Abstract:
:Paternally expressed imprinted gene 1/mesoderm-specific transcript (PEG1/MEST) is an imprinted gene expressed from the paternal allele. Recently, frequent loss of imprinting (LOI) of PEG1/MEST has been reported in lung adenocarcinomas. It is suggested that the LOI may be involved in pathogenesis of lung adenocarcinoma. In the present study, incidence of LOI of PEG1/MEST was examined in lung cancer cell lines, including small cell lung cancer (SCLC). Among 50 cell lines tested, 20 cell lines were heterozygous for the AflIII site of the PEG1/MEST gene. In these heterozygotes, biallelic expression was observed in 9 cell lines (45%), monoallelic in 11 (55%). In cell lines of non-small cell lung cancer (NSCLC), 62% (8 of 13) exhibited biallelic expression. In SCLC, only 1 of 7 cell lines (14%) showed biallelic expression. LOI of PEG1/MEST in the NSCLC cell line is significantly frequent compared with that in SCLC cell lines (p=0.043). This result supports the possibility that LOI may be related to tumorigenesis and malignant transformation, especially in NSCLC.
journal_name
Oncol Repjournal_title
Oncology reportsauthors
Nakanishi H,Suda T,Katoh M,Watanabe A,Igishi T,Kodani M,Matsumoto S,Nakamoto M,Shigeoka Y,Okabe T,Oshimura M,Shimizu Ekeywords:
subject
Has Abstractpub_date
2004-12-01 00:00:00pages
1273-8issue
6eissn
1021-335Xissn
1791-2431journal_volume
12pub_type
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