Expression and cisplatin sensitivity of copper-transporting P-type adenosine triphosphatase (ATP7B) in human solid carcinoma cell lines.

abstract：:Human gonadotropin-releasing hormone receptor (GnRHR) and its natural ligand human gonadotropin-releasing hormone (GnRH) were initially described as signaling complexes that play a key role in reproductive functions. By binding to specific receptors present on pituitary gonadotropes, GnRH regulates the sperm and ovum ...

journal_title：Oncology reports

authors： Aguilar-Rojas A,Huerta-Reyes M

更新日期：2009-11-01 00:00:00

abstract：:The impact of interferon-γ (IFN-γ) late preconditioning on myocardial ischemia-reperfusion injury during cardiopulmonary bypass (CPB) and the underlying mechanism were investigated. Using a porcine model of myocardial ischemia-reperfusion injury during CPB with a 60-min aorta cross-clamp, 20 pigs (15±0.5 kg) were trea...

journal_title：Oncology reports

authors： Yan X,Qiu W,Jia B,Zhong H,Li X,Chen Z

更新日期：2013-11-01 00:00:00

abstract：:Bisphosphonates (BPs) inhibit bone resorption by preventing osteoclast maturation and apoptosis induction. Recently, BPs have also been shown to have antitumor effects against various types of carcinomas in vitro and in vivo. In this study, we investigated the antitumor effect of zoledronic acid (ZOL), a third generat...

journal_title：Oncology reports

authors： Tamura T,Shomori K,Nakabayashi M,Fujii N,Ryoke K,Ito H

更新日期：2011-04-01 00:00:00

abstract：:Telomerase activation is prevalent in most epithelial tumors, and may be a critical step in cellular immortalization and carcinogenesis. However, telomerase activity in tumors of mesenchymal origin is not well understood. In the present study, we examined telomerase activity in clinical samples from osteosarcoma and s...

journal_title：Oncology reports

authors： Terasaki T,Kyo S,Takakura M,Maida Y,Tsuchiya H,Tomita K,Inoue M

更新日期：2004-06-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations occur in a variety of human cancers, suggesting a possible role for mitochondrial respiratory functions in tumorigenesis. Recent studies have demonstrated that SDHD, a nuclear gene encoding one of the mitochondrial complex II subunits, acts as a tumor-suppressor for hereditary parag...

journal_title：Oncology reports

authors： Habano W,Sugai T,Nakamura S,Uesugi N,Higuchi T,Terashima M,Horiuchi S

更新日期：2003-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a common malignant cancer worldwide characterized by high metastatic potential and poor prognosis following radical resection. Metastasin is a Ca(2+)-binding protein associated with tumor metastasis. However, the expression and function of metastasin remain unknown. In the present stu...

journal_title：Oncology reports

authors： Zheng X,Gai X,Wu Z,Liu Q,Yao Y

更新日期：2013-05-01 00:00:00

abstract：:trans‑Resveratrol (Rsv) is a natural compound contained in red wine and grape skins that has various beneficial effects for organisms such as lengthening of their life span. Rsv induces expression of the human TP53 and HELB genes, which are involved in the regulation of DNA maintenance. In the present study, a lucifer...

journal_title：Oncology reports

authors： Uchiumi F,Katsuda C,Akui M,Kusaka M,Tanaka M,Asai M,Tanuma SI

更新日期：2020-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been shown to play an important role in diverse biological processes and cancer progression. The objective of the present study was to investigate the role of miR-497 in ovarian cancer angiogenesis. We found that miR-497 expression was downregulated in human ovarian cancer tissues, and the low ...

journal_title：Oncology reports

authors： Wang W,Ren F,Wu Q,Jiang D,Li H,Shi H

更新日期：2014-11-01 00:00:00

abstract：:A phase I study of S-1 and biweekly docetaxel (DOC) combination therapy was conducted to determine the maximum tolerated dose (MTD) and pharmacokinetic parameters. Fourteen patients with advanced or recurrent gastric cancer were analyzed. The treatment consisted of S-1 [body surface area (BSA) <1.25 m2:80 mg/day, 1.25...

journal_title：Oncology reports

authors： Takahashi I,Emi Y,Kakeji Y,Tokunaga E,Ushiro S,Oki E,Watanabe M,Baba H,Maehara Y

更新日期：2006-04-01 00:00:00

abstract：:Neuropilin-1 (NRP-1), a co-receptor for VEGF165, is overexpressed in various prostate cancer cell lines and in advanced prostate tumors. However, distribution of the NRP-1 in prostate tumors has not yet been evaluated. Using immunohistochemical analysis, we evaluated 21 archival prostate tumors and 5 benign glands for...

journal_title：Oncology reports

authors： Vanveldhuizen PJ,Zulfiqar M,Banerjee S,Cherian R,Saxena NK,Rabe A,Thrasher JB,Banerjee SK

更新日期：2003-09-01 00:00:00

abstract：:Semaphorin 3A (SEMA3A), a secretory protein, is a founding member of the semaphorin family and functions in both the biological behavior of tumor cells and the modulation of tumor-associated macrophages. However, the role of SEMA3A in hepatocellular carcinoma (HCC) is still not well established. In the present study, ...

journal_title：Oncology reports

authors： Li X,Chen Q,Yin D,Shi S,Yu L,Zhou S,Chen E,Zhou Z,Shi Y,Fan J,Zhou J,Dai Z

更新日期：2017-06-01 00:00:00

abstract：:Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in several types of cancers. In non-small cell lung cancer (NSCLC), several genes are known to be frequently methylated and the correlation of their methylation with clinical features has been stud...

journal_title：Oncology reports

authors： Hanabata T,Tsukuda K,Toyooka S,Yano M,Aoe M,Nagahiro I,Sano Y,Date H,Shimizu N

更新日期：2004-07-01 00:00:00

abstract：:Multigene-based combination therapy may be an effective practice in cancer gene therapy. Substantial studies have demonstrated that tumor suppressor p53 acetylation is indispensable for p53 activation. Inhibitor of growth 4 (ING4), as a novel tumor suppressor, is capable of remarkably enhancing p53 acetylation and its...

journal_title：Oncology reports

authors： Wu J,Zhu Y,Xu C,Xu H,Zhou X,Yang J,Xie Y,Tao M

更新日期：2016-01-01 00:00:00

abstract：:OCT4B1, a splice variant of OCT4, is a key regulator in maintaining the properties of pluripotency and self-renewal in embryonic stem (ES) cells. Recent results have shown that OCT4B1 is involved in tumorigenesis. However, the contribution of OCT4B1 in the tumorigenesis and drug resistance of colon cancer remains to b...

journal_title：Oncology reports

authors： Wen KM,Zhang GH,Li J,Chen ZQ,Cheng YL,Su X,Zeng QL

更新日期：2015-12-01 00:00:00

abstract：:It has been recently reported that side population (SP) cells in nasopharyngeal carcinoma (NPC) cell lines display characteristics of cancer stem-like cells. However, the biological behavior and the significance of these cells for NPC progression remain unclear. In this study, we is...

journal_title：Oncology reports

authors： Guo D,Xu BL,Zhang XH,Dong MM

更新日期：2012-07-01 00:00:00

abstract：:Few studies on sarcomas have examined the relationships between microsatellite alterations in particular loci, tumor prognosis and tumorigenesis, because sarcomas are uncommon and those prognoses can be confounded by coexisting factors, such as tumor site. We studied the relationship between microsatellite alterations...

journal_title：Oncology reports

authors： Iyoda A,Hiroshima K,Toyozaki T,Baba M,Fujisawa T,Yusa T,Ohwada H

更新日期：2001-07-01 00:00:00

abstract：:Breast cancer is the most common cancer in women worldwide. Progression and aggressiveness of breast cancer is usually associated with its migration and invasion abilities. Recently, natural products with potential anticancer activity have become attractive candidates for alternative treatment of cancer. A fungal meta...

journal_title：Oncology reports

authors： Kasorn A,Loison F,Kangsamaksin T,Jongrungruangchok S,Ponglikitmongkol M

更新日期：2018-03-01 00:00:00

abstract：:microRNAs (miRNAs), small non-coding RNAs, have emerged as key regulators of a large number of genes. The present study aimed to explore novel biological functions of miR-330 in the human prostate cancer cell lines DU145 and PC3. We confirmed that miR-330 was downregulated and inversely correlated with specificity pro...

journal_title：Oncology reports

authors： Mao Y,Chen H,Lin Y,Xu X,Hu Z,Zhu Y,Wu J,Xu X,Zheng X,Xie L

更新日期：2013-07-01 00:00:00

abstract：:Thyroid cancer is the most commonly diagnosed malignancy of the endocrine system, the incidence of which has increased rapidly in the last 30 years. Genetic alterations in pathways, including the mitogen‑activated protein kinase (MAPK)/extracellular signal‑regulated kinase (Erk) and phosphatidylinositol‑3‑kinase (PI3K...

journal_title：Oncology reports

authors： Chen H,Chen W,Zhang X,Hu L,Tang G,Kong J,Wang Z

更新日期：2019-01-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor-γ (PPAR-γ) coactivator-1β (PGC-1β) is a well-established regulator of mitochondrial biogenesis. However, the underlying mechanism of PGC-1β action remains elusive. This study reveals that knockdown of endogenous PGC-1β by short-hairpin RNA (shRNA) leads to a decrease in t...

journal_title：Oncology reports

authors： Wang L,Liu Q,Li F,Qiu J,Fan H,Ma H,Zhu Y,Wu L,Han X,Yang Z,Jiang H,Wei J,Xia H

更新日期：2013-10-01 00:00:00

abstract：:Esophageal cancer is one of the most aggressive cancers in the world. Novel preventive and therapeutic strategies tend to target the key molecules involved in the signaling transduction pathways for cell growth. It is known that FAK and mTOR are important controllers of cell growth. TAE226, a novel small molecule comp...

journal_title：Oncology reports

authors： Wang ZG,Fukazawa T,Nishikawa T,Watanabe N,Sakurama K,Motoki T,Takaoka M,Hatakeyama S,Omori O,Ohara T,Tanabe S,Fujiwara Y,Shirakawa Y,Yamatsuji T,Tanaka N,Naomoto Y

更新日期：2008-12-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an important mediator of tumor angiogenesis. A high serum VEGF level has been shown to predict poor response to chemotherapy and poor survival in several cancers, but its prognostic value in hepatocellular carcinoma (HCC) remains unknown. We conducted a prospective study to...

journal_title：Oncology reports

authors： Poon RT,Lau C,Yu WC,Fan ST,Wong J

更新日期：2004-05-01 00:00:00

abstract：:Different members of the Ets-family of transcription factors are involved in TMPRSS-2-Ets translocations frequently found in human prostate cancers. We previously reported that Ets-1, which is the prototype of Ets-family members, promotes both migration and invasion of melanoma, Hela and glioma cells. Here, we examine...

journal_title：Oncology reports

authors： Shaikhibrahim Z,Langer B,Lindstrot A,Florin A,Bosserhoff A,Buettner R,Wernert N

更新日期：2011-04-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-mediated signaling is a newly recognized clinical target in prostate cancer, and it is hypothesized that blockade of the IGF receptor (IGF1R) will impair downstream signaling and slow tumor growth. In this study the efficacy of nordihydroguaiaretic a...

journal_title：Oncology reports

authors： Friedlander TW,Weinberg VK,Huang Y,Mi JT,Formaker CG,Small EJ,Harzstark AL,Lin AM,Fong L,Ryan CJ

更新日期：2012-01-01 00:00:00

abstract：:We previously reported that chromosome arm 10q is one of the target regions of allelic loss in human endometrial cancer. To identify the gene in this region responsible for endometrial cancer, we further characterized this region and localized the hBRAG gene. The function of hBRAG has not yet been fully studied, and t...

journal_title：Oncology reports

authors： Yuki M,Yoshinaga K,Yamakawa H,Sakurada K,Sato S,Yajima A,Horii A

更新日期：2000-11-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor, which was confirmed as a tumor suppressor gene in colorectal cancers. KLF4 inhibits colorectal cancer cells proliferation through upregulating p21WAF1/Cip1 and downregulating cyclin D1. We firstly reported that N-Myc downstream regulated gene 2 (NDRG2...

journal_title：Oncology reports

authors： Ma Y,Wu L,Liu X,Xu Y,Shi W,Liang Y,Yao L,Zheng J,Zhang J

更新日期：2017-08-01 00:00:00

abstract：:Hydrogen sulfide (H2S) participates in multifarious physiological and pathophysiologic progresses of cancer both in vitro and in vivo. We have previously demonstrated that exogenous H2S promoted liver cancer cells proliferation/anti‑apoptosis/angiogenesis/migration effects via amplifying the activation of NF-κB pathwa...

journal_title：Oncology reports

authors： Zhen Y,Zhang W,Liu C,He J,Lu Y,Guo R,Feng J,Zhang Y,Chen J

更新日期：2015-11-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are known to migrate to tumor tissues and to play an important role in cancer progression. However, the effects of MSCs on tumor progression remain controversial. The purpose of the present study was to detect the effects of human umbilical cord-derived MSCs (hUC‑MSCs) on the human breast...

journal_title：Oncology reports

authors： Li T,Zhang C,Ding Y,Zhai W,Liu K,Bu F,Tu T,Sun L,Zhu W,Zhou F,Qi W,Hu J,Chen H,Sun X

更新日期：2015-09-01 00:00:00

abstract：:Owing to aggressiveness and chemoresistance, pancreatic ductal adenocarcinoma (PDAC) is characterised by a poor prognosis. To address this disease-spe-cific dilemma we aimed to establish animal models, which can be used for identifying new specific tumor markers, as well as serving ...

journal_title：Oncology reports

authors： Eyol E,Murtaga A,Zhivkova-Galunska M,Georges R,Zepp M,Djandji D,Kleeff J,Berger MR,Adwan H

更新日期：2012-12-01 00:00:00

abstract：:We hypothesized that expression of multidrug resistance-associated protein 2 (MRP2), a major cisplatin transporter, may determine the efficacy of cisplatin as a treatment for patients with hepatocellular carcinoma (HCC). A prospective analysis was conducted of 49 consecutive patients who underwent resection for HCC (1...

journal_title：Oncology reports

authors： Korita PV,Wakai T,Shirai Y,Matsuda Y,Sakata J,Takamura M,Yano M,Sanpei A,Aoyagi Y,Hatakeyama K,Ajioka Y

更新日期：2010-04-01 00:00:00