers, and the best-established risk factor for TC is radiation exposure, particularly during childhood. Since the BER pathway seems to play an important role in the repair of DNA damage induced by IR and oth...

journal_title：Oncology reports

authors： Santos LS,Branco SC,Silva SN,Azevedo AP,Gil OM,Manita I,Ferreira TC,Limbert E,Rueff J,Gaspar JF

更新日期：2012-11-01 00:00:00

abstract：:The blood‑brain barrier (BBB) constitutes an efficient organization of tight junctions that limits the delivery of tumor to the brain. The principal tight junction protein in BBB is claudin‑5 (CLDN5), but its mechanism of action remains largely unknown. Long non‑coding RNAs (lncRNAs) are aberrantly expressed in many c...

journal_title：Oncology reports

authors： Ma SC,Li Q,Peng JY,Zhouwen JL,Zhang DN,Zhang CB,Jiang WG,Jia W

更新日期：2018-03-01 00:00:00

abstract：:Vascular endothelial growth factor C (VEGF-C), a member of VEGF gene family, is considered to induce both lymph node metastasis and lymphatic involvement in various cancers related to lymphangiogenesis. We examined the relationship between VEGF-C expression and clinicopathological features in 112 Japanese patients wit...

journal_title：Oncology reports

authors： Kimura Y,Watanabe M,Ohga T,Saeki H,Kakeji Y,Baba H,Maehara Y

更新日期：2003-11-01 00:00:00

abstract：:Ovarian cancer is one of the most common gynecological malignancies and its pathogenesis and progression are regulated by multiple genes. MicroRNAs (miRNAs) are endogenous non‑coding RNAs that regulate body function by altering post‑transcriptional gene expression. Previous studies have suggested that miRNAs are close...

journal_title：Oncology reports

authors： Wei L,He Y,Bi S,Li X,Zhang J,Zhang S

更新日期：2020-12-11 00:00:00

abstract：:The altered expression of certain genes is frequently detected as a hallmark of malignant tumors. These differentially expressed genes have the potential to become molecular markers. We purified the fecal mRNA from patients with colorectal cancer to identify novel candidates by using oligo-nucleotide microarray hybrid...

journal_title：Oncology reports

authors： Chien CC,Chang CC,Yang SH,Chen SH,Huang CJ

更新日期：2006-04-01 00:00:00

abstract：:Investigations into the cellular processing of radiolabeled monoclonal antibodies (mAbs) for their further use in radioimmunodiagnosis and cancer therapy are needed in order to understand the fate of internalized and catabolized mAbs. The anti-colorectal cancer mAb, A33, was labelled with 76Br and 125I using the direc...

journal_title：Oncology reports

authors： Höglund J,Orlova A,Sundin A,Lundqvist H,Tolmachev V

更新日期：2006-07-01 00:00:00

abstract：:DLC-1 (deleted in liver cancer-1) is a potential tumor suppressor gene, which is inactive in liver carcinogenesis. To observe the effects of DLC-1 gene expression on cell proliferation and migration in the human colon cancer cell line, RNAi Lipo-recombinant of the DLC-1 gene (pGCsil-DLC-1) was constructed and transduc...

journal_title：Oncology reports

authors： Jin Y,Tian X,Shang Y,Huang P

更新日期：2008-03-01 00:00:00

abstract：:Owing to aggressiveness and chemoresistance, pancreatic ductal adenocarcinoma (PDAC) is characterised by a poor prognosis. To address this disease-spe-cific dilemma we aimed to establish animal models, which can be used for identifying new specific tumor markers, as well as serving ...

journal_title：Oncology reports

authors： Eyol E,Murtaga A,Zhivkova-Galunska M,Georges R,Zepp M,Djandji D,Kleeff J,Berger MR,Adwan H

更新日期：2012-12-01 00:00:00

abstract：:Synovial sarcomas (SS) consistently show a characteristic chromosomal translocation, t(X;18)(p11;q11), which usually leads to the formation of 2 chimeric fusion transcripts, SYT-SSX1 and -SSX2. A recent multi-institutional retrospective study revealed that the SYT-SSX fusion type emerged as the only independent signif...

journal_title：Oncology reports

authors： Saito T,Oda Y,Kawaguchi K,Takahira T,Yamamoto H,Tanaka K,Matsuda S,Sakamoto A,Iwamoto Y,Tsuneyoshi M

更新日期：2004-05-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of human esophageal cancer in East Asia. In the present study, we explored the tumor suppressive function of microRNA-181d (miR-181d) in ESCC. Quantitative RT-PCR was used to assess gene levels of miR‑181d in both ESCC cell lines and clinical samples...

journal_title：Oncology reports

authors： Li D,Shi M,Ji H,Chen G,Jiang H,Wang Z

更新日期：2016-10-01 00:00:00

abstract：:Several investigators have demonstrated that TGF-beta stimulated clone-22 (TSC-22) regulates cell growth and differentiation, and cell death. TSC-22 is a putative transcriptional regulator containing a leucine zipper-like structure and a nuclear export signal. We previously showed the cytoplasmic localization of TSC-2...

journal_title：Oncology reports

authors： Hino S,Kawamata H,Omotehara F,Uchida D,Begum NM,Yoshida H,Sato M,Fujimori T

更新日期：2002-03-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor, which was confirmed as a tumor suppressor gene in colorectal cancers. KLF4 inhibits colorectal cancer cells proliferation through upregulating p21WAF1/Cip1 and downregulating cyclin D1. We firstly reported that N-Myc downstream regulated gene 2 (NDRG2...

journal_title：Oncology reports

authors： Ma Y,Wu L,Liu X,Xu Y,Shi W,Liang Y,Yao L,Zheng J,Zhang J

更新日期：2017-08-01 00:00:00

abstract：:Prostate specific antigen (PSA) is still the best available tumour marker in prostate cancer (PCa), but presents some limits. Therefore, there is a need for novel markers in the detection and management of PCa. The 80-kDa soluble form of E-cadherin (sE-cad) and the cytokine IL-6 are being discussed as supplemental ser...

journal_title：Oncology reports

authors： Iacopino F,Pinto F,Bertaccini A,Calarco A,Proietti G,Totaro A,Martorana G,Bassi P,Sica G

更新日期：2012-07-01 00:00:00

abstract：:Bee venom (BV) therapy is a type of alternative medical treatment used to treat various diseases in oriental medicine. The mechanisms underlying the effects of BV remain poorly understood. In the present study, we evaluated the antiviral effect of BV on cervical carcinoma cell lines (CaSki, HeLa, C33A and TC-1). BV tr...

journal_title：Oncology reports

authors： Kim YW,Chaturvedi PK,Chun SN,Lee YG,Ahn WS

更新日期：2015-04-01 00:00:00

abstract：:IncRNAs play an important role in the regulation of gene expression. The present study profiled differentially expressed lncRNAs (DELs) and mRNAs (DEMs) in myelodysplastic syndrome (MDS) to construct a 4‑aminobutyrate aminotransferase (ABAT)‑DEL‑DEM co‑expression network in MDS development using the Agilent human Bead...

journal_title：Oncology reports

authors： Chen Y,Zhao G,Li N,Luo Z,Wang X,Gu J

更新日期：2019-08-01 00:00:00