Immunolabelling of the inhibin/activin-βC subunit in normal and malignant human uterine cervical tissue and cervical cancer cell lines.

abstract：:Mangosteen (Garcinia mangostana) is a tree found in South-East Asia and the pericarp of its fruit has been used in folk medicine for the treatment of many human illnesses. Mangosteen fruit rinds contain a high concentration of xanthone, which is a type of polyphenol. One type of xanthone, α-mangostin, has been reporte...

journal_title：Oncology reports

authors： Fukuda M,Sakashita H,Hayashi H,Shiono J,Miyake G,Komine Y,Taira F,Sakashita H

更新日期：2017-12-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related mortality worldwide. microRNAs (miRNAs) are small post-transcriptional regulatory non-coding RNAs that function as oncogenes or tumor suppressors in human cancers. Emerging evidence reveals that deregulation of miRNAs contributes to the progression of human lung cance...

journal_title：Oncology reports

authors： Jiang X,Chen X,Chen L,Ma Y,Zhou L,Qi Q,Liu Y,Zhang S,Luo J,Zhou X

更新日期：2015-02-01 00:00:00

abstract：:The aim of the study was to compare cross sections with longitudinal sections in histopathological examination of the rat heart after irradiation, to find the most optimal method for the detection of cardiac radiation injuries. For this purpose, rats were irradiated locally on the heart with a single dose of 0 or 20 G...

journal_title：Oncology reports

authors： Boerma M,Zurcher C,Esveldt I,Schutte-Bart CI,Wondergem J

更新日期：2004-08-01 00:00:00

abstract：:The immune suppression of sentinel lymph node (SN) is directly influenced by primary tumors. It has been reported that the T-helper type 1 (Th1) to T-helper type 2 (Th2) ratio or T-cytotoxic type 1 (Tc1) to T-cytotoxic type 2 (Tc2) ratio of lymph node lymphocytes could be used to evaluate direct immunological circumst...

journal_title：Oncology reports

authors： Ehi K,Ishigami S,Masamoto I,Uenosono Y,Natsugoe S,Arigami T,Arima H,Kijima Y,Yoshinaka H,Yanagita S,Kozono T,Funasako Y,Maruyama I,Aikou T

更新日期：2008-03-01 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) caused by NF1 gene mutation is a commonly inherited autosomal dominant disorder. Malignant peripheral nerve sheath tumors (MPNSTs), a type of aggressive sarcoma, are a major cause of mortality in NF1 patients. The malignant transformation of benign plexiform neurofibromas (PNs) to MPNSTs...

journal_title：Oncology reports

authors： Park GH,Lee SJ,Yim H,Han JH,Kim HJ,Sohn YB,Ko JM,Jeong SY

更新日期：2014-10-01 00:00:00

abstract：:X-ray-based radiotherapy is one of the most effective therapeutic strategies for breast cancer patients. However, radioresistance and side-effects continue to be the most challenging issues. B-cell translocation gene 1 (BTG1) is a member of the BTG/Tob family, which inhibits cancer growth and promotes apoptosis. We, t...

journal_title：Oncology reports

authors： Zhu R,Li W,Xu Y,Wan J,Zhang Z

更新日期：2015-12-01 00:00:00

abstract：:Few studies have examined apoptosis induced by low-voltage electric pulses (LVEPs). LVEP-induce changes in membrane potential that are below the membrane breakdown threshold and increase membrane permeability without electroporation (pore formation) through the transport of extracellular substances via phagocytosis. W...

journal_title：Oncology reports

authors： Matsuki N,Takeda M,Ishikawa T,Kinjo A,Hayasaka T,Imai Y,Yamaguchi T

更新日期：2010-05-01 00:00:00

abstract：:Expression of neural differentiation-associated genes was examined by RT-PCR and macroarray analyses during neural differentiation of P19 embryonal carcinoma cells induced by cell aggregation and/or retinoic acid (RA) treatment. Results revealed that the neural genes examined could be classified into 4 groups based on...

journal_title：Oncology reports

authors： Teramoto S,Kihara-Negishi F,Sakurai T,Yamada T,Hashimoto-Tamaoki T,Tamura S,Kohno S,Oikawa T

更新日期：2005-11-01 00:00:00

abstract：:Oral lichen planus (OLP) is a chronic inflammatory disease that may transform to oral squamous cell carcinoma (OSCC), while its carcinogenesis mechanisms are not entirely clear. This study was designed to identify the important genes involved in the malignant transformation of OLP to OSCC. After RNA-sequencing, the di...

journal_title：Oncology reports

authors： Yang Q,Guo B,Sun H,Zhang J,Liu S,Hexige S,Yu X,Wang X

更新日期：2017-04-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is the predominant histologic subtype of esophageal cancer and is characterized by a high mortality rate and geographic differences in incidence. microRNAs (miRNAs) are small, non-coding RNAs that play important roles in the regulation of genes associated with cancer developme...

journal_title：Oncology reports

authors： Zhang N,Fu H,Song L,Ding Y,Wang X,Zhao C,Zhao Y,Jiao F,Zhao Y

更新日期：2014-10-01 00:00:00

abstract：:Mammary small cell carcinoma (SmCC) is a very rare neoplasm with a poor prognosis compared with other invasive carcinomas. We studied the histological and immunohistochemical profiles of two cases of mammary SmCC, and compared them with those of five cases of carcinoma with endocrine features (CEF) and five cases of i...

journal_title：Oncology reports

authors： Yamamoto J,Ohshima K,Nabeshima K,Ikeda S,Iwasaki H,Kikuchi M

更新日期：2004-04-01 00:00:00

abstract：:The present study was performed to investigate the protective effects of tannic acid (TA) on liver injury induced by arsenic trioxide (ATO) and to elucidate the mechanism involved as related to the Kelch‑like ECH‑associated protein 1 (Keap1)‑nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant response eleme...

journal_title：Oncology reports

authors： Li M,Liu P,Xue Y,Liang Y,Shi J,Han X,Zhang J,Chu X,Chu L

更新日期：2020-11-01 00:00:00

abstract：:Phosphatidylinositol 3 kinases (PI-3 kinases) play a crucial role in the inositol phospholipid signaling pathway. The effect of wortmannin, an inhibitor of PI-3 kinases, on the suppression of thermotolerance development was investigated in the temperature-sensitive cell line tsAF8. When wortmannin was added immediatel...

journal_title：Oncology reports

authors： Shibuya K,Kawasaki S,Kuroda M,Takemoto M,Asaumi J,Hiraki Y

更新日期：2002-01-01 00:00:00

abstract：:Glioblastoma is the most common type of primary brain tumour in adults, and its pathogenesis is particularly complicated. Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic ...

journal_title：Oncology reports

authors： Xu PF,Yang JA,Liu JH,Yang X,Liao JM,Yuan FE,Liu BH,Chen QX

更新日期：2019-01-01 00:00:00

abstract：:Bisphosphonates (BPs) inhibit bone resorption by preventing osteoclast maturation and apoptosis induction. Recently, BPs have also been shown to have antitumor effects against various types of carcinomas in vitro and in vivo. In this study, we investigated the antitumor effect of zoledronic acid (ZOL), a third generat...

journal_title：Oncology reports

authors： Tamura T,Shomori K,Nakabayashi M,Fujii N,Ryoke K,Ito H

更新日期：2011-04-01 00:00:00

abstract：:Neoadjuvant chemotherapy is often used in the treatment of advanced esophageal cancer. In this study, we determined the impact of chemotherapy on microRNA (miRNA) expression in esophageal cancer cells, and whether identified changes might have biological relevance. Two esophageal carcinoma cell lines (one adenocarcino...

journal_title：Oncology reports

authors： Hummel R,Wang T,Watson DI,Michael MZ,Van der Hoek M,Haier J,Hussey DJ

更新日期：2011-10-01 00:00:00

abstract：:Multiple drug resistance (MDR) is considered a major challenge in the clinical treatment of non-small cell lung cancer (NSCLC). Both nitric oxide synthase (iNOS) and Wnt signaling pathway participate in the regulation of drug resistance, but the interaction between them remains unclear. In the present study, we detect...

journal_title：Oncology reports

authors： Li Y,Ma C,Shi X,Wen Z,Li D,Sun M,Ding H

更新日期：2014-10-01 00:00:00

abstract：:Orotate phosphoribosyl transferase (OPRT) is the initial enzyme of 5-fluorouracil (5-FU) activation, in which 5-FU is converted to 5-fluorouridinemonophosphate. Dihydropyrimidine dehydrogenase (DPD) is a degrading enzyme that catabolizes 5-FU. In this study, we investigated the expression of these enzymes in normal pr...

journal_title：Oncology reports

authors： Tanaka T,Kawashima H,Matsumura K,Yamashita-Hosono T,Yoshimura R,Kuratsukuri K,Harimoto K,Nakatani T

更新日期：2009-01-01 00:00:00

abstract：:High-mobility group protein box 1 (HMGB1) released from dying tumor cells promotes tumor progression, on the other hand HMGB1 activates dendritic cells and triggers anti-neoplastic response of T-cells in chemotherapy and radiotherapy. HMGB1 expression is up-regulated in many kinds of tumors. To investigate HMGB1 expre...

journal_title：Oncology reports

authors： Shen X,Hong L,Sun H,Shi M,Song Y

更新日期：2009-09-01 00:00:00

abstract：:Previous studies have demonstrated the tremendous tropism of mesenchymal stem cells (MSCs) for malignant gliomas, making these cells a potential vehicle for delivery of therapeutic genes to disseminated glioma cells. However, the mechanisms underlying the tropism of MSCs for gliomas remain poorly defined. It has been ...

journal_title：Oncology reports

authors： Xu F,Shi J,Yu B,Ni W,Wu X,Gu Z

更新日期：2010-06-01 00:00:00

abstract：:Paternally expressed imprinted gene 1/mesoderm-specific transcript (PEG1/MEST) is an imprinted gene expressed from the paternal allele. Recently, frequent loss of imprinting (LOI) of PEG1/MEST has been reported in lung adenocarcinomas. It is suggested that the LOI may be involved in pathogenesis of lung adenocarcinoma...

journal_title：Oncology reports

authors： Nakanishi H,Suda T,Katoh M,Watanabe A,Igishi T,Kodani M,Matsumoto S,Nakamoto M,Shigeoka Y,Okabe T,Oshimura M,Shimizu E

更新日期：2004-12-01 00:00:00

abstract：:The phosphatase and tensin homolog (PTEN) gene, an important tumor-suppressor gene, has been demonstrated to have the potential for inhibiting proliferation, migration and invasion in various types of cancer cells. The aim of the present study was to investigate the effect of PTEN expression on osteosarcoma (OS) cells...

journal_title：Oncology reports

authors： Hu Y,Xu S,Jin W,Yi Q,Wei W

更新日期：2014-10-01 00:00:00

abstract：:Three cases of benign pelvic tumors are presented (2 leiomyomas and 1 fibroma). All three tumors were suspected of being malignant neoplasms because they were visualized as heterogeneous high signal intensity on T2-weighted images, and thus they were difficult to diagnose preoperatively. One of the leiomyomas was loca...

journal_title：Oncology reports

authors： Kojima T,Ishiko O,Ichimura T,Nishimura S,Sumi T,Ueda J,Tsujimura T,Shimura K

更新日期：2001-07-01 00:00:00

abstract：:One of the most important clinical problems in the treatment of human solid carcinoma is the intrinsic/acquired resistance. Cisplatin is a platinum compound that is one of the most effective agents in clinic. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin re...

journal_title：Oncology reports

authors： Nakayama K,Miyazaki K,Kanzaki A,Fukumoto M,Takebayashi Y

更新日期：2001-11-01 00:00:00

abstract：:Aquaporins (AQPs) are a family of small, integral membrane proteins that have been shown to play an important role in tumor development and metastasis. Several studies have demonstrated that expression of AQP3 contributes to the enhanced migration of epithelial cells and is related to differentiation, metastasis and v...

journal_title：Oncology reports

authors： Li A,Lu D,Zhang Y,Li J,Fang Y,Li F,Sun J

更新日期：2013-02-01 00:00:00

abstract：:DNA intrastrand cross-linking agents such as oxaliplatin induce DNA double-strand breaks (DSBs) during DNA repair and replication. In the present study, we hypothesized that DNA intrastrand cross-linking agents may significantly benefit colorectal cancer patients with deficiencies in DSB repair. Seventy-eight patients...

journal_title：Oncology reports

authors： Ihara K,Yamaguchi S,Ueno N,Tani Y,Shida Y,Ogata H,Domeki Y,Okamoto K,Nakajima M,Sasaki K,Tsuchioka T,Mitomi H,Kato H

更新日期：2016-03-01 00:00:00

abstract：:Dendropanax morbifera Leveille is found throughout southwestern Korea, and has been used in traditional medicine for various diseases, such as migraine headache, infectious diseases, skin diseases and dysmenorrhea. However, the molecular mechanisms of D. morbifera concerning its biochemical actions in cancer have not ...

journal_title：Oncology reports

authors： Lee JW,Park C,Han MH,Hong SH,Lee TK,Lee SH,Kim GY,Choi YH

更新日期：2013-09-01 00:00:00

abstract：:Emodin (EMO) has been shown to possess pleiotropic anticancer capabilities in many types of cancer, including epithelial ovarian cancer (EOC). Inhibitory efficacy of EMO on EOC invasion and migration was previously observed, however, the underlying mechanisms have not been completely elucidated. The present study is a...

journal_title：Oncology reports

authors： Hu C,Dong T,Li R,Lu J,Wei X,Liu P

更新日期：2016-04-01 00:00:00

abstract：:Elucidating the effects of genes involved in tumors may improve therapeutic strategies for human cancer. Recently, several studies discovered that Akt1 plays a dual role in mediating cell proliferation, migration and invasion, depending on the cell type. However, the pathophysiological role of Akt1 in hepatocellular c...

journal_title：Oncology reports

authors： Chen L,Kang QH,Chen Y,Zhang YH,Li Q,Xie SQ,Wang CJ

更新日期：2014-02-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most common malignancies, and is the second leading cause of cancer-related deaths worldwide. Macrophages infiltrated in the tumor microenvironment (TME) called tumor-associated macrophages (TAMs) are key orchestrators in TME. In GC, it has been reported that infiltration of TAMs is a...

journal_title：Oncology reports

authors： Guo J,Yan Y,Yan Y,Guo Q,Zhang M,Zhang J,Goltzman D

更新日期：2017-10-01 00:00:00