Association of annexin A2 with cancer development (Review).

abstract：:Triosephosphate isomerase (TPI) is highly expressed in many types of human tumors and is involved in migration and invasion of cancer cells. However, TPI clinicopathological significance and malignant function in gastric cancer (GC) have not been well defined. The present study aimed to examine TPI expression in GC ti...

journal_title：Oncology reports

authors： Chen T,Huang Z,Tian Y,Wang H,Ouyang P,Chen H,Wu L,Lin B,He R

更新日期：2017-09-01 00:00:00

abstract：:Colon cancer (CC) is one of the leading causes of cancer‑related mortality in China and western countries. Several studies have demonstrated that long non‑coding RNAs (lncRNAs) play critical roles in cancer development. However, the function of lncRNA RP11‑619L19.2 in colon cancer remains unclear. The aim of the prese...

journal_title：Oncology reports

authors： Zhang XW,Li SL,Zhang D,Sun XL,Zhai HJ

更新日期：2020-12-01 00:00:00

abstract：:Recombinant hirudin (rH) is a highly potent and specific inhibitor of thrombin, and has been shown to inhibit the growth and metastasis of several types of cancers in experimental tumor models. The objective of this study was to evaluate the antitumor effects and explore the underlying mechanisms of rH in Hep-2 human ...

journal_title：Oncology reports

authors： Lu Q,Lv M,Xu E,Shao F,Feng Y,Yang J,Shi L

更新日期：2015-03-01 00:00:00

abstract：:The development and progression of epithelial cancers are the result of an imbalance in signals promoting and inhibiting cellular proliferation and apoptosis. The aim of this study is to evaluate the expression of cell-cycle and apoptosis regulators and correlate them with clinical outcome in the most frequent carcino...

journal_title：Oncology reports

authors： Abdulkader I,Sánchez L,Cameselle-Teijeiro J,Gude F,Chávez JE,López-López R,Forteza J,Fraga M

更新日期：2005-12-01 00:00:00

abstract：:Cumulative evidence suggests that long non-coding RNAs (lncRNAs) may be good biomarkers in various types of tumors. In the present study, we mined lncRNA expression profiling in 739 lung cancer patients from Gene Expression Omnibus (GEO) datasets. A risk score model was constructed based on the expression data of thes...

journal_title：Oncology reports

authors： Tu Z,He D,Deng X,Xiong M,Huang X,Li X,Hao L,Ding Q,Zhang Q

更新日期：2016-07-01 00:00:00

abstract：:The purpose of this study was to define gene expression profile changes in colorectal tumors in order to identify target genes involved in neoplastic progression. cDNA microarray analysis was used to detect differences in gene expression profiles between colon tumor samples obtained from 20 patients in different tumor...

journal_title：Oncology reports

authors： Bandres E,Catalan V,Sola I,Honorato B,Cubedo E,Cordeu L,Andion E,Escalada A,Zarate R,Salgado E,Zabalegui N,García F,Garcia-Foncillas J

更新日期：2004-08-01 00:00:00

abstract：:Human leukocyte antigen B (HLA-B), a novel member of the NF-kappaB signal pathway in laryngeal squamous cell carcinoma (LSCC), mediates immunological surveillance of tumor cells by presenting peptides to cytotoxic T-lymphocytes (CTLs) together with S100 calcium binding protein A8 (S100A8). The objective of this study ...

journal_title：Oncology reports

authors： Guo Y,Liu J,Xu Z,Sun K,Fu W

更新日期：2008-06-01 00:00:00

abstract：:Dendropanax morbifera Leveille is found throughout southwestern Korea, and has been used in traditional medicine for various diseases, such as migraine headache, infectious diseases, skin diseases and dysmenorrhea. However, the molecular mechanisms of D. morbifera concerning its biochemical actions in cancer have not ...

journal_title：Oncology reports

authors： Lee JW,Park C,Han MH,Hong SH,Lee TK,Lee SH,Kim GY,Choi YH

更新日期：2013-09-01 00:00:00

abstract：:The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we dis...

journal_title：Oncology reports

authors： Malas S,Harrasser M,Lacy KE,Karagiannis SN

更新日期：2014-09-01 00:00:00

abstract：:Glioma is the most frequent and aggressive primary tumor of the brain in humans. Over the last few decades, significant progress has been made in early detection and multi-mode treatments, but the prognosis of gliomas is still extremely poor. MicroRNAs are endogenously expressed non-coding, single strand and short RNA...

journal_title：Oncology reports

authors： Ma J,Yu J,Liu J,Yang X,Lou M,Liu J,Feng F,Ji P,Wang L

更新日期：2017-02-01 00:00:00

abstract：:Cancer immunotherapy is a promising new approach to cancer treatment. It has been demonstrated that a high number of tumor-specific cytotoxic T cells (CTLs) is associated with increased disease-specific survival in lung cancer patients. Identification of superior CTL epitopes from tumor antigens is essential for the d...

journal_title：Oncology reports

authors： Yoshimura M,Tada Y,Ofuzi K,Yamamoto M,Nakatsura T

更新日期：2014-07-01 00:00:00

abstract：:The present study aimed to assess the in vitro and in vivo magnetic resonance imaging (MRI) features of chlorotoxin (CTX)-conjugated superparamagnetic iron oxide (SPIO) nanoprobes. CTX-conjugated nanoprobes were composed of SPIO coated with polyethylene glycol (PEG) and conjugated with CTX. The nanoprobes were termed ...

journal_title：Oncology reports

authors： Chen Z,Xiao EH,Kang Z,Zeng WB,Tan HL,Li HB,Bian DJ,Shang QL

更新日期：2016-05-01 00:00:00

abstract：:The present study aimed to investigate the role of miR‑181a in multiple myeloma (MM) cell lines. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect the expression of microRNA (miR)‑181a. The MM cell line RPMI 8226 stably transduced with miR‑181a mimics or inhibitor was establishe...

journal_title：Oncology reports

authors： Liu N,Yang J,Yuan R,Peng J,Liu L,Guo X

更新日期：2019-07-01 00:00:00

abstract：:Oncolytic viruses are genetically engineered viruses designed for the treatment of solid tumors, and are often coupled with the antitumor immunity of the host. The challenge of using oncolytic herpes simplex virus (oHSV) as an efficacious oncolytic agent is the potential host tissue damage caused by the production of ...

journal_title：Oncology reports

authors： Ren S,Chen X,Huang R,Zhou GG,Yuan Z

更新日期：2019-03-01 00:00:00

abstract：:Recent studies have shown that miRNAs have potent abilities to activate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa). In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal...

journal_title：Oncology reports

authors： Li S,Wang C,Yu X,Wu H,Hu J,Wang S,Ye Z

更新日期：2017-01-01 00:00:00

abstract：:Prostate cancer (PCa) is a leading cause of death among men. The dysregulation of metabolism and autophagy contributes to the progression of PCa. The transcription factor specificity protein 1 (Sp1) is implicated in the regulation of metabolism and autophagy. We confirmed that Sp1 is overexpressed in castration-resist...

journal_title：Oncology reports

authors： Ling Z,Liu D,Zhang G,Liang Q,Xiang P,Xu Y,Han C,Tao T

更新日期：2017-09-01 00:00:00

abstract：:The novel tumor suppressor RASSF1A is frequently inactivated during human tumorigenesis by promoter methylation. In this study, we detected the RASSF1A promoter methylation by methylated-specific PCR and investigated RASSF1A gene expression by semi-quantitative RT-PCR and immunohistochemical staining in 36 cases of br...

journal_title：Oncology reports

authors： Li Y,Wei Q,Cao F,Cao X

更新日期：2008-05-01 00:00:00

abstract：:Post‑transcriptional mechanisms are an important approach in the treatment of cancer, and may also be hijacked by tumor cells to help adapt to the local microenvironment. Filamin B (FLNB), an actin‑binding protein that provides crucial scaffolds for cell motility and signaling, has also been identified as an RNA‑bindi...

journal_title：Oncology reports

authors： Ma HR,Cao L,Wang F,Cheng C,Jiang R,Zhou H,Xie Z,Wuermanbieke S,Qian Z

更新日期：2020-05-01 00:00:00

abstract：:Currently, various types of keratins have been reported to be highly expressed in cancer cells and to be associated with a malignant phenotype. In the present study, it was found that expression levels of keratin 6 (K6), keratin 16 (K16), and keratin 17 (K17) were highly elevated in SNU601 cells resistant to cisplatin...

journal_title：Oncology reports

authors： Lim SC,Parajuli KR,Han SI

更新日期：2019-08-01 00:00:00

abstract：:Cyclooxygenase-2 (Cox-2) is an inducible enzyme that converts arachidonic acid to prostaglandins, and it is hypothesized to induce carcinogenesis and metastasis in colorectal cancer. Our previous data also indicated that a higher expression level of Cox-2 was correlated with colorec...

journal_title：Oncology reports

authors： Li ZG,Wang XY,Chang JL,Xie WB,Liu TF,Zhang QL,Deng YJ,Ding YQ

更新日期：2012-09-01 00:00:00

abstract：:Vimentin is a member of the intermediate filament family, and the NF-kappaB binding site is located in the human vimentin promoter. To gain insight into the role of NF-kappaB in the regulation of the vimentin gene during 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent differentiation of HL-60 cells, the effect of...

journal_title：Oncology reports

authors： Zheng M,Son MY,Park C,Park JI,Jo EK,Yoon WH,Park SK,Hwang BD,Lim K

更新日期：2005-09-01 00:00:00

abstract：:Triple-negative breast cancer is a highly aggressive type of mammalian carcinoma. It is defined by a rather weak expression of estrogen-, progesterone- and Her2-receptor, and is thus difficult to treat, resulting in low disease-free and overall survival rates of the affected patients. Hence it is important to find new...

journal_title：Oncology reports

authors： Andergassen U,Kölbl AC,Mumm JN,Mahner S,Jeschke U

更新日期：2017-05-01 00:00:00

abstract：:In this study, a total of 108 patients with primary colorectal cancer who underwent hybrid 2-port hand-assisted laparoscopic surgery (HALS) were classified as 58 patients with colon cancer and 50 patients with rectal cancer. The mean operating time, mean blood loss, postoperative complications, and mean postoperative ...

journal_title：Oncology reports

authors： Mukai M,Kishima K,Tajima T,Hoshikawa T,Yazawa N,Fukumitsu H,Okada K,Ogoshi K,Makuuchi H

更新日期：2009-10-01 00:00:00

abstract：:Identification of safe, effective radiosensitizing agents is urgently needed to improve the outcome of radiotherapy in nasopharyngeal cancer (NPC). In this study, we assessed the ability of the polyphenol resveratrol to act as a radiosensitizer in vitro and in vivo. CNE-1 cells were treated with 50 µM resveratrol for ...

journal_title：Oncology reports

authors： Tan Y,Wei X,Zhang W,Wang X,Wang K,Du B,Xiao J

更新日期：2017-03-01 00:00:00

abstract：:Adoptive immunotherapy requires the isolation of CD8+ T cells specific for tumor-associated antigens, their expansion in vitro and their transfusion to the patient to mediate a therapeutic effect. MUC1 is an important adenocarcinoma antigen immunogenic for T cells. The MUC1-derived SAPDTRPA (MUC1-8-mer) peptide is a p...

journal_title：Oncology reports

authors： Atzin-Méndez JA,López-González JS,Báez R,Arenas-Del Angel MC,Montaño LF,Silva-Adaya D,Lascurain R,Gorocica P

更新日期：2016-01-01 00:00:00

abstract：:Caspases play an essential role in the initiation/regulation of apoptosis. Aberrant apoptotic regulation has been associated with carcinogenesis and therapeutic resistance. To explore the possible involvement of altered caspase expression in breast cancer, we have systematically examined the expression of both protein...

journal_title：Oncology reports

authors： Yang S,Liu J,Thor AD,Yang X

更新日期：2007-05-01 00:00:00

abstract：:Matrine is a traditional Chinese herbal medicine that shows antitumor efficacy for many types of cancer. The present study evaluated the antitumor efficacy of matrine on cervical cancer and to investigate the underlying mechanisms. We performed MTT assays, and in vitro invasion and migration assays, and P1 L6 found th...

journal_title：Oncology reports

authors： Wu X,Zhou J,Cai D,Li M

更新日期：2017-08-01 00:00:00

abstract：:Given its tumor-specific expression, including liver cancer, OY-TES-1 is a potential molecular marker for the diagnosis and immunotherapy of liver cancers. However, investigations of the mechanisms and the role of OY-TES-1 in liver cancer are rare. In the present study, based on a comprehensive bioinformatic analysis ...

journal_title：Oncology reports

authors： Hu Q,Fu J,Luo B,Huang M,Guo W,Lin Y,Xie X,Xiao S

更新日期：2015-04-01 00:00:00

abstract：:A small subset of cells within a malignant neoplasm, named cancer stem cells (CSCs) or tumour initiating cells, are thought to be capable of initiating the neoplasm itself, and of driving its growth and recurrence after treatment. It is unclear whether CSCs can be identified and experimentally induced within oral squa...

journal_title：Oncology reports

authors： Qiao B,Johnson NW,Chen X,Li R,Tao Q,Gao J

更新日期：2011-08-01 00:00:00

abstract：:Cadmium and nickel have been classified as carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. Given their prevalence in the environment, the fact that cadmium and nickel may cause diseases including cancer even at low doses is a cause for concern. However, the exact ...

journal_title：Oncology reports

authors： Kwon JY,Weon JI,Koedrith P,Park KS,Kim IS,Seo YR

更新日期：2013-09-01 00:00:00