Differential expression profiles of long non-coding RNAs reveal potential biomarkers for identification of human gastric cancer.

abstract：:Recent studies suggest that latexin (Lxn) expression is involved in stem cell regulation and that it plays significant roles in tumor cell migration and invasion. The clinicopathological significance of Lxn expression and its possible correlation with CD133 expression in pancreatic ductal adenocarcinoma (PDAC) is curr...

journal_title：Oncology reports

authors： Xue Z,Zhou Y,Wang C,Zheng J,Zhang P,Zhou L,Wu L,Shan Y,Ye M,He Y,Cai Z

更新日期：2016-01-01 00:00:00

abstract：:Heparanase is endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix and basement membrane. Heparanase has been thought to have an important role in the process of cancer invasion and metastasis. Recent studies have revealed that heparanase has multifunctional mo...

journal_title：Oncology reports

authors： Naomoto Y,Takaoka M,Okawa T,Nobuhisa T,Gunduz M,Tanaka N

更新日期：2005-07-01 00:00:00

abstract：:As tumor-associated antigens are not well characterized for the majority of human tumors, polyvalent vaccines prepared with whole-tumor antigens are an attractive approach for tumor vaccination. Vascular endothelial growth factor receptor-2 (VEGFR2), as a model antigen with which to...

journal_title：Oncology reports

authors： Yan HX,Cheng P,Wei HY,Shen GB,Fu LX,Ni J,Wu Y,Wei YQ

更新日期：2013-04-01 00:00:00

abstract：:Inhibins are dimeric glycoproteins, composed of an α-subunit and one of two possible β-subunits (βA or βB), with substantial roles in human reproduction and in endocrine-responsive tumours. Recently a novel β subunit named βC was described, although it is still unclear if normal or cancerous cervical epithelial cells ...

journal_title：Oncology reports

authors： Blankenstein T,Jückstock J,Shabani N,Kunze S,Brüning A,Bergauer F,Mylonas I

更新日期：2011-01-01 00:00:00

abstract：:In the present study, we investigated the antitumor activity of caudatin in the human hepatoma cell line SMMC‑7721 by analysis of cell viability, cell cycle distribution, apoptosis and metastasis. The results showed that caudatin impaired the cell viability and inhibited the growth of SMMC-7721 cells in a time- and do...

journal_title：Oncology reports

authors： Luo Y,Sun Z,Li Y,Liu L,Cai X,Li Z

更新日期：2013-12-01 00:00:00

abstract：:Long non‑coding RNA (lncRNA) forkhead box P4 antisense RNA 1 (FOXP4‑AS1) has been determined to function as an oncogene in various types of cancer. However, the biological function and the underlying mechanisms of FOXP4‑AS1 in mantle cell lymphoma (MCL) remain to be uncovered. The expression and the associated clinico...

journal_title：Oncology reports

authors： Tao HF,Shen JX,Hou ZW,Chen SY,Su YZ,Fang JL

更新日期：2020-12-11 00:00:00

abstract：:Colorectal cancer (CRC) is still one of the most important neoplasias causing human death. Multidisciplinary therapy has won consensus in the management of CRC, of which, radiotherapy occupies an important position. However, radioresistance is still a major obstacle in local control of CRC. Overexpression of long non-...

journal_title：Oncology reports

authors： Yang XD,Xu HT,Xu XH,Ru G,Liu W,Zhu JJ,Wu YY,Zhao K,Wu Y,Xing CG,Zhang SY,Cao JP,Li M

更新日期：2016-01-01 00:00:00

abstract：:The metabolism of arachidonic acid by either the cyclooxygenase or lipoxygenase (LOX) pathway is believed to play an important role in tumor promotion. We investigated the expression of 5- and 12-LOX in renal cell carcinoma (RCC), as well as the effects of their inhibitors on cell proliferation in 2 RCC cell lines (Ca...

journal_title：Oncology reports

authors： Matsuyama M,Yoshimura R,Mitsuhashi M,Tsuchida K,Takemoto Y,Kawahito Y,Sano H,Nakatani T

更新日期：2005-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) are reported to be involved in renal hypoxia/reoxygenation (H/R) damage. To investigate this further, human kidney (HK‑2) cells were cultured, subjected to H/R and the function of miR‑30a‑5p and glutamate dehydrogenase 1 (GLUD1) was evaluated. The results showed that, miR‑30‑5p was downregulated and...

journal_title：Oncology reports

authors： He Y,Lang X,Cheng D,Zhang T,Yang Z,Xiong R

更新日期：2020-10-01 00:00:00

abstract：:Activation of ras genes and human papilloma virus (HPV) infection have been extensively described in cervical carcinomas while information concerning their implication in premalignant lesions of the cervix is limited. We investigated the incidence of K-ras codon 12 point mutations and HPV infection in cases of cervici...

journal_title：Oncology reports

authors： Prokopakis P,Sourvinos G,Koumantaki Y,Koumantakis E,Spandidos DA

更新日期：2002-01-01 00:00:00

abstract：:Human chorionic gonadotropin β (β-hCG) is a well-known and accurate marker for the diagnosis and monitoring of pregnancy, trophoblastic tumors and ovarian germ cell tumors. Recently, β-hCG has been found to be closely related to poor prognosis and metastasis in various other malignant tumors, while its role and mechan...

journal_title：Oncology reports

authors： Liu N,Peng SM,Zhan GX,Yu J,Wu WM,Gao H,Li XF,Guo XQ

更新日期：2017-09-01 00:00:00

abstract：:Predicting the tumor response to radiotherapy is one of the major goals of human cancer treatment. Identification of the genes that are differentially expressed between radiosensitive and radioresistant cancers by global gene analysis may provide new insights into the mechanisms underlying clinical radioresistance and...

journal_title：Oncology reports

authors： Ogawa K,Murayama S,Mori M

更新日期：2007-11-01 00:00:00

abstract：:In preclinical studies, antagonists of growth hormone-releasing hormone (GHRH) have demonstrated inhibitory effects on the growth of various types of cancers expressing the pituitary type of GHRH receptors (pGHRH-R) and/or its active splice variant 1 (SV1). In this study, we investigated the effectiveness of the treat...

journal_title：Oncology reports

authors： Seitz S,Rick FG,Schally AV,Treszl A,Hohla F,Szalontay L,Zarandi M,Ortmann O,Engel JB,Buchholz S

更新日期：2013-07-01 00:00:00

abstract：:Metastasis is the primary cause of death in lung cancer patients and EMT (epithelial-mesenchymal transition) promotes metastasis. Previous study revealed that DAL-1 (differentially expressed in adenocarcinoma of the lung) could attenuate EMT and metastasis in non-small cell lung cancer (NSCLC). Further study proved th...

journal_title：Oncology reports

authors： Qiu X,Guan X,Liu W,Zhang Y

更新日期：2017-11-01 00:00:00

abstract：:Caspases play an essential role in the initiation/regulation of apoptosis. Aberrant apoptotic regulation has been associated with carcinogenesis and therapeutic resistance. To explore the possible involvement of altered caspase expression in breast cancer, we have systematically examined the expression of both protein...

journal_title：Oncology reports

authors： Yang S,Liu J,Thor AD,Yang X

更新日期：2007-05-01 00:00:00

abstract：:In this study, we demonstrate an important role of activation of the hypoxia-inducible factor-1 (HIF-1) pathway in endometrial carcinogenesis and tumor phenotype development of endometrial carcinoma, and suggest a unique role of the HIF-1-target gene, differentiated embryo chondrocyte 2 (DEC2), in carcinogenesis. Hypo...

journal_title：Oncology reports

authors： Yunokawa M,Tanimoto K,Nakamura H,Nagai N,Kudo Y,Kawamoto T,Kato Y,Hiyama E,Hiyama K,Nishiyama M

更新日期：2007-04-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC), the main subtype of esophageal cancer (EC), is a common lethal type of cancer with a high mortality rate. The aim of the present study was to select key relevant genes and identify potential mechanisms involved in the development of ESCC based on bioinformatics analysis. Mini...

journal_title：Oncology reports

authors： Li X,Ren Z,Xiong C,Geng J,Li Y,Liu C,Ren C,Liu H

更新日期：2020-09-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been widely accepted as critical molecules playing regulatory roles in various biological processes, including proliferation, differentiation and apoptotic/ferroptotic/necrotic cell death. Emerging evidence suggests that ROS may be involved in the induction of epithelial‑to‑mesenchym...

journal_title：Oncology reports

authors： Peng G,Tang Z,Xiang Y,Chen W

更新日期：2019-02-01 00:00:00

abstract：:Orotate phosphoribosyl transferase (OPRT) is an enzyme playing an important role in exertion of the effect of 5-fluorouracil (5-FU). A type of gene polymorphism, single nucleotide polymorphism (SNP), is considered to be a factor affecting individual differences in exertion of drug effects, and its analysis has recentl...

journal_title：Oncology reports

authors： Kitajima M,Takita N,Hata M,Maeda T,Sakamoto K,Kamano T,Ochiai T

更新日期：2006-01-01 00:00:00

abstract：:More than 80% of hepatocellular carcinoma (HCC) arises in HBV based liver cirrhotic patients, suggesting that patients with cirrhosis form the main risk group of HCC. α fetoprotein (AFP) has poor sensitivity for the detection of AFP-negative and/or small tumors in HCC patients. Screening serum markers, along with HCC ...

journal_title：Oncology reports

authors： Shu H,Kang X,Guo K,Li S,Li M,Sun L,Gan L,Liu Y,Qin X

更新日期：2010-11-01 00:00:00

abstract：:Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) are considered to be key enzymes affecting the prognosis for patients with various cancers. We tried to prove the correlation of TP and DPD expression in hepatocellular carcinoma (HCC) and liver metastasis. We quantified TP and DPD levels by an enz...

journal_title：Oncology reports

authors： Hotta T,Kobayashi Y,Taniguchi K,Johata K,Sahara M,Watanabe T,Ochiai M,Tanimura H,Tsubota YT

更新日期：2004-08-01 00:00:00

abstract：:Chromatin assembly factor 1 subunit B (CHAF1B) participates in DNA synthesis and repair. High CHAF1B expression has been associated with a poor prognosis in several types of cancers. However, no study has evaluated the clinical significance and biological function of CHAF1B in non‑small cell lung cancer (NSCLC). In th...

journal_title：Oncology reports

authors： Duan Y,Liu T,Li S,Huang M,Li X,Zhao H,Li J

更新日期：2019-04-01 00:00:00

abstract：:Store‑operated calcium entry (SOCE) is critical for regulating the proliferation and metastasis of various cancer types. The present study aimed to investigate the role of SOCE on nicotine‑promoted proliferation of non‑small cell lung cancer (NSCLC) A549 cells. Cell proliferation was evaluated by BrdU incorporation as...

journal_title：Oncology reports

authors： Wang Y,He J,Jiang H,Zhang Q,Yang H,Xu X,Zhang C,Xu C,Wang J,Lu W

更新日期：2018-10-01 00:00:00

abstract：:HIF-1 is a heterodimer consisting of the HIF-1alpha and HIF-1beta subunits, and HIF-1alpha is the unique oxygen regulated subunit that determines HIF-1 activity. HIF-1alpha upgrades many gene products which include the glucose transporter protein 1 (Glut-1). Immunohistochemical studies using a monoclonal antibody spec...

journal_title：Oncology reports

authors： Palit V,Phillips RM,Puri R,Shah T,Bibby MC

更新日期：2005-10-01 00:00:00

abstract：:Elevated serum CA15‑3 assessed by enzyme‑linked immunosorbent assay (ELISA) has been considered a diagnostic marker of breast cancer. However, accumulating data indicate that the current ELISA system for detecting CA15‑3, which targets the peptide backbone of CA15‑3, is not sufficiently sensitive to detect early or lo...

journal_title：Oncology reports

authors： Choi JW,Moon BI,Lee JW,Kim HJ,Jin Y,Kim HJ

更新日期：2018-07-01 00:00:00

abstract：:Tumor size indicates the extent of cell proliferation in most cases of colorectal cancer (CRC), although there are some advanced small tumors with metastases. Lymph node metastasis is a significant factor that greatly impacts disease prognosis in CRC cases. The underlying factors that cause lymph node metastasis in CR...

journal_title：Oncology reports

authors： Takahashi Y,Sawada G,Sato T,Kurashige J,Mima K,Matsumura T,Uchi R,Ueo H,Ishibashi M,Takano Y,Akiyoshi S,Eguchi H,Sudo T,Sugimachi K,Tanaka J,Kudo SE,Doki Y,Mori M,Mimori K

更新日期：2013-09-01 00:00:00

abstract：:The human homologue of Drosophila disc large tumor suppressor protein (hDlg) is one of the proteins known to act cooperatively in regulating cell polarity and proliferation, suggesting an important connection between epithelial organization and cellular growth control. An abnormal expression of hDlg has been reported ...

journal_title：Oncology reports

authors： Niimi R,Matsumine A,Iino T,Murata T,Shintani K,Nakazora S,Nakamura T,Uehara Y,Kusuzaki K,Akiyama T,Uchida A

更新日期：2010-03-01 00:00:00

abstract：:Benign prostatic hyperplasia (BPH) is a common chronic disease in older males. The pathogenesis of BPH remains elusive but may be associated with chronic inflammation. Chemokines and chemokine receptors have been implicated as critical mediators in the immune response and inflammatory processes. In the present study, ...

journal_title：Oncology reports

authors： Pang Y,Li H,Gong Y,Jing S,Peng C,Liu W,Zhao Y,Wang H,Kaushik D,Rodriguez R,Wang Z

更新日期：2019-04-01 00:00:00

abstract：:Arginine is a critical amino acid in specific cancer types including hepatocellular carcinoma (HCC) and melanoma. Novel molecular mechanisms and therapeutic targets in arginine metabolism-mediated cancer formation await further identification. Our laboratory has previously demonstrated that arginine metabolic enzyme a...

journal_title：Oncology reports

authors： Hung YH,Huang HL,Chen WC,Yen MC,Cho CY,Weng TY,Wang CY,Chen YL,Chen LT,Lai MD

更新日期：2017-02-01 00:00:00

abstract：:Investigations into extracellular vesicles (EVs) have significantly increased since their role in physiological and pathological processes has become more clearly understood. Furthermore, it has become increasingly clear that several subpopulations of EVs exist, such as exosomes (EXOs) and microvesicles (MVs). Various...

journal_title：Oncology reports

authors： Giusti I,Di Francesco M,Cantone L,D'Ascenzo S,Bollati V,Carta G,Dolo V

更新日期：2015-11-01 00:00:00