Abstract:
:Emodin is an active ingredient derived from root and rhizome of Rheum palmatum L and many studies have reported that it exhibits anticancer effects in a number of human tumors. However, there is little information demonstrating the possible effects of emodin on the proliferation and apoptosis of hepatocellular carcinoma (HCC). In the present study, we show that emodin may inhibit the proliferation of SMMC-7721 cells in a dose- and time-dependent manner and induced apoptosis of cells in a concentration-dependent manner after treatment for 24 h. Moreover, we further discovered that the possible molecular mechanisms involved may relate to the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT signaling pathways. Emodin may induce the phosphorylation of extracellular-signal-regulated kinase (ERK) and p38 while mildly suppressed the expression of p-c-Jun-N-terminal kinase (p-JNK). However, emodin did not affect the expression of the total (t)-ERK, t-p38 or t-JNK. Furthermore, emodin also suppressed the activation of p-AKT, but not the t-AKT. In vivo, we found that emodin suppressed tumor growth in experimental mice without an obvious change in body weight, which may work through the antiproliferation and apoptosis inducing effects. Moreover, emodin improves the liver and kidney function in mice, revealing that emodin may improve the life quality of the mice with implanted tumors. In conclusion, the above findings indicate that emodin may be a potentially effective and safe drug to induce apoptosis of HCC.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Lin W,Zhong M,Yin H,Chen Y,Cao Q,Wang C,Ling Cdoi
10.3892/or.2016.4861subject
Has Abstractpub_date
2016-08-01 00:00:00pages
961-7issue
2eissn
1021-335Xissn
1791-2431journal_volume
36pub_type
杂志文章相关文献
ONCOLOGY REPORTS文献大全abstract::Gastroenteropancreatic neuroendocrine tumors (GEP‑NETs) are relatively uncommon. Unfortunately, epidemiological studies on the incidence of GEP‑NETs worldwide have reported a marked increase in the detection of these tumors. Although they often exhibit relatively indolent clinical courses, GEP‑NETs have the potential ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5170
更新日期:2016-12-01 00:00:00
abstract::Glucocorticoids (GCs) are known potent clinical drugs, however, their mode of action is still complex and debatable. Macrophages are the most important target of GCs and play a key role in tumor immunity in vivo, but their relationship is also controversial. In the present study, the lentivirus system was used to over...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7434
更新日期:2020-02-01 00:00:00
abstract::MicroRNAs (miRNAs) play an important role in the genesis and development of gastric cancer. In the present study, we determined whether miRNA-135a-5p expression was increased in gastric cancer compared with adjacent non-tumor tissues using 20 pairs of gastric cancer and para-carcinoma tissue samples which were assesse...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3546
更新日期:2014-12-01 00:00:00
abstract::Distant metastases represent the major cause of death after curative surgery of colorectal cancer. The aim of this study was to evaluate the role of Smad4 and KRAS genetic alterations in colorectal metastases taking into account both the site (hepatic versus extrahepatic) and the time (synchronous versus metachronous)...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
abstract::The incidence and associated mortality of melanoma continues to increase worldwide. At present, there is no curative therapy for advanced stage of melanoma. It is necessary to find new indicators of prognosis and therapeutic targets. Increasing evidence shows that miRNA can provide potential candidate biomarkers for m...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5020
更新日期:2016-10-01 00:00:00
abstract::To evaluate the efficacy of long-term postoperative adjuvant chemotherapy with low-dose cisplatin (CDDP) plus 5-fluorouracil (5-FU) (CDDP/5-FU), we retrospectively examined 167 patients with squamous cell carcinoma of the esophagus who received the treatment after curative surgery (R0 resection). We classified the pat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-04-01 00:00:00
abstract::Quercetin, a kind of flavonoid, is found in edible fruits and vegetables and has anti-tumorigenic activity. However, the mechanism of activity has not been elucidated. We show for the first time that gadd45 is a molecular target of quercetin, which inhibits growth of human cervical cancer HeLa cells. Apoptosis was det...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract::Identification of safe, effective radiosensitizing agents is urgently needed to improve the outcome of radiotherapy in nasopharyngeal cancer (NPC). In this study, we assessed the ability of the polyphenol resveratrol to act as a radiosensitizer in vitro and in vivo. CNE-1 cells were treated with 50 µM resveratrol for ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5413
更新日期:2017-03-01 00:00:00
abstract::Ras-association domain family of proteins (RASSF) is characterized by the Ras-association (RA) domain at the C-terminal. Frequent inactivation of RASSF1A gene in human cancers suggests that other members of the family may also play an important role in tumorigenesis. By in silico gene searches, the number of RASSF fam...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::The endoplasmic reticulum (ER) is a membranous network within cells that is important for several cellular functions including translation and folding of secretory and membrane proteins, lipid biogenesis and sequestration of Ca2+. Disruption of ER structure might affect the normal physiology of the cells. In yeast, ex...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5209
更新日期:2016-12-01 00:00:00
abstract::Patients with ulcerative colitis (UC) exhibit an increased risk for the development of cancer of the colon and rectum. This association is widely attributed to colonic inflammation. However, the severity of colonic inflammation necessary for the development of dysplasia and/or cancer remains unknown. In this study, we...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00
abstract::Gastric cancer (GC) is one of the most common malignancies, and is the second leading cause of cancer-related deaths worldwide. Macrophages infiltrated in the tumor microenvironment (TME) called tumor-associated macrophages (TAMs) are key orchestrators in TME. In GC, it has been reported that infiltration of TAMs is a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5877
更新日期:2017-10-01 00:00:00
abstract::Iodine-125 (125I) seed irradiation can be used as an important supplementary treatment for unresectable advanced gastric cancer. However, the radiobiological mechanism underlying brachytherapy remains unclear. Therefore, we investigated the influence of continuous and low-energy 125I irradiation on the cell cycle dist...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3255
更新日期:2014-08-01 00:00:00
abstract::The aim of this study was to investigate the effect of temozolomide (TZM) in combination with X-rays on proliferation and migration in human glioma spheroids. Multicellular spheroids were derived from GaMg and U87 cell lines. Spheroids were treated with various concentrations of TZM (5 micromol, 0.025 mmol, 0.05 mmol)...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
abstract::MicroRNAs (miRNAs) that negatively regulate gene expression play a key role in the development and progression of cancer. Aberrant expression of hsa-miR-187 (miR-187) has been reported in various malignancies. However, the function of miR-187 in tumor progression remains controversial and its role in non-small cell lu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5548
更新日期:2017-05-01 00:00:00
abstract::DLC-1 (deleted in liver cancer-1) is a potential tumor suppressor gene, which is inactive in liver carcinogenesis. To observe the effects of DLC-1 gene expression on cell proliferation and migration in the human colon cancer cell line, RNAi Lipo-recombinant of the DLC-1 gene (pGCsil-DLC-1) was constructed and transduc...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::In the development and progression of cancer, tumor suppressor genes may be silenced by mechanisms such as methylation. Thus the discovery of new genes silenced by methylation may uncover new tumor suppressor genes, and improve our understanding of cancer biology. In this study we investigated the methylation of 19 ge...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or_00000325
更新日期:2009-04-01 00:00:00
abstract::Chemokine (C-C motif) ligand 2 (CCL2) has been shown to play an important role in the regulation of tumor cell growth, metastasis and host immune response. CCL2 preferentially binds to the C-C chemokine receptor type 2 (CCR2), which is expressed in various tissues. However, the role of the CCL2/CCR2 axis in hepatocell...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.6069
更新日期:2018-01-01 00:00:00
abstract::The aim of the present study was to evaluate the antitumor effects of the curcumin analogue GL63 on radioresistant nasopharyngeal carcinoma (NPC) CNE2R cells and parental CNE2 cells. The cell viability and proliferation of NPC cells were detected by MTT assay and colony formation assay. The suppressive effect on tumor...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2013.2457
更新日期:2013-07-01 00:00:00
abstract::Recent research indicates that the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway may play an important role in chronic inflammation which promotes cancer progression, yet the mechanism is not clear. The present study aimed to investigate the role of the JAK/STAT3 pathway in the gr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3609
更新日期:2015-01-01 00:00:00
abstract::Combined chemotherapy with 5-fluorouracil and leucovorin (LV) has been widely used for the treatment of patients with colorectal cancer. Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), whic...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1206
更新日期:2011-05-01 00:00:00
abstract::We present a case of resected hepatocellular carcinoma (HCC) which invaded the gallbladder with a metastasis to a lymph node. It was extremely difficult to make a differential diagnosis between HCC and gallbladder cancer preoperatively. A 68-year old man was admitted to hospital with complaint of a fever. Ultrasonogra...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.8.2.331
更新日期:2001-03-01 00:00:00
abstract::WNT signaling pathway networks with Hedgehog, Notch and FGF signaling pathways during carcinogenesis and embryogenesis. FZD8 is up-regulated in HeLa S3 and A549 cells. Here we identified and characterized rat Fzd8 gene by using bioinformatics. Rat Fzd8 gene was identified within AC131883.2 genome sequence. Rat Fzd8 (6...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
abstract::Regulated intramembrane proteolysis of epithelial cell adhesion molecule (EpCAM) results in shedding of the extracellular domain (EpEX) and release of the intra-cellular domain (EpICD) into the cytoplasm. Released EpICD associates with FHL2, β-catenin and Lef-1 to form a nuclear complex and triggers oncogenic signalin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4789
更新日期:2016-07-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the most common form of adult liver cancer and accounts for approximately 90% of all cases of primary liver cancer annually. Rhotekin (RTKN), which functions as a cancer promoter, can be frequently detected in many human cancers, including gastric cancer, colorectal carcinoma and blad...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5290
更新日期:2017-02-01 00:00:00
abstract::Genetically modified tumour cells producing cytokines such as interleukin 12 (IL-12) are potent activators of the antitumour immune responses and represent a promising therapeutic modality when combined with chemotherapy. The objective of this study was to examine whether IL-12-producing cellular vaccines can augment ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2011.1221
更新日期:2011-06-01 00:00:00
abstract::Fluoroquinolones affect the proliferation and apoptotic cell death of several human malignancies. Therefore, we investigated whether new 6-aminoquinolone derivatives, initially synthesized as anti-HIV agents, could affect the proliferation and apoptotic cell death of human prostate cancer cell lines. PC3 and LNCaP cel...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract::The human Igf-1 gene not only produces insulin‑like growth factor-I (IGF-I), but also different carboxy‑terminal extensions, known as E peptides, through alternative splicing. We and others have shown that human Eb peptide (hEb) derived from Igf-1 has intrinsic biological activity and is localized to nuclei of transfe...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3329
更新日期:2014-09-01 00:00:00
abstract::Fecal microRNAs (miRNAs) are increasingly explored as non-invasive markers of colorectal cancer (CRC). However, its holistic profile in Asian CRC patients remains elusive. In the present study, the global human fecal miRNAs in Asian Chinese CRC patients was assayed to elucidate novel diagnostic fecal markers. Addition...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2014.3193
更新日期:2014-07-01 00:00:00
abstract::The process of angiogenesis is essential for tumor development and metastasis. Vascular endothelial growth factor (VEGF), which is overexpressed in most human cancers, has been demonstrated to be a major modulator of angiogenesis. Thus, inhibition of VEGF signaling has the potential for tumor anti-angiogenic therapy. ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4761
更新日期:2016-06-01 00:00:00