miR-216b inhibits glioma cell migration and invasion through suppression of FoxM1.

abstract：:To study the role of the chemokine receptor CCR7 in the metastatic process, a murine CCR7 gene was transduced in two mammary cancer cell lines with different origins and molecular features; TS/A, derived from a spontaneous mammary cancer of BALB/c strain, and N202.1A, derived from a HER-2/neu transgenic mammary cancer...

journal_title：Oncology reports

authors： Croci S,Nicoletti G,Landuzzi L,Palladini A,Chiarini F,Nanni P,Lollini PL,De Giovanni C

更新日期：2007-08-01 00:00:00

abstract：:In recent years, several antioxidant substances have been found to have an antiproliferative effect on various types of carcinomas. α-lipoic acid (ALA) induces apoptosis in several types of cancer cell lines, but it is difficult to apply α-lipoic acid in clinical use as it is easily oxidized and unstable. Recently, we...

journal_title：Oncology reports

authors： Hiratsuka T,Inomata M,Kono Y,Yokoyama S,Shiraishi N,Kitano S

更新日期：2013-06-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) inhibitors have been proven to represent superior clinical agents targeting DNA repair mechanisms in cancer therapy. We investigated PARP inhibitory effects of the natural and synthetic flavonoids (quercetin, rutin, monoglucosyl rutin and maltooligosyl rutin) and tested the synthetic...

journal_title：Oncology reports

authors： Maeda J,Roybal EJ,Brents CA,Uesaka M,Aizawa Y,Kato TA

更新日期：2014-02-01 00:00:00

abstract：:In this study, we investigated the sequence variation and different transcriptional activities of the upstream regulatory region (URR) in HPV 16 E7 variants in cervical cancer tissue from Korean women. Using PCR-directed sequencing, the presence of sequence variations in URRs were analyzed and the sites of sequence va...

journal_title：Oncology reports

authors： Kim YB,Song YS,Jeon YT,Park JS,Um SJ,Kim JW,Park NH,Kang SB,Lee HP

更新日期：2005-08-01 00:00:00

abstract：:Currently, various types of keratins have been reported to be highly expressed in cancer cells and to be associated with a malignant phenotype. In the present study, it was found that expression levels of keratin 6 (K6), keratin 16 (K16), and keratin 17 (K17) were highly elevated in SNU601 cells resistant to cisplatin...

journal_title：Oncology reports

authors： Lim SC,Parajuli KR,Han SI

更新日期：2019-08-01 00:00:00

abstract：:A growing body of evidence suggests that microRNA-365 (miR-365) played crucial role in the initiation and development of many types of cancers. However, the biological role of miR-365 in human glioma remains unclear. Herein, the aims of this study were to investigate the role and underlying mechanisms of miR-365 in gl...

journal_title：Oncology reports

authors： Zhu Y,Zhao H,Rao M,Xu S

更新日期：2017-04-01 00:00:00

abstract：:The aim of this study was to evaluate variations of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and protein expression after adjuvant treatment in glioblastoma patients. Sixteen patients with a glioblastoma underwent 34 microsurgeries including 18 re-operations. After surgery, patients underwent...

journal_title：Oncology reports

authors： Jung TY,Jung S,Moon KS,Kim IY,Kang SS,Kim YH,Park CS,Lee KH

更新日期：2010-05-01 00:00:00

abstract：:Recent research indicates that the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway may play an important role in chronic inflammation which promotes cancer progression, yet the mechanism is not clear. The present study aimed to investigate the role of the JAK/STAT3 pathway in the gr...

journal_title：Oncology reports

authors： Fang J,Chu L,Li C,Chen Y,Hu F,Zhang X,Zhao H,Liu Z,Xu Q

更新日期：2015-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that are involved in tumor initiation and development by suppressing target gene expression. miRNA-154 has been shown to be important in tumorigenesis in many types of cancers. However, its role in osteosarcoma (OS) remains unknown. In the present study, we focused on the r...

journal_title：Oncology reports

authors： Zhou H,Zhang M,Yuan H,Zheng W,Meng C,Zhao D

更新日期：2016-03-01 00:00:00

abstract：:The usefulness of the in vitro chemosensitivity test, the collagen gel droplet embedded culture drug- sensitivity test (CD-DST, Int J Oncol 11: 449, 1997), in cisplatin-based combined chemotherapy for postoperative recurrent tumors in non-small cell lung cancer (NSCLC) patients was retrospectively analyzed. CD-DST dat...

journal_title：Oncology reports

authors： Higashiyama M,Kodama K,Yokouchi H,Takami K,Nakagawa H,Imamura F,Minamigawa K,Kobayashi H

更新日期：2001-03-01 00:00:00

abstract：:Neuroblastoma is a tumor accounting for approximately 10% of all childhood malignancies and 50% of all childhood cancer-related deaths. MYCN gene copy number variation represents the most important prognostic factor in neuroblastoma. Prognostic significance of MYCN gene expression is more complicated and may depend on...

journal_title：Oncology reports

authors： Prochazka P,Hrabeta J,Vicha A,Cipro S,Stejskalova E,Musil Z,Vodicka P,Eckschlager T

更新日期：2013-06-01 00:00:00

abstract：:This retrospective study was designed to evaluate the prognostic value of immunohistochemically detected nm23-expression in invasive breast cancer. Cellular expression of nm23 was assessed in 325 primary breast cancer tissues by immunohistochemistry. The data were correlated to established functional factors of progno...

journal_title：Oncology reports

authors： Göhring UJ,Eustermann I,Becker M,Neuhaus W,Rein DT,Schöndorf T

更新日期：2002-11-01 00:00:00

abstract：:Apoptosis has to be drastically controlled in organs with important cell turnover such as the colon. Deregulation of this process is often present in tumor progression. Tissues of 82 patients treated for colorectal cancer (CRC) were analyzed using antibodies against AIF, p53, DR4, DR5, cleaved caspase-3 and the TUNEL ...

journal_title：Oncology reports

authors： Perraud A,Akil H,Nouaille M,Petit D,Labrousse F,Jauberteau MO,Mathonnet M

更新日期：2011-11-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in tumor invasion, but their prognostic significance is still under discussion. We set out to analyze the epithelial and stromal expression of MMP-2, MMP-7, MMP-9, MT1-MMP, TIMP-1 and TIMP-2 in advanced epithelial ovarian cancers and to ...

journal_title：Oncology reports

authors： Brun JL,Cortez A,Lesieur B,Uzan S,Rouzier R,Daraï E

更新日期：2012-04-01 00:00:00

abstract：:The aim of this study was to assess the use of human papillomavirus (HPV) E6/E7 mRNA testing in the follow-up of women treated for cervical intraepithelial neoplasia (CIN) by conization and to compare the prognostic value of HPV E6/E7 mRNA to HPV L1 DNA and cytology. One hundred and...

journal_title：Oncology reports

authors： Persson M,Brismar Wendel S,Ljungblad L,Johansson B,Weiderpass E,Andersson S

更新日期：2012-07-01 00:00:00

abstract：:Gastric cancer (GC), a type of gastric mucosal epithelium disease caused by common malignant tumors, has become a major threat to human health and survival. Tumor necrosis factor‑α‑induced protein‑8 like‑2 (TIPE2) is a negative immune regulatory factor that is selectively expressed in immune organs, immune cells and v...

journal_title：Oncology reports

authors： Lin Z,Liu W,Xiao C,Fan Y,Zhuang G,Qi Z

更新日期：2018-09-01 00:00:00

abstract：:The blood‑brain barrier (BBB) constitutes an efficient organization of tight junctions that limits the delivery of tumor to the brain. The principal tight junction protein in BBB is claudin‑5 (CLDN5), but its mechanism of action remains largely unknown. Long non‑coding RNAs (lncRNAs) are aberrantly expressed in many c...

journal_title：Oncology reports

authors： Ma SC,Li Q,Peng JY,Zhouwen JL,Zhang DN,Zhang CB,Jiang WG,Jia W

更新日期：2018-03-01 00:00:00

abstract：:Distant metastases represent the major cause of death after curative surgery of colorectal cancer. The aim of this study was to evaluate the role of Smad4 and KRAS genetic alterations in colorectal metastases taking into account both the site (hepatic versus extrahepatic) and the time (synchronous versus metachronous)...

journal_title：Oncology reports

authors： Losi L,Bouzourene H,Benhattar J

更新日期：2007-05-01 00:00:00

abstract：:Agaricus blazei is well known as a traditional medicinal mushroom and it has been shown to exhibit immunostimulatory and anti-cancer activity. However, the cellular and molecular mechanism of cell cycle arrest and apoptosis of cancer cells is poorly understood. In this study, we have investigated whether A. blazei ext...

journal_title：Oncology reports

authors： Jin CY,Choi YH,Moon DO,Park C,Park YM,Jeong SC,Heo MS,Lee TH,Lee JD,Kim GY

更新日期：2006-12-01 00:00:00

abstract：:The number of new lung cancer cases diagnosed yearly is high, and the mortality rate has not substantially declined. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, and adenocarcinoma accounts for the largest proportion of NSCLC. Currently, platinum-based combined chemotherapy, particularly ...

journal_title：Oncology reports

authors： Cheng R,Lu C,Zhang G,Zhang G,Zhao G

更新日期：2017-04-01 00:00:00

abstract：:The aim of the present study was to investigate the role of miR‑203a‑3p in colorectal cancer (CRC) and identify the target gene of microRNA (miR)‑203a‑3p. A total of 59 sets of cancer tissues and corresponding adjacent non‑tumor tissues were collected from CRC patients (aged 31‑78 years) between October 2016 and May 2...

journal_title：Oncology reports

authors： Qian Z,Gong L,Mou Y,Han Y,Zheng S

更新日期：2019-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a common malignant cancer worldwide characterized by high metastatic potential and poor prognosis following radical resection. Metastasin is a Ca(2+)-binding protein associated with tumor metastasis. However, the expression and function of metastasin remain unknown. In the present stu...

journal_title：Oncology reports

authors： Zheng X,Gai X,Wu Z,Liu Q,Yao Y

更新日期：2013-05-01 00:00:00

abstract：:Breast cancer is one of the major health issues confronting women; however, treatment with conventional chemotherapeutic drugs is limited. Currently, paclitaxel is used as a therapeutic clinical agent to treat breast cancer that exerts antitumor activity in numerous types of cancer cell. Curcumin (diferuloylmethane), ...

journal_title：Oncology reports

authors： Calaf GM,Ponce-Cusi R,Carrión F

更新日期：2018-10-01 00:00:00

abstract：:The objective of this study was to examine how splenectomy affects the immune response, particularly T cells, in chemically-induced mammary tumors. Female rats were splenectomized and then exposed to 9,10-dimethyl-1,2-benz(a)anthracene (DMBA) to induce mammary tumors. Splenectomy significantly decreased the rate of tu...

journal_title：Oncology reports

authors： Kossoy G,Ben-Hur H,Lifschitz O,Zusman I

更新日期：2002-01-01 00:00:00

abstract：:Thrombospondin-1 (TSP1) is known to possess tumor suppressor functions. In contradiction, TSP1 enhances the stromal vascularization and growth of certain cancers. A cell adhesion receptor, CD36, has been shown to interact with a ligand TSP1. We studied how CD36 affects the growth of the osteosarcoma cell line (HOS) ex...

journal_title：Oncology reports

authors： Yamazaki H,Handa A,Nishi M,Tokunaga T,Tomisawa M,Hatanaka H,Abe Y,Kijima H,Ueyama Y,Nakamura M

更新日期：2004-02-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations are frequently found in a variety of tumors. However, the role of mtDNA mutations in tumor behavior is poorly understood. We explored the effects of mtDNA mutations on tumor phenotype employing mtDNA-depleted SK-Hep1 rho0 hepatoma cells. Expression of hypoxia inducible factor (HIF)-...

journal_title：Oncology reports

authors： Cheon H,Moon HE,Lee MS,Kim SS

更新日期：2010-03-01 00:00:00

abstract：:A growing number of studies suggest that the hepatitis B virus X protein (HBx) enhances the protein stability of the hypoxia-inducible factor-1α (HIF-1α). However, the relationship between hepatitis B virus (HBV), HBx and hypoxia-inducible factor-2α (HIF-2α) has not yet been fully elucidated. Immunohistochemical analy...

journal_title：Oncology reports

authors： Hu JL,Liu LP,Yang SL,Fang X,Wen L,Ren QG,Yu C

更新日期：2016-03-01 00:00:00

abstract：:The human multidrug resistance gene 1 (MDR-1) encodes a plasma membrane P-glycoprotein (P-gp) that functions as the transmembrane efflux pump for various structurally unrelated anticancer agents and toxins. Polymorphisms in the MDR-1 gene may have an impact on the expression and function of P-gp, thereby influencing t...

journal_title：Oncology reports

authors： Zubor P,Lasabova Z,Hatok J,Stanclova A,Danko J

更新日期：2007-07-01 00:00:00

abstract：:The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we dis...

journal_title：Oncology reports

authors： Malas S,Harrasser M,Lacy KE,Karagiannis SN

更新日期：2014-09-01 00:00:00

abstract：:Sirtuin 6 (SIRT6) is a member of the mammalian NAD+‑dependent deacetylase sirtuin family that acts to maintain genomic stability and to repress genes. SIRT6 has recently been reported to be a tumor suppressor that controls cancer metabolism, although this effect of SIRT6 is still in dispute. Moreover, the role of SIRT...

journal_title：Oncology reports

authors： Feng J,Yan PF,Zhao HY,Zhang FC,Zhao WH,Feng M

更新日期：2016-03-01 00:00:00