The usefulness and limits of magnetic resonance imaging in the differential diagnosis of pelvic tumors.

abstract：:Hepatocellular carcinoma (HCC) is highly resistant to chemotherapy, leading to a poor prognosis of advanced disease. Inhibitors of histone deacetylase (HDACi) induce re-differentiation in tumor cells and thereby re-establish sensitivity towards apoptotic stimuli. HDACi are entering the clinical stage of tumor treatmen...

journal_title：Oncology reports

authors： Schuchmann M,Schulze-Bergkamen H,Fleischer B,Schattenberg JM,Siebler J,Weinmann A,Teufel A,Wörns M,Fischer T,Strand S,Lohse AW,Galle PR

更新日期：2006-01-01 00:00:00

abstract：:Bcl-2 is overexpressed in various types of human tumors, including Burkitt's lymphoma, and it is involved in tumorigenesis and chemoresistance, therefore, it is regarded as a potential target of gene therapy. In this study, RNA interference using short hairpin RNA (shRNA)-mediated R...

journal_title：Oncology reports

authors： Liu Y,Shen Y,Qin C,Shi Y,Rong G,Yu X

更新日期：2013-01-01 00:00:00

abstract：:We showed that the HER2/Grb2/Akt pathway induces all-trans retinoic acid (ATRA) resistance in breast cancer cells by suppressing the DNA binding activity of retinoic acid receptors (RAR). AP-1 activation was shown to induce ATRA resistance. Here, we determined whether AP-1 binding activity is correlated with ATRA resi...

journal_title：Oncology reports

authors： Mendoza-Gamboa E,Siwak DR,Tari AM

更新日期：2004-10-01 00:00:00

abstract：:The tumor suppressor p53 is a transcription factor that induces the transcription of various target genes in response to DNA damage and it protects the cells from malignant transformation. In this study, we performed cDNA microarray analysis and found that the transmembrane protein containing sushi domain (TMPS) gene,...

journal_title：Oncology reports

authors： Cui H,Kamino H,Nakamura Y,Kitamura N,Miyamoto T,Shinogi D,Goda O,Arakara H,Futamura M

更新日期：2010-11-01 00:00:00

abstract：:Orotate phosphoribosyl transferase (OPRT) is the initial enzyme of 5-fluorouracil (5-FU) activation, in which 5-FU is converted to 5-fluorouridinemonophosphate. Dihydropyrimidine dehydrogenase (DPD) is a degrading enzyme that catabolizes 5-FU. In this study, we investigated the expression of these enzymes in normal pr...

journal_title：Oncology reports

authors： Tanaka T,Kawashima H,Matsumura K,Yamashita-Hosono T,Yoshimura R,Kuratsukuri K,Harimoto K,Nakatani T

更新日期：2009-01-01 00:00:00

abstract：:Orotate phosphoribosyl transferase (OPRT) is an enzyme playing an important role in exertion of the effect of 5-fluorouracil (5-FU). A type of gene polymorphism, single nucleotide polymorphism (SNP), is considered to be a factor affecting individual differences in exertion of drug effects, and its analysis has recentl...

journal_title：Oncology reports

authors： Kitajima M,Takita N,Hata M,Maeda T,Sakamoto K,Kamano T,Ochiai T

更新日期：2006-01-01 00:00:00

abstract：:Irinotecan HCl (CPT-11) has frequently been used in chemotherapy or concurrent chemoradiotherapy for patients with advanced cervical cancer, although an effective protocol for chemoradiotherapy with CPT-11 has not yet been established. Using the radiosensitive human cervical squamous cell carcinoma cell line ME180 and...

journal_title：Oncology reports

authors： Tanaka T,Yukawa K,Umesaki N

更新日期：2005-11-01 00:00:00

abstract：:Highly malignant gliomas are characterized by pronounced intra‑ and intertumoral heterogeneity. On the genetic level, this heterogeneity may be caused by spontaneous mutation events, but recent studies have reported distinct mutational signatures that may be caused by an enzyme family with cytidine desaminase activity...

journal_title：Oncology reports

authors： Schmitt C,Lucius R,Synowitz M,Held-Feindt J,Hattermann K

更新日期：2018-11-01 00:00:00

abstract：:Post‑transcriptional mechanisms are an important approach in the treatment of cancer, and may also be hijacked by tumor cells to help adapt to the local microenvironment. Filamin B (FLNB), an actin‑binding protein that provides crucial scaffolds for cell motility and signaling, has also been identified as an RNA‑bindi...

journal_title：Oncology reports

authors： Ma HR,Cao L,Wang F,Cheng C,Jiang R,Zhou H,Xie Z,Wuermanbieke S,Qian Z

更新日期：2020-05-01 00:00:00

abstract：:Arginine is a critical amino acid in specific cancer types including hepatocellular carcinoma (HCC) and melanoma. Novel molecular mechanisms and therapeutic targets in arginine metabolism-mediated cancer formation await further identification. Our laboratory has previously demonstrated that arginine metabolic enzyme a...

journal_title：Oncology reports

authors： Hung YH,Huang HL,Chen WC,Yen MC,Cho CY,Weng TY,Wang CY,Chen YL,Chen LT,Lai MD

更新日期：2017-02-01 00:00:00

abstract：:c‑mesenchymal‑epithelial transition (Met) is a transmembrane tyrosine kinase receptor of hepatocyte growth factor (HGF). HGF/Met signaling stimulates numerous pathways, including the Ras/mitogenactivated protein kinase (MAPK), phosphatidylinositol 3‑kinase/protein kinase B and Wnt/β‑catenin pathways, which serve impor...

journal_title：Oncology reports

authors： Liu D,Zhong M,Zhan D,Zhang Y,Liu S

更新日期：2020-12-01 00:00:00

abstract：:Chemokines are small chemotactic cytokines that can induce the migration of leukocytes, activate inflammatory/immune responses and have recently been implicated in the regulation of tumor growth and organ-specific spread. In this setting, the macrophage inflammatory protein-1alpha (CCL3) chemokine displays a diversity...

journal_title：Oncology reports

authors： Silva TA,Ribeiro FL,Oliveira-Neto HH,Watanabe S,Alencar Rde C,Fukada SY,Cunha FQ,Leles CR,Mendonça EF,Batista AC

更新日期：2007-11-01 00:00:00

abstract：:The emerging role of microRNA-181A (miR-181A) in CRC patients with late liver metastases was studied. In the present study we investigated the association between expression and mechanism of miRNA-181A, liver metastasis and prognosis of colorectal cancer (CRC). The expression of miR-181A and PTEN in CRC patients with ...

journal_title：Oncology reports

authors： Li Z,Wang H,Xu Z,Sun Y,Han J

更新日期：2016-03-01 00:00:00

abstract：:As a common malignancy of the endocrine system, papillary thyroid carcinoma (PTC) seriously affects the quality of life of patients. lncRNA PAX8‑AS1:28, or lnc‑PSD4‑1:14 has been reported to be abnormally expressed in PTC. However, the function of PAX8‑AS1:28 in PTC is still unknown. Therefore, the present study aimed...

journal_title：Oncology reports

authors： Zhang Y,Li F,Chen J

更新日期：2019-04-01 00:00:00

abstract：:Effective therapy for advanced hepatocellular carcinoma (HCC) is lacking. Conventional chemotherapy was judged to be ineffective. We previously demonstrated that the histone deacetylase inhibitor Trichostatin A (TSA) blocks growth of HCC cells in vitro. The anti-tumoral effect of a combination of more than 2 classes o...

journal_title：Oncology reports

authors： Ganslmayer M,Ocker M,Zopf S,Leitner S,Hahn EG,Schuppan D,Herold C

更新日期：2004-05-01 00:00:00

abstract：:Increasing evidence suggests that tumor necrosis factor receptor-associated factor 4 (TRAF4) is an oncogene which is frequently overexpressed in many human carcinomas. Although TRAF4 was originally identified in breast cancer, the underlying mechanism of TRAF4 in tumorigenesis remains largely unknown. In the present s...

journal_title：Oncology reports

authors： Zhang J,Li X,Yang W,Jiang X,Li N

更新日期：2014-09-01 00:00:00

abstract：:Regulator of G protein signaling 5 (RGS5) belongs to the R4 subfamily of RGS proteins, a family of GTPase activating proteins, which is dynamically regulated in various biological processes including blood pressure regulation, smooth muscle cell pathology, fat metabolism and tumor angiogenesis. Low-expression of RGS5 ...

journal_title：Oncology reports

authors： Xu Z,Zuo Y,Wang J,Yu Z,Peng F,Chen Y,Dong Y,Hu X,Zhou Q,Ma H,Bao Y,Chen M

更新日期：2015-06-01 00:00:00

abstract：:Osteosarcoma harbors highly metastatic properties, accounting for postoperative recurrence and metastasis. Actin-like protein 6A (ACTL6A) regulates cell proliferation, migration and differentiation. However, the biologic role of ACTL6A in osteosarcoma remains unknown. In this study, the results showed that, by analysi...

journal_title：Oncology reports

authors： Sun W,Wang W,Lei J,Li H,Wu Y

更新日期：2017-04-01 00:00:00

abstract：:Ovarian cancer (OC) is one of the most lethal gynecological malignancies in the world. The aim of the present study was to examine the role of microRNA (miR)-134-3p in OC. Reverse transcription-quantitative PCR was used to measure the expression levels of miR-134-3p. Cell Counting Kit-8, TUNEL, flow cytometric and col...

journal_title：Oncology reports

authors： Zhao M,Ji H,Fu Q,Cheng Q,Zhang Y,Yang Y

更新日期：2021-01-01 00:00:00

abstract：:Histamine receptor H3 (HRH3) is mainly expressed in the central nervous system, where it is involved in the regulation of the release of various neurotransmitters in the brain. Recent studies have demonstrated that the expression of HRH3 is upregulated in several types of cancer. However, the functional effect of HRH3...

journal_title：Oncology reports

authors： Yu D,Zhao J,Wang Y,Hu J,Zhao Q,Li J,Zhu J

更新日期：2019-06-01 00:00:00

abstract：:The TP53 mutation (R175H) is one of the most common mutations in human cancer. It is a highly attractive strategy for cancer therapy to find the genes that lead the R175H-expressing cancer cells. The aim of this study was to identify the synthetic sick/lethal gene interacting with R175H. Using lentiviral bar-coded com...

journal_title：Oncology reports

authors： Imai H,Kato S,Sakamoto Y,Kakudo Y,Shimodaira H,Ishioka C

更新日期：2014-03-01 00:00:00

abstract：:Iodine-125 (125I) seed irradiation can be used as an important supplementary treatment for unresectable advanced gastric cancer. However, the radiobiological mechanism underlying brachytherapy remains unclear. Therefore, we investigated the influence of continuous and low-energy 125I irradiation on the cell cycle dist...

journal_title：Oncology reports

authors： Zhang WF,Jin WD,Li B,Wang MC,Li XG,Mao WY,Luo KY

更新日期：2014-08-01 00:00:00

abstract：:E1A binding protein P300 (EP300), tumor protein P53 (TP53) and BCL2 associated X, apoptosis regulator (BAX) genes encode proteins which cooperate to regulate important cellular processes. The present study aimed to determine the expression levels of EP300, TP53 and BAX in colorectal cancer (CRC) and to investigate the...

journal_title：Oncology reports

authors： Kowalczyk AE,Krazinski BE,Godlewski J,Kiewisz J,Kwiatkowski P,Sliwinska-Jewsiewicka A,Kiezun J,Sulik M,Kmiec Z

更新日期：2017-07-01 00:00:00

abstract：:Sarcosine is currently one of the most discussed markers of prostate cancer. It is involved in amino acid metabolism and methylation processes that occur during the progression of prostate cancer. In this study, we monitored the effect of the addition of sarcosine (0; 10; 250; 500; 1,000 and 1,500 µM) in a time-depend...

journal_title：Oncology reports

authors： Cernei N,Zitka O,Skalickova S,Gumulec J,Sztalmachova M,Rodrigo MA,Sochor J,Masarik M,Adam V,Hubalek J,Trnkova L,Kruseova J,Eckschlager T,Kizek R

更新日期：2013-06-01 00:00:00

abstract：:The model animal of renal cell carcinoma (RCC), the Eker rat, has a germline mutation in the tuberous sclerosis 2 (Tsc2) gene. Heterozygous mutants develop RCCs by second hit in the wild-type Tsc2 allele, whereas homozygous mutants are embryonic lethal. In the present study, a new cell differentiation model was develo...

journal_title：Oncology reports

authors： Kawano H,Ito Y,Kanai F,Nakamura E,Tada N,Takai S,Horie S,Kobayashi T,Hino O

更新日期：2015-11-01 00:00:00

abstract：:Telomere-associated proteins function as survival factors in telomere maintenance, which are major contributors to radiosensitivity in human cancers. The aim of this study was to investigate the association of telomere-associated gene expression and radiation resistance in human larynx squamous carcinoma. The changes ...

journal_title：Oncology reports

authors： Tang T,Zhou FX,Lei H,Yu HJ,Xie CH,Zhou YF,Liu SQ

更新日期：2009-06-01 00:00:00

abstract：:Several studies have shown that curcumin can induce apoptosis and inhibit growth in human A549 lung adenocarcinoma cells. However, the mechanism is not completely understood yet. The present study was designed to investigate the effects of curcumin on A549 cells to better understand its apoptosis and apoptosis-related...

journal_title：Oncology reports

authors： Chen Q,Wang Y,Xu K,Lu G,Ying Z,Wu L,Zhan J,Fang R,Wu Y,Zhou J

更新日期：2010-02-01 00:00:00

abstract：:To investigate whether the expression of Topoisomerase II-alpha (TII-alpha) can serve as a prognostic factor in renal cell carcinoma (RCC), histological sections from 27 renal tumors were stained immunohistochemically for TII-alpha expression. The percentage of positive cells in the area of greatest staining was recor...

journal_title：Oncology reports

authors： Dekel Y,Frede T,Kugel V,Neumann G,Rassweiler J,Koren R

更新日期：2005-07-01 00:00:00

abstract：:The histogenesis of depressed adenoma of the colon has not been sufficiently investigated. Pericryptal myofibroblasts are stromal cells expressing smooth muscle actin, and are involved in the differentiation and multiplication of epithelial cells in the colonic epithelium. COX-2 has been reported to be involved in the...

journal_title：Oncology reports

authors： Harada K,Higaki S,Amano A,Hashimoto K,Hashimoto S,Gondo T,Sakaida I

更新日期：2007-06-01 00:00:00

abstract：:Toll-like receptor (TLR)-mediated signaling induces cell migration or invasion in several tumors and various stages of cancer. Interactions of mesothelin, a 40-kDa cell surface glycoprotein, with cancer antigen 125 (CA125) is associated with drug resistance, metastasis, and poor clinical outcome of ovarian cancer pati...

journal_title：Oncology reports

authors： Park GB,Kim D

更新日期：2017-11-01 00:00:00