Expression of DNA double-strand break repair proteins predicts the response and prognosis of colorectal cancer patients undergoing oxaliplatin-based chemotherapy.

abstract：:A number of possible preventive agents for cancers in different organs have been reported, however, little information is available regarding the effective agents for the development of gastric cancers. The rice components are known to be effective for the prevention of the development of cancers. Our group has demons...

journal_title：Oncology reports

authors： Tomita H,Kuno T,Yamada Y,Oyama T,Asano N,Miyazaki Y,Baba S,Taguchi A,Hara A,Iwasaki T,Kobayashi H,Mori H

更新日期：2008-01-01 00:00:00

abstract：:Bmi-1, a member of the polycomb family, it is involved in self renewal of stem cells and functions as an oncogene in many malignant human cancer types. Recent studies have demonstrated that Bmi-1 is a predictive factor for poor patient prognosis. However, the underlying mechanisms o...

journal_title：Oncology reports

authors： Liu ZG,Liu L,Xu LH,Yi W,Tao YL,Tu ZW,Li MZ,Zeng MS,Xia YF

更新日期：2012-04-01 00:00:00

abstract：:Prostate cancer (PCa) remains a leading cause of mortality among men in the United States and Western Europe. The molecular mechanism of PCa pathogenesis has not been fully elucidated. In the present study, the expression profile of E2F transcription factor 7 (E2F7) in PCa was examined using immunohistochemistry and r...

journal_title：Oncology reports

authors： Wang Y,Pei X,Xu P,Tan Z,Zhu Z,Zhang G,Jiang Z,Deng Z

更新日期：2020-09-01 00:00:00

abstract：:The present study was designed to investigate the effects of Bowman-Birk inhibitor (BBI) on up-regulation of connexin (Cx) expression to estimate BBI's tumor-suppressor effect in mice with M5076 ovarian sarcoma. The relative tumor weight (p<0.05, r(2)=0.301) and proliferating cell nuclear antigen (PCNA, p<0.01, r(2)=0...

journal_title：Oncology reports

authors： Suzuki K,Yano T,Sadzuka Y,Sugiyama T,Seki T,Asano R

更新日期：2005-06-01 00:00:00

abstract：:HIF-1 is a heterodimer consisting of the HIF-1alpha and HIF-1beta subunits, and HIF-1alpha is the unique oxygen regulated subunit that determines HIF-1 activity. HIF-1alpha upgrades many gene products which include the glucose transporter protein 1 (Glut-1). Immunohistochemical studies using a monoclonal antibody spec...

journal_title：Oncology reports

authors： Palit V,Phillips RM,Puri R,Shah T,Bibby MC

更新日期：2005-10-01 00:00:00

abstract：:Metastasis-associated protein 1 (MTA1) is highly upregulated in cancer cells with metastatic potential; however, the molecular mechanism by which MTA1 increases the metastatic potential of cancer cells is far from clear. We characterized the functional consequences of MTA1 overexpression on p53-induced apoptosis of ca...

journal_title：Oncology reports

authors： Moon HE,Cheon H,Lee MS

更新日期：2007-11-01 00:00:00

abstract：:Male breast cancer (MBC) is extremely rare, with an incidence in the general US population of <1%. It tends to be diagnosed at later stages than breast cancer in females, likely because of low awareness on the part of the patient and low suspicion by the physician. Risk factors include genetic predisposition, alterati...

journal_title：Oncology reports

authors： Johansen Taber KA,Morisy LR,Osbahr AJ 3rd,Dickinson BD

更新日期：2010-11-01 00:00:00

abstract：:The incidence of well‑differentiated thyroid cancer (WDTC) is rapidly increasing. Poor survival follows distant metastasis (DM) and recurrence. In the present study, we aimed to analyze the expression alterations in different stages of WDTC and the regulatory mechanism of DM and the recurrence of DM. A male patient di...

journal_title：Oncology reports

authors： Zhang YJ,Ma YS,Xia Q,Yu F,Lv ZW,Jia CY,Jiang XX,Zhang L,Shao YC,Xie WT,Lu GX,Yv XQ,Zhong P,Fu D,Wang XF

更新日期：2018-12-01 00:00:00

abstract：:Lung cancer is one of the most common cancers worldwide and accounts for 28% of all cancer-related deaths. The expression of the β2‑adrenergic receptor (β2‑AR), one of the stress‑inducible receptors, has been reported to be closely correlated with malignant tumors. However, the role of β2‑AR activation in human lung e...

journal_title：Oncology reports

authors： Hu P,He J,Liu S,Wang M,Pan B,Zhang W

更新日期：2016-09-01 00:00:00

abstract：:WNT5B is a member of the WNT family that has been reported to be overexpressed in a variety of cancer cell lines and tissues, including colorectal cancer (CRC). However, the potential roles of WNT5B in tumorigenesis have not been reported. In the present study, the WNT5B gene was transfected into CRC cells and generat...

journal_title：Oncology reports

authors： Zhang Y,Lin L,Jin Y,Lin Y,Cao Y,Zheng C

更新日期：2016-07-01 00:00:00

abstract：:It has been reported that granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) can mobilize endothelial progenitor cells (EPCs) in bone marrow cells (BMCs) into peripheral blood (PB) in vivo. Previously, we also reported that macrophage-colony stimulating factor (...

journal_title：Oncology reports

authors： Zhang Y,Adachi Y,Iwasaki M,Minamino K,Suzuki Y,Nakano K,Koike Y,Mukaide H,Shigematsu A,Kiriyama N,Li C,Ikehara S

更新日期：2006-06-01 00:00:00

abstract：:Oxymatrine, a traditional Chinese herb extracted from Sophora flavescens Ait., displays strong anti-inflammatory and anticancer activities, but how oxymatrine exhibits anticarcinogenic effects in human colorectal cancer (CRC) remains uncertain. The present study aimed to elucidate the exact mechanism by which oxymatri...

journal_title：Oncology reports

authors： Liang L,Huang J

更新日期：2016-09-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) plays a key role in the transformation of normal cells to cancerous cells. Although inhibitors of STAT3 have been shown to suppress the growth of multiple cancer types in vitro and in vivo, such agents are of particular interest for the prevention of breast ca...

journal_title：Oncology reports

authors： Shoemaker RH,Fox JT,Juliana MM,Moeinpour FL,Grubbs CJ

更新日期：2019-09-01 00:00:00

abstract：:Resolvins, an endogenous lipid mediator derived from eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) of fish oil, has been reported to have anti-inflammatory and antitumor effect in various pathogenic processes. However, there are no studies about the effects of resolvin D1 and E1 on concanavalin A-induced h...

journal_title：Oncology reports

authors： Kuang H,Hua X,Zhou J,Yang R

更新日期：2016-01-01 00:00:00

abstract：:We investigated whether or not the mitochondrial genotypes affect radiation-induced micronucleus (MN) formation. For that purpose, the rho+, KT1 and rho0 human osteosarcoma cell lines were used, which carry the wild-type mitochondrial DNA (mtDNA), the tRNALys mutant mtDNA and no mtDNA, respectively. Despite no signifi...

journal_title：Oncology reports

authors： Yoshida K,Yamazaki H,Ozeki S,Inoue T,Yoshioka Y,Yoneda M,Fujiwara Y,Inoue T

更新日期：2001-05-01 00:00:00

abstract：:Emodin is an active ingredient derived from root and rhizome of Rheum palmatum L and many studies have reported that it exhibits anticancer effects in a number of human tumors. However, there is little information demonstrating the possible effects of emodin on the proliferation and apoptosis of hepatocellular carcino...

journal_title：Oncology reports

authors： Lin W,Zhong M,Yin H,Chen Y,Cao Q,Wang C,Ling C

更新日期：2016-08-01 00:00:00

abstract：:Neuroblastoma is an aggressive pediatric tumor that accounts for 15% of cancer-related deaths in children. More than half of high-risk neuroblastoma patients develop tumor relapse that is lethal in most cases. A small population of tumor-initiating cells (TICs), recently identified from high-risk neuroblastoma patient...

journal_title：Oncology reports

authors： Pham TV,Hartomo TB,Lee MJ,Hasegawa D,Ishida T,Kawasaki K,Kosaka Y,Yamamoto T,Morikawa S,Yamamoto N,Kubokawa I,Mori T,Yanai T,Hayakawa A,Takeshima Y,Iijima K,Matsuo M,Nishio H,Nishimura N

更新日期：2012-06-01 00:00:00

abstract：:The aim of the present study was to discover the signaling pathways associated with 2-(3-hydroxy-5-methoxy-phenyl)-6,7-methylenedioxyquinolin-4-one (YYK1)-induced apoptosis in HL-60 human leukemia cells. YYK1 induced cytotoxic effects, cell morphological changes, decreased the cell ...

journal_title：Oncology reports

authors： Cheng YY,Yang JS,Tsai SC,Liaw CC,Chung JG,Huang LJ,Lee KH,Lu CC,Chien HC,Tsuzuki M,Kuo SC

更新日期：2012-10-01 00:00:00

abstract：:Cyclin‑dependent kinase 5 regulatory subunit‑​associated protein 3 (CDK5RAP3 or C53) is involved in the development of various types of tumor, and alternative splicing of C53 results in numerous transcription variants that encode different isoforms. The present study aimed to clone human C53 isoform d (IC53d) and expl...

journal_title：Oncology reports

authors： Lin JX,Xie XS,Weng XF,Qiu SL,Xie JW,Wang JB,Lu J,Chen QY,Cao LL,Lin M,Tu RH,Li P,Huang CM,Zheng CH

更新日期：2019-05-01 00:00:00

abstract：:Breast cancer is the most common cancer in women worldwide. Progression and aggressiveness of breast cancer is usually associated with its migration and invasion abilities. Recently, natural products with potential anticancer activity have become attractive candidates for alternative treatment of cancer. A fungal meta...

journal_title：Oncology reports

authors： Kasorn A,Loison F,Kangsamaksin T,Jongrungruangchok S,Ponglikitmongkol M

更新日期：2018-03-01 00:00:00

abstract：:The novel gene human Biot2 (hBiot2) was first reported by our laboratory. Previously, we indicated its function of proliferation and carcinogenesis in human endometrial cancer. In the present study, we aimed to investigate whether hBiot2 played a similar role in human cervical cancer. We tested hBiot2 expression profi...

journal_title：Oncology reports

authors： Shen YM,He X,Deng HX,Xie YP,Wang CT,Wei YQ,Zhao X

更新日期：2011-01-01 00:00:00

abstract：:Ovarian cancer (OC) is one of the most lethal gynecological malignancies in the world. The aim of the present study was to examine the role of microRNA (miR)-134-3p in OC. Reverse transcription-quantitative PCR was used to measure the expression levels of miR-134-3p. Cell Counting Kit-8, TUNEL, flow cytometric and col...

journal_title：Oncology reports

authors： Zhao M,Ji H,Fu Q,Cheng Q,Zhang Y,Yang Y

更新日期：2021-01-01 00:00:00

abstract：:The identification of the specific molecular targets, which underlie liver carcinogenesis is essential for the establishment of an effective strategy for the prevention and/or treatment of hepatocellular carcinomas (HCCs). We previously found that a malfunction of RXRalpha due to its aberrant phosphorylation was assoc...

journal_title：Oncology reports

authors： Ando N,Shimizu M,Okuno M,Matsushima-Nishiwaki R,Tsurumi H,Tanaka T,Moriwaki H

更新日期：2007-10-01 00:00:00

abstract：:To elucidate the mechanism of resistance to 5-fluorouracil (5-FU) in human gastric cancer cells, we established a cell line MKN45/F2R, which acquired 5-FU resistance as a result of continuous exposure to increasing dosages of 5-FU over a year. The cell line showed 157-fold elevated 5-FU resistance compared to the MKN4...

journal_title：Oncology reports

authors： Tsutani Y,Yoshida K,Sanada Y,Wada Y,Konishi K,Fukushima M,Okada M

更新日期：2008-12-01 00:00:00

abstract：:Carboxypeptidase X, M14 family member 2 (CPXM2), has been associated with several human disorders such as developmental diseases. However, whether CPXM2 is involved in oncogenesis or tumor progression remains unclear. In the present study, we used clinical samples from gastric cancer (GC) patients to investigate poten...

journal_title：Oncology reports

authors： Niu G,Yang Y,Ren J,Song T,Hu Z,Chen L,Hong R,Xia J,Ke C,Wang X

更新日期：2019-10-01 00:00:00

abstract：:Annexin A2 (ANXA2) is a well-known calcium-dependent phospholipid binding protein widely distributed in the nucleus, cytoplasm and extracellular surface of various eukaryotic cells. It has been recognized as a pleiotropic protein affecting a wide range of molecular and cellular processes. Dysregulation and abnormal ex...

journal_title：Oncology reports

authors： Xu XH,Pan W,Kang LH,Feng H,Song YQ

更新日期：2015-05-01 00:00:00

abstract：:Hydrogen sulfide (H2S), regarded as the third gaseous transmitter, mediates and induces various biological effects. The present study investigated the effects of H2S on multiple myeloma cell progression via amplifying the activation of Akt pathway in multiple myeloma cells. The level of H2S produced in multiple myelom...

journal_title：Oncology reports

authors： Zheng D,Chen Z,Chen J,Zhuang X,Feng J,Li J

更新日期：2016-10-01 00:00:00

abstract：:Glioma is the most frequent and aggressive primary tumor of the brain in humans. Over the last few decades, significant progress has been made in early detection and multi-mode treatments, but the prognosis of gliomas is still extremely poor. MicroRNAs are endogenously expressed non-coding, single strand and short RNA...

journal_title：Oncology reports

authors： Ma J,Yu J,Liu J,Yang X,Lou M,Liu J,Feng F,Ji P,Wang L

更新日期：2017-02-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) has a typical progressive course with transition from a chronic phase to a terminal blast crisis phase. However, the mechanisms that lead to disease progression remain unclear. Bone marrow mesenchymal stem cells (BMMSCs) play important roles in maintaining the bone marrow microenviro...

journal_title：Oncology reports

authors： Han Y,Wang Y,Xu Z,Li J,Yang J,Li Y,Shang Y,Luo J

更新日期：2013-08-01 00:00:00

abstract：:Mitogene-inducible gene-6 (Mig-6) is involved in the intracellular signaling pathway as an adaptor molecule. Mig-6 expression is rapidly induced upon various kinds of mitogenic and stressful stimulations. We previously demonstrated that Mig-6 expression is induced by activated Ki-ras in human colon cancer cells and th...

journal_title：Oncology reports

authors： Mabuchi R,Sasazuki T,Shirasawa S

更新日期：2005-03-01 00:00:00