The relationship between 5-fluorouracil sensitivity and single nucleotide polymorphisms of the orotate phosphoribosyl transferase gene in colorectal cancer.

abstract：:Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid carcinoma with a poor prognosis. Thus, suitable preclinical tumor models are required for the development of new ATC therapies. In the present study, orthotopic tumor xenograft models were established using ATC cell lines and SCID mice, and tumor invasion an...

journal_title：Oncology reports

authors： Aoyama M,Takizawa H,Otani T,Inoue S,Kawakita N,Tsuboi M,Bando Y,Uehara H,Kondo K,Tangoku A

更新日期：2020-10-01 00:00:00

abstract：:MHC class I-related chain molecules A and B (MICA and B) expressed on the cell-surface of tumor cells are ligands for an activating receptor, NKG2D, expressed on natural killer (NK) cells and stimulate the NK cell-mediated cytotoxicity. On the other hand, the soluble form of MICA and B produced by proteolytic cleavage...

journal_title：Oncology reports

authors： Yamanegi K,Yamane J,Kobayashi K,Kato-Kogoe N,Ohyama H,Nakasho K,Yamada N,Hata M,Nishioka T,Fukunaga S,Futani H,Okamura H,Terada N

更新日期：2010-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) play crucial roles in the initiation and progression of various cancers, including melanoma. Recently, the genetic variants and deregulation of miR-605 have been reported to participate in carcinogenesis. However, the expression status of the miR-605 in melanoma tissues and its role in melanoma prog...

journal_title：Oncology reports

authors： Chen L,Cao Y,Rong D,Wang Y,Cao Y

更新日期：2017-08-01 00:00:00

abstract：:Taxanes, a new class of antitumor drugs, are effective against a large number of human tumors, although there are problems with drug resistance. The novel taxane, IDN5109, is characterized by its high tolerability, antitumor efficacy, ability to overcome multidrug resistance, and oral bioavailabilty. We investigated t...

journal_title：Oncology reports

authors： Sano D,Matsuda H,Ishiguro Y,Nishimura G,Kawakami M,Tsukuda M

更新日期：2006-02-01 00:00:00

abstract：:The goal of this study was to evaluate the effect of the Na+/H+ exchanger-1 (NHE-1) antisense gene on drug-resistant human small cell lung cancer (SCLC) cell proliferation and apoptosis. A recombinant NHE-1 antisense gene was transfected into drug-resistant human SCLC H446/CDDP cells. Intracellular pH (pHi) was measur...

journal_title：Oncology reports

authors： Li S,Bao P,Li Z,Ouyang H,Wu C,Qian G

更新日期：2009-05-01 00:00:00

abstract：:Oxymatrine, a traditional Chinese herb extracted from Sophora flavescens Ait., displays strong anti-inflammatory and anticancer activities, but how oxymatrine exhibits anticarcinogenic effects in human colorectal cancer (CRC) remains uncertain. The present study aimed to elucidate the exact mechanism by which oxymatri...

journal_title：Oncology reports

authors： Liang L,Huang J

更新日期：2016-09-01 00:00:00

abstract：:To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the co...

journal_title：Oncology reports

authors： Ge MH,Chen C,Xu JJ,Ling ZQ

更新日期：2011-08-01 00:00:00

abstract：:The altered expression of certain genes is frequently detected as a hallmark of malignant tumors. These differentially expressed genes have the potential to become molecular markers. We purified the fecal mRNA from patients with colorectal cancer to identify novel candidates by using oligo-nucleotide microarray hybrid...

journal_title：Oncology reports

authors： Chien CC,Chang CC,Yang SH,Chen SH,Huang CJ

更新日期：2006-04-01 00:00:00

abstract：:To investigate the antitumor action of arsenic trioxide (As2O3) by intratumoral injection into solid tumors, tumor growth inhibition (TGI) and angiogenesis of heterotransplanted esophageal carcinoma in mice was carried out. The cultured human esophageal carcinoma cells were inoculated into both laterals of the abdomin...

journal_title：Oncology reports

authors： Shen ZY,Shen J,Chen MH,Wu XY,Wu MH,Zeng Y

更新日期：2003-11-01 00:00:00

abstract：:To better understand the molecular mechanisms of carcinogenesis induced in uterine endometrium by therapeutic anti-estrogenic Tamoxifen (TAM) exposure, 27 uterine tumors (4 benign endometrial polyps and 23 carcinomas) associated with TAM exposure were analyzed for the presence and spectrum of p53 and K-ras mutations. ...

journal_title：Oncology reports

authors： Fujiwara K,Enomoto T,Fujita M,Kanda T,Fujii S,Ito K,Wakasa K,Ishiko O,Ueda M,Yamaguchi S,Kimura T,Umesaki N

更新日期：2008-05-01 00:00:00

abstract：:The objective of the study was to investigate the dynamic changes of cortisol and soluble TNF-alpha p-55 and p-75 receptors in serum of advanced cancer patients during 24 h. The examined group consisted of 42 patients suffering from advanced gastrointestinal neoplasms (colorectal, gastric and pancreatic cancer). Serum...

journal_title：Oncology reports

authors： Zubelewicz-Szkodzinska B,Muc-Wierzgon M,Wierzgon J,Brodziak A

更新日期：2001-01-01 00:00:00

abstract：:The clinicopathological significance of cell-cycle proteins has remained unclear in oral tongue squamous cell carcinomas (OTSCC). In the current study, we evaluated several cell-cycle proteins in relation to clinicopathological parameters and disease outcome for OTSCC. A total of 123 previously untreated patients with...

journal_title：Oncology reports

authors： Goto M,Tsukamoto T,Inada K,Mizoshita T,Ogawa T,Terada A,Hyodo I,Shimozato K,Hasegawa Y,Tatematsu M

更新日期：2005-10-01 00:00:00

abstract：:The aim of the present study was to research the apoptosis of human hepatocellular carcinoma cell line HepG 2 induced by pitavastatin. HepG 2 cells were treated with increasing doses of pitavastatin or with mevalonic acid for 48 h. The proliferation of cells was detected with WST-8. The morphology of the nucleus was o...

journal_title：Oncology reports

authors： Wang J,Xu Z,Zhang M

更新日期：2007-08-01 00:00:00

abstract：:Tumor growth is accelerated by induction of angiogenesis regulated by many cytokines and growth factors. In a tumor mass, various angiogenic factors and their receptors are simultaneously expressed and the overlapped expressions of various factors may contribute to the aggressive growth of tumor. However, the possible...

journal_title：Oncology reports

authors： Lee YM,Bae MH,Lee OH,Moon EJ,Moon CK,Kim WH,Kim KW

更新日期：2004-10-01 00:00:00

abstract：:We investigated the effects of combined treatment with 5-fluorouracil and apigenin on proliferation and apoptosis, as well as the underlying mechanism, in human breast cancer MDA-MB-453 cells. The MDA-MB-453 cells, which have been shown to overexpress ErbB2, were resistant to 5-fluorouracil; 5-fluorouracil exhibited a...

journal_title：Oncology reports

authors： Choi EJ,Kim GH

更新日期：2009-12-01 00:00:00

abstract：:The BRAF T1799A mutation is a heterozygous point mutation and its reported prevalence in papillary thyroid carcinoma (PTC) has varied from 29 to 83%, with an overall mean of 44%. In Korea, the reported mutation rate reached 83% in PTC and 52% in micropapillary carcinoma. We hypothesized that the differences in prevale...

journal_title：Oncology reports

authors： Kim HS,Kim JO,Lee DH,Lee HC,Kim HJ,Kim JH,Jang YS,Lee JM,Kim SY,Kim YS

更新日期：2011-06-01 00:00:00

abstract：:Retinoblastoma, a well-vascularized tumor that is dependent on a very robust angiogenic response, is the most common intraocular malignancy in children. Tissue factor (TF) is known to regulate tumor progression and in the present study we demonstrated that TF regulates tumor angioge...

journal_title：Oncology reports

authors： Song HB,Park KD,Kim JH,Kim DH,Yu YS,Kim JH

更新日期：2012-12-01 00:00:00

abstract：:We investigated the prevalence of human papillomavirus (HPV) in a clinical series of 72 patients with head and neck squamous cell carcinoma (HNSCC) using a retrospective and prospective study design. The majority of patients were smokers and/or drinkers and were treated with concomitant chemoradiotherapy (CCR). Furthe...

journal_title：Oncology reports

authors： Duray A,Descamps G,Decaestecker C,Sirtaine N,Gilles A,Khalifé M,Chantrain G,Depuydt CE,Delvenne P,Saussez S

更新日期：2013-07-01 00:00:00

abstract：:Triple-negative breast cancer is a highly aggressive type of mammalian carcinoma. It is defined by a rather weak expression of estrogen-, progesterone- and Her2-receptor, and is thus difficult to treat, resulting in low disease-free and overall survival rates of the affected patients. Hence it is important to find new...

journal_title：Oncology reports

authors： Andergassen U,Kölbl AC,Mumm JN,Mahner S,Jeschke U

更新日期：2017-05-01 00:00:00

abstract：:The model animal of renal cell carcinoma (RCC), the Eker rat, has a germline mutation in the tuberous sclerosis 2 (Tsc2) gene. Heterozygous mutants develop RCCs by second hit in the wild-type Tsc2 allele, whereas homozygous mutants are embryonic lethal. In the present study, a new cell differentiation model was develo...

journal_title：Oncology reports

authors： Kawano H,Ito Y,Kanai F,Nakamura E,Tada N,Takai S,Horie S,Kobayashi T,Hino O

更新日期：2015-11-01 00:00:00

abstract：:Esculetin, a phenolic compound, has been shown to inhibit the growth of colon tumors in animal studies. However, the roles of signaling pathways and cell cycle regulation in the esculetin-induced inhibition of cancer cell growth, remain to be elucidated. The present study suggests a novel mechanism for the Ras/ERK1/2 ...

journal_title：Oncology reports

authors： Park SS,Park SK,Lim JH,Choi YH,Kim WJ,Moon SK

更新日期：2011-01-01 00:00:00

abstract：:Dendritic cells (DCs) as 'professional' antigen-presenting cells (APCs) initiate and regulate immune responses to various antigens. DC-based vaccines have become a promising modality in cancer immunotherapy. Cytokeratin 19 (CK19) protein is expressed at high levels in lung cancer and many other tumor cells, suggesting...

journal_title：Oncology reports

authors： Sun QF,Zhao XN,Peng CL,Hao YT,Zhao YP,Jiang N,Xue H,Guo JZ,Yun CH,Cong B,Zhao XG

更新日期：2015-11-01 00:00:00

abstract：:In a screen for thoracic malignancy-associated markers, thyroid stimulating hormone receptor (TSHR) was identified as a candidate as it binds to the previously-characterized lung cancer marker NKX2-1. We screened for mutations in all coding regions of the TSHR gene in 96 lung adenoc...

journal_title：Oncology reports

authors： Kim JW,Lee S,Lui N,Choi H,Mulvihill M,Fang LT,Kang HC,Kwon YW,Jablons D,Kim IJ

更新日期：2012-10-01 00:00:00

abstract：:Metastasis-associated protein 1 (MTA1) is highly upregulated in cancer cells with metastatic potential; however, the molecular mechanism by which MTA1 increases the metastatic potential of cancer cells is far from clear. We characterized the functional consequences of MTA1 overexpression on p53-induced apoptosis of ca...

journal_title：Oncology reports

authors： Moon HE,Cheon H,Lee MS

更新日期：2007-11-01 00:00:00

abstract：:Flavonoids exhibit chemopreventive and chemotherapeutic effects. Butein, a bioactive flavonoid isolated from numerous native plants, has been shown to induce apoptosis in human cancer cells. In the current study, the molecular mechanisms of butein action on cell proliferation and apoptosis of neuroblastoma cells were ...

journal_title：Oncology reports

authors： Chen YH,Yeh CW,Lo HC,Su SL,Hseu YC,Hsu LS

更新日期：2012-04-01 00:00:00

abstract：:SET domain bifurcated 1 (SETDB1) is a histone H3 lysine 9 methyltransferase that is highly expressed in various tumor types, including breast cancer. However, how SETDB1 functions in breast cancer is unclear. In the present study, proliferation, migration and invasion assays were performed to explore the role of SETDB...

journal_title：Oncology reports

authors： Yang W,Su Y,Hou C,Chen L,Zhou D,Ren K,Zhou Z,Zhang R,Liu X

更新日期：2019-02-01 00:00:00

abstract：:The aim of this study was to assess the ability of a new magnetic resonance (MR) angiography technique that does not use contrast enhancement medium to depict the vascularity of musculoskeletal neoplasms, and evaluate its clinical utility. We performed 3D fresh blood imaging (FBI) MR angiography in 57 patients with bo...

journal_title：Oncology reports

authors： Doi H,Ono A,Kawai A,Morimoto Y,Kunisada T,Nakata E,Ozaki T

更新日期：2006-03-01 00:00:00

abstract：:The abilities of 5,6-benzoflavone (5,6-BF, a synthetic flavonoid), indole-3-carbinol (I3C, a plant derived product) or diindolylmethane (DIM, a condensation product of I3C) to alter the induction of mammary cancers induced by the carcinogens 7,12-dimethylbenzanthracene (DMBA) or N-methyl-N-nitrosourea (MNU) were evalu...

journal_title：Oncology reports

authors： Lubet RA,Heckman BM,De Flora SL,Steele VE,Crowell JA,Juliana MM,Grubbs CJ

更新日期：2011-09-01 00:00:00

abstract：:The aim of this study was to evaluate HSP27 expression in fetal, normal and inflamed oral mucosal epithelium and in oral premalignant epithelial lesions and in their ensuing invasive cancers. In developing human oral epithelia, immunoreactions for HSP27 were moderately observed in suprabasal keratinocytes of palate an...

journal_title：Oncology reports

authors： Leonardi R,Pannone G,Magro G,Kudo Y,Takata T,Lo Muzio L

更新日期：2002-03-01 00:00:00

abstract：:Fecal microRNAs (miRNAs) are increasingly explored as non-invasive markers of colorectal cancer (CRC). However, its holistic profile in Asian CRC patients remains elusive. In the present study, the global human fecal miRNAs in Asian Chinese CRC patients was assayed to elucidate novel diagnostic fecal markers. Addition...

journal_title：Oncology reports

authors： Phua LC,Chue XP,Koh PK,Cheah PY,Chan EC,Ho HK

更新日期：2014-07-01 00:00:00