Multivariate analysis of metastasis‑related risk factors for patients with gastroenteropancreatic neuroendocrine tumors based on clinicopathological and endoscopic features.

abstract：:Signal transducer and activator of transcription (STAT) 5, including STAT 5a and STAT 5b, was reported to play important roles in the malignant biological behaviors of tumors. However, their roles in gastric cancer, especially for STAT 5b remain unknown. This study aimed to detect the expression of STAT 5b in gastric ...

journal_title：Oncology reports

authors： Sun T,Jia Y,Xiao D

更新日期：2015-07-01 00:00:00

abstract：:Our aim was to carry out mutational analysis of Smad7 exon 4 that codes for the Smad7 MH2 domain in human cervical cancer tissues. This study is warranted since genetic abnormalities of components of the transforming growth factor-beta (TGF-beta)/Smad signaling system have been implicated in a variety of human cancers...

journal_title：Oncology reports

authors： Hariharan R,Babu JM,P R,Pillai MR

更新日期：2009-04-01 00:00:00

abstract：:The present study was designed to retrospectively examine the efficacy of postoperative adjuvant chemotherapy in 107 patients with stage II primary colorectal cancer who underwent curative resection. The chemotherapy regimen was intravenous 5FU/LV in 30 patients (FL-IV group) and oral UFT/PSK in 77 patients (oral grou...

journal_title：Oncology reports

authors： Ito I,Mukai M,Ninomiya H,Kishima K,Tsuchiya K,Tajima T,Oida Y,Nakamura M,Makuuchi H

更新日期：2008-11-01 00:00:00

abstract：:DLC-1 (deleted in liver cancer-1) is a potential tumor suppressor gene, which is inactive in liver carcinogenesis. To observe the effects of DLC-1 gene expression on cell proliferation and migration in the human colon cancer cell line, RNAi Lipo-recombinant of the DLC-1 gene (pGCsil-DLC-1) was constructed and transduc...

journal_title：Oncology reports

authors： Jin Y,Tian X,Shang Y,Huang P

更新日期：2008-03-01 00:00:00

abstract：:Many prostate cancer (PCa) patients die of recurrent disease due to the emergence of hormone-independent cancer cells of which the mechanism is not fully understood. Our previous studies demonstrated that most castration- resistant prostate cancers (CRPC) overexpress the HOXB13 transcription factor to confer positive ...

journal_title：Oncology reports

authors： Kim YR,Kang TW,To PK,Xuan Nguyen NT,Cho YS,Jung C,Kim MS

更新日期：2016-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) that negatively regulate gene expression play a key role in the development and progression of cancer. Aberrant expression of hsa-miR-187 (miR-187) has been reported in various malignancies. However, the function of miR-187 in tumor progression remains controversial and its role in non-small cell lu...

journal_title：Oncology reports

authors： Cai Y,Ruan J,Yao X,Zhao L,Wang B

更新日期：2017-05-01 00:00:00

abstract：:MAP kinase signaling proteins have major implications in the molecular oncogenesis of breast cancers and have been extensively investigated as putative targets for therapy. This study reports the investigation of the expression of P38 MAPK and its phosphorylated form (p-P38 MAPK) in clinical specimens of invasive brea...

journal_title：Oncology reports

authors： Merlin JL,Harlé A,Lion M,Ramacci C,Leroux A

更新日期：2013-10-01 00:00:00

abstract：:Investigations into extracellular vesicles (EVs) have significantly increased since their role in physiological and pathological processes has become more clearly understood. Furthermore, it has become increasingly clear that several subpopulations of EVs exist, such as exosomes (EXOs) and microvesicles (MVs). Various...

journal_title：Oncology reports

authors： Giusti I,Di Francesco M,Cantone L,D'Ascenzo S,Bollati V,Carta G,Dolo V

更新日期：2015-11-01 00:00:00

abstract：:Dendropanax morbifera Leveille is found throughout southwestern Korea, and has been used in traditional medicine for various diseases, such as migraine headache, infectious diseases, skin diseases and dysmenorrhea. However, the molecular mechanisms of D. morbifera concerning its biochemical actions in cancer have not ...

journal_title：Oncology reports

authors： Lee JW,Park C,Han MH,Hong SH,Lee TK,Lee SH,Kim GY,Choi YH

更新日期：2013-09-01 00:00:00

abstract：:Using a series of potential biomarkers relevant to mechanisms of protein synthesis, we observed that estrogen receptor (ER)-positive breast tumor cells exist in two distinct yet interconvertible phenotypic states (of roughly equal proportion) which differ in the degree of differentiation and use of IRES-mediated trans...

journal_title：Oncology reports

authors： Vaklavas C,Zinn KR,Samuel SL,Meng Z,Grizzle WE,Choi H,Blume SW

更新日期：2018-06-01 00:00:00

abstract：:Studies of tumor-infiltrating immune cells have revealed that immune escape plays an important role in tumor growth. The aim of the present study was to investigate the impact of metastasis affecting CD4+ T cell subsets in human clinical samples. Single-cell suspensions derived from tumor-draining lymph node (TDLN) an...

journal_title：Oncology reports

authors： Okita Y,Ohira M,Tanaka H,Tokumoto M,Go Y,Sakurai K,Toyokawa T,Kubo N,Muguruma K,Sawada T,Maeda K,Hirakawa K

更新日期：2015-08-01 00:00:00

abstract：:Licochalcone A (LicA) is a chalcone extracted from liquorice which has been used as a traditional Chinese medicine for many generations. Increased glucose consumption and glycolytic activity are important hallmarks of cancer cells, and hexokinase 2 (HK2) upregulation is a major contributor to the elevation of glycolys...

journal_title：Oncology reports

authors： Wu J,Zhang X,Wang Y,Sun Q,Chen M,Liu S,Zou X

更新日期：2018-03-01 00:00:00

abstract：:Currently, there are emerging multiple studies on human epididymis protein 4 (HE4) in ovarian cancer. HE4 possesses higher sensitivity and specificity than CA125 in the confirmative early diagnosis for ovarian cancer. Although much attention has been given to explore its clinical application, research of the basic mec...

journal_title：Oncology reports

authors： Zhu L,Guo Q,Jin S,Feng H,Zhuang H,Liu C,Tan M,Liu J,Li X,Lin B

更新日期：2016-09-01 00:00:00

abstract：:The immunohistochemical expression of type 1 blood group antigens (type 1 BGAs) was analyzed for 30 cases of testicular germ cell tumors (TGCTs), using monoclonal antibodies against DU-PAN-2, CA19-9, Lewis(a) (Le(a)), and Lewis(b) (Le(b)). DU-PAN-2 was expressed very frequently in all of the embryonal carcinomas (ECs)...

journal_title：Oncology reports

authors： Kamoshida S,Satoh Y,Yasuda M,Kajiwara H,Tsukinoki K,Osamura RY

更新日期：2002-07-01 00:00:00

abstract：:To better understand the molecular mechanisms of carcinogenesis induced in uterine endometrium by therapeutic anti-estrogenic Tamoxifen (TAM) exposure, 27 uterine tumors (4 benign endometrial polyps and 23 carcinomas) associated with TAM exposure were analyzed for the presence and spectrum of p53 and K-ras mutations. ...

journal_title：Oncology reports

authors： Fujiwara K,Enomoto T,Fujita M,Kanda T,Fujii S,Ito K,Wakasa K,Ishiko O,Ueda M,Yamaguchi S,Kimura T,Umesaki N

更新日期：2008-05-01 00:00:00

abstract：:Garlic and its constituents are reported to have a preventive effect against colorectal cancer in animal models. Aged garlic extract (AGE), which is produced by natural extraction from fresh garlic for more than 10 months in aqueous ethanol, also has reputed chemopreventive effects on colon carcinogenesis, but has nev...

journal_title：Oncology reports

authors： Jikihara H,Qi G,Nozoe K,Hirokawa M,Sato H,Sugihara Y,Shimamoto F

更新日期：2015-03-01 00:00:00

abstract：:To evaluate the prognostic values of different protein expression in the progression of squamous cell carcinoma of the head and neck (SCCHN) patients, we conducted immunohistochemical (IHC) analysis in tissue samples of different patients enrolled on SWOG protocol S0420. S0420 was a phase II trial to evaluate the effi...

journal_title：Oncology reports

authors： Mehta S,Moon J,Hashmi M,Leblanc M,Huang CH,Rinehart E,Wolf GT,Urba SG,Banerjee SK,Williamson S

更新日期：2013-06-01 00:00:00

abstract：:Pien Tze Huang (PZH) is a well-known traditional Chinese formula that was first prescribed by a royal physician in the Ming Dynasty. PZH has been used to treat various types of cancers including osteosarcoma. Previous studies have shown that PZH may effectively inhibit osteosarcoma cell growth in vivo and in vitro via...

journal_title：Oncology reports

authors： Zhang Y,Wang Q,Niu S,Liu J,Zhang L

更新日期：2014-02-01 00:00:00

abstract：:Cancer represents a significant challenge for humankind, as early diagnosis and treatment are difficult to achieve. To systemically investigate the effect of sex, body mass index (BMI) and age on cancer incidence and prognosis, the data from 14,504 cases of cancer were downloaded from The Cancer Genome Atlas (TCGA). B...

journal_title：Oncology reports

authors： Huang X,Shu C,Chen L,Yao B

更新日期：2018-09-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDIs) as well as non-steroidal anti-inflammatory drugs including aspirin show promise as antineoplastic agents. The treatment with both HDIs and aspirin can result in hyperacetylation of proteins. In this study, we investigated whether HDIs and aspirin interacted in inducing anticancer ...

journal_title：Oncology reports

authors： Sonnemann J,Hüls I,Sigler M,Palani CD,Hong le TT,Völker U,Kroemer HK,Beck JF

更新日期：2008-07-01 00:00:00

abstract：:TRIM58 (tripartite motif containing 58) has been reported as a novel methylated gene in hepatocellular carcinoma (HCC) by methylation microarrays. However, its associations with mRNA expression and clinicopathological characteristics have not been evaluated. In this study, we explored the potential clinical implicatio...

journal_title：Oncology reports

authors： Qiu X,Huang Y,Zhou Y,Zheng F

更新日期：2016-08-01 00:00:00

abstract：:Activation of p53-independent pathways plays an important role in phytochemical-induced apoptosis and is considered to be a crucial factor in the invasion and metastasis of cancer. Previous studies have shown that combined effects of Stephania tetrandra with medicinal herbs exhibit beneficial effects in cancer patient...

journal_title：Oncology reports

authors： Yu VW,Ho WS

更新日期：2013-06-01 00:00:00

abstract：:Previously, we showed that the herbal extract EYK (Epimedium koreanum Nakai) can regulate the immune response. Other studies showed that EYK has beneficial effects in human lung cancer, angiogenesis and Alzheimer's disease (AD). However, it remains unknown whether EYK can affect cancer cell migration and invasion in h...

journal_title：Oncology reports

authors： Lee W,Nam JH,Cho HJ,Lee JY,Cho WK,Kim Υ,We YM,Ma JY,Hoe HS

更新日期：2017-12-01 00:00:00

abstract：:Treatment of patients affected by advanced or inoperable GIST was revolutionized by the use of the tyrosine kinase inhibitors. Despite the fact that most patients have a good durable response of disease, they develop a resistance to treatments after a median time of 24 months. The acquired resistance is an emerging as...

journal_title：Oncology reports

authors： Maleddu A,Pantaleo MA,Nannini M,Di Battista M,Saponara M,Lolli C,Biasco G

更新日期：2009-06-01 00:00:00

abstract：:Melanoma is the most aggressive cutaneous cancer due to its propensity to metastasise and proliferate. Melanoma accounts for 80‑90% of skin‑cancer related deaths worldwide. Alhough numerous published studies have attempted to define the markers of diagnosis and prognosis of melanoma, a sensitive and specific biomarker...

journal_title：Oncology reports

authors： Wei C,Lu N,Wang L,Zhang Y,Feng Z,Yang Y,Qi F,Gu J

更新日期：2018-06-01 00:00:00

abstract：:Secreted frizzled-related protein 1 (SFRP1) is a candidate tumor suppressor gene located at 8p11.2 and antagonizes the Wnt signaling pathway. Epigenetic inactivation of SFRP1 by methylation of its promoter CpG island has recently been reported in several types of cancers. In the present study, we examined the expressi...

journal_title：Oncology reports

authors： Awakura Y,Nakamura E,Ito N,Kamoto T,Ogawa O

更新日期：2008-11-01 00:00:00

abstract：:The mechanisms responsible for human inflammatory bowel disease remain poorly understood. The pathogenic factors for dextran sulfate sodium (DSS)-induced colitis, one of the experimental animal colitis models, also remain unknown. Furthermore, detailed studies on DSS metabolism in the gut lumen have not been reported....

journal_title：Oncology reports

authors： Araki Y,Bamba T,Mukaisho K,Kanauchi O,Ban H,Bamba S,Andoh A,Fujiyama Y,Hattori T,Sugihara H

更新日期：2012-11-01 00:00:00

abstract：:More than 80% of hepatocellular carcinoma (HCC) arises in HBV based liver cirrhotic patients, suggesting that patients with cirrhosis form the main risk group of HCC. α fetoprotein (AFP) has poor sensitivity for the detection of AFP-negative and/or small tumors in HCC patients. Screening serum markers, along with HCC ...

journal_title：Oncology reports

authors： Shu H,Kang X,Guo K,Li S,Li M,Sun L,Gan L,Liu Y,Qin X

更新日期：2010-11-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common type of primary central nervous system tumor in adults, which has high mortality and morbidity rates, and short survival time, namely <15 months after the diagnosis and application of standard therapy, which includes surgery, radiation therapy and chemotherapy; thus, novel therape...

journal_title：Oncology reports

authors： Yang K,Tang XJ,Xu FF,Liu JH,Tan YQ,Gao L,Sun Q,Ding X,Liu BH,Chen QX

更新日期：2020-03-01 00:00:00

abstract：:HIF-1 is a heterodimer consisting of the HIF-1alpha and HIF-1beta subunits, and HIF-1alpha is the unique oxygen regulated subunit that determines HIF-1 activity. HIF-1alpha upgrades many gene products which include the glucose transporter protein 1 (Glut-1). Immunohistochemical studies using a monoclonal antibody spec...

journal_title：Oncology reports

authors： Palit V,Phillips RM,Puri R,Shah T,Bibby MC

更新日期：2005-10-01 00:00:00