Expression of a functional CCR7 chemokine receptor inhibits the post-intravasation steps of metastasis in malignant murine mammary cancer cells.

Abstract:

:To study the role of the chemokine receptor CCR7 in the metastatic process, a murine CCR7 gene was transduced in two mammary cancer cell lines with different origins and molecular features; TS/A, derived from a spontaneous mammary cancer of BALB/c strain, and N202.1A, derived from a HER-2/neu transgenic mammary cancer (FVB background) and characterized by a high expression of HER-2/neu. Transduced CCR7 conferred to mammary cancer cells a chemotactic response towards CCL21 (a CCR7 ligand), but did not consistently affect in vitro growth properties. In vivo, CCR7-engineered cells gave rise to tumors in syngeneic hosts with growth rates similar to or slightly lower than the controls and with similar patterns of spontaneous metastases. When injected directly intravenously to study the late post-intravasation phases of metastasis, CCR7-engineered cells showed a strongly decreased lung colonizing ability. Such an effect was observed both with HER-2/neu-positive and -negative mammary cancer cells. When used as a prophylactic vaccine, CCR7-transduced cell vaccine succeeded in the long-term control of mammary tumorigenesis in 25% of the HER-2/neu transgenic females, suggesting an increased immunogenicity of CCR7-engineered cells.

journal_name

Oncol Rep

journal_title

Oncology reports

authors

Croci S,Nicoletti G,Landuzzi L,Palladini A,Chiarini F,Nanni P,Lollini PL,De Giovanni C

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

451-6

issue

2

eissn

1021-335X

issn

1791-2431

journal_volume

18

pub_type

杂志文章
  • Upregulation of thioredoxin and its reductase attenuates arsenic trioxide‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress.

    abstract::The thioredoxin (Trx) system is an important enzymatic complex involved in cellular redox homeostasis. Arsenic trioxide (ATO; As2O3) is known to trigger cell death in vascular smooth muscle cells (VSMCs) via oxidative stress. In the present study, the effects of changes in thioredoxin 1 (Trx1) and Trx reductase1 (TrxR...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2019.7414

    authors: Park WH

    更新日期:2020-01-01 00:00:00

  • Actin disruption agents induce phosphorylation of histone H2AX in human breast adenocarcinoma MCF-7 cells.

    abstract::Modified actin dynamics are a unique feature of transformed cancer cells and thereby promising targets for cancer chemotherapy. While latrunculin B (LB) and pectenotoxin-2 (PTX-2), both derived from natural sources, inhibit actin polymerization, jasplakinolide (JSP) prevents actin depolymerization. The purpose of this...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2011.1214

    authors: Shin IJ,Ahn YT,Kim Y,Kim JM,An WG

    更新日期:2011-05-01 00:00:00

  • Accuracy of criteria for predicting recurrence and metastasis in stage II and III gastric cancer patients with lymph node metastasis.

    abstract::This study assessed the prediction of gastric cancer recurrence based on detection of occult neoplastic cells (ONCs) in lymph nodes, and by using criteria that were developed to identify patients with a high risk of recurrence/metastasis. The subjects were 60 patients of stage II or III gastric cancer with lymph node ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Mukai M,Sato S,Komatsu N,Kimura T,Ninomiya H,Kawada M,Nakasaki H,Ogoshi K,Makuuchi H

    更新日期:2004-07-01 00:00:00

  • Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells.

    abstract::Deregulation of c-Jun NH2-terminal kinase (JNK) signaling is now increasingly reported in a variety of human malignancies. Non-small cell lung cancer (NSCLC) is among such human malignancies with aberrant JNK activation; yet the exact role(s) of JNK deregulation in NSCLC biology, in particular in vivo, remains unclear...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2655

    authors: Okada M,Shibuya K,Sato A,Seino S,Watanabe E,Suzuki S,Seino M,Kitanaka C

    更新日期:2013-10-01 00:00:00

  • Reduced expression of SRY-box containing gene 17 correlates with an unfavorable melanoma patient survival.

    abstract::SRY-box containing gene 17 (Sox17), a transcription factor, is considered as an antagonist to canonical Wnt/β‑catenin signaling in several types of malignant tumors. As the influence of Sox17 in the pathogenesis of human melanoma is still unknown, the investigation of Sox17 expression in melanoma is warranted and its ...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3534

    authors: Lu J,Zhang G,Cheng Y,Tang Y,Dong Z,McElwee KJ,Li G

    更新日期:2014-12-01 00:00:00

  • Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1.

    abstract::Lung cancer is still the leading cause of cancer-related deaths worldwide. Identifying new oncogenic drivers and developing efficient inhibitors through molecular targeting approaches are crucial for improving therapies. The aim of this study was to investigate whether targeting fibroblast growth factor receptor 1 (FG...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2013.2386

    authors: Ren M,Hong M,Liu G,Wang H,Patel V,Biddinger P,Silva J,Cowell J,Hao Z

    更新日期:2013-06-01 00:00:00

  • Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases.

    abstract::To investigate the components of the prostaglandin biosynthetic pathway, the characteristics of cyclooxygenase (COX)-1, COX-2, hematopoietic prostaglandin D synthase (hPGDS), microsomal prostaglandin E synthase (mPGES), and thromboxane synthase (TXS) were examined for autopsied cases with small cell lung cancer (SCLC)...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Yoshimoto A,Kasahara K,Kawashima A,Fujimura M,Nakao S

    更新日期:2005-06-01 00:00:00

  • Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis.

    abstract::Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Saiko P,Ozsvar-Kozma M,Graser G,Lackner A,Grusch M,Madlener S,Krupitza G,Jaeger W,Hidvegi M,Agarwal RP,Fritzer-Szekeres M,Szekeres T

    更新日期:2009-03-01 00:00:00

  • Expression analysis of pancreatic cancer cell lines reveals association of enhanced gene transcription and genomic amplifications at the 8q22.1 and 8q24.22 loci.

    abstract::Despite tremendous effort and progress in the diagnostics of pancreatic cancer with respect to imaging techniques and molecular genetics, only very few patients can be cured by surgery leading to a 5-year survival rate of only 3%. Especially the lack of chemotherapeutical options in this entity requires a better under...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Domagk D,Schaefer KL,Eisenacher M,Braun Y,Wai DH,Schleicher C,Diallo-Danebrock R,Bojar H,Roeder G,Gabbert HE,Domschke W,Poremba C

    更新日期:2007-02-01 00:00:00

  • Non‑coding RNAs that regulate the Wnt/β‑catenin signaling pathway in gastric cancer: Good cop, bad cop? (Review).

    abstract::Gastric cancer (GC) is one of the most common causes of cancer‑related mortality worldwide. Despite remarkable progress in the diagnosis and treatment of GC, a large number of cases are diagnosed as advanced GC, and treatment failure occurs. Emerging evidence has shown that non‑coding RNAs (ncRNAs), especially microRN...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2020.7705

    authors: Shao Z,Gao D,Chen L,Ding W,Yu Q

    更新日期:2020-10-01 00:00:00

  • Hepatitis B virus X protein sensitizes HL-7702 cells to oxidative stress-induced apoptosis through modulation of the mitochondrial permeability transition pore.

    abstract::Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and cancer. Among the pathogenic factors of HBV, HBV X protein (HBx) is attracting increased attention. Although it is documented that HBx is a multifunctional regulator that modulates cell inflammation and apoptosis, the exact mechanism r...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2016.5225

    authors: Gao WY,Li D,Cai DE,Huang XY,Zheng BY,Huang YH,Chen ZX,Wang XZ

    更新日期:2017-01-01 00:00:00

  • CHST15 promotes the proliferation of TE‑1 cells via multiple pathways in esophageal cancer.

    abstract::Esophageal squamous cell carcinoma (ESCC) is a common type of esophageal cancer and is prevalent worldwide. Understanding the mechanisms underlying its formation and the search for more effective therapeutic strategies are critical due to the occurrence of chemotherapeutic drug resistance. The aim of the present study...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2019.7395

    authors: Wang X,Cheng G,Zhang T,Deng L,Xu K,Xu X,Wang W,Zhou Z,Feng Q,Chen D,Bi N,Wang L

    更新日期:2020-01-01 00:00:00

  • Activation of caspases and apoptosis in response to low-voltage electric pulses.

    abstract::Few studies have examined apoptosis induced by low-voltage electric pulses (LVEPs). LVEP-induce changes in membrane potential that are below the membrane breakdown threshold and increase membrane permeability without electroporation (pore formation) through the transport of extracellular substances via phagocytosis. W...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or_00000780

    authors: Matsuki N,Takeda M,Ishikawa T,Kinjo A,Hayasaka T,Imai Y,Yamaguchi T

    更新日期:2010-05-01 00:00:00

  • Simvastatin protects Sertoli cells against cisplatin cytotoxicity through enhanced gap junction intercellular communication.

    abstract::Cisplatin, an important chemotherapeutic agent against testicular germ cell cancer, induces testicular toxicity on Leydig and Sertoli cells, leading to serious side-effects such as azoospermia and infertility. In a previous study, it was found that simvastatin enhanced the sensitivity of Leydig tumor cells to chemothe...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.4192

    authors: Wang L,Peng J,Huang H,Wang Q,Yu M,Tao L

    更新日期:2015-10-01 00:00:00

  • Tissue-specific regulation of Apaf-1 expression by p53.

    abstract::The p53 tumor suppressor is a transcription factor that regulates cell cycle and apoptosis in response to a variety of environmental stress conditions. Recent studies indicated that the apoptotic protease activating factor-1 (Apaf-1) is a direct transcriptional target of p53 in DNA damage-induced apoptosis. However, t...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Ho CK,Bush JA,Li G

    更新日期:2003-09-01 00:00:00

  • Paeonol exerts an anticancer effect on human colorectal cancer cells through inhibition of PGE₂ synthesis and COX-2 expression.

    abstract::Cyclooxygenase-2 (COX-2) and its metabolite prostaglandin E2 (PGE2) can potentially affect most of the events in cancer development, including promotion of proliferation, resistance to apoptosis, angiogenesis, immune suppression and invasion. However, worldwide attention has predominantly centered on the cardiovascula...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3543

    authors: Li M,Tan SY,Wang XF

    更新日期:2014-12-01 00:00:00

  • BMI-1 suppression increases the radiosensitivity of oesophageal carcinoma via the PI3K/Akt signaling pathway.

    abstract::B-cell‑specific Moloney murine leukaemia virus integration site-1 (BMI-1) contributes to the growth of tumour cells post-irradiation (IR). The aim of the present study was to characterize the effects of BMI-1 on cell viability, radiosensitivity and its mechanisms of action in oesophageal squamous cell cancer (ESCC). W...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.6136

    authors: Yang XX,Ma M,Sang MX,Zhang XY,Liu ZK,Song H,Zhu SC

    更新日期:2018-02-01 00:00:00

  • Decreased orotate phosphoribosyltransferase activity produces 5-fluorouracil resistance in a human gastric cancer cell line.

    abstract::To elucidate the mechanism of resistance to 5-fluorouracil (5-FU) in human gastric cancer cells, we established a cell line MKN45/F2R, which acquired 5-FU resistance as a result of continuous exposure to increasing dosages of 5-FU over a year. The cell line showed 157-fold elevated 5-FU resistance compared to the MKN4...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Tsutani Y,Yoshida K,Sanada Y,Wada Y,Konishi K,Fukushima M,Okada M

    更新日期:2008-12-01 00:00:00

  • Long non‑coding RNA RP1‑163G9.1 is downregulated in gastric adenocarcinoma and is associated with a poor prognosis.

    abstract::The aim of the present study was to investigate the expression, function and underlying molecular mechanism of the long non‑coding (lnc) RNA RP1‑163G9.1 in patients with gastric adenocarcinoma (GA). The expression levels of lncRNA RP1‑163G9.1 were determined in 112 paired clinical GA tissues by reverse transcription‑q...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2019.7127

    authors: Sun B,Dang Y,Zhang F,Li K,Ouyang X,Wang K,Huang Q

    更新日期:2019-06-01 00:00:00

  • Expression spectra of matrix metalloproteinases in metastatic non-small cell lung cancer.

    abstract::By combining suppression subtractive hybridization and microarray to examine gene expressions between metastatic and non-metastatic non-small cell lung cancer (NSCLC), we have identified differential expression spectra of matrix metalloproteinases (MMP). Among MMPs, expressions of MMP-13, -14, -15 and -24 decreased, t...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Lin TS,Chiou SH,Wang LS,Huang HH,Chiang SF,Shih AY,Chen YL,Chen CY,Hsu CP,Hsu NY,Chou MC,Kuo SJ,Chow KC

    更新日期:2004-10-01 00:00:00

  • Activation of PAR2 or/and TLR4 promotes SW620 cell proliferation and migration via phosphorylation of ERK1/2.

    abstract::Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor and its activation has been associated with the pathogenetic progress in certain cancers. Toll-like receptor 4 (TLR4), one member of Toll-like receptors family, is mainly contributed to the innate immune response. However, recent studies have shown t...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2010.1077

    authors: Zhou B,Zhou H,Ling S,Guo D,Yan Y,Zhou F,Wu Y

    更新日期:2011-02-01 00:00:00

  • Metastasis-associated protein 1 inhibits p53-induced apoptosis.

    abstract::Metastasis-associated protein 1 (MTA1) is highly upregulated in cancer cells with metastatic potential; however, the molecular mechanism by which MTA1 increases the metastatic potential of cancer cells is far from clear. We characterized the functional consequences of MTA1 overexpression on p53-induced apoptosis of ca...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Moon HE,Cheon H,Lee MS

    更新日期:2007-11-01 00:00:00

  • Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway.

    abstract::Licochalcone A (LicA) is a chalcone extracted from liquorice which has been used as a traditional Chinese medicine for many generations. Increased glucose consumption and glycolytic activity are important hallmarks of cancer cells, and hexokinase 2 (HK2) upregulation is a major contributor to the elevation of glycolys...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.6155

    authors: Wu J,Zhang X,Wang Y,Sun Q,Chen M,Liu S,Zou X

    更新日期:2018-03-01 00:00:00

  • Expression of KLF9 in pancreatic cancer and its effects on the invasion, migration, apoptosis, cell cycle distribution, and proliferation of pancreatic cancer cell lines.

    abstract::Kruppel-like factor 9 (KLF9), a transcription factor, is critical for the inhibition of growth and development of tumors, whereas its effects in pancreatic cancer remains unclear. The purpose of the present study was to investigate the expression and functional significance of KLF9 in vitro, by assessing the expressio...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2018.6760

    authors: Zhong Z,Zhou F,Wang D,Wu M,Zhou W,Zou Y,Li J,Wu L,Yin X

    更新日期:2018-12-01 00:00:00

  • Alteration of gene expression and DNA methylation in drug-resistant gastric cancer.

    abstract::The mechanisms of drug resistance in cancer are not fully elucidated. To study the drug resistance of gastric cancer, we analyzed gene expression and DNA methylation profiles of 5-fluorouracil (5-FU)- and cisplatin (CDDP)-resistant gastric cancer cells and biopsy specimens. Drug-resistant gastric cancer cells were est...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2014.3014

    authors: Maeda O,Ando T,Ohmiya N,Ishiguro K,Watanabe O,Miyahara R,Hibi Y,Nagai T,Yamada K,Goto H

    更新日期:2014-04-01 00:00:00

  • Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells.

    abstract::The lipogenic enzyme fatty acid synthase (FAS) is differentially overexpressed and hyperactivated in a biologically aggressive subset of breast carcinomas and minimally in most normal adult tissues, rendering it an interesting target for anti-neoplastic therapy development. Current trends in the treatment of human bre...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:

    authors: Menendez JA,Colomer R,Lupu R

    更新日期:2004-08-01 00:00:00

  • In vivo real-time imaging of chemotherapy response on the liver metastatic tumor microenvironment using multiphoton microscopy.

    abstract::In vivo real-time visualization of chemotherapy response at the cellular level provides us with direct evidence of what happens on the tumor microenvironment of metastatic organs. We imaged the response of metastatic tumor cells and host stromal cells to chemotherapeutics on liver m...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.1983

    authors: Tanaka K,Okigami M,Toiyama Y,Morimoto Y,Matsushita K,Kawamura M,Hashimoto K,Saigusa S,Okugawa Y,Inoue Y,Uchida K,Araki T,Mohri Y,Mizoguchi A,Kusunoki M

    更新日期:2012-11-01 00:00:00

  • Serum interleukin-15 levels in cancer patients with cachexia.

    abstract::Interleukin-15 (IL-15) has important anabolic effects on muscle protein metabolism through a decrease in the ATP-ubiquitin-dependent proteolytic pathway. The role of IL-15 in human cancer cachexia is unknown. The aim of this study was to assess the relationship between interleukin-1...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2012.1928

    authors: Martínez-Hernández PL,Hernanz-Macías Á,Gómez-Candela C,Grande-Aragón C,Feliu-Batlle J,Castro-Carpeño J,Martínez-Muñoz I,Zurita-Rosa L,Villarino-Sanz M,Prados-Sánchez C,Sánchez García-Girón J

    更新日期:2012-10-01 00:00:00

  • GnRH participates in the self-renewal of A549-derived lung cancer stem-like cells through upregulation of the JNK signaling pathway.

    abstract::Lung cancer is the leading cause of cancer-related mortality in humans. Exploration of the mechanisms underlying the self-renewal and stemness maintenance of cancer stem-like cells (CSLCs) will open new avenues in lung cancer diagnosis and therapy. Here, we isolated and identified a subpopulation of lung cancer stem-l...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2015.3956

    authors: Lu C,Huang T,Chen W,Lu H

    更新日期:2015-07-01 00:00:00

  • Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells.

    abstract::The aim of the present study was to search for an effective regimen among existing chemotherapies for head and neck squamous cell carcinoma (HNSCC). Among the tested drugs, we focused on combined SN-38, which is the active metabolite produced from irinotecan hydrochloride - a type I DNA topoisomerase inhibitor - after...

    journal_title:Oncology reports

    pub_type: 杂志文章

    doi:10.3892/or.2017.6105

    authors: Nanbu T,Umemura N,Ohkoshi E,Nanbu K,Sakagami H,Shimada J

    更新日期:2018-01-01 00:00:00