Abstract:
:Given its tumor-specific expression, including liver cancer, OY-TES-1 is a potential molecular marker for the diagnosis and immunotherapy of liver cancers. However, investigations of the mechanisms and the role of OY-TES-1 in liver cancer are rare. In the present study, based on a comprehensive bioinformatic analysis combined with RNA interference (RNAi) and oligonucleotide microarray, we report for the first time that downregulation of OY-TES-1 resulted in significant changes in expression of NANOG, CD9, CCND2 and CDCA3 in the liver cancer cell line BEL-7404. NANOG, CD9, CCND2 and CDCA3 may be involved in cell proliferation, migration, invasion and apoptosis, yet also may be functionally related to each other and OY-TES-1. Among these molecules, we identified that NANOG, containing a Kazal-2 binding motif and homeobox, may be the most likely candidate protein interacting with OY-TES-1 in liver cancer. Thus, the present study may provide important information for further investigation of the roles of OY-TES-1 in liver cancer.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Hu Q,Fu J,Luo B,Huang M,Guo W,Lin Y,Xie X,Xiao Sdoi
10.3892/or.2015.3792subject
Has Abstractpub_date
2015-04-01 00:00:00pages
1965-75issue
4eissn
1021-335Xissn
1791-2431journal_volume
33pub_type
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